New insights on the use of dietary polyphenols or probiotics for the management of arterial hypertension

Frontiers in Physiology

Volumn 7, Issue OCT, 2016, Pages

  Alves, José L de Brito ^a,b   de Sousa, Vanessa P ^a   Neto, Marinaldo P Cavalcanti ^c   Magnani, Marciane ^a   Braga, Valdir de Andrade ^a   da Costa Silva, João H ^d   Leandro, Carol G ^d   Vidal, Hubert ^b   Pirola, Luciano ^b  

^a FEDERAL UNIVERSITY OF PARAÍBA   (Brazil)

^b UNIVERSITÉ LYON 1   (France)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

^d FEDERAL UNIVERSITY OF PERNAMBUCO   (Brazil)

Author keywords

Blood pressure; Dietary polyphenols; Hypertension; Probiotics

Indexed keywords

DIETARY POLYPHENOL; HESPERIDIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; POLYPHENOL; PROBIOTIC AGENT; QUERCETIN; RESVERATROL; UNCLASSIFIED DRUG;

ANTIHYPERTENSIVE ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; BIFIDOBACTERIUM; BLOOD PRESSURE REGULATION; DIET SUPPLEMENTATION; DIETARY INTAKE; DRUG EFFECT; DRUG MECHANISM; EXPERIMENTAL STUDY; HEART PROTECTION; HUMAN; HYPERTENSION; INTESTINE FLORA; INTESTINE MUCOSA PERMEABILITY; LACTOBACILLUS; LACTOBACILLUS CORYNIFORMIS; LACTOBACILLUS FERMENTUM; LACTOBACILLUS PLANTARUM; NONHUMAN; OUTCOME ASSESSMENT; OXIDATIVE STRESS; PROTEIN EXPRESSION; SACCHAROMYCES BOULARDII; SHORT SURVEY; SYSTOLIC BLOOD PRESSURE;

EID: 84995960765     PISSN: None     EISSN: 1664042X     Source Type: Journal    
DOI: 10.3389/fphys.2016.00448     Document Type: Short Survey

References (82)

