메뉴 건너뛰기




Volumn 15, Issue 3, 2016, Pages 425-444

The chemistry of gut microbial metabolism of polyphenols

Author keywords

Catabolism; Flavonoid; Gut microbiota; Mechanism; Metabolic pathway

Indexed keywords

ALKENE; CARBON; CATECHIN; CHALCONE DERIVATIVE; CURCUMIN; DAIDZEIN; DIHYDROCHALCONE; DIHYDRORESVERATROL; DIOXYGENASE; ELLAGITANNIN; EQUOL; FLAVANONE DERIVATIVE; FLAVONOL; ISOFLAVONE; ISOFLAVONE DERIVATIVE; POLYPHENOL; PROANTHOCYANIDIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; RESVERATROL; TETRAHYDROCURCUMIN; UNCLASSIFIED DRUG;

EID: 84960392949     PISSN: 15687767     EISSN: 1572980X     Source Type: Journal    
DOI: 10.1007/s11101-016-9459-z     Document Type: Review
Times cited : (168)

References (125)
  • 1
    • 84930178829 scopus 로고    scopus 로고
    • Anthocyanins and their physiologically relevant metabolites alter the expression of IL-6 and VCAM-1 in CD40L and oxidized LDL challenged vascular endothelial cells
    • COI: 1:CAS:528:DC%2BC2MXnsVWktrc%3D, PID: 25787755
    • Amin HP, Czank C, Raheem S et al (2015) Anthocyanins and their physiologically relevant metabolites alter the expression of IL-6 and VCAM-1 in CD40L and oxidized LDL challenged vascular endothelial cells. Mol Nutr Food Res 59:1095–1106
    • (2015) Mol Nutr Food Res , vol.59 , pp. 1095-1106
    • Amin, H.P.1    Czank, C.2    Raheem, S.3
  • 2
    • 61449211248 scopus 로고    scopus 로고
    • Procyanidin dimers are metabolized by human microbiota with 2-(3,4-dihydroxyphenyl)acetic acid and 5-(3,4-dihydroxyphenyl)-gamma-valerolactone as the major metabolites
    • COI: 1:CAS:528:DC%2BD1MXls1artQ%3D%3D, PID: 19191673
    • Appeldoorn MM, Vincken JP, Aura AM et al (2009) Procyanidin dimers are metabolized by human microbiota with 2-(3,4-dihydroxyphenyl)acetic acid and 5-(3,4-dihydroxyphenyl)-gamma-valerolactone as the major metabolites. J Agric Food Chem 57:1084–1092
    • (2009) J Agric Food Chem , vol.57 , pp. 1084-1092
    • Appeldoorn, M.M.1    Vincken, J.P.2    Aura, A.M.3
  • 3
    • 17844374062 scopus 로고    scopus 로고
    • In vitro metabolism of anthocyanins by human gut microflora
    • COI: 1:CAS:528:DC%2BD2MXkslKltL0%3D, PID: 15309431
    • Aura AM, Martin-Lopez P, O’Leary KA et al (2005) In vitro metabolism of anthocyanins by human gut microflora. Eur J Nutr 44:133–142
    • (2005) Eur J Nutr , vol.44 , pp. 133-142
    • Aura, A.M.1    Martin-Lopez, P.2    O’Leary, K.A.3
  • 4
    • 84886537483 scopus 로고    scopus 로고
    • Lactobacillus plantarum IFPL935 favors the initial metabolism of red wine polyphenols when added to a colonic microbiota
    • COI: 1:CAS:528:DC%2BC3sXhsFehu73E, PID: 24073689
    • Barroso E, Sanchez-Patan F, Martin-Alvarez PJ et al (2013) Lactobacillus plantarum IFPL935 favors the initial metabolism of red wine polyphenols when added to a colonic microbiota. J Agric Food Chem 61:10163–10172
    • (2013) J Agric Food Chem , vol.61 , pp. 10163-10172
    • Barroso, E.1    Sanchez-Patan, F.2    Martin-Alvarez, P.J.3
  • 5
    • 2542494981 scopus 로고    scopus 로고
    • Bioavailability of anthocyanidin-3-glycosides following consumption of elderberry extract and blackcurrant juice
    • COI: 1:CAS:528:DC%2BD2cXksFGmtLk%3D, PID: 15176653
    • Bitsch I, Janssen M, Netzel M et al (2004) Bioavailability of anthocyanidin-3-glycosides following consumption of elderberry extract and blackcurrant juice. Int J Clin Pharmacol Ther 42:293–300
    • (2004) Int J Clin Pharmacol Ther , vol.42 , pp. 293-300
    • Bitsch, I.1    Janssen, M.2    Netzel, M.3
  • 6
    • 84873368632 scopus 로고    scopus 로고
    • In vivo and in vitro metabolism of trans-resveratrol by human gut microbiota
    • COI: 1:CAS:528:DC%2BC3sXhs1Ojurc%3D, PID: 23283496
    • Bode LM, Bunzel D, Huch M et al (2013) In vivo and in vitro metabolism of trans-resveratrol by human gut microbiota. Am J Clin Nutr 97:295–309
    • (2013) Am J Clin Nutr , vol.97 , pp. 295-309
    • Bode, L.M.1    Bunzel, D.2    Huch, M.3
  • 7
    • 33644863745 scopus 로고    scopus 로고
    • Characterization of PhlG, a hydrolase that specifically degrades the antifungal compound 2,4-diacetylphloroglucinol in the biocontrol agent Pseudomonas fluorescens CHA0
    • COI: 1:CAS:528:DC%2BD28XmtFarug%3D%3D, PID: 16391073
    • Bottiglieri M, Keel C (2006) Characterization of PhlG, a hydrolase that specifically degrades the antifungal compound 2,4-diacetylphloroglucinol in the biocontrol agent Pseudomonas fluorescens CHA0. Appl Environ Microbiol 72:418–427
    • (2006) Appl Environ Microbiol , vol.72 , pp. 418-427
    • Bottiglieri, M.1    Keel, C.2
  • 8
    • 1642573174 scopus 로고    scopus 로고
    • Bacillus subtilis YxaG is a novel Fe-containing quercetin 2,3-dioxygenase
    • COI: 1:CAS:528:DC%2BD2cXltV2rsw%3D%3D, PID: 14741339
    • Bowater L, Fairhurst SA, Just VJ et al (2004) Bacillus subtilis YxaG is a novel Fe-containing quercetin 2,3-dioxygenase. FEBS Lett 557:45–48
    • (2004) FEBS Lett , vol.557 , pp. 45-48
    • Bowater, L.1    Fairhurst, S.A.2    Just, V.J.3
  • 9
    • 0037401122 scopus 로고    scopus 로고
    • Metabolism of isoflavones and lignans by the gut microflora: a study in germ-free and human flora associated rats
    • COI: 1:CAS:528:DC%2BD3sXit1KnsLY%3D, PID: 12659715
    • Bowey E, Adlercreutz H, Rowland I (2003) Metabolism of isoflavones and lignans by the gut microflora: a study in germ-free and human flora associated rats. Food Chem Toxicol 41:631–636
    • (2003) Food Chem Toxicol , vol.41 , pp. 631-636
    • Bowey, E.1    Adlercreutz, H.2    Rowland, I.3
  • 10
    • 0032994684 scopus 로고    scopus 로고
    • Phytoestrogens: the “natural” selective estrogen receptor modulators?
