메뉴 건너뛰기




Volumn 5, Issue 7, 2016, Pages

Effects of Quercetin on Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

(15)  Serban, Maria Corina a,e   Sahebkar, Amirhossein b   Zanchetti, Alberto c   Mikhailidis, Dimitri P d   Howard, George a   Antal, Diana e   Andrica, Florina e   Ahmed, Ali f   Aronow, Wilbert S g   Muntner, Paul a   Lip, Gregory Y H h   Graham, Ian i   Wong, Nathan j   Rysz, Jacek k   Banach, Maciej k  


Author keywords

Blood pressure; Flavonoids; High blood pressure; Hypertension; Lipids; Meta analysis; Nutrition; Quercetin

Indexed keywords

QUERCETIN; ANTIOXIDANT;

EID: 85016802301     PISSN: None     EISSN: 20479980     Source Type: Journal    
DOI: 10.1161/JAHA.115.002713     Document Type: Article
Times cited : (239)

References (57)
  • 2
    • 84929386175 scopus 로고    scopus 로고
    • Effect of sour tea (Hibiscus sabdariffa L.) on arterial hypertension: a systematic review and meta-analysis of randomized controlled trials
    • Serban C, Sahebkar A, Ursoniu S, Andrica F, Banach M. Effect of sour tea (Hibiscus sabdariffa L.) on arterial hypertension: a systematic review and meta-analysis of randomized controlled trials. J Hypertens. 2015;33:1119–1127.
    • (2015) J Hypertens , vol.33 , pp. 1119-1127
    • Serban, C1    Sahebkar, A2    Ursoniu, S3    Andrica, F4    Banach, M.5
  • 3
    • 84930606919 scopus 로고    scopus 로고
    • Effects of flaxseed supplements on blood pressure: a systematic review and meta-analysis of controlled clinical trial
    • Ursoniu S, Sahebkar A, Andrica F, Serban C, Banach M. Effects of flaxseed supplements on blood pressure: a systematic review and meta-analysis of controlled clinical trial. Clin Nutr. 2016;35:615–625.
    • (2016) Clin Nutr , vol.35 , pp. 615-625
    • Ursoniu, S1    Sahebkar, A2    Andrica, F3    Serban, C4    Banach, M.5
  • 5
    • 0032965758 scopus 로고    scopus 로고
    • Flavonoids in food and natural antioxidants in wine
    • Lairon D, Amiot MJ. Flavonoids in food and natural antioxidants in wine. Curr Opin Lipidol. 1999;10:23–28.
    • (1999) Curr Opin Lipidol , vol.10 , pp. 23-28
    • Lairon, D1    Amiot, MJ.2
  • 6
    • 85125044963 scopus 로고    scopus 로고
    • Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study. Lancet. 1993;342:1007–1011. 7. Kelly GS. Quercetin. Monograph
    • Altern Med Rev. 2011;16:172–194
    • Hertog MG, Feskens EJ, Kromhout D, Hollman P, Katan M. Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study. Lancet. 1993;342:1007–1011. 7. Kelly GS. Quercetin. Monograph. Altern Med Rev. 2011;16:172–194.
    • Hertog, MG1    Feskens, EJ2    Kromhout, D3    Hollman, P4    Katan, M.5
  • 7
    • 10044246299 scopus 로고    scopus 로고
    • Review of the flavonoids quercetin, hesperetin, and naringenin. Dietary sources, bioactivities, bioavailability, and epidemiology
    • Erlund I. Review of the flavonoids quercetin, hesperetin, and naringenin. Dietary sources, bioactivities, bioavailability, and epidemiology. Nutr Res. 2004;24:851–874.
    • (2004) Nutr Res , vol.24 , pp. 851-874
    • Erlund, I.1
  • 8
    • 85027942097 scopus 로고    scopus 로고
    • The flavonoid paradox: conjuga-tion and deconjugation as key steps for the biological activity of flavonoids
    • Perez-Vizcaino F, Duarte J, Santos-Buelga C. The flavonoid paradox: conjuga-tion and deconjugation as key steps for the biological activity of flavonoids. J Sci Food Agric. 2012;92:1822–1825.
