Acute intake of quercetin from onion skin extract does not influence postprandial blood pressure and endothelial function in overweight-to-obese adults with hypertension: a randomized, double-blind, placebo-controlled, crossover trial

European Journal of Nutrition

Volumn 56, Issue 3, 2017, Pages 1347-1357

  Brüll, Verena ^a   Burak, Constanze ^a   Stoffel Wagner, Birgit ^b   Wolffram, Siegfried ^c   Nickenig, Georg ^b   Müller, Cornelius ^b   Langguth, Peter ^d   Alteheld, Birgit ^a   Fimmers, Rolf ^b   Stehle, Peter ^a   Egert, Sarah ^a  

^a UNIVERSITY OF BONN   (Germany)

^b UNIVERSITY HOSPITAL BONN   (Germany)

^c UNIVERSITY OF KIEL   (Germany)

^d JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

Blood pressure; Cardiovascular diseases; Endothelial function; Postprandial metabolism; Quercetin

Indexed keywords

ALPHA TOCOPHEROL; BETA CAROTENE; BIOLOGICAL MARKER; C REACTIVE PROTEIN; CARBOHYDRATE; CELL ADHESION MOLECULE; CHOLESTEROL; ENDOTHELIN 1; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; INTERCELLULAR ADHESION MOLECULE 1; N(G),N(G) DIMETHYLARGININE; QUERCETIN; RETINOL; SATURATED FATTY ACID; TRIACYLGLYCEROL; TROLOX C; VASCULAR CELL ADHESION MOLECULE 1; ARGININE; DIMETHYLARGININE; PLANT EXTRACT;

ADULT; AGED; ARTICLE; BLOOD PRESSURE; BLOOD VESSEL REACTIVITY; CARDIOVASCULAR DISEASE ASSESSMENT; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIASTOLIC BLOOD PRESSURE; DOUBLE BLIND PROCEDURE; ENERGY METABOLISM; FEMALE; FOOD INTAKE; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; HUMAN; HYPERTENSION; INSULIN BLOOD LEVEL; LIPOPROTEIN BLOOD LEVEL; MALE; METABOLISM; OBESITY; ONION; POSTPRANDIAL STATE; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; REACTIVE HYPEREMIA INDEX; SYSTOLIC BLOOD PRESSURE; TEST MEAL; TRIACYLGLYCEROL BLOOD LEVEL; VITAMIN BLOOD LEVEL; ANALOGS AND DERIVATIVES; BLOOD; CHEMISTRY; COMPLICATION; DRUG EFFECTS; MIDDLE AGED;

ADULT; AGED; ARGININE; BETA CAROTENE; BLOOD PRESSURE; C-REACTIVE PROTEIN; CHOLESTEROL; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; ENDOTHELIN-1; FEMALE; HUMANS; HYPERTENSION; INSULIN; INTERCELLULAR ADHESION MOLECULE-1; MALE; MIDDLE AGED; OBESITY; ONIONS; OVERWEIGHT; PLANT EXTRACTS; POSTPRANDIAL PERIOD; QUERCETIN; TRIGLYCERIDES; VASCULAR CELL ADHESION MOLECULE-1; VITAMIN A;

EID: 84959344856     PISSN: 14366207     EISSN: 14366215     Source Type: Journal    
DOI: 10.1007/s00394-016-1185-1     Document Type: Article

References (49)