    • COI: 1:CAS:528:DyaK1MXjt1KksLw%3D, PID: 10428321
    • Brzezinski A, Debi A (1999) Phytoestrogens: the “natural” selective estrogen receptor modulators? Eur J Obstet Gynecol Reprod Biol 85:47–51
    • (1999) Eur J Obstet Gynecol Reprod Biol , vol.85 , pp. 47-51
    • Brzezinski, A.1    Debi, A.2
  • 11
    • 0034788719 scopus 로고    scopus 로고
    • Malvidin-3-glucoside bioavailability in humans after ingestion of red wine, dealcoholized red wine and red grape juice
    • COI: 1:CAS:528:DC%2BD3MXot1Oqsbk%3D, PID: 11697443
    • Bub A, Watzl B, Heeb D et al (2001) Malvidin-3-glucoside bioavailability in humans after ingestion of red wine, dealcoholized red wine and red grape juice. Eur J Nutr 40:113–120
    • (2001) Eur J Nutr , vol.40 , pp. 113-120
    • Bub, A.1    Watzl, B.2    Heeb, D.3
  • 12
    • 33750331207 scopus 로고    scopus 로고
    • Radical enzymes in anaerobes
    • COI: 1:CAS:528:DC%2BD28Xht1Whtb%2FJ, PID: 16704345
    • Buckel W, Golding BT (2006) Radical enzymes in anaerobes. Annu Rev Microbiol 60:27–49
    • (2006) Annu Rev Microbiol , vol.60 , pp. 27-49
    • Buckel, W.1    Golding, B.T.2
  • 13
    • 0031745637 scopus 로고    scopus 로고
    • Comparison of different analytical methods for assessing total antioxidant capacity of human serum
    • COI: 1:CAS:528:DyaK1cXjslCqsrg%3D, PID: 9625058
    • Cao G, Prior RL (1998) Comparison of different analytical methods for assessing total antioxidant capacity of human serum. Clin Chem 44:1309–1315
    • (1998) Clin Chem , vol.44 , pp. 1309-1315
    • Cao, G.1    Prior, R.L.2
  • 14
    • 63849112848 scopus 로고    scopus 로고
    • Anaerobic Catabolism of Aromatic Compounds: a Genetic and Genomic View
    • COI: 1:CAS:528:DC%2BD1MXktlKmt74%3D, PID: 19258534
    • Carmona M, Zamarro MT, Blazquez B et al (2009) Anaerobic Catabolism of Aromatic Compounds: a Genetic and Genomic View. Microbiol Mol Biol Rev 73:71
    • (2009) Microbiol Mol Biol Rev , vol.73 , pp. 71
    • Carmona, M.1    Zamarro, M.T.2    Blazquez, B.3
  • 15
    • 0026463538 scopus 로고
    • Role of the gastrointestinal mucosa and microflora in the bioactivation of dietary and environmental mutagens or carcinogens
    • COI: 1:CAS:528:DyaK3sXjtl2rug%3D%3D, PID: 1289035
    • Chadwick RW, George SE, Claxton LD (1992) Role of the gastrointestinal mucosa and microflora in the bioactivation of dietary and environmental mutagens or carcinogens. Drug Metab Rev 24:425–492
    • (1992) Drug Metab Rev , vol.24 , pp. 425-492
    • Chadwick, R.W.1    George, S.E.2    Claxton, L.D.3
  • 16
    • 84876912589 scopus 로고    scopus 로고
    • Human metabolism and elimination of the anthocyanin, cyanidin-3-glucoside: a (13) C-tracer study
    • COI: 1:CAS:528:DC%2BC3sXmvFSmtrw%3D, PID: 23604435
    • Czank C, Cassidy A, Zhang Q et al (2013) Human metabolism and elimination of the anthocyanin, cyanidin-3-glucoside: a (13) C-tracer study. Am J Clin Nutr 97:995–1003
    • (2013) Am J Clin Nutr , vol.97 , pp. 995-1003
    • Czank, C.1    Cassidy, A.2    Zhang, Q.3
  • 17
    • 0036229187 scopus 로고    scopus 로고
    • Procyanidins are not bioavailable in rats fed a single meal containing a grapeseed extract or the procyanidin dimer B3
    • COI: 1:CAS:528:DC%2BD38XjtlWlsrg%3D, PID: 12064339
    • Donovan JL, Manach C, Rios L et al (2002) Procyanidins are not bioavailable in rats fed a single meal containing a grapeseed extract or the procyanidin dimer B3. Br J Nutr 87:299–306
    • (2002) Br J Nutr , vol.87 , pp. 299-306
    • Donovan, J.L.1    Manach, C.2    Rios, L.3
  • 18
    • 53449101213 scopus 로고    scopus 로고
    • Molecular mechanisms of natural products in chemoprevention: induction of cytoprotective enzymes by Nrf2
    • PID: 18435489
    • Eggler AL, Gay KA, Mesecar AD (2008) Molecular mechanisms of natural products in chemoprevention: induction of cytoprotective enzymes by Nrf2. Mol Nutr Food Res 52:S84–S94
    • (2008) Mol Nutr Food Res , vol.52 , pp. S84-S94
    • Eggler, A.L.1    Gay, K.A.2    Mesecar, A.D.3
  • 19
    • 68749091158 scopus 로고    scopus 로고
    • Cul3-mediated Nrf2 ubiquitination and antioxidant response element (ARE) activation are dependent on the partial molar volume at position 151 of Keap1
    • COI: 1:CAS:528:DC%2BD1MXhtVGhs7fP, PID: 19489739
    • Eggler AL, Small E, Hannink M et al (2009) Cul3-mediated Nrf2 ubiquitination and antioxidant response element (ARE) activation are dependent on the partial molar volume at position 151 of Keap1. Biochem J 422:171–180
    • (2009) Biochem J , vol.422 , pp. 171-180
    • Eggler, A.L.1    Small, E.2    Hannink, M.3
  • 20
    • 0038671799 scopus 로고    scopus 로고
    • Strawberry anthocyanins are recovered in urine as glucuro- and sulfoconjugates in humans
    • COI: 1:CAS:528:DC%2BD3sXjs1Oqt74%3D, PID: 12730413
    • Felgines C, Talavera S, Gonthier MP et al (2003) Strawberry anthocyanins are recovered in urine as glucuro- and sulfoconjugates in humans. J Nutr 133:1296–1301
    • (2003) J Nutr , vol.133 , pp. 1296-1301
    • Felgines, C.1    Talavera, S.2    Gonthier, M.P.3
  • 21
    • 84861180869 scopus 로고    scopus 로고
    • Ring-cleaving dioxygenases with a cupin fold
    • COI: 1:CAS:528:DC%2BC38XlsVSls74%3D, PID: 22287012
    • Fetzner S (2012) Ring-cleaving dioxygenases with a cupin fold. Appl Environ Microbiol 78:2505–2514
    • (2012) Appl Environ Microbiol , vol.78 , pp. 2505-2514
    • Fetzner, S.1
  • 22
    • 84893976023 scopus 로고    scopus 로고
    • Enzymatic conversion of flavonoids using bacterial chalcone isomerase and enoate reductase
    • COI: 1:CAS:528:DC%2BC3sXhvFOmu7fE, PID: 24459060
    • Gall M, Thomsen M, Peters C et al (2014) Enzymatic conversion of flavonoids using bacterial chalcone isomerase and enoate reductase. Angew Chem Int Ed Engl 53:1439–1442
    • (2014) Angew Chem Int Ed Engl , vol.53 , pp. 1439-1442
    • Gall, M.1    Thomsen, M.2    Peters, C.3
  • 23
    • 84884468326 scopus 로고    scopus 로고
    • Time course production of urolithins from ellagic acid by human gut microbiota
    • COI: 1:CAS:528:DC%2BC3sXhtlChtL3E, PID: 23984796
    • Garcia-Villalba R, Beltran D, Espin JC et al (2013) Time course production of urolithins from ellagic acid by human gut microbiota. J Agric Food Chem 61:8797–8806
    • (2013) J Agric Food Chem , vol.61 , pp. 8797-8806
    • Garcia-Villalba, R.1    Beltran, D.2    Espin, J.C.3
  • 24
    • 84894233648 scopus 로고    scopus 로고
    • R(–)–O–desmethylangolensin is the main enantiomeric form of daidzein metabolite produced by human in vitro and in vivo
    • PID: 24561352
    • Gardana C, Canzi E, Simonetti P (2014) R(–)–O–desmethylangolensin is the main enantiomeric form of daidzein metabolite produced by human in vitro and in vivo. J Chromatogr B Analyt Technol Biomed Life Sci 953–954:30–37
    • (2014) J Chromatogr B Analyt Technol Biomed Life Sci , vol.953-954 , pp. 30-37
    • Gardana, C.1    Canzi, E.2    Simonetti, P.3
  • 25
    • 0037316953 scopus 로고    scopus 로고
    • Microbial aromatic acid metabolites formed in the gut account for a major fraction of the polyphenols excreted in urine of rats fed red wine polyphenols
    • COI: 1:CAS:528:DC%2BD3sXhtV2ntbY%3D, PID: 12566484
    • Gonthier MP, Cheynier V, Donovan JL et al (2003) Microbial aromatic acid metabolites formed in the gut account for a major fraction of the polyphenols excreted in urine of rats fed red wine polyphenols. J Nutr 133:461–467
    • (2003) J Nutr , vol.133 , pp. 461-467
    • Gonthier, M.P.1    Cheynier, V.2    Donovan, J.L.3
  • 26
    • 77649297783 scopus 로고    scopus 로고
    • Occurrence of urolithins, gut microbiota ellagic acid metabolites and proliferation markers expression response in the human prostate gland upon consumption of walnuts and pomegranate juice
    • COI: 1:CAS:528:DC%2BC3cXjtFKhsrg%3D, PID: 19885850
    • Gonzalez-Sarrias A, Gimenez-Bastida JA, Garcia-Conesa MT et al (2010) Occurrence of urolithins, gut microbiota ellagic acid metabolites and proliferation markers expression response in the human prostate gland upon consumption of walnuts and pomegranate juice. Mol Nutr Food Res 54:311–322
    • (2010) Mol Nutr Food Res , vol.54 , pp. 311-322
    • Gonzalez-Sarrias, A.1    Gimenez-Bastida, J.A.2    Garcia-Conesa, M.T.3