    • (2012) J Sci Food Agric , vol.92 , pp. 1822-1825
    • Perez-Vizcaino, F1    Duarte, J2    Santos-Buelga, C.3
  • 11
    • 2442543550 scopus 로고    scopus 로고
    • Quercetin inhibits collagen-stimulated platelet activation through inhibition of multiple components of the glycoprotein VI signaling pathway
    • Hubbard G, Stevens J, Cicmil M, Sage T, Jordan P, Williams C, Lovegrove J, Gibbins J. Quercetin inhibits collagen-stimulated platelet activation through inhibition of multiple components of the glycoprotein VI signaling pathway. J Thromb Haemost. 2003;1:1079–1088.
    • (2003) J Thromb Haemost , vol.1 , pp. 1079-1088
    • Hubbard, G1    Stevens, J2    Cicmil, M3    Sage, T4    Jordan, P5    Williams, C6    Lovegrove, J7    Gibbins, J.8
  • 12
    • 79959246025 scopus 로고    scopus 로고
    • Quercetin as a potential anti-allergic drug: which perspectives?
    • Chirumbolo S. Quercetin as a potential anti-allergic drug: which perspectives? Iran J Allergy Asthma Immunol. 2011;10:139–140.
    • (2011) Iran J Allergy Asthma Immunol , vol.10 , pp. 139-140
    • Chirumbolo, S.1
  • 13
    • 84904244316 scopus 로고    scopus 로고
    • Protective effect of quercetin on hyper-glycemia, oxidative stress and DNA damage in alloxan induced type 2 diabetic mice
    • Alam MM, Meerza D, Naseem I. Protective effect of quercetin on hyper-glycemia, oxidative stress and DNA damage in alloxan induced type 2 diabetic mice. Life Sci. 2014;109:8–14.
    • (2014) Life Sci , vol.109 , pp. 8-14
    • Alam, MM1    Meerza, D2    Naseem, I.3
  • 14
    • 84923320950 scopus 로고    scopus 로고
    • Role of quercetin as an alternative for obesity treatment: you are what you eat!
    • Nabavi SF, Russo GL, Daglia M, Nabavi SM. Role of quercetin as an alternative for obesity treatment: you are what you eat! Food Chem. 2015;179C:305–310.
    • (2015) Food Chem , vol.179C , pp. 305-310
    • Nabavi, SF1    Russo, GL2    Daglia, M3    Nabavi, SM.4
  • 15
    • 79751471302 scopus 로고    scopus 로고
    • The role of quercetin, flavonols and flavones in modulating inflammatory cell function
    • Chirumbolo S. The role of quercetin, flavonols and flavones in modulating inflammatory cell function. Inflamm Allergy Drug Targets. 2010;9:263–285.
    • (2010) Inflamm Allergy Drug Targets , vol.9 , pp. 263-285
    • Chirumbolo, S.1
  • 16
    • 84918573386 scopus 로고    scopus 로고
    • Quercetin promotes cell apoptosis and inhibits the expression of MMP-9 and fibronectin via the AKT and ERK signalling pathways in human glioma cells
    • Pan H-C, Jiang Q, Yu Y, Mei J-P, Cui Y-K, Zhao W-J. Quercetin promotes cell apoptosis and inhibits the expression of MMP-9 and fibronectin via the AKT and ERK signalling pathways in human glioma cells. Neurochem Int. 2015;80:60–71.
    • (2015) Neurochem Int , vol.80 , pp. 60-71
    • Pan, H-C1    Jiang, Q2    Yu, Y3    Mei, J-P4    Cui, Y-K5    Zhao, W-J.6
  • 17
    • 80052273994 scopus 로고    scopus 로고
    • Anti-inflammatory, anti-proliferative and anti-atherosclerotic effects of quercetin in human in vitro and in vivo models
    • Kleemann R, Verschuren L, Morrison M, Zadelaar S, van Erk MJ, Wielinga PY, Kooistra T. Anti-inflammatory, anti-proliferative and anti-atherosclerotic effects of quercetin in human in vitro and in vivo models. Atherosclerosis. 2011;218:44–52.
    • (2011) Atherosclerosis , vol.218 , pp. 44-52
    • Kleemann, R1    Verschuren, L2    Morrison, M3    Zadelaar, S4    van Erk, MJ5    Wielinga, PY6    Kooistra, T.7
  • 19
    • 84859717981 scopus 로고    scopus 로고
    • Quercetin attenuates the progression of monocrotaline-induced pulmonary hypertension in rats
    • Gao H, Chen C, Huang S, Li B. Quercetin attenuates the progression of monocrotaline-induced pulmonary hypertension in rats. J Biomed Res. 2012;26:98–102.