1. Agrawal, Y. O., Sharma, P. K., Shrivastava, B., Ojha, S., Upadhya, H. M., Arya, D. S., et al. (2014). Hesperidin produces cardioprotective activity via PPAR-gamma pathway in ischemic heart disease model in diabetic rats. PLoS ONE 9:e111212. doi: 10.1371/journal.pone.0111212
2. Ahrén, I. L., Xu, J., Önning, G., Olsson, C., Ahrné, S., and Molin, G. (2015). Antihypertensive activity of blueberries fermented by Lactobacillus plantarum DSM 15313 and effects on the gut microbiota in healthy rats. Clin. Nutr. 34, 719-726. doi: 10.1016/j.clnu.2014.08.009
3. Amiot, M. J., Riva, C., and Vinet, A. (2016). Effects of dietary polyphenols on metabolic syndrome features in humans: a systematic review. Obes. Rev. 17, 573-586. doi: 10.1111/obr.12409
4. Anhê, F. F., Pilon, G., Roy, D., Desjardins, Y., Levy, E., and Marette, A. (2016). Triggering Akkermansia with dietary polyphenols: a new weapon to combat the metabolic syndrome? Gut Microbes 7, 146-153. doi: 10.1080/19490976.2016.1142036
5. Anhê, F. F., Roy, D., Pilon, G., Dudonné, S., Matamoros, S., Varin, T. V., et al. (2015). A polyphenol-rich cranberry extract protects from diet-induced obesity, insulin resistance and intestinal inflammation in association with increased Akkermansia spp. population in the gut microbiota of mice. Gut 64, 872-883. doi: 10.1136/gutjnl-2014-307142
6. Annuzzi, G., Bozzetto, L., Costabile, G., Giacco, R., Mangione, A., Anniballi, G., et al. (2014). Diets naturally rich in polyphenols improve fasting and postprandial dyslipidemia and reduce oxidative stress: a randomized controlled trial. Am. J. Clin. Nutr. 99, 463-471. doi: 10.3945/ajcn.113.073445
7. Bäckhed, F., Ding, H., Wang, T., Hooper, L. V., Koh, G. Y., Nagy, A., et al. (2004). The gut microbiota as an environmental factor that regulates fat storage. Proc. Natl. Acad. Sci. U.S.A. 101, 15718-15723. doi: 10.1073/pnas.0407076101
8. Barreto, F. M., Colado Simão, A. N., Morimoto, H. K., Batisti Lozovoy, M. A., Dichi, I., and Helena da Silva Miglioranza, L. (2014). Beneficial effects of Lactobacillus plantarum on glycemia and homocysteine levels in postmenopausal women with metabolic syndrome. Nutrition 30, 939-942. doi: 10.1016/j.nut.2013.12.004
9. Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A., Lerin, C., Kalra, A., et al. (2006). Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444, 337-342. doi: 10.1038/nature05354
10. Bjerregaard, P. (2010). Nutritional transition-where do we go from here? J. Hum. Nutr. Diet. 23(Suppl. 1), 1-2. doi: 10.1111/j.1365-277X.2010.01091.x
11. Blanton, C., He, Z., Gottschall-Pass, K. T., and Sweeney, M. I. (2015). Probiotics blunt the anti-hypertensive effect of blueberry feeding in hypertensive rats without altering hippuric acid production. PLoS ONE 10:e0142036. doi: 10.1371/journal.pone.0142036
12. Brüll, V., Burak, C., Stoffel-Wagner, B., Wolffram, S., Nickenig, G., Muller, C., et al. (2015). Effects of a quercetin-rich onion skin extract on 24 h ambulatory blood pressure and endothelial function in overweight-to-obese patients with (pre-)hypertension: a randomised double-blinded placebo-controlled cross-over trial. Br. J. Nutr. 114, 1263-1277. doi: 10.1017/S0007114515002950
