The dual roles of nutrients as antioxidants and prooxidants: Their effects on tumor cell growth

Journal of Nutrition

Volumn 126, Issue 4 SUPPL., 1996, Pages

  Schwartz, Joel L ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

ascorbic acid; carotenoids; chemoprevention; retinoids; tocopherols; tumor suppressor genes

Indexed keywords

ASCORBIC ACID; CAROTENOID; TOCOPHEROL;

ANTIOXIDANT ACTIVITY; CANCER; CANCER GROWTH; CANCER PREVENTION; CANCER RISK; CONFERENCE PAPER; HUMAN; TUMOR SUPPRESSOR GENE; VITAMIN METABOLISM;

EID: 0029868539     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/126.suppl_4.1221s     Document Type: Conference Paper

References (42)

1. Alcain, F. J., Binon, M. I., Rodriquez-Aquileera, J. C., Villalba, J. M. & Navas, P. (1990) Ascorbate free radical stimulates the growth of a human promyelocytic leukemia cell line. Cancer Res. 50: 5887-5891.
2. Allard, J. P., Rayall, D., Kurian, R., Muggli, R. & Jeejeebhoy, K. N. (1994) Effects of beta carotene supplementation on lipid perooxidation in humans. Am. J. Clin. Nutr. 59: 884-890.
3. Athanassiades, T. (1981) Adjuvant effect of vitamin A palmitate and analogs on cell-mediated immunity. J. Natl. Cancer. Inst. 67: 1153-1156.
4. Boone, C. W., Kelloff, G. J. & Malone, W. E. (1990) Identification of candidate cancer chemoprevention agents and their evaluation in animal models and human clinical trials. A review. Cancer Res. 50: 2-9.
5. Calabrese, E. (1985) Influence of dietary vitamin E on susceptibility to ozone exposure. Bull. Environ. Contain. Toxicol. 34: 417-422.
6. Freinkel, R. K. (1969) Pathogenesis of acne vulgaris. N. Engl. J. Med. 280: 1161-1172.
7. Garewal, H. S. (1993) Beta carotene and vitamin E in oral cancer prevention. J. Cell Biochem. Suppl. 17F: 262-269.
8. Herbert, V., Shaw, S., Jayatilleke, E. & Stopler-Kasdan, T. (1994) Most free radical iniury is iron-related. It is promoted by iron, hemin, holoferritin, and vitamin C, and inhibited by deferoxamine, and apoferritin. Stem Cells 12: 289-303.
9. Hwang, M. T., Ferraro, T. & Ho, C. T. (1994) Cancer chemoprevention by phytochemicals in fruits and vegetables: an overview. ACS Symp. Ser. 546: 2-16.
10. Janero, D R. (1991) Therapeutic potential of vitamin E in the pathogenesis of spontaneous atherosclerosis. Free Radic. Biol. Med. 11: 129-144.
11. Jurin, M. &Tannock, I. (1992) Influence of vitamin A on immunological response. Immunology 23: 283-287.
12. Kim, J. & Shklar, G. (1983) The effect of vitamin E on the healing of gingival wounds m rats. J. Periodontal. 54: 305-308.
13. Knekt, P., Reunanen, A., Jarvinen, R., Seppanen, R., Heliovaara, M. & Aromaa, A. (1994) Antioxidant vitamin intake and coronary mortality in a longitudinal population study. Am. J. Epidemiol. 139: 1180-1189.
14. Lambert, L. A., Warmer, W. G., Wei, R. R., Lava, S., Chirtel, S. J. & Kernhauser, A. (1994) The protective but nonsynergistic effect of dietary beta-carotene and vitamin E on skin tumongenesis in SKH mice. Nutr. Cancer 21: 1-12.
15. Lippman, S. M., Benner, S. E. & Hong, W. K. (1994) Cancer chemoprevention. J. Clin. Oncol 12: 851-873.
16. Manoharan, S. & Nagini, S. (1994) Lipid peroxidation and antioxidants status in oral cancer patients. Med Sci. Res. 50: 5887-5891.
17. Maxwell, S. R. (1993) Can antioxidants prevent ischemic heart disease? J. Clin. Pharmacol. Ther. 18: 85-95.
18. National Research Council (1992) Diet nutrition and cancer. National Academy Press, Washington, DC.
19. Nigro, J. M., Baker, S. J. & Preisingeer, A. C. (1989) Mutations in the p53 gene occur in diverse human tumor types. Nature 342: 705-708.
20. Ortanos, C., Ehlert, R. & Gollnick, H. (1987) The retinoids: a review of their clinical pharmacologic and therapeutic use. Drugs 34: 459-503.
21. Prasad, K. N. & Edwards-Prasad, J. (1982) Effects of tocopherol (vitamin E) acid succinate on morphological alterations and growth inhibition in melanoma cells in culture. Cancer Res. 42: 550-555.
