Design, synthesis, and biological activity of potent and orally available g protein-coupled receptor 40 agonists

Journal of Medicinal Chemistry

Volumn 54, Issue 5, 2011, Pages 1365-1378

  Sasaki, Shinobu ^a   Kitamura, Shuji ^a   Negoro, Nobuyuki ^a   Suzuki, Masami ^a   Tsujihata, Yoshiyuki ^a   Suzuki, Nobuhiro ^a   Santou, Takashi ^a   Kanzaki, Naoyuki ^a   Harada, Masataka ^a   Tanaka, Yasuhiro ^a   Kobayashi, Makoto ^a   Tada, Norio ^a   Funami, Miyuki ^a   Tanaka, Toshimasa ^a   Yamamoto, Yoshio ^a   Fukatsu, Kohji ^a   Yasuma, Tsuneo ^a   Momose, Yu ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

3 [4 (BIPHENYL 2 YLMETHOXY)PHENYL]PROPANOIC ACID; 3 [4 (BIPHENYL 3 YLMETHOXY)PHENYL]PROPANOIC ACID; 3 [4 (BIPHENYL 4 YLMETHOXY)PHENYL]PROPANOIC ACID; 3 [4 [(2 PHENOXYBENZYL)OXY]PHENYL]PROPANOIC ACID; 3 [4 [(2' FLUOROBIPHENYL 3 YL)METHOXY]PHENYL]PROPANOIC ACID; 3 [4 [(2' METHOXYBIPHENYL 3 YL)METHOXY]PHENYL]PROPANOIC ACID; 3 [4 [(2' METHYLBIPHENYL 3 YL)METHOXY]PHENYL]PROPANOIC ACID; 3 [4 [(2',6' DIMETHYLBIPHENYL 3 YL)METHOXY] 2 FLUOROPHENYL]PROPANOIC ACID; 3 [4 [(2',6' DIMETHYLBIPHENYL 3 YL)METHOXY] 2 METHOXYPHENYL]PROPANOIC ACID; 3 [4 [(2',6' DIMETHYLBIPHENYL 3 YL)METHOXY] 2 METHYLPHENYL]PROPANOIC ACID; 3 [4 [(2',6' DIMETHYLBIPHENYL 3 YL)METHOXY] 2,6 DIFLUOROPHENYL]PROPANOIC ACID; 3 [4 [(2',6' DIMETHYLBIPHENYL 3 YL)METHOXY]PHENYL] 2 METHYLPROPANOIC ACID; 3 [4 [(2',6' DIMETHYLBIPHENYL 3 YL)METHOXY]PHENYL]BUTANOIC ACID; 3 [4 [(3 PHENOXYBENZYL)OXY]PHENYL]PROPANOIC ACID; 3 [4 [(3' METHYLBIPHENYL 3 YL)METHOXY]PHENYL]PROPANOIC ACID; 3 [4 [(4 PHENOXYBENZYL)OXY]PHENYL]PROPANOIC ACID; 3 [4 [(4' METHYLBIPHENYL 3 YL)METHOXY]PHENYL]PROPANOIC ACID; 3 [4 [[(2',6' DIMETHYLBIPHENYL 3 YL)METHYL]SULFANYL]PHENYL]PROPANOIC ACID; 3 [4 [[3 (2 METHYLPHENOXY)BENZYL]OXY]PHENYL]PROPANOIC ACID; 3 [4 [[3 (2 PHENYLETHOXY)BENZYL]OXY]PHENYL]PROPANOIC ACID; 3 [4 [[3 (2,6 DIMETHYLPHENOXY)BENZYL]OXY]PHENYL]PROPANOIC ACID; 3 [4 [[3 (3 METHYLPHENOXY)BENZYL]OXY]PHENYL]PROPANOIC ACID; 3 [4 [[3 (4 METHYLPHENOXY)BENZYL]OXY]PHENYL]PROPANOIC ACID; 3 [4 [[3 (BENZYLOXY)BENZYL]OXY]PHENYL]PROPANOIC ACID; ANTIDIABETIC AGENT; G PROTEIN COUPLED RECEPTOR 40 AGONIST; METHYL 3 [4 [(3 BROMOBENZYL)OXY]PHENYL]PROPANOIC ACID; PROPIONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHEMICAL MODIFICATION; CHO CELL; CONTROLLED STUDY; DIABETES MELLITUS; DRUG ACTIVITY; DRUG DESIGN; DRUG EFFECT; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; MALE; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; RAT;

ADMINISTRATION, ORAL; ANIMALS; BIPHENYL COMPOUNDS; BLOOD GLUCOSE; CHO CELLS; CRICETINAE; CRICETULUS; DIABETES MELLITUS, EXPERIMENTAL; DRUG DESIGN; GLUCOSE TOLERANCE TEST; HUMANS; HYPOGLYCEMIC AGENTS; MALE; PHENYLPROPIONATES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, G-PROTEIN-COUPLED; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79952261037     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm101405t     Document Type: Article

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