13. Brüll, V., Burak, C., Stoffel-Wagner, B., Wolffram, S., Nickenig, G., Muller, C., et al. (2016). Acute intake of quercetin from onion skin extract does not influence postprandial blood pressure and endothelial function in overweight-to-obese adults with hypertension: a randomized, double-blind, placebo-controlled, crossover trial. Eur. J. Nutr. doi: 10.1007/s00394-016-1185-1. [Epub ahead of print].
14. Buettner, R., Schölmerich, J., and Bollheimer, L. C. (2007). High-fat diets: modeling the metabolic disorders of human obesity in rodents. Obesity (Silver. Spring). 15, 798-808. doi: 10.1038/oby.2007.608
15. Cani, P. D. (2014). Metabolism in 2013: The gut microbiota manages host metabolism. Nat. Rev. Endocrinol. 10, 74-76. doi: 10.1038/nrendo.2013.240
16. Care, A. S., Sung, M. M., Panahi, S., Gragasin, F. S., Dyck, J. R., Davidge, S. T., et al. (2016). Perinatal resveratrol supplementation to spontaneously hypertensive rat dams mitigates the development of hypertension in adult offspring. Hypertension 67, 1038-1044. doi: 10.1161/HYPERTENSIONAHA.115.06793
17. Carthy, E. R. (2014). Autonomic dysfunction in essential hypertension: a systematic review. Ann. Med. Surg. (Lond.). 3, 2-7. doi: 10.1016/j.amsu.2013.11.002
18. Champagne, C. P., Ross, R. P., Saarela, M., Hansen, K. F., and Charalampopoulos, D. (2011). Recommendations for the viability assessment of probiotics as concentrated cultures and in food matrices. Int. J. Food Microbiol. 149, 185-193. doi: 10.1016/j.ijfoodmicro.2011.07.005
19. Chen, S., Zhao, X., Ran, L., Wan, J., Wang, X., Qin, Y., et al. (2015). Resveratrol improves insulin resistance, glucose and lipid metabolism in patients with non-alcoholic fatty liver disease: a randomized controlled trial. Dig. Liver Dis. 47, 226-232. doi: 10.1016/j.dld.2014.11.015
20. Choi, J. S., Islam, M. N., Ali, M. Y., Kim, E. J., Kim, Y. M., and Jung, H. A. (2014). Effects of C-glycosylation on anti-diabetic, anti-Alzheimer's disease and anti-inflammatory potential of apigenin. Food Chem. Toxicol. 64, 27-33. doi: 10.1016/j.fct.2013.11.020
21. Corry, D. B., and Tuck, M. L. (1999). Obesity, hypertension, and sympathetic nervous system activity. Curr. Hypertens. Rep. 1, 119-126. doi: 10.1007/s11906-999-0005-x
22. Davinelli, S., and Scapagnini, G. (2016). Polyphenols: a Promising Nutritional Approach to Prevent or Reduce the Progression of Prehypertension. High Blood Press. Cardiovasc. Prev. 23, 197-202. doi: 10.1007/s40292-016-0149-0
23. de Brito Alves, J. L., Nogueira, V. O., Cavalcanti Neto, M. P., Leopoldino, A. M., Curti, C., Colombari, D. S., et al. (2015). Maternal protein restriction increases respiratory and sympathetic activities and sensitizes peripheral chemoreflex in male rat offspring. J. Nutr. 145, 907-914. doi: 10.3945/jn.114.202804
24. Ding, S., Chi, M. M., Scull, B. P., Rigby, R., Schwerbrock, N. M., Magness, S., et al. (2010). High-fat diet: bacteria interactions promote intestinal inflammation which precedes and correlates with obesity and insulin resistance in mouse. PLoS ONE 5:e12191. doi: 10.1371/journal.pone.0012191
25. Dolinsky, V. W., Chakrabarti, S., Pereira, T. J., Oka, T., Levasseur, J., Beker, D., et al. (2013). Resveratrol prevents hypertension and cardiac hypertrophy in hypertensive rats and mice. Biochim. Biophys. Acta 1832, 1723-1733. doi: 10.1016/j.bbadis.2013.05.018
26. Edwards, R. L., Lyon, T., Litwin, S. E., Rabovsky, A., Symons, J. D., and Jalili, T. (2007). Quercetin reduces blood pressure in hypertensive subjects. J. Nutr. 137, 2405-2411.