1. Crozier A, Jaganath IB, Clifford MN (2009) Dietary phenolics: chemistry, bioavailability and effects on health. Nat Prod Rep 26:1001–1043
2. Wang X, Ouyang YY, Liu J, Zhao G (2014) Flavonoid intake and risk of CVD: a systematic review and meta-analysis of prospective cohort studies. Br J Nutr 111(1):1–11
3. Larson AJ, Symons JD, Jalili T (2012) Therapeutic potential of quercetin to decrease blood pressure: review of efficacy and mechanisms. Adv Nutr 3:39–46
4. Boots AW, Haenen GR, Bast A (2008) Health effects of quercetin: from antioxidant to nutraceutical. Eur J Pharmacol 585:325–337
5. Perez-Vizcaino F, Duarte J (2010) Flavonols and cardiovascular disease. Mol Asp Med 31:478–494
6. Rivera L, Moron R, Sanchez M, Zarzuelo A, Galisteo M (2008) Quercetin ameliorates metabolic syndrome and improves the inflammatory status in obese Zucker rats. Obes (Silver Spring) 16:2081–2087
7. Jeong SM, Kang MJ, Choi HN, Kim JH, Kim JI (2012) Quercetin ameliorates hyperglycemia and dyslipidemia and improves antioxidant status in type 2 diabetic db/db mice. Nutr Res Pract 6:201–207
8. Kobori M, Masumoto S, Akimoto Y, Oike H (2011) Chronic dietary intake of quercetin alleviates hepatic fat accumulation associated with consumption of a Western-style diet in C57/BL6 J mice. Mol Nutr Food Res 55:530–540
9. Duarte J, Jimenez R, O’Valle F, Galisteo M, Perez-Palencia R, Vargas F, Perez-Vizcaino F, Zarzuelo A, Tamargo J (2002) Protective effects of the flavonoid quercetin in chronic nitric oxide deficient rats. J Hypertens 20:1843–1854
10. Galindo P, Rodriguez-Gomez I, Gonzalez-Manzano S, Duenas M, Jimenez R, Menendez C, Vargas F, Tamargo J, Santos-Buelga C, Perez-Vizcaino F, Duarte J (2012) Glucuronidated quercetin lowers blood pressure in spontaneously hypertensive rats via deconjugation. PLoS ONE 7:e32673
11. Sanchez M, Galisteo M, Vera R, Villar IC, Zarzuelo A, Tamargo J, Perez-Vizcaino F, Duarte J (2006) Quercetin downregulates NADPH oxidase, increases eNOS activity and prevents endothelial dysfunction in spontaneously hypertensive rats. J Hypertens 24:75–84
12. Egert S, Bosy-Westphal A, Seiberl J, Kurbitz C, Settler U, Plachta-Danielzik S, Wagner AE, Frank J, Schrezenmeir J, Rimbach G, Wolffram S, Müller MJ (2009) Quercetin reduces systolic blood pressure and plasma oxidised low-density lipoprotein concentrations in overweight subjects with a high-cardiovascular disease risk phenotype: a double-blinded, placebo-controlled cross-over study. Br J Nutr 102:1065–1074
13. Egert S, Boesch-Saadatmandi C, Wolffram S, Rimbach G, Müller MJ (2010) Serum lipid and blood pressure responses to quercetin vary in overweight patients by apolipoprotein E genotype. J Nutr 140:278–284
14. Brüll V, Burak C, Stoffel-Wagner B, Wolffram S, Nickenig G, Müller C, Langguth P, Alteheld B, Fimmers R, Naaf S, Zimmermann BF, Stehle P, Egert S (2015) Effects of a quercetin-rich onion skin extract on 24 hours ambulatory blood pressure and endothelial function in overweight-to-obese patients with (pre-)hypertension: a randomized double-blinded placebo-controlled crossover trial. Br J Nutr 114(8):1263–1277
15. Burton-Freeman B (2010) Postprandial metabolic events and fruit-derived phenolics: a review of the science. Br J Nutr 104(Suppl 3):S1–S14
16. Sies H, Stahl W, Sevanian A (2005) Nutritional, dietary and postprandial oxidative stress. J Nutr 135:969–972