  • 27
    • 84897430278 scopus 로고    scopus 로고
    • Simultaneous UPLC-MS/MS analysis of native catechins and procyanidins and their microbial metabolites in intestinal contents and tissues of male Wistar Furth inbred rats
    • COI: 1:CAS:528:DC%2BC2cXmvV2ntrg%3D, PID: 24704909
    • Goodrich KM, Neilson AP (2014) Simultaneous UPLC-MS/MS analysis of native catechins and procyanidins and their microbial metabolites in intestinal contents and tissues of male Wistar Furth inbred rats. J Chromatogr B Analyt Technol Biomed Life Sci 958:63–74
    • (2014) J Chromatogr B Analyt Technol Biomed Life Sci , vol.958 , pp. 63-74
    • Goodrich, K.M.1    Neilson, A.P.2
  • 28
    • 84925738746 scopus 로고    scopus 로고
    • Centella asiatica attenuates amyloid-beta-induced oxidative stress and mitochondrial dysfunction
    • PID: 25633675
    • Gray NE, Sampath H, Zweig JA et al (2015) Centella asiatica attenuates amyloid-beta-induced oxidative stress and mitochondrial dysfunction. J Alzheimers Dis 45:933–946
    • (2015) J Alzheimers Dis , vol.45 , pp. 933-946
    • Gray, N.E.1    Sampath, H.2    Zweig, J.A.3
  • 29
    • 1542286856 scopus 로고    scopus 로고
    • Concentrations of proanthocyanidins in common foods and estimations of normal consumption
    • COI: 1:CAS:528:DC%2BD2cXitlCqs74%3D, PID: 14988456
    • Gu L, Kelm MA, Hammerstone JF et al (2004) Concentrations of proanthocyanidins in common foods and estimations of normal consumption. J Nutr 134:613–617
    • (2004) J Nutr , vol.134 , pp. 613-617
    • Gu, L.1    Kelm, M.A.2    Hammerstone, J.F.3
  • 30
    • 66749131330 scopus 로고    scopus 로고
    • The bioavailability of apigenin-7-glucoside is influenced by human intestinal microbiota in rats
    • COI: 1:CAS:528:DC%2BD1MXhtlWrtrfI, PID: 19403720
    • Hanske L, Loh G, Sczesny S et al (2009) The bioavailability of apigenin-7-glucoside is influenced by human intestinal microbiota in rats. J Nutr 139:1095–1102
    • (2009) J Nutr , vol.139 , pp. 1095-1102
    • Hanske, L.1    Loh, G.2    Sczesny, S.3
  • 31
    • 79952198053 scopus 로고    scopus 로고
    • Recovery and metabolism of xanthohumol in germ-free and human microbiota-associated rats
    • COI: 1:CAS:528:DC%2BC3cXhsVKrtLzP, PID: 20397197
    • Hanske L, Loh G, Sczesny S et al (2010) Recovery and metabolism of xanthohumol in germ-free and human microbiota-associated rats. Mol Nutr Food Res 54:1405–1413
    • (2010) Mol Nutr Food Res , vol.54 , pp. 1405-1413
    • Hanske, L.1    Loh, G.2    Sczesny, S.3
  • 32
    • 77953175292 scopus 로고    scopus 로고
    • Antihyperglycemic effect of protocatechuic acid on streptozotocin-diabetic rats
    • PID: 20506690
    • Harini R, Pugalendi KV (2010) Antihyperglycemic effect of protocatechuic acid on streptozotocin-diabetic rats. J Basic Clin Physiol Pharmacol 21:79–91
    • (2010) J Basic Clin Physiol Pharmacol , vol.21 , pp. 79-91
    • Harini, R.1    Pugalendi, K.V.2
  • 33
    • 79955598016 scopus 로고    scopus 로고
    • Discovery of the curcumin metabolic pathway involving a unique enzyme in an intestinal microorganism
    • COI: 1:CAS:528:DC%2BC3MXlt1eqtLg%3D, PID: 21467222
    • Hassaninasab A, Hashimoto Y, Tomita-Yokotani K et al (2011) Discovery of the curcumin metabolic pathway involving a unique enzyme in an intestinal microorganism. Proc Natl Acad Sci USA 108:6615–6620
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 6615-6620
    • Hassaninasab, A.1    Hashimoto, Y.2    Tomita-Yokotani, K.3
  • 34
    • 77951203140 scopus 로고    scopus 로고
    • Crystal structure and computational analyses provide insights into the catalytic mechanism of 2,4-diacetylphloroglucinol hydrolase PhlG from Pseudomonas fluorescens
    • COI: 1:CAS:528:DC%2BC3cXhs1aksr0%3D, PID: 20018877
    • He YX, Huang L, Xue Y et al (2010) Crystal structure and computational analyses provide insights into the catalytic mechanism of 2,4-diacetylphloroglucinol hydrolase PhlG from Pseudomonas fluorescens. J Biol Chem 285:4603–4611
    • (2010) J Biol Chem , vol.285 , pp. 4603-4611
    • He, Y.X.1    Huang, L.2    Xue, Y.3
  • 35
    • 41849099278 scopus 로고    scopus 로고
    • Deconjugation and degradation of flavonol glycosides by pig cecal microbiota characterized by Fluorescence in situ hybridization (FISH)
    • COI: 1:CAS:528:DC%2BD1cXisFWltbk%3D, PID: 18303842
    • Hein EM, Rose K, van’t Slot G et al (2008) Deconjugation and degradation of flavonol glycosides by pig cecal microbiota characterized by Fluorescence in situ hybridization (FISH). J Agric Food Chem 56:2281–2290
    • (2008) J Agric Food Chem , vol.56 , pp. 2281-2290
    • Hein, E.M.1    Rose, K.2    van’t Slot, G.3
  • 36
    • 84929888251 scopus 로고    scopus 로고
    • Anoxic conditions promote species-specific mutualism between gut microbes in silico
    • COI: 1:CAS:528:DC%2BC2MXpvF2gs70%3D, PID: 25841013
    • Heinken A, Thiele I (2015) Anoxic conditions promote species-specific mutualism between gut microbes in silico. Appl Environ Microbiol 81:4049–4061
    • (2015) Appl Environ Microbiol , vol.81 , pp. 4049-4061
    • Heinken, A.1    Thiele, I.2
  • 37
    • 0347992819 scopus 로고    scopus 로고
    • Metabolism of the soy isoflavones daidzein, genistein and glycitein in human subjects: identification of new metabolites having an intact isoflavonoid skeleton
    • COI: 1:CAS:528:DC%2BD3sXhtVSjtbnP, PID: 14698210
    • Heinonen S-M, Hoikkala A, Wähälä K et al (2003) Metabolism of the soy isoflavones daidzein, genistein and glycitein in human subjects: identification of new metabolites having an intact isoflavonoid skeleton. J Steroid Biochem Mol Biol 87:285–299
    • (2003) J Steroid Biochem Mol Biol , vol.87 , pp. 285-299
    • Heinonen, S.-M.1    Hoikkala, A.2    Wähälä, K.3
  • 38
    • 3142586896 scopus 로고    scopus 로고
    • First bacterial chalcone isomerase isolated from Eubacterium ramulus
    • COI: 1:CAS:528:DC%2BD2cXks1Citrc%3D, PID: 15127184
    • Herles C, Braune A, Blaut M (2004) First bacterial chalcone isomerase isolated from Eubacterium ramulus. Arch Microbiol 181:428–434
    • (2004) Arch Microbiol , vol.181 , pp. 428-434
    • Herles, C.1    Braune, A.2    Blaut, M.3
  • 39
    • 77955376981 scopus 로고    scopus 로고
    • excess production of bacillus subtilis quercetin 2,3-dioxygenase affects cell viability in the presence of quercetin
    • COI: 1:CAS:528:DC%2BC3cXnt1GmsLg%3D, PID: 20460727
    • Hirooka K, Fujita Y (2010) excess production of bacillus subtilis quercetin 2,3-dioxygenase affects cell viability in the presence of quercetin. Biosci Biotechnol Biochem 74:1030–1038
    • (2010) Biosci Biotechnol Biochem , vol.74 , pp. 1030-1038
    • Hirooka, K.1    Fujita, Y.2
  • 40
    • 0029153686 scopus 로고
    • The anaerobic life of Bacillus subtilis: cloning of the genes encoding the respiratory nitrate reductase system
    • COI: 1:CAS:528:DyaK2MXnslyhtb8%3D, PID: 7557333
    • Hoffmann T, Troup B, Szabo A et al (1995) The anaerobic life of Bacillus subtilis: cloning of the genes encoding the respiratory nitrate reductase system. FEMS Microbiol Lett 131:219–225
    • (1995) FEMS Microbiol Lett , vol.131 , pp. 219-225
    • Hoffmann, T.1    Troup, B.2    Szabo, A.3
  • 41
    • 0018222291 scopus 로고
    • The metabolism and excretion of curcumin (1,7-bis-(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) in the rat
    • COI: 1:CAS:528:DyaE1MXks1yhs7k%3D, PID: 726520
    • Holder GM, Plummer JL, Ryan AJ (1978) The metabolism and excretion of curcumin (1,7-bis-(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) in the rat. Xenobiotica 8:761–768
    • (1978) Xenobiotica , vol.8 , pp. 761-768
    • Holder, G.M.1    Plummer, J.L.2    Ryan, A.J.3
  • 42
    • 60949087042 scopus 로고    scopus 로고
    • Bacillus subtilis isolated from the human gastrointestinal tract
    • COI: 1:CAS:528:DC%2BD1MXivVSht7s%3D, PID: 19068230
    • Hong HA, Khaneja R, Tam NM et al (2009) Bacillus subtilis isolated from the human gastrointestinal tract. Res Microbiol 160:134–143
    • (2009) Res Microbiol , vol.160 , pp. 134-143
    • Hong, H.A.1    Khaneja, R.2    Tam, N.M.3
  • 43
    • 15544383555 scopus 로고    scopus 로고
    • The chemistry behind antioxidant capacity assays