27. Estruch, R., Ros, E., and Martinez-Gonzalez, M. A. (2013). Mediterranean diet for primary prevention of cardiovascular disease. N. Engl. J. Med. 369, 676-677. doi: 10.1056/nejmoa1200303
28. Ettinger, G., MacDonald, K., Reid, G., and Burton, J. P. (2014). The influence of the human microbiome and probiotics on cardiovascular health. Gut Microbes 5, 719-728. doi: 10.4161/19490976.2014.983775
29. Faghihzadeh, F., Adibi, P., and Hekmatdoost, A. (2015). The effects of resveratrol supplementation on cardiovascular risk factors in patients with non-alcoholic fatty liver disease: a randomised, double-blind, placebo-controlled study. Br. J. Nutr. 114, 796-803. doi: 10.1017/S0007114515002433
30. Fröjdö, S., Durand, C., and Pirola, L. (2008). Metabolic effects of resveratrol in mammals-a link between improved insulin action and aging. Curr. Aging Sci. 1, 145-151. doi: 10.2174/1874609810801030145
31. Gómez-Guzmán, M., Toral, M., Romero, M., Jiménez, R., Galindo, P., Sánchez, M., et al. (2015). Antihypertensive effects of probiotics Lactobacillus strains in spontaneously hypertensive rats. Mol. Nutr. Food Res. 59, 2326-2336. doi: 10.1002/mnfr.201500290
32. Grosso, G., Stepaniak, U., Micek, A., Stefler, D., Bobak, M., and Pajak, A. (2016). Dietary polyphenols are inversely associated with metabolic syndrome in Polish adults of the HAPIEE study. Eur. J. Nutr. doi: 10.1007/s00394-016-1187-z. [Epub ahead of print].
33. Hariri, M., Salehi, R., Feizi, A., Mirlohi, M., Kamali, S., and Ghiasvand, R. (2015). The effect of probiotic soy milk and soy milk on anthropometric measures and blood pressure in patients with type II diabetes mellitus: a randomized double-blind clinical trial. ARYA Atheroscler. 11, 74-80.
34. Hedner, T., Kjeldsen, S. E., and Narkiewicz, K. (2012). State of global health-hypertension burden and control. Blood Press 21(Suppl 1), 1-2. doi: 10.3109/08037051.2012.704786
35. Hertog, M. G., Feskens, E. J., Hollman, P. C., Katan, M. B., and Kromhout, D. (1993). Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study. Lancet 342, 1007-1011. doi: 10.1016/0140-6736(93)92876-U
36. Ikemura, M., Sasaki, Y., Giddings, J. C., and Yamamoto, J. (2012). Preventive effects of hesperidin, glucosyl hesperidin and naringin on hypertension and cerebral thrombosis in stroke-prone spontaneously hypertensive rats. Phytother. Res. 26, 1272-1277. doi: 10.1002/ptr.3724
37. Ingram, D. K., Zhu, M., Mamczarz, J., Zou, S., Lane, M. A., Roth, G. S., et al. (2006). Calorie restriction mimetics: an emerging research field. Aging Cell 5, 97-108. doi: 10.1111/j.1474-9726.2006.00202.x
38. Ivey, K. L., Hodgson, J. M., Kerr, D. A., Thompson, P. L., Stojceski, B., and Prince, R. L. (2015). The effect of yoghurt and its probiotics on blood pressure and serum lipid profile; a randomised controlled trial. Nutr. Metab. Cardiovasc. Dis. 25, 46-51. doi: 10.1016/j.numecd.2014.07.012
39. Jang, M., Cai, L., Udeani, G. O., Slowing, K. V., Thomas, C. F., Beecher, C. W., et al. (1997). Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science 275, 218-220. doi: 10.1126/science.275.5297.218
40. Jankovic, I., Sybesma, W., Phothirath, P., Ananta, E., and Mercenier, A. (2010). Application of probiotics in food products-challenges and new approaches. Curr. Opin. Biotechnol. 21, 175-181. doi: 10.1016/j.copbio.2010.03.009
41. Jose, P. A., and Raj, D. (2015). Gut microbiota in hypertension. Curr. Opin. Nephrol. Hypertens. 24, 403-409. doi: 10.1097/MNH.0000000000000149