17. Jackson KG, Poppitt SD, Minihane AM (2012) Postprandial lipemia and cardiovascular disease risk: interrelationships between dietary, physiological and genetic determinants. Atherosclerosis 220:22–33
18. Egert S, Wolffram S, Bosy-Westphal A, Boesch-Saadatmandi C, Wagner AE, Frank J, Rimbach G, Müller MJ (2008) Daily quercetin supplementation dose-dependently increases plasma quercetin concentrations in healthy humans. J Nutr 138:1615–1621
19. Pickering TG, Hall JE, Appel LJ, Falkner BE, Graves J, Hill MN, Jones DW, Kurtz T, Sheps SG, Roccella EJ (2005) Recommendations for blood pressure measurement in humans and experimental animals: part 1: blood pressure measurement in humans: a statement for professionals from the Subcommittee of Professional and Public Education of the American Heart Association Council on High Blood Pressure Research. Hypertension 45:142–161
20. Axtell AL, Gomari FA, Cooke JP (2010) Assessing endothelial vasodilator function with the Endo-PAT 2000. J Vis Exp. doi:10.3791/2167
21. Kuvin JT, Patel AR, Sliney KA, Pandian NG, Sheffy J, Schnall RP, Karas RH, Udelson JE (2003) Assessment of peripheral vascular endothelial function with finger arterial pulse wave amplitude. Am Heart J 146:168–174
22. Nohria A, Gerhard-Herman M, Creager MA, Hurley S, Mitra D, Ganz P (2006) Role of nitric oxide in the regulation of digital pulse volume amplitude in humans. J Appl Physiol 101:545–548
23. Bonetti PO, Pumper GM, Higano ST, Holmes DR Jr, Kuvin JT, Lerman A (2004) Noninvasive identification of patients with early coronary atherosclerosis by assessment of digital reactive hyperemia. J Am Coll Cardiol 44:2137–2141
24. Hamburg NM, Keyes MJ, Larson MG, Vasan RS, Schnabel R, Pryde MM, Mitchell GF, Sheffy J, Vita JA, Benjamin EJ (2008) Cross-sectional relations of digital vascular function to cardiovascular risk factors in the Framingham Heart Study. Circulation 117:2467–2474
25. Fürst P, Pollack L, Graser TA, Godel H, Stehle P (1990) Appraisal of four pre-column derivatization methods for the high-performance liquid chromatographic determination of free amino acids in biological materials. J Chromatogr 499:557–569
26. Bieger J, Cermak R, Blank R, de Boer VC, Hollman PC, Kamphues J, Wolffram S (2008) Tissue distribution of quercetin in pigs after long-term dietary supplementation. J Nutr 138:1417–1420
27. Miller NJ, Rice-Evans C, Davies MJ, Gopinathan V, Milner A (1993) A novel method for measuring antioxidant capacity and its application to monitoring the antioxidant status in premature neonates. Clin Sci (Lond) 84:407–412
28. Lacroix S, Rosiers CD, Tardif JC, Nigam A (2012) The role of oxidative stress in postprandial endothelial dysfunction. Nutr Res Rev 25:288–301
29. Jackson KG, Armah CK, Minihane AM (2007) Meal fatty acids and postprandial vascular reactivity. Biochem Soc Trans 35:451–453
30. Wallace JP, Johnson B, Padilla J, Mather K (2010) Postprandial lipaemia, oxidative stress and endothelial function: a review. Int J Clin Pract 64:389–403
31. Pfeuffer MA, Auinger A, Bley U, Kraus-Stojanowic I, Lauce C, Winkler P, Rüfer CE, Frank J, Boesch-Saadatmandi C, Rimbach G, Schrezenmeir J (2013) Effect of quercetin on traits of the metabolic syndrome, endothelial function and inflammatory parameters in men with different APOE isoforms. Nutr Metab Cardiovasc Dis 23:403–409
32. Rontoyanni VG, Chowienczyk PJ, Sanders TA (2010) Postprandial lipaemia does not affect resting haemodynamic responses but does influence cardiovascular reactivity to dynamic exercise. Br J Nutr 104:863–871