    • (2012) J Biomed Res , vol.26 , pp. 98-102
    • Gao, H1    Chen, C2    Huang, S3    Li, B.4
  • 21
    • 41349100106 scopus 로고    scopus 로고
    • The antihypertensive effects of quercetin in a salt-sensitive model of hypertension
    • Mackraj I, Govender T, Ramesar S. The antihypertensive effects of quercetin in a salt-sensitive model of hypertension. J Cardiovasc Pharmacol. 2008;51:239– 245.
    • (2008) J Cardiovasc Pharmacol , vol.51 , pp. 239-245
    • Mackraj, I1    Govender, T2    Ramesar, S.3
  • 24
    • 43049176634 scopus 로고    scopus 로고
    • Health effects of quercetin: from antioxidant to nutraceutical
    • Boots AW, Haenen GR, Bast A. Health effects of quercetin: from antioxidant to nutraceutical. Eur J Pharmacol. 2008;585:325–337.
    • (2008) Eur J Pharmacol , vol.585 , pp. 325-337
    • Boots, AW1    Haenen, GR2    Bast, A.3
  • 25
    • 84897402994 scopus 로고    scopus 로고
    • An update on the cardiovascular effects of quercetin, a plant flavonoid
    • Islam MA, Schmidt RW, Gunaseelan S, Sanchez A. An update on the cardiovascular effects of quercetin, a plant flavonoid. Curr Nutr Food Sci. 2014;10:36–48.
    • (2014) Curr Nutr Food Sci , vol.10 , pp. 36-48
    • Islam, MA1    Schmidt, RW2    Gunaseelan, S3    Sanchez, A.4
  • 28
    • 0037374008 scopus 로고    scopus 로고
    • Validity of indirect comparison for estimating efficacy of competing interventions: empirical evidence from published meta-analyses
    • Song F, Altman DG, Glenny A-M, Deeks JJ. Validity of indirect comparison for estimating efficacy of competing interventions: empirical evidence from published meta-analyses. BMJ. 2003;326:472.
    • (2003) BMJ , vol.326 , pp. 472
    • Song, F1    Altman, DG2    Glenny, A-M3    Deeks, JJ.4
  • 29
    • 0030793120 scopus 로고    scopus 로고
    • The results of direct and indirect treatment comparisons in meta-analysis of randomized controlled trials
    • Bucher HC, Guyatt GH, Griffith LE, Walter SD. The results of direct and indirect treatment comparisons in meta-analysis of randomized controlled trials. J Clin Epidemiol. 1997;50:683–691.
    • (1997) J Clin Epidemiol , vol.50 , pp. 683-691
    • Bucher, HC1    Guyatt, GH2    Griffith, LE3    Walter, SD.4
  • 30
    • 0033934949 scopus 로고    scopus 로고
    • Trim and fill: a simple funnel-plot–based method of testing and adjusting for publication bias in meta-analysis
    • Duval S, Tweedie R. Trim and fill: a simple funnel-plot–based method of testing and adjusting for publication bias in meta-analysis. Biometrics. 2000;56:455– 463.
    • (2000) Biometrics , vol.56 , pp. 455-463
    • Duval, S1    Tweedie, R.2
  • 31
    • 84897823795 scopus 로고    scopus 로고
    • The effect of quercetin on plasma oxidative status, C-reactive protein and blood pressure in women with rheumatoid arthritis
    • Javadi F, Eghtesadi S, Ahmadzadeh A, Aryaeian N, Zabihiyeganeh M, Foroushani AR, Jazayeri S. The effect of quercetin on plasma oxidative status, C-reactive protein and blood pressure in women with rheumatoid arthritis. Int J Prev Med. 2014;5:293.
    • (2014) Int J Prev Med , vol.5 , pp. 293
    • Javadi, F1    Eghtesadi, S2    Ahmadzadeh, A3    Aryaeian, N4    Zabihiyeganeh, M5    Foroushani, AR6    Jazayeri, S.7
  • 32
    • 84883860974 scopus 로고    scopus 로고
    • Does quercetin improve cardiovascular risk factors and inflammatory biomarkers in women with type 2 diabetes: a double-blind randomized controlled clinical trial
    • Zahedi M, Ghiasvand R, Feizi A, Asgari G, Darvish L. Does quercetin improve cardiovascular risk factors and inflammatory biomarkers in women with type 2 diabetes: a double-blind randomized controlled clinical trial. Int J Prev Med. 2013;4:777.