42. Khalesi, S., Sun, J., Buys, N., and Jayasinghe, R. (2014). Effect of probiotics on blood pressure: a systematic review and meta-analysis of randomized, controlled trials. Hypertension 64, 897-903. doi: 10.1161/HYPERTENSIONAHA.114.03469
43. Lilly, D. M., and Stillwell, R. H. (1965). Probiotics: growth-promoting factors produced by microorganisms. Science 147, 747-748. doi: 10.1126/science.147.3659.747
44. Liu, Y., Ma, W., Zhang, P., He, S., and Huang, D. (2015). Effect of resveratrol on blood pressure: a meta-analysis of randomized controlled trials. Clin. Nutr. 34, 27-34. doi: 10.1016/j.clnu.2014.03.009
45. Lockyer, S., Corona, G., Yaqoob, P., Spencer, J. P., and Rowland, I. (2015). Secoiridoids delivered as olive leaf extract induce acute improvements in human vascular function and reduction of an inflammatory cytokine: a randomised, double-blind, placebo-controlled, cross-over trial. Br. J. Nutr. 114, 75-83. doi: 10.1017/S0007114515001269
46. Lockyer, S., Rowland, I., Spencer, J. P., Yaqoob, P., and Stonehouse, W. (2016). Impact of phenolic-rich olive leaf extract on blood pressure, plasma lipids and inflammatory markers: a randomised controlled trial. Eur. J. Nutr. doi: 10.1007/s00394-016-1188-y. [Epub ahead of print].
47. Mahboobi, S., Iraj, B., Maghsoudi, Z., Feizi, A., Ghiasvand, R., Askari, G., et al. (2014). The effects of probiotic supplementation on markers of blood lipids, and blood pressure in patients with prediabetes: a randomized clinical trial. Int. J. Prev. Med. 5, 1239-1246.
48. Medina-Remón, A., Casas, R., Tressserra-Rimbau, A., Ros, E., Martínez-González, M. A., Fitó, M., et al. (2016). Polyphenol intake from a Mediterranean diet decreases inflammatory biomarkers related to atherosclerosis: A sub-study of The PREDIMED trial. Br. J. Clin. Pharmacol. doi: 10.1111/bcp.12986. [Epub ahead of print].
49. Mell, B., Jala, V. R., Mathew, A. V., Byun, J., Waghulde, H., Zhang, Y., et al. (2015). Evidence for a link between gut microbiota and hypertension in the Dahl rat. Physiol. Genomics 47, 187-197. doi: 10.1152/physiolgenomics.00136.2014
50. Mendes-Junior, L., Monteiro, M. M., Carvalho Ados, S., de Queiroz, T. M., and Braga Vde, A. (2013). Oral supplementation with the rutin improves cardiovagal baroreflex sensitivity and vascular reactivity in hypertensive rats. Appl. Physiol. Nutr. Metab. 38, 1099-1106. doi: 10.1139/apnm-2013-0091
51. Mogollon, J. A., Bujold, E., Lemieux, S., Bourdages, M., Blanchet, C., Bazinet, L., et al. (2013). Blood pressure and endothelial function in healthy, pregnant women after acute and daily consumption of flavanol-rich chocolate: a pilot, randomized controlled trial. Nutr. J. 12:41. doi: 10.1186/1475-2891-12-41
52. Moreno-Luna, R., Munoz-Hernandez, R., Miranda, M. L., Costa, A. F., Jimenez-Jimenez, L., Vallejo-Vaz, A. J., et al. (2012). Olive oil polyphenols decrease blood pressure and improve endothelial function in young women with mild hypertension. Am. J. Hypertens. 25, 1299-1304. doi: 10.1038/ajh.2012.128
53. Naruszewicz, M., Johansson, M. L., Zapolska-Downar, D., and Bukowska, H. (2002). Effect of Lactobacillus plantarum 299v on cardiovascular disease risk factors in smokers. Am. J. Clin. Nutr. 76, 1249-1255.
54. Novelle, M. G., Wahl, D., Diéguez, C., Bernier, M., and de Cabo, R. (2015). Resveratrol supplementation: where are we now and where should we go? Ageing Res. Rev. 21, 1-15. doi: 10.1016/j.arr.2015.01.002
