Evidence for pro-oxidant effects of carotenoids in vitro and in vivo: Implications in health and disease

Carotenoids in Health and Disease

Volumn , Issue , 2004, Pages 127-150

  Palozza, Paola ^a  

^a CATHOLIC UNIVERSITY   (Italy)

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EID: 84995608627     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (110)

1. Mayne ST. Beta-carotene, carotenoids and disease prevention in humans. FASEB J 1996; 10: 690-701.
2. Ziegler RG, Mayne ST, Swanson CA. Nutrition and lung cancer. Cancer Causes Control 1996; 7: 157-177.
3. Omenn GS, Goodman GE, Thornquist MD, Balmes J, Cullen MR, Glass A, Keogh JP, Meyskens FL, Valanis B, Williams JH, Barnhart S, Hammar S. Effects of a combination of β-carotene and vitamin A on lung cancer and cardiovascular disease. N Engl J Med 1996; 334: 1150-1155.
4. The Alpha-tocopherol, Beta-Carotene Cancer Prevention Study Group. The effect of vitamin E and β-carotene on the incidence of lung cancer and other cancers in male smokers. N Engl J Med 1994; 330: 1029-1035.
5. Palozza P, Krinsky NI. Antioxidant effects of carotenoids in vivo and in vitro: an overview. Meth Enzymol 1992; 213: 403-420.
6. Krinsky NI. Actions of carotenoids in biological systems. Annu Rev Nutr 1993; 13: 561-587.
7. Sies H, Stahl W. Vitamins E and C, β-carotene and other carotenoids as antioxidants. Am J Clin Nutr 1995; 62 (suppl): 1315S-1321S.
8. Palozza P. Prooxidant actions of carotenoids in biological systems. Nutr Rev 1998; 56: 257-265.
9. Young AJ, Lowe GM. Antioxidant and prooxidant properties of carotenoids. Arch Biochem Biophys 2001; 385: 20-27.
10. Schwartz JL. The dual roles of nutrients as antioxidants and prooxidants: their effects on tumor cell growth. J Nutr 1996; 126: 1221S-1227S.
11. Olson JA. Benefits and liabilities of vitamin A and carotenoids. J Nutr 1996; 126: 1208S-1212S.
12. Burton GW, Ingold KU. b-Carotene: an unusual type of lipid antioxidant. Science 1984; 224: 569-573.
13. Britton, G. Structure and properties of carotenoids in relation to functions. FASEB J 1995; 9: 1551-1558.
14. Truscott TG. b-Carotene and disease: a suggested prooxidant and antioxidant mechanism and speculations concerning its role in cigarette smoking. J Photochem Photobiol 1996; 35: 233-235.
15. Edge R, Truscott TG. Prooxidant and antioxidant reaction mechanisms of carotene and radical interactions with vitamins E and C. Nutr 1997; 13: 992-994.
16. Bohm F, Egde R, Land EJ, McGarvey DJ, Schalch W, Truscott TG. Vitamin E and carotenoids: synergetic protection against human cell damage. FEBS Lett 1998; 436: 387-389.
17. Mortensen A, Skibsted LH and Truscott TG. The interaction of dietary carotenoids with radical species. Arch Biochem Biophys 2001; 385: 13-19.
18. Mayne ST, Handelman GJ, Beecher G. β-carotene and lung cancer promotion in heavy smokers-a plausible relationship? J Natl Cancer Inst 1996; 88: 1513-1515.
19. Handelman GJ, van Kuijk FJGM, Chatterjee A, Krinsky NI. Characterization of products formed during the autooxidation of β-carotene. Free Radic Biol Med 1991; 10: 427-437.
20. Liebler DC, McClure TD. Antioxidant reactions of β-carotene: identification of carotenoid-radical adducts. Chem Res Toxicol 1996; 9: 8-11.
21. Yamauchi R, Miyake N, Inoue H, Kato K. Products formed by peroxyl radical oxidation of β-carotene. J Agric Food Chem 1993; 41: 708-713.