    • COI: 1:CAS:528:DC%2BD2MXhslaltLo%3D, PID: 15769103
    • Huang D, Ou B, Prior RL (2005) The chemistry behind antioxidant capacity assays. J Agric Food Chem 53:1841–1856
    • (2005) J Agric Food Chem , vol.53 , pp. 1841-1856
    • Huang, D.1    Ou, B.2    Prior, R.L.3
  • 44
    • 0036278213 scopus 로고    scopus 로고
    • Isolation of an anaerobic intestinal bacterium capable of cleaving the C-ring of the isoflavonoid daidzein
    • COI: 1:CAS:528:DC%2BD38XlsFGjt7w%3D, PID: 12070764
    • Hur HG, Beger RD, Heinze TM et al (2002) Isolation of an anaerobic intestinal bacterium capable of cleaving the C-ring of the isoflavonoid daidzein. Arch Microbiol 178:8–12
    • (2002) Arch Microbiol , vol.178 , pp. 8-12
    • Hur, H.G.1    Beger, R.D.2    Heinze, T.M.3
  • 45
    • 41949105582 scopus 로고    scopus 로고
    • Effect on both aglycone and sugar moiety towards Phase II metabolism of anthocyanins
    • COI: 1:CAS:528:DC%2BD1cXkvVeks74%3D, PID: 26049244
    • Ichiyanagi T, Shida Y, Rahman MM et al (2008) Effect on both aglycone and sugar moiety towards Phase II metabolism of anthocyanins. Food Chem 110:493–500
    • (2008) Food Chem , vol.110 , pp. 493-500
    • Ichiyanagi, T.1    Shida, Y.2    Rahman, M.M.3
  • 46
    • 0036160713 scopus 로고    scopus 로고
    • Metabolism of the cancer chemopreventive agent curcumin in human and rat intestine
    • COI: 1:CAS:528:DC%2BD38XhvFGitbY%3D
    • Ireson CR, Jones DJ, Orr S et al (2002) Metabolism of the cancer chemopreventive agent curcumin in human and rat intestine. Cancer Epidemiol Biomark Prev 11:105–111
    • (2002) Cancer Epidemiol Biomark Prev , vol.11 , pp. 105-111
    • Ireson, C.R.1    Jones, D.J.2    Orr, S.3
  • 47
    • 84922648197 scopus 로고    scopus 로고
    • Faecal metabolomic fingerprint after moderate consumption of red wine by healthy subjects
    • COI: 1:CAS:528:DC%2BC2cXitVOhs7fK, PID: 25496753
    • Jimenez-Giron A, Ibanez C, Cifuentes A et al (2015) Faecal metabolomic fingerprint after moderate consumption of red wine by healthy subjects. J Proteome Res 14:897–905
    • (2015) J Proteome Res , vol.14 , pp. 897-905
    • Jimenez-Giron, A.1    Ibanez, C.2    Cifuentes, A.3
  • 48
    • 0029099538 scopus 로고
    • A urinary profile study of dietary phytoestrogens. The identification and mode of metabolism of new isoflavonoids
    • COI: 1:CAS:528:DyaK2MXnvVOmtLo%3D, PID: 7662591
    • Joannou GE, Kelly GE, Reeder AY et al (1995) A urinary profile study of dietary phytoestrogens. The identification and mode of metabolism of new isoflavonoids. J Steroid Biochem Mol Biol 54:167–184
    • (1995) J Steroid Biochem Mol Biol , vol.54 , pp. 167-184
    • Joannou, G.E.1    Kelly, G.E.2    Reeder, A.Y.3
  • 49
    • 84914109280 scopus 로고    scopus 로고
    • A review on protocatechuic Acid and its pharmacological potential
    • PID: 25006494
    • Kakkar S, Bais S (2014) A review on protocatechuic Acid and its pharmacological potential. ISRN Pharmacol 2014:952943
    • (2014) ISRN Pharmacol , vol.2014 , pp. 952943
    • Kakkar, S.1    Bais, S.2
  • 50
    • 78650523303 scopus 로고    scopus 로고
    • Oxidation of benzoins to benzoic acids using sodium hydride under oxygen atmosphere
    • COI: 1:CAS:528:DC%2BC3cXhs1SqsLzF
    • Kang S, Joo C, Kim SM et al (2011) Oxidation of benzoins to benzoic acids using sodium hydride under oxygen atmosphere. Tetrahedron Lett 52:502–504
    • (2011) Tetrahedron Lett , vol.52 , pp. 502-504
    • Kang, S.1    Joo, C.2    Kim, S.M.3
  • 51
    • 0029557273 scopus 로고
    • Flavoprotein structure and mechanism. 8. Structure-function relations for old yellow enzyme
    • COI: 1:CAS:528:DyaK28XhsVCltQ%3D%3D, PID: 8529830
    • Karplus PA, Fox KM, Massey V (1995) Flavoprotein structure and mechanism. 8. Structure-function relations for old yellow enzyme. FASEB J 9:1518–1526
    • (1995) FASEB J , vol.9 , pp. 1518-1526
    • Karplus, P.A.1    Fox, K.M.2    Massey, V.3
  • 52
    • 58149133711 scopus 로고    scopus 로고
    • Medium- and short-chain dehydrogenase/reductase gene and protein families: the SDR superfamily: functional and structural diversity within a family of metabolic and regulatory enzymes
    • COI: 1:CAS:528:DC%2BD1cXhsFCgs7nO, PID: 19011750
    • Kavanagh KL, Jornvall H, Persson B et al (2008) Medium- and short-chain dehydrogenase/reductase gene and protein families: the SDR superfamily: functional and structural diversity within a family of metabolic and regulatory enzymes. Cell Mol Life Sci 65:3895–3906
    • (2008) Cell Mol Life Sci , vol.65 , pp. 3895-3906
    • Kavanagh, K.L.1    Jornvall, H.2    Persson, B.3
  • 53
    • 3142516348 scopus 로고    scopus 로고
    • Anthocyanin metabolites in human urine and serum
    • COI: 1:CAS:528:DC%2BD2cXltlGlsrs%3D, PID: 15228048
    • Kay CD, Mazza G, Holub BJ et al (2004) Anthocyanin metabolites in human urine and serum. Br J Nutr 91:933–942
    • (2004) Br J Nutr , vol.91 , pp. 933-942
    • Kay, C.D.1    Mazza, G.2    Holub, B.J.3
  • 54
    • 84906937353 scopus 로고    scopus 로고
    • Chiroptical study and absolute configuration of (–)–O–DMA produced from daidzein metabolism
    • COI: 1:CAS:528:DC%2BC2cXitlShtLw%3D, PID: 24519947
    • Kim M, Han J (2014) Chiroptical study and absolute configuration of (–)–O–DMA produced from daidzein metabolism. Chirality 26:434–437
    • (2014) Chirality , vol.26 , pp. 434-437
    • Kim, M.1    Han, J.2
  • 55
    • 66249090545 scopus 로고    scopus 로고
    • Stereospecific biotransformation of dihydrodaidzein into (3S)-equol by the human intestinal bacterium Eggerthella strain Julong 732
    • COI: 1:CAS:528:DC%2BD1MXmsFWis7k%3D, PID: 19304836
    • Kim M, Kim SI, Han J et al (2009) Stereospecific biotransformation of dihydrodaidzein into (3S)-equol by the human intestinal bacterium Eggerthella strain Julong 732. Appl Environ Microbiol 75:3062–3068
    • (2009) Appl Environ Microbiol , vol.75 , pp. 3062-3068
    • Kim, M.1    Kim, S.I.2    Han, J.3
  • 56
    • 77954203090 scopus 로고    scopus 로고
    • Conversion of (3S,4R)-tetrahydrodaidzein to (3S)-equol by THD reductase: proposed mechanism involving a radical intermediate
    • COI: 1:CAS:528:DC%2BC3cXnt1CmsLo%3D, PID: 20515029
    • Kim M, Marsh EN, Kim SU et al (2010) Conversion of (3S,4R)-tetrahydrodaidzein to (3S)-equol by THD reductase: proposed mechanism involving a radical intermediate. Biochemistry 49:5582–5587
    • (2010) Biochemistry , vol.49 , pp. 5582-5587
    • Kim, M.1    Marsh, E.N.2    Kim, S.U.3
  • 57
    • 84908067044 scopus 로고    scopus 로고
    • Rethinking “enterotypes
    • COI: 1:CAS:528:DC%2BC2cXhs1KltL3N, PID: 25299329
    • Knights D, Ward TL, McKinlay CE et al (2014) Rethinking “enterotypes”. Cell Host Microbe 16:433–437
    • (2014) Cell Host Microbe , vol.16 , pp. 433-437
    • Knights, D.1    Ward, T.L.2    McKinlay, C.E.3
  • 58
    • 84890109914 scopus 로고    scopus 로고
    • Natural product-derived pharmacological modulators of Nrf2/ARE pathway for chronic diseases
    • COI: 1:CAS:528:DC%2BC3sXhvVyqsr%2FP, PID: 24292194
    • Kumar H, Kim I-S, More SV et al (2014) Natural product-derived pharmacological modulators of Nrf2/ARE pathway for chronic diseases. Nat Prod Rep 31:109–139
    • (2014) Nat Prod Rep , vol.31 , pp. 109-139
    • Kumar, H.1    Kim, I.-S.2    More, S.V.3
  • 59
    • 78651259607 scopus 로고    scopus 로고
    • Anti-inflammatory activity of xanthohumol involves heme oxygenase-1 induction via NRF2-ARE signaling in microglial BV2 cells
    • COI: 1:CAS:528:DC%2BC3MXktVShsw%3D%3D, PID: 21093515
    • Lee I-S, Lim J, Gal J et al (2011) Anti-inflammatory activity of xanthohumol involves heme oxygenase-1 induction via NRF2-ARE signaling in microglial BV2 cells. Neurochem Int 58:153–160
    • (2011) Neurochem Int , vol.58 , pp. 153-160
    • Lee, I.-S.1    Lim, J.2    Gal, J.3
  • 60
    • 33845273100 scopus 로고    scopus 로고
    • Pro-oxidant activity of flavonoids induces EpRE-mediated gene expression
    • COI: 1:CAS:528:DC%2BD28XhtVOqsb7I, PID: 17112238
    • Lee-Hilz YY, Boerboom AM, Westphal AH et al (2006) Pro-oxidant activity of flavonoids induces EpRE-mediated gene expression. Chem Res Toxicol 19:1499–1505
    • (2006) Chem Res Toxicol , vol.19 , pp. 1499-1505