22. Rotitzki, L., Logemann, E., Huber, G., Keck, E. & Keul, J. (1994) Alpha-tocopherol supplementation in racing cyclists during extreme endurance. Training Int. J. Spot Nutr. 4: 253-264.
23. Schwartz, J. L. (1992a) The clinical control of tumor growth through the action of carotenoids, retinoids, and tocopherols. In: Adjuvant Nutrition Treatment for Cancer. (Williams, R. M. & Quillian, P. P., eds.), pp. 173-233. Cancer Treatment Research Foundation, Arlington Heights, IL.
24. Schwartz, J. L. (1994) Molecular and biochemical control of tumor growth following treatment with carotenoids or tocopherols. In: Nutrition and Cancer: Prevention and Treatment (Prasad, K. & Santamaria, K., eds.). Humana Press, Totowa, NJ, pp 287-316.
25. Schwartz, J. L., Antoniades, D. Z. & Zhao, S. (1993a) Molecular and biochemical reprogramming of oncogenesis through the activity of proxidants and antioxidants. Ann. N. Y. Acad. Sci. 1228: 262-279.
26. Schwartz, J. L. & Shklar, D. (1993b) Suppression of oral cancer, growth, and mutant p53 by vitamin E. J. Dent. Res. 1297 (abs.).
27. Schwartz, J. L., Shklar, G. & Trickler, D. (1993c) Vitamin C enhances the development of carcinogenesis in the hamster buccal pouch experimental model. Oral Surg. Oral Med. Oral Pathol. 76: 718-722.
28. Schwartz, J. L., Singh, R., Teicher, B. & Wright, J. E. (1991) Induction of a 70-kDa protein associated with the selective cytotoxicity of beta carotene in human epidermal carcinoma. Biochem. Biophys. Res. Commun. 169: 941-946.
29. Schwartz, J. L., Tanaka, J., Khandekar, N., Herman, T. S. & Teicher, B. A. (1992b) β-carotene and/or vitamin E as modulators of alkylating agents in SCC-25 human squamous carcinoma cells. Chemother. Clin. Pharm. 50: 367-373.
30. Sharma, S., Stutzman, J. D., Kelloff, G. J. & Steele, V. E. (1994) Screening of potential chemoprevention agents using biochemical markers of carcinogenesis. Cancer Res. 54: 5848-5855.
31. Shklar, G. & Schwartz, J. L. (1988) Tumor necrosis factor in experimental cancer: regression with alpha tocopherol, beta carotene, and algae extract. Eur. J. Cancer Clin. Oncol. 24: 839-850.
32. Shklar, G. & Schwartz, J. L. (1993) Oral cancer inhibition by micronutrients. The experimental basis for clinical trials. Eur. J. Clin. Oncol. Oral Oncol. 29B: 9-16.
33. Shklar, G. A. Schwartz, J. L. (1994) A common pathway for the destruction of cancer cells: experimental evidence and clinical implications (review). Int. J. Oncol. 4: 213-224.
34. Shklar, G., Schwartz, J. L., Trickler, D. & Reid, S. (1989) Regression of experimental cancer by oral administration of combined alpha tocopherol and beta carotene. Nutr. Cancer 12: 321-325.
35. Silverman, A., Ellis, C. & Voorhees, J. (1987) Hypervitaminosis A syndrome. A paradign of retinoid side-effects. J. Am. Acad. Dermatol. 16: 1027-1039.
36. Smith, M. A., Parkinson, D. R., Cheson, B. D. & Friedman, M. A. (1992) Retinoids in cancer therapy. J. Clin. Oncol. 10: 839-864.
37. Sokol, R. J. (1989) Vitamin E and neurologic function in man. Free. Radic. Biol. Med. 6: 189-207.
38. Suda, D., Schwartz, J. L. & Shklar, G. (1987) GGT reduction in beta carotene inhibition of hamster buccal pouch carcinogenesis. Eur. J. Cancer Clin. Oncol. 23: 43-46.
39. Trevithick, J. R., Robenston, J. M. & Mitton, K. P. (1993) Vitamin E and the eye. In: Vitamin E in Health Disease (Packer, L. & Fuchs, J., eds.), pp. 873-926. Dekker, New York, NY.
40. Wagner, B. A., Buettner, G. R. & Burns, P. C. (1993) Increasd generation of lipid-derived and ascorbate free radicals by L1210 cells exposed to the other lipid edelofosine. Cancer Res. 53: 711-713.
41. Wald, C. (1968) The molecular basis of visual excitation. Nature 219: 800-803.
42. Zhang, L. X., Cooney, R. V. & Bertram, J. S. (1991) Carotenoids enhance gap junctions communications and inhibit lipid peroxidation in C3H/10/T1/2 cells. Relationships to their cancer chemopreventative action. Carcinogenesis 12: 2109-2114.