22. Wang XD, Liu C, Bronson RT, Smith DE, Krinsky NI, Russell RM. Retinoid signalling and activator protein-1 expression in ferrets given β-carotene supplements and exposed to tobacco smoke. J Natl Cancer Inst 1999; 91: 60-66.
23. Arora A, Willhite CA, Liebler DC. Interactions of β-carotene and cigarette smoke in human bronchial epithelial cells. Carcinogenesis 2001; 22: 1173-1178.
24. Palozza P, Calviello G, Serini S, Maggiano N, Lanza P, Ranelletti FO, Bartoli GM. b-Carotene at high concentrations induces apoptosis by enhancing oxy-radical production in human adenocarcinoma cells. Free Radic Biol Med 2001; 30: 1000-1007.
25. Palozza P, Serini S, Torsello A, Boninsegna A, Covacci V, Maggiano M, Ranelletti FO, Wolf FI and Calviello G. Regulation of cell cycle progression and apoptosis by β-carotene in undifferentiated and differentiated HL-60 leukemia cells: possible involvement of a redox mechanism. Int J Cancer 2002; 97: 593-600.
26. Palozza P, Serini S, Di Nicuolo F and Calviello G. Mitogenic and apoptotic signaling by carotenoids: involvement of a redox mechanism. IUBMB Life 2001; 52: 1-5.
27. Lowe GM, Booth LA, Bilton RF, Young AJ. Lycopene and β-carotene protect against oxidative damage in HT29 cells at low concentrations but rapidly lose this capacity at higher doses. Free Radic Res 1999; 30: 141-151.
28. Woods JA, Young AJ, Bilton RF. Carotene enhances hydrogen peroxide- induced DNA damage in human hepatocellular HepG2 cells. FEBS Lett 1999; 449: 255-258.
29. Woodall AA, Britton G, Jackson MJ. Carotenoids and protection of phospholipids in solution or in liposomes against oxidation by peroxyl radicals: relationship between carotenoid structure and protective ability. Biochim Biophys Acta 1997; 1336: 575-586.
30. Palozza P, Luberto C, Calviello G, Ricci P, and Bartoli GM. Antioxidant and prooxidant role of β-carotene in murine normal and tumor thymocytes: effects of oxygen partial pressure. Free Radic Biol Med 1997; 22: 1065-1073.
31. Shen Q, Chada S, Whiteney C, Newburger PE. Regulation of the human cellular glutathione peroxidase gene during in vitro myeloid and monocytic differentiation. Blood 1994; 84: 3902-3908.
32. Lykkesfeldt J, Christen S, Wallock LM, Chang HH, Jacob RA, Ames BN. Ascorbate is depleted by smoking and repleted by moderate supplementation: a study in male smokers and nonsmokers with matched antioxidant intakes. Am J Clin Nutr 2000; 71: 530-536.
33. Palozza P and Krinsky NI. b-Carotene and α-tocopherol are synergistic antioxidants. Arch Biochem Biophys 1992; 297: 184-187.
34. Leibovitz B, Hu ML, Tappel AL. Dietary supplements of vitamin E, β-carotene, coenzyme Q10 and selenium protect tissues against lipid peroxidation in rat tissue slices. J Nutr 1990; 120: 97-104.
35. Chen H, Tappel AL. Protection of vitamin E, selenium trolox C, ascorbic acid palmitate, acetylcysteine, coenzyme Q10, β-carotene, canthaxanthin and (þ)- catechin against oxidative damage to rat blood and tissues in vivo. Free Radic Biol Med 1995; 5: 949-953.
36. Halliwell B and Cross CE. Oxygen derived species: their relation to human diseases and environmental stress. Environ Health Perspect 1994; 102: 5-12.
37. Palozza P, Serini S, Torsello A, Di Nicuolo F, Piccioni E, Ubaldi V, Pioli C, Wolf FI, Calviello G. b-Carotene regulates NF-kB DNA-binding activity by a redox mechanism in human leukemia and colon adenocarcinoma cells. J Nutr 2003; 133: 381-388.
38. Palozza P, Serini S, Maggiano N, Angelini M, Boninsegna A, Di Nicuolo F, Ranelletti FO, Calviello G. Induction of cell cycle arrest and apoptosis in human colon adenocarcinoma cell lines by β-carotene through down-regulation of cyclin A and Bcl-2 family proteins. Carcinogenesis 2002; 23: 11-18.