    • (2013) Int J Prev Med , vol.4 , pp. 777
    • Zahedi, M1    Ghiasvand, R2    Feizi, A3    Asgari, G4    Darvish, L.5
  • 33
    • 0031956125 scopus 로고    scopus 로고
    • Supplementation with quercetin markedly increases plasma quercetin concentration without effect on selected risk factors for heart disease in healthy subjects
    • Conquer J, Maiani G, Azzini E, Raguzzini A, Holub B. Supplementation with quercetin markedly increases plasma quercetin concentration without effect on selected risk factors for heart disease in healthy subjects. J Nutr. 1998;128:593–597.
    • (1998) J Nutr , vol.128 , pp. 593-597
    • Conquer, J1    Maiani, G2    Azzini, E3    Raguzzini, A4    Holub, B.5
  • 34
    • 35848966547 scopus 로고    scopus 로고
    • Quercetin reduces blood pressure in hypertensive subjects
    • Edwards RL, Lyon T, Litwin SE, Rabovsky A, Symons JD, Jalili T. Quercetin reduces blood pressure in hypertensive subjects. J Nutr. 2007;137:2405– 2411.
    • (2007) J Nutr , vol.137 , pp. 2405-2411
    • Edwards, RL1    Lyon, T2    Litwin, SE3    Rabovsky, A4    Symons, JD5    Jalili, T.6
  • 35
    • 73749083955 scopus 로고    scopus 로고
    • Quercetin reduces systolic blood pressure and plasma oxidised low-density lipoprotein concentrations in overweight subjects with a high-cardiovascular disease risk phenotype: a double-blinded, placebo-controlled cross-over study
    • Egert S, Bosy-Westphal A, Seiberl J, Kurbitz C, Settler U, Plachta-Danielzik S, Wagner AE, Frank J, Schrezenmeir J, Rimbach G. Quercetin reduces systolic blood pressure and plasma oxidised low-density lipoprotein concentrations in overweight subjects with a high-cardiovascular disease risk phenotype: a double-blinded, placebo-controlled cross-over study. Br J Nutr. 2009;102:1065–1074.
    • (2009) Br J Nutr , vol.102 , pp. 1065-1074
    • Egert, S1    Bosy-Westphal, A2    Seiberl, J3    Kurbitz, C4    Settler, U5    Plachta-Danielzik, S6    Wagner, AE7    Frank, J8    Schrezenmeir, J9    Rimbach, G.10
  • 36
    • 79955583955 scopus 로고    scopus 로고
    • Effects of daily quercetin-rich supplementation on cardiometabolic risks in male smokers
    • Lee K-H, Park E, Lee H-J, Kim M-O, Cha Y-J, Kim J-M, Lee H, Shin M-J. Effects of daily quercetin-rich supplementation on cardiometabolic risks in male smokers. Nutr Res Pract. 2011;5:28–33.
    • (2011) Nutr Res Pract , vol.5 , pp. 28-33
    • Lee, K-H1    Park, E2    Lee, H-J3    Kim, M-O4    Cha, Y-J5    Kim, J-M6    Lee, H7    Shin, M-J.8
  • 38
    • 84878083345 scopus 로고    scopus 로고
    • Quercetin protects against diabetes-induced exaggerated vasoconstriction in rats: effect on low grade inflammation
    • Mahmoud MF, Hassan NA, El Bassossy HM, Fahmy A. Quercetin protects against diabetes-induced exaggerated vasoconstriction in rats: effect on low grade inflammation. PLoS One. 2013;8:e63784.
    • (2013) PLoS One , vol.8 , pp. e63784
    • Mahmoud, MF1    Hassan, NA2    El Bassossy, HM3    Fahmy, A.4
  • 39
    • 77951949716 scopus 로고    scopus 로고
    • Quercetin: a treatment for hypertension?—a review of efficacy and mechanisms
    • Larson AJ, Symons JD, Jalili T. Quercetin: a treatment for hypertension?—a review of efficacy and mechanisms. Pharmaceuticals. 2010;3:237–250.