    • Lee-Hilz, Y.Y.1    Boerboom, A.M.2    Westphal, A.H.3
  • 61
    • 84859175244 scopus 로고    scopus 로고
    • Pharmacokinetics of xanthohumol and metabolites in rats after oral and intravenous administration
    • COI: 1:CAS:528:DC%2BC3MXhsFOitLnM, PID: 22147307
    • Legette L, Ma L, Reed RL et al (2012) Pharmacokinetics of xanthohumol and metabolites in rats after oral and intravenous administration. Mol Nutr Food Res 56:466–474
    • (2012) Mol Nutr Food Res , vol.56 , pp. 466-474
    • Legette, L.1    Ma, L.2    Reed, R.L.3
  • 62
    • 84878890534 scopus 로고    scopus 로고
    • Xanthohumol lowers body weight and fasting plasma glucose in obese male Zucker fa/fa rats
    • COI: 1:CAS:528:DC%2BC3sXptV2msLg%3D, PID: 22640929
    • Legette LL, Luna AY, Reed RL et al (2013) Xanthohumol lowers body weight and fasting plasma glucose in obese male Zucker fa/fa rats. Phytochemistry 91:236–241
    • (2013) Phytochemistry , vol.91 , pp. 236-241
    • Legette, L.L.1    Luna, A.Y.2    Reed, R.L.3
  • 63
    • 84894161954 scopus 로고    scopus 로고
    • Pharmacokinetics of equol, a soy isoflavone metabolite, changes with the form of equol (dietary versus intestinal production) in ovariectomized rats
    • COI: 1:CAS:528:DC%2BC2cXhtVKks7c%3D, PID: 24446705
    • Legette LL, Prasain J, King J et al (2014) Pharmacokinetics of equol, a soy isoflavone metabolite, changes with the form of equol (dietary versus intestinal production) in ovariectomized rats. J Agric Food Chem 62:1294–1300
    • (2014) J Agric Food Chem , vol.62 , pp. 1294-1300
    • Legette, L.L.1    Prasain, J.2    King, J.3
  • 64
    • 78650095235 scopus 로고    scopus 로고
    • Protocatechuic acid inhibits cancer cell metastasis involving the down-regulation of Ras/Akt/NF-kappaB pathway and MMP-2 production by targeting RhoB activation
    • COI: 1:CAS:528:DC%2BC3MXks10%3D, PID: 20840540
    • Lin HH, Chen JH, Chou FP et al (2011) Protocatechuic acid inhibits cancer cell metastasis involving the down-regulation of Ras/Akt/NF-kappaB pathway and MMP-2 production by targeting RhoB activation. Br J Pharmacol 162:237–254
    • (2011) Br J Pharmacol , vol.162 , pp. 237-254
    • Lin, H.H.1    Chen, J.H.2    Chou, F.P.3
  • 65
    • 75149171430 scopus 로고    scopus 로고
    • ferulic acid protects human umbilical vein endothelial cells from radiation induced oxidative stress by phosphatidylinositol 3-kinase and extracellular signal-regulated kinase pathways
    • COI: 1:CAS:528:DC%2BC3cXos1Ont7c%3D, PID: 20045931
    • Ma Z-C, Hong Q, Wang Y-G et al (2010) ferulic acid protects human umbilical vein endothelial cells from radiation induced oxidative stress by phosphatidylinositol 3-kinase and extracellular signal-regulated kinase pathways. Biol Pharm Bull 33:29–34
    • (2010) Biol Pharm Bull , vol.33 , pp. 29-34
    • Ma, Z.-C.1    Hong, Q.2    Wang, Y.-G.3
  • 66
    • 84905753789 scopus 로고    scopus 로고
    • A rapid method to determine colonic microbial metabolites derived from grape flavanols in rat plasma by liquid chromatography-tandem mass spectrometry
    • COI: 1:CAS:528:DC%2BC2cXhtFOqtbfJ, PID: 25069016
    • Margalef M, Pons Z, Muguerza B et al (2014) A rapid method to determine colonic microbial metabolites derived from grape flavanols in rat plasma by liquid chromatography-tandem mass spectrometry. J Agric Food Chem 62:7698–7706
    • (2014) J Agric Food Chem , vol.62 , pp. 7698-7706
    • Margalef, M.1    Pons, Z.2    Muguerza, B.3
  • 67
    • 47049107667 scopus 로고    scopus 로고
    • Adlercreutzia equolifaciens gen. nov., sp. nov., an equol-producing bacterium isolated from human faeces, and emended description of the genus Eggerthella
    • COI: 1:CAS:528:DC%2BD1cXns1amtLs%3D, PID: 18450717
    • Maruo T, Sakamoto M, Ito C et al (2008) Adlercreutzia equolifaciens gen. nov., sp. nov., an equol-producing bacterium isolated from human faeces, and emended description of the genus Eggerthella. Int J Syst Evol Microbiol 58:1221–1227
    • (2008) Int J Syst Evol Microbiol , vol.58 , pp. 1221-1227
    • Maruo, T.1    Sakamoto, M.2    Ito, C.3
  • 68
    • 84861905935 scopus 로고    scopus 로고
    • Protocatechuic acid and human disease prevention: biological activities and molecular mechanisms
    • COI: 1:CAS:528:DC%2BC38XovFersbo%3D, PID: 22519395
    • Masella R, Santangelo C, D’Archivio M et al (2012) Protocatechuic acid and human disease prevention: biological activities and molecular mechanisms. Curr Med Chem 19:2901–2917
    • (2012) Curr Med Chem , vol.19 , pp. 2901-2917
    • Masella, R.1    Santangelo, C.2    D’Archivio, M.3
  • 69
    • 84855565780 scopus 로고    scopus 로고
    • Daidzein and genistein are converted to equol and 5-hydroxy-equol by human intestinal Slackia isoflavoniconvertens in gnotobiotic rats
    • COI: 1:CAS:528:DC%2BC38XktlKksA%3D%3D, PID: 22113864
    • Matthies A, Loh G, Blaut M et al (2012) Daidzein and genistein are converted to equol and 5-hydroxy-equol by human intestinal Slackia isoflavoniconvertens in gnotobiotic rats. J Nutr 142:40–46
    • (2012) J Nutr , vol.142 , pp. 40-46
    • Matthies, A.1    Loh, G.2    Blaut, M.3
  • 71
    • 52649120818 scopus 로고    scopus 로고
    • Pharmacokinetics of anthocyanins and antioxidant effects after the consumption of anthocyanin-rich acai juice and pulp (Euterpe oleracea Mart.) in human healthy volunteers
    • COI: 1:CAS:528:DC%2BD1cXpslaht7c%3D, PID: 18693743
    • Mertens-Talcott SU, Rios J, Jilma-Stohlawetz P et al (2008) Pharmacokinetics of anthocyanins and antioxidant effects after the consumption of anthocyanin-rich acai juice and pulp (Euterpe oleracea Mart.) in human healthy volunteers. J Agric Food Chem 56:7796–7802
    • (2008) J Agric Food Chem , vol.56 , pp. 7796-7802
    • Mertens-Talcott, S.U.1    Rios, J.2    Jilma-Stohlawetz, P.3
  • 72
    • 0034485521 scopus 로고    scopus 로고
    • The endocrine activities of 8-prenylnaringenin and related hop (Humulus lupulus L.) flavonoids
    • COI: 1:CAS:528:DC%2BD3MXis1GitQ%3D%3D, PID: 11134162
    • Milligan SR, Kalita JC, Pocock V et al (2000) The endocrine activities of 8-prenylnaringenin and related hop (Humulus lupulus L.) flavonoids. J Clin Endocrinol Metab 85:4912–4915
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 4912-4915
    • Milligan, S.R.1    Kalita, J.C.2    Pocock, V.3
  • 73
    • 84928647961 scopus 로고    scopus 로고
    • Highly sensitive analysis of polyphenols and their metabolites in human blood cells using dispersive SPE extraction and LC-MS/MS
    • PID: 25579463
    • Mulek M, Hogger P (2015) Highly sensitive analysis of polyphenols and their metabolites in human blood cells using dispersive SPE extraction and LC-MS/MS. Anal Bioanal Chem 407:1885–1899
    • (2015) Anal Bioanal Chem , vol.407 , pp. 1885-1899
    • Mulek, M.1    Hogger, P.2
  • 74
    • 84901940928 scopus 로고    scopus 로고
    • Targeted metabolic profiling of pomegranate polyphenols and urolithins in plasma, urine and colon tissues from colorectal cancer patients
    • COI: 1:CAS:528:DC%2BC2cXisFOhs7k%3D, PID: 24532260
    • Nunez-Sanchez MA, Garcia-Villalba R, Monedero-Saiz T et al (2014) Targeted metabolic profiling of pomegranate polyphenols and urolithins in plasma, urine and colon tissues from colorectal cancer patients. Mol Nutr Food Res 58:1199–1211
    • (2014) Mol Nutr Food Res , vol.58 , pp. 1199-1211
    • Nunez-Sanchez, M.A.1    Garcia-Villalba, R.2    Monedero-Saiz, T.3
  • 75
    • 12744267344 scopus 로고    scopus 로고
    • Short-chain dehydrogenases/reductases (SDR): the 2002 update
    • PID: 12604210
    • Oppermann U, Filling C, Hult M et al (2003) Short-chain dehydrogenases/reductases (SDR): the 2002 update. Chem Biol Interact 143–144:247–253
    • (2003) Chem Biol Interact , vol.143-144 , pp. 247-253
    • Oppermann, U.1    Filling, C.2    Hult, M.3
  • 76
    • 84903515257 scopus 로고    scopus 로고
    • Chemoprevention of esophageal cancer with black raspberries, their component anthocyanins, and a major anthocyanin metabolite, protocatechuic acid
    • COI: 1:CAS:528:DC%2BC2cXpsVGlsbY%3D
    • Peiffer DS, Zimmerman NP, Wang LS et al (2014) Chemoprevention of esophageal cancer with black raspberries, their component anthocyanins, and a major anthocyanin metabolite, protocatechuic acid. Cancer Prev Res (Phila) 7:574–584