39. Murata M, Kawanishi S. Oxidative DNA damage by vitamin A and its derivative via superoxide generation. J Biol Chem 2000; 275: 2003-2008.
40. Palozza P, Calviello G, De Leo ME, Serini S, Bartoli GM. Canthaxanthin supplementation alters antioxidant enzymes and iron concentration in liver of Balb/c mice. J Nutr 2000; 130: 1303-1308.
41. Garcia-Casal MN, Layrisse M, Solano L, Baron MA, Arguello F, Llovera D, Ramirez J, Leets I and Tropper E. Vitamin A and β-carotene can improve nonheme iron absorption from rice, wheat and corn by humans. J Nutr 1998; 128: 646-650.
42. Halliwell B, Gutteridge MC. Role of free radicals and catalytic metal ions in human disease: an overview. Meth Enzymol 1990; 186: 1-85.
43. De Leo ME, Landriscina M, Palazzotti B, Borrello S, Galeotti T. Iron modulation of LPS-induced manganese superoxide dismutase gene expression in rat tissues. FEBS Lett 1997; 403: 131-135.
44. Paolini M, Antelli A, Pozzetti L, Spetlova D, Perocco P, Valgimigli L, Pedulli GF, Cantelli-Forti G. Induction of cytochrome P450 enzymes and overgeneration of oxygen radicals in β-carotene supplemented rats. Carcinogenesis 2001; 22: 1483-1495.
45. Terao J, Yamauchi R, Murakami H, Matsushita S. Inhibitory effects of tocopherols and β-carotene on singlet oxygen-initiated photooxidation of methyl linoleate and soybean oil. J Food Proc Preserv 1980; 4: 79-93.
46. Haila K, Heinonen M. Action of β-carotene on purified rapeseed oil during light storage. Lebensm Wiss Technol 1994; 27: 573-577.
47. Haila KM, Lievonen SM, Heinonen MI. Effects of lutein, lycopene, annatto and g-tocopherol on autooxidation of triglycerides. J Agric Food Chem 1996; 44: 2096-2100.
48. Palozza P, Krinsky NI. The inhibition of radical-initiated peroxidation of microsomal lipids by both α-tocopherol and β-carotene. Free Radic Biol Med 1991; 11: 407-414.
49. Palozza P, Moualla S, Krinsky NI. Effects of β-carotene and α-tocopherol on radical-initiated peroxidation of microsomes. Free Radic Biol Med 1992; 13: 127-136.
50. Palozza P, Luberto C, Ricci P, Sgarlata E, Calviello G, Bartoli GM. Effect of bcarotene and canthaxanthin on tert-butyl hydroperoxide-induced lipid peroxidation in normal and tumor thymocytes. Arch Biochem Biophys 1996; 325: 145-151.
51. Mortensen A, Skibsted LH, Willnow A, Everett, SA. Re-appraisal of the tocopheroxyl radical reaction with β-carotene: evidence for oxidation of vitamin E by the β-carotene radical cation. Free Radic Res 1998; 28: 69-80.
52. Palozza P, Piccioni E, Avanzi L, Vertuani S, Calviello G, Manfredini S. Design, synthesis and antioxidant activity of Fe-AOX-6, a novel agent deriving from a molecular combination of the chromanyl and polyisoprenyl moieties. Free Radic Biol Med 2002; 33: 1724-1735.
53. Palozza P, Calviello G, Serini S, Moscato P, Bartoli GM. Supplementation with canthaxanthin affects plasma and tissue distribution of α- and g-tocopherols in mice. J Nutr 1998; 128: 1989-1994.
54. Wang XD, Marini RP, Hebuterne X, Fox JG, Krinsky NI, Russell RM. Vitamin E enhances the lymphatic transport of β-carotene and its conversion to vitamin A in the ferret. Gastroenterology 1995; 108: 719-726.
55. Packer L. Antioxidant action of carotenoids in vitro and in vivo and protection against oxidation of human low-density lipoproteins. Ann N Y Acad Sci 1993; 691: 48-60.