    • (2010) Pharmaceuticals , vol.3 , pp. 237-250
    • Larson, AJ1    Symons, JD2    Jalili, T.3
  • 40
    • 84862251868 scopus 로고    scopus 로고
    • Therapeutic potential of quercetin to decrease blood pressure: review of efficacy and mechanisms
    • Larson AJ, Symons JD, Jalili T. Therapeutic potential of quercetin to decrease blood pressure: review of efficacy and mechanisms. Adv Nutr. 2012;3:39–46.
    • (2012) Adv Nutr , vol.3 , pp. 39-46
    • Larson, AJ1    Symons, JD2    Jalili, T.3
  • 41
    • 0035996227 scopus 로고    scopus 로고
    • Inhibition of angiotensin-converting enzyme by quercetin alters the vascular response to bradykinin and angiotensin I
    • Hackl L, Cuttle G, Dovichi S, Lima-Landman M, Nicolau M. Inhibition of angiotensin-converting enzyme by quercetin alters the vascular response to bradykinin and angiotensin I. Pharmacology. 2002;65:182–186.
    • (2002) Pharmacology , vol.65 , pp. 182-186
    • Hackl, L1    Cuttle, G2    Dovichi, S3    Lima-Landman, M4    Nicolau, M.5
  • 42
    • 33646145080 scopus 로고    scopus 로고
    • Antihypertensive effect of quercetin in rats fed with a high-fat high-sucrose diet
    • Yamamoto Y, Oue E. Antihypertensive effect of quercetin in rats fed with a high-fat high-sucrose diet. Biosci Biotechnol Biochem. 2006;70:933–939.
    • (2006) Biosci Biotechnol Biochem , vol.70 , pp. 933-939
    • Yamamoto, Y1    Oue, E.2
  • 43
    • 38749131263 scopus 로고    scopus 로고
    • Effects of dietary polyphenols on gene expression in human vascular endothelial cells
    • Nicholson SK, Tucker GA, Brameld JM. Effects of dietary polyphenols on gene expression in human vascular endothelial cells. Proc Nutr Soc. 2008;67:42– 47.
    • (2008) Proc Nutr Soc , vol.67 , pp. 42-47
    • Nicholson, SK1    Tucker, GA2    Brameld, JM.3
  • 44
    • 29144446282 scopus 로고    scopus 로고
    • Quercetin downregulates NADPH oxidase, increases eNOS activity and prevents endothelial dysfunction in spontaneously hypertensive rats
    • Sanchez M, Galisteo M, Vera R, Villar IC, Zarzuelo A, Tamargo J, Perez-Vizcaıno F, Duarte J. Quercetin downregulates NADPH oxidase, increases eNOS activity and prevents endothelial dysfunction in spontaneously hypertensive rats. J Hypertens. 2006;24:75–84.
    • (2006) J Hypertens , vol.24 , pp. 75-84
    • Sanchez, M1    Galisteo, M2    Vera, R3    Villar, IC4    Zarzuelo, A5    Tamargo, J6    Perez-Vizcaıno, F7    Duarte, J.8
  • 46
    • 13844281685 scopus 로고    scopus 로고
    • Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies
    • Manach C, Williamson G, Morand C, Scalbert A, Remesy C. Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am J Clin Nutr. 2005;81:230S–242S.
    • (2005) Am J Clin Nutr , vol.81 , pp. 230S-242S
    • Manach, C1    Williamson, G2    Morand, C3    Scalbert, A4    Remesy, C.5
  • 47
    • 75549086308 scopus 로고    scopus 로고
    • The relationship between fasting plasma concentrations of selected flavonoids and their ordinary dietary intake
    • Cao J, Zhang Y, Chen W, Zhao X. The relationship between fasting plasma concentrations of selected flavonoids and their ordinary dietary intake. Br J Nutr. 2010;103:249–255.
    • (2010) Br J Nutr , vol.103 , pp. 249-255
    • Cao, J1    Zhang, Y2    Chen, W3    Zhao, X.4
  • 48
    • 42749089226 scopus 로고    scopus 로고
    • Activation of EpRE-mediated gene transcription by quercetin glucuronides depends on their deconjugation
    • Lee-Hilz YY, Stolaki M, van Berkel WJ, Aarts JM, Rietjens IM. Activation of EpRE-mediated gene transcription by quercetin glucuronides depends on their deconjugation. Food Chem Toxicol. 2008;46:2128–2134.