55. Ozdal, T., Sela, D. A., Xiao, J., Boyacioglu, D., Chen, F., and Capanoglu, E. (2016). The reciprocal interactions between polyphenols and gut microbiota and effects on bioaccessibility. Nutrients 8:78. doi: 10.3390/nu8020078
56. Parvez, S., Malik, K. A., Ah Kang, S., and Kim, H. Y. (2006). Probiotics and their fermented food products are beneficial for health. J. Appl. Microbiol. 100, 1171-1185. doi: 10.1111/j.1365-2672.2006.02963.x
57. Popkin, B. M. (2011). Contemporary nutritional transition: determinants of diet and its impact on body composition. Proc. Nutr. Soc. 70, 82-91. doi: 10.1017/S0029665110003903
58. Psaltopoulou, T., Naska, A., Orfanos, P., Trichopoulos, D., Mountokalakis, T., and Trichopoulou, A. (2004). Olive oil, the Mediterranean diet, and arterial blood pressure: the Greek European Prospective Investigation into Cancer and Nutrition (EPIC) study. Am. J. Clin. Nutr. 80, 1012-1018.
59. Rashid, S.K., Idris-Khodja, N., Auger, C., Alhosin, M., Boehm, N., Oswald-Mammosser, M., et al., (2014). Probiotics (VSL#3) prevent endothelial dysfunction in rats with portal hypertension: role of the angiotensin system. PLoS ONE 9:e97458. doi: 10.1371/journal.pone.0097458
60. Ras, R. T., Zock, P. L., Zebregs, Y. E., Johnston, N. R., Webb, D. J., and Draijer, R. (2013). Effect of polyphenol-rich grape seed extract on ambulatory blood pressure in subjects with pre-and stage I hypertension. Br. J. Nutr. 110, 2234-2241. doi: 10.1017/S000711451300161X
61. Rerksuppaphol, S., and Rerksuppaphol, L. (2015). A randomized double-blind controlled trial of lactobacillus acidophilus plus bifidobacterium bifidum versus placebo in patients with hypercholesterolemia. J. Clin. Diagn Res. 9, KC01-KC04. doi: 10.7860/jcdr/2015/11867.5728
62. Rivera-Espinoza, Y., and Gallardo-Navarro, Y. (2010). Non-dairy probiotic products. Food Microbiol. 27, 1-11. doi: 10.1016/j.fm.2008.06.008
63. Roohbakhsh, A., Parhiz, H., Soltani, F., Rezaee, R., and Iranshahi, M. (2015). Molecular mechanisms behind the biological effects of hesperidin and hesperetin for the prevention of cancer and cardiovascular diseases. Life Sci. 124, 64-74. doi: 10.1016/j.lfs.2014.12.030
64. Sahebkar, A., Serban, C., Ursoniu, S., Wong, N. D., Muntner, P., Graham, I. M., et al. (2015). Lack of efficacy of resveratrol on C-reactive protein and selected cardiovascular risk factors-Results from a systematic review and meta-analysis of randomized controlled trials. Int. J. Cardiol. 189, 47-55. doi: 10.1016/j.ijcard.2015.04.008
65. Schwarzer, M., Makki, K., Storelli, G., Machuca-Gayet, I., Srutkova, D., Hermanova, P., et al. (2016). Lactobacillus plantarum strain maintains growth of infant mice during chronic undernutrition. Science 351, 854-857. doi: 10.1126/science.aad8588
66. Serban, M. C., Sahebkar, A., Zanchetti, A., Mikhailidis, D. P., Howard, G., Antal, D., et al. (2016). Effects of quercetin on blood pressure: a systematic review and meta-analysis of randomized controlled trials. J. Am. Heart Assoc. 5:e002713. doi: 10.1161/JAHA.115.002713
67. Sharafedtinov, K. K., Plotnikova, O. A., Alexeeva, R. I., Sentsova, T. B., Songisepp, E., Stsepetova, J., et al. (2013). Hypocaloric diet supplemented with probiotic cheese improves body mass index and blood pressure indices of obese hypertensive patients-a randomized double-blind placebo-controlled pilot study. Nutr. J. 12:138. doi: 10.1186/1475-2891-12-138