    • (2014) Cancer Prev Res (Phila) , vol.7 , pp. 574-584
    • Peiffer, D.S.1    Zimmerman, N.P.2    Wang, L.S.3
  • 77
    • 84899048608 scopus 로고    scopus 로고
    • In vitro catabolism of quercetin by human fecal bacteria and the antioxidant capacity of its catabolites
    • Peng X, Zhang Z, Zhang N et al (2014) In vitro catabolism of quercetin by human fecal bacteria and the antioxidant capacity of its catabolites. Food Nutr Res 58:23406
    • (2014) Food Nutr Res , vol.58 , pp. 23406
    • Peng, X.1    Zhang, Z.2    Zhang, N.3
  • 78
    • 84902176297 scopus 로고    scopus 로고
    • The use of total antioxidant capacity as surrogate marker for food quality and its effect on health is to be discouraged
    • COI: 1:CAS:528:DC%2BC2cXhtFSru7%2FP, PID: 24984994
    • Pompella A, Sies H, Wacker R et al (2014) The use of total antioxidant capacity as surrogate marker for food quality and its effect on health is to be discouraged. Nutrition 30:791–793
    • (2014) Nutrition , vol.30 , pp. 791-793
    • Pompella, A.1    Sies, H.2    Wacker, R.3
  • 79
    • 23844436615 scopus 로고    scopus 로고
    • Activation of proestrogens from hops (Humulus lupulus L.) by intestinal microbiota; conversion of isoxanthohumol into 8-prenylnaringenin
    • COI: 1:CAS:528:DC%2BD2MXmt1Wkurs%3D, PID: 16076107
    • Possemiers S, Heyerick A, Robbens V et al (2005) Activation of proestrogens from hops (Humulus lupulus L.) by intestinal microbiota; conversion of isoxanthohumol into 8-prenylnaringenin. J Agric Food Chem 53:6281–6288
    • (2005) J Agric Food Chem , vol.53 , pp. 6281-6288
    • Possemiers, S.1    Heyerick, A.2    Robbens, V.3
  • 80
    • 33745670638 scopus 로고    scopus 로고
    • The prenylflavonoid isoxanthohumol from hops (Humulus lupulus L.) is activated into the potent phytoestrogen 8-prenylnaringenin in vitro and in the human intestine
    • COI: 1:CAS:528:DC%2BD28Xmtlyiu7Y%3D, PID: 16772450
    • Possemiers S, Bolca S, Grootaert C et al (2006) The prenylflavonoid isoxanthohumol from hops (Humulus lupulus L.) is activated into the potent phytoestrogen 8-prenylnaringenin in vitro and in the human intestine. J Nutr 136:1862–1867
    • (2006) J Nutr , vol.136 , pp. 1862-1867
    • Possemiers, S.1    Bolca, S.2    Grootaert, C.3
  • 81
    • 84947246123 scopus 로고    scopus 로고
    • The role of colonic bacteria in the metabolism of the natural isoflavone daidzin to equol
    • PID: 25594250
    • Rafii F (2015) The role of colonic bacteria in the metabolism of the natural isoflavone daidzin to equol. Metabolites 5:56–73
    • (2015) Metabolites , vol.5 , pp. 56-73
    • Rafii, F.1
  • 82
    • 15044340025 scopus 로고    scopus 로고
    • Dietary proanthocyanidins: occurrence, dietary intake, bioavailability, and protection against cardiovascular disease
    • COI: 1:CAS:528:DC%2BD2MXis1Kmsbw%3D, PID: 15635686
    • Rasmussen SE, Frederiksen H, Struntze Krogholm K et al (2005) Dietary proanthocyanidins: occurrence, dietary intake, bioavailability, and protection against cardiovascular disease. Mol Nutr Food Res 49:159–174
    • (2005) Mol Nutr Food Res , vol.49 , pp. 159-174
    • Rasmussen, S.E.1    Frederiksen, H.2    Struntze Krogholm, K.3
  • 83
    • 1642546332 scopus 로고    scopus 로고
    • Colonic metabolism of dietary polyphenols: influence of structure on microbial fermentation products
    • COI: 1:CAS:528:DC%2BD2cXnvVGktA%3D%3D, PID: 14744633
    • Rechner AR, Smith MA, Kuhnle G et al (2004) Colonic metabolism of dietary polyphenols: influence of structure on microbial fermentation products. Free Radic Biol Med 36:212–225
    • (2004) Free Radic Biol Med , vol.36 , pp. 212-225
    • Rechner, A.R.1    Smith, M.A.2    Kuhnle, G.3
  • 84
    • 31044441352 scopus 로고    scopus 로고
    • Kinetic and spectroscopic studies on the quercetin 2,3-dioxygenase from Bacillus subtilis
    • COI: 1:CAS:528:DC%2BD2MXhtlars7zP, PID: 16411777
    • Schaab MR, Barney BM, Francisco WA (2006) Kinetic and spectroscopic studies on the quercetin 2,3-dioxygenase from Bacillus subtilis. Biochemistry 45:1009–1016
    • (2006) Biochemistry , vol.45 , pp. 1009-1016
    • Schaab, M.R.1    Barney, B.M.2    Francisco, W.A.3
  • 85
    • 0034528031 scopus 로고    scopus 로고
    • Degradation of quercetin-3-glucoside in gnotobiotic rats associated with human intestinal bacteria
    • COI: 1:CAS:528:DC%2BD3MXot1SmsA%3D%3D, PID: 11123476
    • Schneider H, Simmering R, Hartmann L et al (2000) Degradation of quercetin-3-glucoside in gnotobiotic rats associated with human intestinal bacteria. J Appl Microbiol 89:1027–1037
    • (2000) J Appl Microbiol , vol.89 , pp. 1027-1037
    • Schneider, H.1    Simmering, R.2    Hartmann, L.3
  • 86
    • 0033974559 scopus 로고    scopus 로고
    • Autoinduction of 2,4-diacetylphloroglucinol biosynthesis in the biocontrol agent Pseudomonas fluorescens CHA0 and repression by the bacterial metabolites salicylate and pyoluteorin
    • COI: 1:CAS:528:DC%2BD3cXhtF2ltLs%3D, PID: 10671440
    • Schnider-Keel U, Seematter A, Maurhofer M et al (2000) Autoinduction of 2,4-diacetylphloroglucinol biosynthesis in the biocontrol agent Pseudomonas fluorescens CHA0 and repression by the bacterial metabolites salicylate and pyoluteorin. J Bacteriol 182:1215–1225
    • (2000) J Bacteriol , vol.182 , pp. 1215-1225
    • Schnider-Keel, U.1    Seematter, A.2    Maurhofer, M.3
  • 87
    • 0037022964 scopus 로고    scopus 로고
    • Anaerobic C-ring cleavage of genistein and daidzein by Eubacterium ramulus
    • COI: 1:CAS:528:DC%2BD38XivVagsbs%3D, PID: 11959436
    • Schoefer L, Mohan R, Braune A et al (2002) Anaerobic C-ring cleavage of genistein and daidzein by Eubacterium ramulus. FEMS Microbiol Lett 208:197–202
    • (2002) FEMS Microbiol Lett , vol.208 , pp. 197-202
    • Schoefer, L.1    Mohan, R.2    Braune, A.3
  • 88
    • 8144230744 scopus 로고    scopus 로고
    • Cloning and expression of a phloretin hydrolase gene from Eubacterium ramulus and characterization of the recombinant enzyme
    • COI: 1:CAS:528:DC%2BD2cXosl2hs7w%3D, PID: 15466559
    • Schoefer L, Braune A, Blaut M (2004) Cloning and expression of a phloretin hydrolase gene from Eubacterium ramulus and characterization of the recombinant enzyme. Appl Environ Microbiol 70:6131–6137
    • (2004) Appl Environ Microbiol , vol.70 , pp. 6131-6137
    • Schoefer, L.1    Braune, A.2    Blaut, M.3
  • 89
    • 84877106681 scopus 로고    scopus 로고
    • Identification and expression of genes involved in the conversion of daidzein and genistein by the equol-forming bacterium Slackia isoflavoniconvertens
    • PID: 23542626
    • Schroder C, Matthies A, Engst W et al (2013) Identification and expression of genes involved in the conversion of daidzein and genistein by the equol-forming bacterium Slackia isoflavoniconvertens. Appl Environ Microbiol 79:3494–3502
    • (2013) Appl Environ Microbiol , vol.79 , pp. 3494-3502
    • Schroder, C.1    Matthies, A.2    Engst, W.3
  • 90
    • 84905049318 scopus 로고    scopus 로고
    • Description of urolithin production capacity from ellagic acid of two human intestinal Gordonibacter species
    • COI: 1:CAS:528:DC%2BC2cXht1Wlu7nL, PID: 24909569
    • Selma MV, Beltran D, Garcia-Villalba R et al (2014a) Description of urolithin production capacity from ellagic acid of two human intestinal Gordonibacter species. Food Funct 5:1779–1784
    • (2014) Food Funct , vol.5 , pp. 1779-1784
    • Selma, M.V.1    Beltran, D.2    Garcia-Villalba, R.3
  • 91
    • 84904500536 scopus 로고    scopus 로고
    • Gordonibacter urolithinfaciens sp. nov., a urolithin-producing bacterium isolated from the human gut
    • COI: 1:CAS:528:DC%2BC2cXhslChtb7M, PID: 24744017
    • Selma MV, Tomas-Barberan FA, Beltran D et al (2014b) Gordonibacter urolithinfaciens sp. nov., a urolithin-producing bacterium isolated from the human gut. Int J Syst Evol Microbiol 64:2346–2352
    • (2014) Int J Syst Evol Microbiol , vol.64 , pp. 2346-2352
    • Selma, M.V.1    Tomas-Barberan, F.A.2    Beltran, D.3
  • 92
    • 80052261264 scopus 로고    scopus 로고
    • Metabolic pathways of the colonic metabolism of flavonoids (flavonols, flavones and flavanones) and phenolic acids