    • (2008) Food Chem Toxicol , vol.46 , pp. 2128-2134
    • Lee-Hilz, YY1    Stolaki, M2    van Berkel, WJ3    Aarts, JM4    Rietjens, IM.5
  • 49
    • 74949133831 scopus 로고    scopus 로고
    • Serum lipid and blood pressure responses to quercetin vary in overweight patients by apolipoprotein E genotype
    • Egert S, Boesch-Saadatmandi C, Wolffram S, Rimbach G, Muller MJ. Serum lipid and blood pressure responses to quercetin vary in overweight patients by apolipoprotein E genotype. J Nutr. 2010;140:278–284.
    • (2010) J Nutr , vol.140 , pp. 278-284
    • Egert, S1    Boesch-Saadatmandi, C2    Wolffram, S3    Rimbach, G4    Muller, MJ.5
  • 50
    • 0035201891 scopus 로고    scopus 로고
    • Deglucuronidation of a flavonoid, luteolin monoglucuronide, during inflamma-tion
    • Shimoi K, Saka N, Nozawa R, Sato M, Amano I, Nakayama T, Kinae N. Deglucuronidation of a flavonoid, luteolin monoglucuronide, during inflamma-tion. Drug Metab Dispos. 2001;29:1521–1524.
    • (2001) Drug Metab Dispos , vol.29 , pp. 1521-1524
    • Shimoi, K1    Saka, N2    Nozawa, R3    Sato, M4    Amano, I5    Nakayama, T6    Kinae, N.7
  • 51
    • 84856370253 scopus 로고    scopus 로고
    • Flavonoid intake and cardiovascular disease mortality in a prospective cohort of US adults
    • McCullough ML, Peterson JJ, Patel R, Jacques PF, Shah R, Dwyer JT. Flavonoid intake and cardiovascular disease mortality in a prospective cohort of US adults. Am J Clin Nutr. 2012;95:454–464.
    • (2012) Am J Clin Nutr , vol.95 , pp. 454-464
    • McCullough, ML1    Peterson, JJ2    Patel, R3    Jacques, PF4    Shah, R5    Dwyer, JT.6
  • 53
    • 34548812546 scopus 로고    scopus 로고
    • A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties
    • Harwood M, Danielewska-Nikiel B, Borzelleca J, Flamm G, Williams G, Lines T. A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties. Food Chem Toxicol. 2007;45:2179–2205.
    • (2007) Food Chem Toxicol , vol.45 , pp. 2179-2205
    • Harwood, M1    Danielewska-Nikiel, B2    Borzelleca, J3    Flamm, G4    Williams, G5    Lines, T.6
  • 54
    • 85078376849 scopus 로고    scopus 로고
    • Scientific opinion on the substantiation of health claims related to quercetin and protection of DNA, proteins and lipids from oxidative damage (ID 1647), “cardiovascular system” (ID 1844), “mental state and performance” (ID 1845), and “liver, kidneys” (ID 1846) pursuant to article 13(1) of regulation (EC) no 1924/2006
    • [2015]
    • EFSA panel on dietetic products, nutrition and allergies (NDA). Scientific opinion on the substantiation of health claims related to quercetin and protection of DNA, proteins and lipids from oxidative damage (ID 1647), “cardiovascular system” (ID 1844), “mental state and performance” (ID 1845), and “liver, kidneys” (ID 1846) pursuant to article 13(1) of regulation (EC) no 1924/2006. EFSA J. 2011;9:2067 [2015 pp.]
    • (2011) EFSA J , vol.9 , pp. 2067
  • 55
    • 84928943647 scopus 로고    scopus 로고
    • Flavonoids at the pharma-nutrition interface: is a therapeutic index in demand?
    • Peluso I, Palmery M. Flavonoids at the pharma-nutrition interface: is a therapeutic index in demand? Biomed Pharmacother. 2015;71:102–107.
    • (2015) Biomed Pharmacother , vol.71 , pp. 102-107
    • Peluso, I1    Palmery, M.2
  • 57
    • 0037154405 scopus 로고    scopus 로고
    • Flavonoids—potent and versatile biologically active compounds interacting with cytochromes P450
    • Hodek P, Trefil P, Stiborova M. Flavonoids—potent and versatile biologically active compounds interacting with cytochromes P450. Chem Biol Interact. 2002;139:1–21.
    • (2002) Chem Biol Interact , vol.139 , pp. 1-21
    • Hodek, P1    Trefil, P2    Stiborova, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.