56. Jialal J, Grundy SM. Preservation of the endogenous antioxidants in low-density lipoproteins by ascorbate but not probucol during oxidative modifications. J Clin Invest 1991; 87: 597-601.
57. Reaven PD, Ferguson E, Navab M, Pouel FL. Susceptibility of human LDL to oxidative modifications: effects of variations in β-carotene concentration and oxygen tension. Arterioscler Thromb Vasc Biol 1994; 14: 1162-1169.
58. He Y, Root MM, Parker RS, Campbell TC. Effects of carotenoid-rich food extracts on the development of preneoplastic lesions in rat liver and on in vivo and in vitro antioxidant status. Nutr Cancer 1997; 27: 238-244.
59. Schwartz JL, Tanaka J, Khandekar V. The effectiveness of a mixture of β-carotene, α-tocopherol, glutathione, and ascorbic acid for cancer prevention. Nutr Cancer 1993; 20: 145-151.
60. Blakely SR, Slaughter L, Adkins J, Knight EV. Effects of β-carotene and retinyl palmitate on corn oil-induced superoxide dismutase and catalase in rats. J Nutr 1988; 118: 152-158.
61. Dixon ZR, Burri BJ, Clifford A, Frankel EN, Schneeman BO, Parks E, Keim NL, Barbieri T, Wu M-M, Fong AKH, Kretsch MJ, Sowell AL, Erdman JW Jr. Effects of a carotene-deficient diet on measures of oxidative susceptibility and superoxide dismutase activity in adult women. Free Radic Biol Med 1994; 17: 537-544.
62. Lawlor SM, O’Brien NM. Modulation of paraquat toxicity by β-carotene at low oxygen partial pressure in chicken embryo fibroblasts. Br J Nutr 1997; 77: 133-140.
63. Lawlor SM, O’Brien NM. Modulation of oxidative stress by β-carotene in chicken embryo fibroblasts. Br J Nutr 1995; 73: 841-850.
64. Collins AR. Carotenoids and genomic stability. Mutat Res 2001; 475: 21-28.
65. Lee BM, Lee SK, Kim HS. Inhibition of oxidative DNA damage, 8-OH-dG, and carbonyl contents in smokers treated with antioxidants (vitamin E, vitamin C, bcarotene and red ginseng). Cancer Lett 1998; 132: 219-227.
66. Rao AV, Agarwal S. Bioavailability and in vivo antioxidant properties of lycopene from tomato products and their possible role in prevention of cancer. Nutr Cancer 1998; 31: 199-203.
67. Pool-Zobel BL, Bub A, Muller H, Wollowski I, Rechkemmer G. Consumption of vegetables reduces genetic damage in humans: first results of a human intervention trial with carotenoid-rich foods. Carcinogenesis 1997; 18: 1847-1850.
68. Cozzi R, Ricordy R, Aglitti T, Gatta V, Perticone P, De Salvia R. Ascorbic acid and β-carotene as modulators of oxidative damage. Carcinogenesis 1997; 18: 223-228.
69. Salvadori DMF, Ribeiro RR, Natarajan AT. Effects of β-carotene on clastogenic effects of mytomycin C, methyl methanesulphonate and bleomycin in Chinese hamster ovary cells. Mutagenesis 1994; 9: 53-57.
70. Zhang P, Omaye ST. DNA strand breakage and oxygen tension: effects of β-carotene, α-tocopherol, and ascorbic acid. Food ChemToxicol 2001; 39: 239-246.
71. Yeh SL, Hu ML. Induction of oxidative DNA damage in human foreskin fibroblast Hs68 cells by oxidized β-carotene and lycopene. Free Radic Res 2001; 35: 203-213.
72. Palozza P, Calviello G, Bartoli GM. Prooxidant activity of β-carotene under 100% oxygen pressure in rat liver microsomes. Free Radic Biol Med 1995; 19: 887-892.
73. Yeh S, Hu M. Antioxidant and prooxidant effects of lycopene in comparison with β-carotene on oxidant-induced damage in Hs68 cells. J Nutr Biochem 2000; 11: 548-554.