68. Sharma, M., Akhtar, N., Sambhav, K., Shete, G., Bansal, A. K., and Sharma, S. S. (2015). Emerging potential of citrus flavanones as an antioxidant in diabetes and its complications. Curr. Top. Med. Chem. 15, 187-195. doi: 10.2174/1568026615666141209163013
69. Sharma, M., and Devi, M. (2014). Probiotics: a comprehensive approach toward health foods. Crit. Rev. Food Sci. Nutr. 54, 537-552. doi: 10.1080/10408398.2011.594185
70. Sigel, H., Fischer, B., and Prijs, B. (1977). Biological implications from the stability of ternary complexes in solution.1 Mixed-ligand complexes with manganese (II) and other 3d ions. J. Am. Chem. Soc. 99, 4489-4496. doi: 10.1021/ja00455a047
71. Stevens, J. F., and Maier, C. S. (2016). The chemistry of gut microbial metabolism of polyphenols. Phytochem. Rev. 15, 425-444. doi: 10.1007/s11101-016-9459-z
72. Tapsell, L. C. (2015). Fermented dairy food and CVD risk. Br. J. Nutr. 113(Suppl 2), S131-S135. doi: 10.1017/s0007114514002359
73. Thushara, R. M., Gangadaran, S., Solati, Z., and Moghadasian, M. H. (2016). Cardiovascular benefits of probiotics: a review of experimental and clinical studies. Food Funct. 7, 632-642. doi: 10.1039/C5FO01190F
74. van der Made, S. M., Plat, J., and Mensink, R. P. (2015). Resveratrol does not influence metabolic risk markers related to cardiovascular health in overweight and slightly obese subjects: a randomized, placebo-controlled crossover trial. PLoS ONE 10:e0118393. doi: 10.1371/journal.pone.0118393
75. Vijaya Kumar, B., Vijayendra, S. V., and Reddy, O. V. (2015). Trends in dairy and non-dairy probiotic products-a review. J. Food Sci. Technol. 52, 6112-6124. doi: 10.1007/s13197-015-1795-2
76. Vitali, B., Minervini, G., Rizzello, C. G., Spisni, E., Maccaferri, S., Brigidi, P., et al. (2012). Novel probiotic candidates for humans isolated from raw fruits and vegetables. Food Microbiol. 31, 116-125. doi: 10.1016/j.fm.2011.12.027
77. Wilmsen, P. K., Spada, D. S., and Salvador, M. (2005). Antioxidant activity of the flavonoid hesperidin in chemical and biological systems. J. Agric. Food Chem. 53, 4757-4761. doi: 10.1021/jf0502000
78. Wohlgemuth, S., Loh, G., and Blaut, M. (2010). Recent developments and perspectives in the investigation of probiotic effects. Int. J. Med. Microbiol. 300, 3-10. doi: 10.1016/j.ijmm.2009.08.003
79. Wong, R. H., Howe, P. R., Buckley, J. D., Coates, A. M., Kunz, I., and Berry, N. M. (2011). Acute resveratrol supplementation improves flow-mediated dilatation in overweight/obese individuals with mildly elevated blood pressure. Nutr. Metab. Cardiovasc. Dis. 21, 851-856. doi: 10.1016/j.numecd.2010.03.003
80. Wu, J. M., Hsieh, T. C., and Wang, Z. (2011). Cardioprotection by resveratrol: a review of effects/targets in cultured cells and animal tissues. Am. J. Cardiovasc. Dis. 1, 38-47.
81. Yamamoto, M., Suzuki, A., and Hase, T. (2008). Short-term effects of glucosyl hesperidin and hesperetin on blood pressure and vascular endothelial function in spontaneously hypertensive rats. J. Nutr. Sci. Vitaminol. 54, 95-98. doi: 10.3177/jnsv.54.95
82. Yang, G., Jiang, Y., Yang, W., Du, F., Yao, Y., Shi, C., et al. (2015). Effective treatment of hypertension by recombinant Lactobacillus plantarum expressing angiotensin converting enzyme inhibitory peptide. Microb. Cell Fact. 14:202. doi: 10.1186/s12934-015-0394-2