33. Berryman CE, Grieger JA, West SG, Chen CY, Blumberg JB, Rothblat GH, Sankaranarayanan S, Kris-Etherton PM (2013) Acute consumption of walnuts and walnut components differentially affect postprandial lipemia, endothelial function, oxidative stress, and cholesterol efflux in humans with mild hypercholesterolemia. J Nutr 143:788–794
34. Gnoni GV, Paglialonga G, Siculella L (2009) Quercetin inhibits fatty acid and triacylglycerol synthesis in rat-liver cells. Eur J Clin Invest 39:761–768
35. Liu Y, Daleke DL, Fly AD (2012) Enhanced vascular function after acute fat-rich snacking in healthy males. Nutr Res 32:565–572
36. Gokce N, Duffy SJ, Hunter LM, Keaney JF, Vita JA (2001) Acute hypertriglyceridemia is associated with peripheral vasodilation and increased basal flow in healthy young adults. Am J Cardiol 88:153–159
37. Raitakari OT, Lai N, Griffiths K, McCredie R, Sullivan D, Celermajer DS (2000) Enhanced peripheral vasodilation in humans after a fatty meal. J Am Coll Cardiol 36:417–422
38. Li Z, Henning SM, Zhang Y, Rahnama N, Zerlin A, Thames G, Tseng CH, Heber D (2013) Decrease of postprandial endothelial dysfunction by spice mix added to high-fat hamburger meat in men with Type 2 diabetes mellitus. Diabet Med 30:590–595
39. Padilla J, Harris RA, Fly AD, Rink LD, Wallace JP (2006) The effect of acute exercise on endothelial function following a high-fat meal. Eur J Appl Physiol 98:256–262
40. Berry SE, Tucker S, Banerji R, Jiang B, Chowienczyk PJ, Charles SM, Sanders TA (2008) Impaired postprandial endothelial function depends on the type of fat consumed by healthy men. J Nutr 138:1910–1914
41. Tushuizen ME, Nieuwland R, Scheffer PG, Sturk A, Heine RJ, Diamant M (2006) Two consecutive high-fat meals affect endothelial-dependent vasodilation, oxidative stress and cellular microparticles in healthy men. J Thromb Haemost 4:1003–1010
42. Paschos GK, FitzGerald GA (2010) Circadian clocks and vascular function. Circ Res 106:833–841
43. Otto ME, Svatikova A, Barretto RB, Santos S, Hoffmann M, Khandheria B, Somers V (2004) Early morning attenuation of endothelial function in healthy humans. Circulation 109:2507–2510
44. Etsuda H, Takase B, Uehata A, Kusano H, Hamabe A, Kuhara R, Akima T, Matsushima Y, Arakawa K, Satomura K, Kurita A, Ohsuzu F (1999) Morning attenuation of endothelium-dependent, flow-mediated dilation in healthy young men: possible connection to morning peak of cardiac events? Clin Cardiol 22:417–421
45. Tunctan B, Weigl Y, Dotan A, Peleg L, Zengil H, Ashkenazi I, Abacioglu N (2002) Circadian variation of nitric oxide synthase activity in mouse tissue. Chronobiol Int 19:393–404
46. Baron AD (1994) Hemodynamic actions of insulin. Am J Physiol 267:E187–E202
47. Valensi P, Cosson E (2006) Hemodynamic changes in postprandial state. Diabetes Metab 32(Spec No 2):2S37–S241
48. Kukongviriyapan U, Sompamit K, Pannangpetch P, Kukongviriyapan V, Donpunha W (2012) Preventive and therapeutic effects of quercetin on lipopolysaccharide-induced oxidative stress and vascular dysfunction in mice. Can J Physiol Pharmacol 90:1345–1353
49. Calabriso N, Scoditti E, Massaro M, Pellegrino M, Storelli C, Ingrosso I, Giovinazzo G, Carluccio MA (2015) Multiple anti-inflammatory and anti-atherosclerotic properties of red wine polyphenolic extracts: differential role of hydroxycinnamic acids, flavonols and stilbenes on endothelial inflammatory gene expression. Eur J Nutr 55(2):477–489