74. Gaziano JM, Hatta A, Flyn M, Johnson EJ, Krinsky NI, Ridker PM, Hennekens CH, Frei B. Supplementation with β-carotene in vivo and in vitro does not inhibit lowdensity lipoprotein oxidation. Atherosclerosis 1995; 112: 187-195.
75. Andersen HR, Andersen O. Effects of dietary α-tocopherol and β-carotene on lipid peroxidation induced by methyl mercuric chloride in mice. Pharmacol Toxicol 1993; 73: 192-201.
76. Lomnitski L, Bergman M, Schon I, Grossman S. The effect of dietary vitamin E and β-carotene on oxidation processes in rat testis. Biochim Biophys Acta 1991; 1082: 101-107.
77. Alam SQ, Alam BS. Lipid peroxide, α-tocopherol, and retinoid levels in plasma and liver of rats fed diets containing β-carotene and 13-cis-retinoic acid. J Nutr 1983; 113: 2608-2614.
78. Zhang P, Omaye ST. b-Carotene and protein oxidation: effects of ascorbic acid and α-tocopherol. Toxicology 2000; 146: 37-47.
79. Andersen HJ, Chen H, Pellett LJ, Tappel AL. Ferrous-iron-induced oxidation in chicken liver slices as measured by hemichrome formation and thiobarbituric acidreactive substances: effects of dietary vitamin E and β-carotene. Free Radic Biol Med 1993; 15: 37-48.
80. Kane D J, Sarafian TA, Anton R, Hahn H, Gralla EB, Valentine JS, Ord T, Bredesen DE. Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species. Science 1993; 262: 1274-1277.
81. Esposito F, Russo L, Russo T, Cimino F. Retinoblastoma protein dephosphorylation is an early event of cellular response to prooxidant conditions. FEBS Lett 2000; 470: 211-215.
82. Schwartz JL. In vitro biological methods for determination of carotenoid activity. Meth Enzymol 1993; 214: 226-256.
83. Schwartz JL, Singh RP, Teicher B, Wright JE, Trites DH, Shklar G. Induction of a 70 kD protein associated with the selective cytotoxicity of β-carotene in human epidermal carcinoma. Biochem Biophys Res Commun 1990; 169: 941-946.
84. Toba T, Shidoji Y, Fujii J, Moriwaki H, Muto Y, Suzuki T, Ohishi N, Yagi K. Growth suppression and induction of heat-shock protein-70 by 9-cisb- carotene in cervical dysplasia-derived cells. Life Sci 1997; 61: 839-845.
85. Abdel-Fatth G, Watzl B, Huang D and Watson RR. b-Carotene in vitro stimulates tumor necrosis factor-a and interleukin-1a secretion by human peripheral blood mononuclear cells. Nutr Res 1993; 13: 863-871.
86. Paolini M, Cantelli-Forti G, Perocco P, Pedulli GF, Abdel-Rahman SZ, Legator MS. Co-carcinogenic effect of β-carotene. Nature 1999; 398: 760-761.
87. Perocco P, Paolini M, Mazzullo M, Biagi GL, Cantelli-Forti G. b-Carotene as enhancer of cell-transforming activity of powerful carcinogens and cigarette-smoke condensate on Balb/c3T3 cells in vitro. Mutat Res 1999; 440: 83-90.
88. Kessova IG, Leo MA, Liebler CS. Effect of β-carotene on hepatic cytochrome P450 in ethanol-fed rats. Alcohol Clin Exp Res 2001; 25: 1368-1372.
89. Gradelet S, Le Bon AM, Berges R, Suschetet M. Dietary carotenoids inhibit aflatoxin B1-induced liver preneoplastic foci and DNA damage in the rat: role of the modulation of aflatoxin B1 metabolism. Carcinogenesis 1998; 19: 403-411.
90. Sharoni Y, Danilenko M, Walfisch S, Amir H, Nahum A, Ben-Dor A, Hirsch K, Khanin M, Steiner M, Agemy L, Zango G, Levy J. Role of gene-regulation in the anticancer activity of carotenoids. Pure Appl Chem 2002; 74: 1469-1477.
