Discovery of TUG-770: A highly potent free fatty acid receptor 1 (FFA1/GPR40) agonist for treatment of type 2 diabetes

ACS Medicinal Chemistry Letters

Volumn 4, Issue 5, 2013, Pages 441-445

  Christiansen, Elisabeth ^a   Hansen, Steffen V F ^a   Urban, Christian ^b   Hudson, Brian D ^c   Wargent, Edward T ^d   Grundmann, Manuel ^e   Jenkins, Laura ^c   Zaibi, Mohamed ^d   Stocker, Claire J ^d   Ullrich, Susanne ^f   Kostenis, Evi ^e   Kassack, Matthias U ^b   Milligan, Graeme ^c   Cawthorne, Michael A ^d   Ulven, Trond ^a  

^a UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^b HEINRICH HEINE UNIVERSITY   (Germany)

^c UNIVERSITY OF GLASGOW   (United Kingdom)

^d UNIVERSITY OF BUCKINGHAM   (United Kingdom)

^e UNIVERSITY OF BONN   (Germany)

^f UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

FFA1 agonist; free fatty acid receptor; GPR40 agonist; insulin secretagogue; TUG 770; Type 2 diabetes

Indexed keywords

ANTIDIABETIC AGENT; G PROTEIN COUPLED RECEPTOR 40; GLUCOSE; INSULIN; SITAGLIPTIN; TUG 770; UNCLASSIFIED DRUG;

ARTICLE; DIET; DRUG SYNTHESIS; GLUCOSE TOLERANCE; INSULIN RELEASE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PANCREAS ISLET BETA CELL; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; TREATMENT DURATION;

EID: 84877710397     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml4000673     Document Type: Article

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