    • COI: 1:CAS:528:DC%2BC3MXhtVygs77I
    • Serra A, Macia A, Romero MP et al (2012) Metabolic pathways of the colonic metabolism of flavonoids (flavonols, flavones and flavanones) and phenolic acids. Food Chem 130:383–393
    • (2012) Food Chem , vol.130 , pp. 383-393
    • Serra, A.1    Macia, A.2    Romero, M.P.3
  • 93
    • 20544476987 scopus 로고    scopus 로고
    • S-equol, a potent ligand for estrogen receptor beta, is the exclusive enantiomeric form of the soy isoflavone metabolite produced by human intestinal bacterial flora
    • COI: 1:CAS:528:DC%2BD2MXktlylurk%3D, PID: 15883431
    • Setchell KD, Clerici C, Lephart ED et al (2005) S-equol, a potent ligand for estrogen receptor beta, is the exclusive enantiomeric form of the soy isoflavone metabolite produced by human intestinal bacterial flora. Am J Clin Nutr 81:1072–1079
    • (2005) Am J Clin Nutr , vol.81 , pp. 1072-1079
    • Setchell, K.D.1    Clerici, C.2    Lephart, E.D.3
  • 94
    • 77956580699 scopus 로고    scopus 로고
    • Cloning and expression of a novel NADP(H)-dependent daidzein reductase, an enzyme involved in the metabolism of daidzein, from equol-producing Lactococcus strain 20-92
    • COI: 1:CAS:528:DC%2BC3cXht1Wms7fL, PID: 20639368
    • Shimada Y, Yasuda S, Takahashi M et al (2010) Cloning and expression of a novel NADP(H)-dependent daidzein reductase, an enzyme involved in the metabolism of daidzein, from equol-producing Lactococcus strain 20-92. Appl Environ Microbiol 76:5892–5901
    • (2010) Appl Environ Microbiol , vol.76 , pp. 5892-5901
    • Shimada, Y.1    Yasuda, S.2    Takahashi, M.3
  • 95
    • 84856468660 scopus 로고    scopus 로고
    • Identification of two novel reductases involved in equol biosynthesis in Lactococcus strain 20-92
    • COI: 1:CAS:528:DC%2BC38XhsVWktro%3D, PID: 22286043
    • Shimada Y, Takahashi M, Miyazawa N et al (2011) Identification of two novel reductases involved in equol biosynthesis in Lactococcus strain 20-92. J Mol Microbiol Biotechnol 21:160–172
    • (2011) J Mol Microbiol Biotechnol , vol.21 , pp. 160-172
    • Shimada, Y.1    Takahashi, M.2    Miyazawa, N.3
  • 96
    • 84863746870 scopus 로고    scopus 로고
    • Identification of a novel dihydrodaidzein racemase essential for biosynthesis of equol from daidzein in Lactococcus sp. strain 20-92
    • COI: 1:CAS:528:DC%2BC38XhtVegtr3O, PID: 22582059
    • Shimada Y, Takahashi M, Miyazawa N et al (2012) Identification of a novel dihydrodaidzein racemase essential for biosynthesis of equol from daidzein in Lactococcus sp. strain 20-92. Appl Environ Microbiol 78:4902–4907
    • (2012) Appl Environ Microbiol , vol.78 , pp. 4902-4907
    • Shimada, Y.1    Takahashi, M.2    Miyazawa, N.3
  • 97
    • 84896881843 scopus 로고    scopus 로고
    • Glycyl radical activating enzymes: structure, mechanism, and substrate interactions
    • COI: 1:CAS:528:DC%2BC2cXksFahtr4%3D, PID: 24486374
    • Shisler KA, Broderick JB (2014) Glycyl radical activating enzymes: structure, mechanism, and substrate interactions. Arch Biochem Biophys 546:64–71
    • (2014) Arch Biochem Biophys , vol.546 , pp. 64-71
    • Shisler, K.A.1    Broderick, J.B.2
  • 99
    • 0034720446 scopus 로고    scopus 로고
    • Decomposition of cocoa procyanidins in the gastric milieu
    • COI: 1:CAS:528:DC%2BD3cXkt1ansbY%3D, PID: 10872833
    • Spencer JP, Chaudry F, Pannala AS et al (2000) Decomposition of cocoa procyanidins in the gastric milieu. Biochem Biophys Res Commun 272:236–241
    • (2000) Biochem Biophys Res Commun , vol.272 , pp. 236-241
    • Spencer, J.P.1    Chaudry, F.2    Pannala, A.S.3
  • 100
    • 0037168426 scopus 로고    scopus 로고
    • Anaerobic enzyme·substrate structures provide insight into the reaction mechanism of the copper-dependent quercetin 2,3-dioxygenase
    • COI: 1:CAS:528:DC%2BD3sXhvVyqug%3D%3D, PID: 12486225
    • Steiner RA, Kalk KH, Dijkstra BW (2002) Anaerobic enzyme·substrate structures provide insight into the reaction mechanism of the copper-dependent quercetin 2,3-dioxygenase. Proc Natl Acad Sci 99:16625–16630
    • (2002) Proc Natl Acad Sci , vol.99 , pp. 16625-16630
    • Steiner, R.A.1    Kalk, K.H.2    Dijkstra, B.W.3
  • 101
    • 84938773548 scopus 로고    scopus 로고
    • Catalytic dioxygenation of flavonol by M-complexes (M=Mn, Fe, Co, Ni, Cu and Zn)—mimicking the M-substituted quercetin 2,3-dioxygenase
    • COI: 1:CAS:528:DC%2BC2MXhtFelsrfN, PID: 26153684
    • Sun YJ, Huang QQ, Li P et al (2015) Catalytic dioxygenation of flavonol by M-complexes (M=Mn, Fe, Co, Ni, Cu and Zn)—mimicking the M-substituted quercetin 2,3-dioxygenase. Dalton Trans 44:13926–13938
    • (2015) Dalton Trans , vol.44 , pp. 13926-13938
    • Sun, Y.J.1    Huang, Q.Q.2    Li, P.3
  • 102
    • 84878218577 scopus 로고    scopus 로고
    • Catabolism of (+)-catechin and (−)-epicatechin by rat intestinal microbiota
    • COI: 1:CAS:528:DC%2BC3sXmsFelsrk%3D, PID: 23621128
    • Takagaki A, Nanjo F (2013) Catabolism of (+)-catechin and (−)-epicatechin by rat intestinal microbiota. J Agric Food Chem 61:4927–4935
    • (2013) J Agric Food Chem , vol.61 , pp. 4927-4935
    • Takagaki, A.1    Nanjo, F.2
  • 103
    • 36849055112 scopus 로고    scopus 로고
    • Hypoxia and gastrointestinal disease
    • Taylor CT, Colgan SP (2007) Hypoxia and gastrointestinal disease. J Mol Med (Berl) 85:1295–1300
    • (2007) J Mol Med (Berl) , vol.85 , pp. 1295-1300
    • Taylor, C.T.1    Colgan, S.P.2
  • 104
    • 84927644901 scopus 로고    scopus 로고
    • Structure and catalytic mechanism of the evolutionarily unique bacterial chalcone isomerase
    • COI: 1:CAS:528:DC%2BC2MXlvV2it7k%3D, PID: 25849401
    • Thomsen M, Tuukkanen A, Dickerhoff J et al (2015) Structure and catalytic mechanism of the evolutionarily unique bacterial chalcone isomerase. Acta Crystallogr D Biol Crystallogr 71:907–917
    • (2015) Acta Crystallogr D Biol Crystallogr , vol.71 , pp. 907-917
    • Thomsen, M.1    Tuukkanen, A.2    Dickerhoff, J.3
  • 105
    • 84999053640 scopus 로고    scopus 로고
    • Complete genome sequence of the equol-producing bacterium adlercreutzia equolifaciens DSM 19450T
    • PID: 24051320
    • Toh H, Oshima K, Suzuki T et al (2013) Complete genome sequence of the equol-producing bacterium adlercreutzia equolifaciens DSM 19450T. Genome Announc 1:e00742
    • (2013) Genome Announc , vol.1 , pp. e00742
    • Toh, H.1    Oshima, K.2    Suzuki, T.3
  • 106
    • 84904437984 scopus 로고    scopus 로고
    • Ellagic acid metabolism by human gut microbiota: consistent observation of three urolithin phenotypes in intervention trials, independent of food source, age, and health status
    • COI: 1:CAS:528:DC%2BC2cXhtVKnsbrN, PID: 24976365
    • Tomas-Barberan FA, Garcia-Villalba R, Gonzalez-Sarrias A et al (2014) Ellagic acid metabolism by human gut microbiota: consistent observation of three urolithin phenotypes in intervention trials, independent of food source, age, and health status. J Agric Food Chem 62:6535–6538
    • (2014) J Agric Food Chem , vol.62 , pp. 6535-6538
    • Tomas-Barberan, F.A.1    Garcia-Villalba, R.2    Gonzalez-Sarrias, A.3
  • 107
    • 84862192813 scopus 로고    scopus 로고
    • Strawberry processing does not affect the production and urinary excretion of urolithins, ellagic acid metabolites, in humans
    • COI: 1:CAS:528:DC%2BC3MXhsFejtbvI, PID: 22126674
    • Truchado P, Larrosa M, Garcia-Conesa MT et al (2012) Strawberry processing does not affect the production and urinary excretion of urolithins, ellagic acid metabolites, in humans. J Agric Food Chem 60:5749–5754
    • (2012) J Agric Food Chem , vol.60 , pp. 5749-5754
    • Truchado, P.1    Larrosa, M.2    Garcia-Conesa, M.T.3
  • 108
    • 84911439157 scopus 로고    scopus 로고
    • Protocatechuic acid inhibits lung cancer cells by modulating FAK, MAPK, and NF-kappaB pathways
    • COI: 1:CAS:528:DC%2BC2cXhvVylurvE, PID: 25356681
    • Tsao SM, Hsia TC, Yin MC (2014) Protocatechuic acid inhibits lung cancer cells by modulating FAK, MAPK, and NF-kappaB pathways. Nutr Cancer 66:1331–1341
    • (2014) Nutr Cancer , vol.66 , pp. 1331-1341
    • Tsao, S.M.1    Hsia, T.C.2    Yin, M.C.3
  • 109
    • 77952096064 scopus 로고    scopus 로고