91. Obermuller-Jevic UC, Francz PI, Frank J, Flaccus A, Biesalski HK. Enhancement of the UVA-induction of haem oxygenase-1 expression by β-carotene in human skin fibroblasts. FEBS Lett 1999; 460: 212-216.
92. Owuor ED, Kong A-N T. Antioxidants and oxidants regulated signal transduction pathways. Biochem Pharmacol 2002; 64: 765-770.
93. Schulze-Osthoff K, Los M, Baeuerle PA. Redox signalling by transcription factors NF-kB and AP-1 in the immune system. Biochem Pharmacol 1995; 50: 735-741.
94. Sen CH and Packer L. Antioxidant and redox regulation of gene transcription. FASEB J 1996; 10: 709-720.
95. Flohé L, Brigelius-Flohé R, Saliou C, Traber MG, Packer L. Redox regulation of NF-kappa;B activation. Free Radic Biol Med 1997; 22: 1115-1126.
96. Ginn-Pease ME, Whisler RL. Redox signals and NF-kB activation in T cells. Free Radic Biol Med 1998; 25: 346-361.
97. Mercurio F, Manning AM. NF-kB as a primary regulator of the stress response. Oncogene 1999; 18: 6163-6171.
98. Bowie A and O’Neill LAJ. Oxidative stress and nuclear factor-kB activation. Biochem Pharmacol 2000; 59: 13-23.
99. La Rosa FA, Pierce JW, Sonenshein GE. Differential regulation of the c-myc oncogene promoter by the NF-kB Rel family of transcription factor. Mol Cell Biol 1994; 14: 1039-1044.
100. Lotan R. Lung cancer promotion by β-carotene and tobacco smoke: relationship to suppression of retinoic acid receptor-b and increased activator protein-1. J Natl Cancer Inst 1999; 91: 7-9.
101. Tibaduiza EC, Fleet JC, Russell RM, Krinsky NI. Excentric cleavage products of β-carotene inhibit estrogen receptor positive and negative breast tumor cell growth in vitro and inhibit activator protein-1-mediated transcriptional activation. Nutr Cancer 2002; 132: 1368-1375.
102. Krinsky NI. Effects of carotenoids in cellular and animal systems. Am J Clin Nutr 1991; 53: 238S-246S.
103. Gerster H. b-Carotene, vitamin E and vitamin C in different stages of experimental carcinogenesis. Eur J Clin Nutr 1995; 49: 155-168.
104. Guttenplan JB, Chen M, Kosinska W, Thompson S, Zhao Z, Cohen LA. Effects of a lycopene-rich diet on spontaneous and benzo(a)pyrene-induced mutagenesis in prostate, colon and lungs of the lacZ mouse. Cancer Lett 2001; 164: 1-6.
105. Zhao Z, Khachik F, Richie JP Jr, Cohen LA. Lycopene uptake and tissue disposition in male and female rats. Proc Soc Exp Biol Med 1998; 218: 109-114.
106. Black HS. Radical interception by carotenoids and effects on UV carcinogenesis. Nutr Cancer 1998; 31: 212-217.
107. Biesalski HK, Obermueller-Jevic UC. UV-light, β-carotene and human skin: beneficial and potentially harmful effects. Arch Biochem Biophys 2001; 389: 1-6.
108. Liu C, Wang X-D, Bronson R, Smith DE, Krinsky NI, Russell RM. Effects of physiological versus pharmacological β-carotene supplementation on cell proliferation and histopathological changes in the lungs of cigarette smoke-exposed ferrets. Carcinogenesis 2000; 21: 2245-2253.
109. Jones, S, McArdle F, Jack CI, Jackson MJ. Effect of antioxidant supplementation on the adaptive response of human skin fibroblast to UV-induced oxidative stress. Redox Rep 1999; 4: 291-299.
110. Rom WN, Bitterman PB, Rennard, SI, Cantin A, Crystal RG. Characterization of the lower respiratory tract inflammation of non-smoking individuals with interstitial lung disease associated with chronic inhalation of inorganic dusts. Am Rev Respir Dis 1987; 136: 1429-1434.