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Bioorganic and Medicinal Chemistry Letters

Volumn 26, Issue 1, 2016, Pages 15-20

Discovery of the imidazole-derived GPR40 agonist AM-3189

(18) Ma, Zhihua a Lin, Daniel C H a Sharma, Rajiv a Liu, Jinqian a Zhu, Liusheng a Li, An Rong a Kohn, Todd a Wang, Yingcai a Liu, Jiwen a Bartberger, Michael D a Medina, Julio C a Zhuang, Run a Li, Frank a Zhang, Jane a Luo, Jian a Wong, Simon a Tonn, George R a Houze, Jonathan B a

a AMGEN INC (United States)

Author keywords

Agonist; AM 3189; AMG 837; FFAR1; GPCR; GPR40; Insulin secretagogue; Type II diabetes

Indexed keywords

AM 3189; ANTIDIABETIC AGENT; G PROTEIN COUPLED RECEPTOR 40; GLUCOSE; UNCLASSIFIED DRUG; AM-3189; FFAR1 PROTEIN, HUMAN; G PROTEIN COUPLED RECEPTOR; IMIDAZOLE; IMIDAZOLE DERIVATIVE;

ARTICLE; CHO CELL LINE; DRUG EFFICACY; ENANTIOMER; FOLLOW UP; GLUCOSE BLOOD LEVEL; IN VIVO STUDY; INSULIN RELEASE; LIGAND BINDING; NON INSULIN DEPENDENT DIABETES MELLITUS; RACEMIC MIXTURE; STRUCTURE ACTIVITY RELATION; SUZUKI REACTION; AGONISTS; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; DOG; DOSE RESPONSE; DRUG DEVELOPMENT; HUMAN; MACACA FASCICULARIS; MOUSE; RAT; SYNTHESIS;

ANIMALS; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; HUMANS; IMIDAZOLES; MACACA FASCICULARIS; MICE; MOLECULAR STRUCTURE; RATS; RECEPTORS, G-PROTEIN-COUPLED; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84949604818 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2015.11.050 Document Type: Article

Times cited : (17)

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