    • Isolation and characterization of the equol-producing bacterium Slackia sp. strain NATTS
    • COI: 1:CAS:528:DC%2BC3cXjtlags74%3D, PID: 20237913
    • Tsuji H, Moriyama K, Nomoto K et al (2010) Isolation and characterization of the equol-producing bacterium Slackia sp. strain NATTS. Arch Microbiol 192:279–287
    • (2010) Arch Microbiol , vol.192 , pp. 279-287
    • Tsuji, H.1    Moriyama, K.2    Nomoto, K.3
  • 110
    • 84857080143 scopus 로고    scopus 로고
    • Identification of an enzyme system for daidzein-to-equol conversion in Slackia sp. strain NATTS
    • COI: 1:CAS:528:DC%2BC38XitVKru7s%3D, PID: 22179235
    • Tsuji H, Moriyama K, Nomoto K et al (2012) Identification of an enzyme system for daidzein-to-equol conversion in Slackia sp. strain NATTS. Appl Environ Microbiol 78:1228–1236
    • (2012) Appl Environ Microbiol , vol.78 , pp. 1228-1236
    • Tsuji, H.1    Moriyama, K.2    Nomoto, K.3
  • 111
    • 84866411779 scopus 로고    scopus 로고
    • Urolithins are the main urinary microbial-derived phenolic metabolites discriminating a moderate consumption of nuts in free-living subjects with diagnosed metabolic syndrome
    • COI: 1:CAS:528:DC%2BC38XnsFOmtL4%3D, PID: 22631214
    • Tulipani S, Urpi-Sarda M, Garcia-Villalba R et al (2012) Urolithins are the main urinary microbial-derived phenolic metabolites discriminating a moderate consumption of nuts in free-living subjects with diagnosed metabolic syndrome. J Agric Food Chem 60:8930–8940
    • (2012) J Agric Food Chem , vol.60 , pp. 8930-8940
    • Tulipani, S.1    Urpi-Sarda, M.2    Garcia-Villalba, R.3
  • 112
    • 77950669604 scopus 로고    scopus 로고
    • The effect of diet on the human gut microbiome: a metagenomic analysis in humanized gnotobiotic mice
    • PID: 20368178
    • Turnbaugh PJ, Ridaura VK, Faith JJ et al (2009) The effect of diet on the human gut microbiome: a metagenomic analysis in humanized gnotobiotic mice. Sci Transl Med 1:6ra14
    • (2009) Sci Transl Med , vol.1 , pp. 6ra14
    • Turnbaugh, P.J.1    Ridaura, V.K.2    Faith, J.J.3
  • 113
    • 84971306855 scopus 로고    scopus 로고
    • Equol-producing lactic acid bacteria-containing composition
    • Uchiyama S, Ueno T, Suzuki T (2013) Equol-producing lactic acid bacteria-containing composition. PCT/JP2004/009484
    • (2013) PCT/JP2004/009484
    • Uchiyama, S.1    Ueno, T.2    Suzuki, T.3
  • 114
    • 84949115106 scopus 로고    scopus 로고
    • The microbial degradation of onion flavonol glucosides and their roasting products by the human gut bacteria Eubacterium ramulus and Flavonifractor plautii
    • COI: 1:CAS:528:DC%2BC2cXitV2mtbbK
    • Ulbrich K, Reichardt N, Braune A et al (2015) The microbial degradation of onion flavonol glucosides and their roasting products by the human gut bacteria Eubacterium ramulus and Flavonifractor plautii. Food Res Int 67:349–355
    • (2015) Food Res Int , vol.67 , pp. 349-355
    • Ulbrich, K.1    Reichardt, N.2    Braune, A.3
  • 115
    • 79952774089 scopus 로고    scopus 로고
    • Metabolic fate of polyphenols in the human superorganism
    • PID: 20615997
    • van Duynhoven J, Vaughan EE, Jacobs DM et al (2011) Metabolic fate of polyphenols in the human superorganism. Proc Natl Acad Sci USA 108(Suppl 1):4531–4538
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 4531-4538
    • van Duynhoven, J.1    Vaughan, E.E.2    Jacobs, D.M.3
  • 116
    • 79954574731 scopus 로고    scopus 로고
    • Protocatechuic acid induces antioxidant/detoxifying enzyme expression through JNK-mediated Nrf2 activation in murine macrophages
    • PID: 20621462
    • Varì R, D’Archivio M, Filesi C et al (2011) Protocatechuic acid induces antioxidant/detoxifying enzyme expression through JNK-mediated Nrf2 activation in murine macrophages. J Nutr Biochem 22:409–417
    • (2011) J Nutr Biochem , vol.22 , pp. 409-417
    • Varì, R.1    D’Archivio, M.2    Filesi, C.3
  • 117
    • 51349128983 scopus 로고    scopus 로고
    • Anthocyanins and their role in cancer prevention
    • COI: 1:CAS:528:DC%2BD1cXhtFWlsrjJ, PID: 18571839
    • Wang LS, Stoner GD (2008) Anthocyanins and their role in cancer prevention. Cancer Lett 269:281–290
    • (2008) Cancer Lett , vol.269 , pp. 281-290
    • Wang, L.S.1    Stoner, G.D.2
  • 118
    • 4444348423 scopus 로고    scopus 로고
    • C-ring cleavage of isoflavones daidzein and genistein by a newly-isolated human intestinal bacterium Eubacterium ramulus Julong 601
    • COI: 1:CAS:528:DC%2BD2cXot1ygsLk%3D
    • Wang XL, Kim KT, Lee JH et al (2004) C-ring cleavage of isoflavones daidzein and genistein by a newly-isolated human intestinal bacterium Eubacterium ramulus Julong 601. J Microbiol Biotechnol 14:766–771
    • (2004) J Microbiol Biotechnol , vol.14 , pp. 766-771
    • Wang, X.L.1    Kim, K.T.2    Lee, J.H.3
  • 119
    • 84866973849 scopus 로고    scopus 로고
    • Gut microbiota metabolism of anthocyanin promotes reverse cholesterol transport in mice via repressing miRNA-10b
    • COI: 1:CAS:528:DC%2BC38XhsVWmt77M, PID: 22821931
    • Wang D, Xia M, Yan X et al (2012) Gut microbiota metabolism of anthocyanin promotes reverse cholesterol transport in mice via repressing miRNA-10b. Circ Res 111:967–981
    • (2012) Circ Res , vol.111 , pp. 967-981
    • Wang, D.1    Xia, M.2    Yan, X.3
  • 120
    • 78049432112 scopus 로고    scopus 로고
    • Colonic metabolites of berry polyphenols: the missing link to biological activity?
    • COI: 1:CAS:528:DC%2BC3cXhtlSjsrvL, PID: 20955650
    • Williamson G, Clifford MN (2010) Colonic metabolites of berry polyphenols: the missing link to biological activity? Br J Nutr 104(Suppl 3):S48–S66
    • (2010) Br J Nutr , vol.104 , pp. S48-S66
    • Williamson, G.1    Clifford, M.N.2
  • 121
    • 79952174576 scopus 로고    scopus 로고
    • Anthocyanin-derived phenolic acids form glucuronides following simulated gastrointestinal digestion and microsomal glucuronidation
    • COI: 1:CAS:528:DC%2BC3MXisFynu7k%3D, PID: 21370450
    • Woodward GM, Needs PW, Kay CD (2011) Anthocyanin-derived phenolic acids form glucuronides following simulated gastrointestinal digestion and microsomal glucuronidation. Mol Nutr Food Res 55:378–386
    • (2011) Mol Nutr Food Res , vol.55 , pp. 378-386
    • Woodward, G.M.1    Needs, P.W.2    Kay, C.D.3
  • 122
    • 0142026205 scopus 로고    scopus 로고
    • Honor thy symbionts
    • COI: 1:CAS:528:DC%2BD3sXntFyns7k%3D, PID: 12923294
    • Xu J, Gordon JI (2003) Honor thy symbionts. Proc Natl Acad Sci USA 100:10452–10459
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 10452-10459
    • Xu, J.1    Gordon, J.I.2
  • 123
    • 67650905172 scopus 로고    scopus 로고
    • Apoptotic effects of protocatechuic acid in human breast, lung, liver, cervix, and prostate cancer cells: potential mechanisms of action
    • COI: 1:CAS:528:DC%2BD1MXnsFKntLo%3D, PID: 19601677
    • Yin MC, Lin CC, Wu HC et al (2009) Apoptotic effects of protocatechuic acid in human breast, lung, liver, cervix, and prostate cancer cells: potential mechanisms of action. J Agric Food Chem 57:6468–6473
    • (2009) J Agric Food Chem , vol.57 , pp. 6468-6473
    • Yin, M.C.1    Lin, C.C.2    Wu, H.C.3
  • 124
    • 80053608103 scopus 로고    scopus 로고
    • Complete genomic sequence of the equol-producing bacterium Eggerthella sp. strain YY7918, isolated from adult human intestine
    • COI: 1:CAS:528:DC%2BC3MXhtlyhsbjI, PID: 21914883
    • Yokoyama S, Oshima K, Nomura I et al (2011) Complete genomic sequence of the equol-producing bacterium Eggerthella sp. strain YY7918, isolated from adult human intestine. J Bacteriol 193:5570–5571
    • (2011) J Bacteriol , vol.193 , pp. 5570-5571
    • Yokoyama, S.1    Oshima, K.2    Nomura, I.3
  • 125
    • 34547485050 scopus 로고    scopus 로고
    • Metabolism of dietary soy isoflavones to equol by human intestinal microflora–implications for health
    • COI: 1:CAS:528:DC%2BD2sXot1OjtL0%3D, PID: 17579894
    • Yuan JP, Wang JH, Liu X (2007) Metabolism of dietary soy isoflavones to equol by human intestinal microflora–implications for health. Mol Nutr Food Res 51:765–781
    • (2007) Mol Nutr Food Res , vol.51 , pp. 765-781
    • Yuan, J.P.1    Wang, J.H.2    Liu, X.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.