메뉴 건너뛰기




Volumn 14, Issue 1, 2017, Pages 9-21

The intestinal epithelial barrier: A therapeutic target?

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; CYTOSKELETON PROTEIN; REGULATOR PROTEIN;

EID: 84995481695     PISSN: 17595045     EISSN: 17595053     Source Type: Journal    
DOI: 10.1038/nrgastro.2016.169     Document Type: Review
Times cited : (876)

References (222)
  • 3
    • 70350509805 scopus 로고    scopus 로고
    • Intestinal mucosal barrier function in health and disease
    • Turner, J. R. Intestinal mucosal barrier function in health and disease. Nat. Rev. Immunol. 9, 799-809 (2009).
    • (2009) Nat. Rev. Immunol. , vol.9 , pp. 799-809
    • Turner, J.R.1
  • 4
    • 79953307656 scopus 로고    scopus 로고
    • Loss of intestinal core 1-derived O-glycans causes spontaneous colitis in mice
    • Fu, J. et al. Loss of intestinal core 1-derived O-glycans causes spontaneous colitis in mice. J. Clin. Invest. 121, 1657-1666 (2011).
    • (2011) J. Clin. Invest. , vol.121 , pp. 1657-1666
    • Fu, J.1
  • 5
    • 54449083567 scopus 로고    scopus 로고
    • The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria
    • Johansson, M. E. et al. The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria. Proc. Natl Acad. Sci. USA 105, 15064-15069 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 15064-15069
    • Johansson, M.E.1
  • 6
    • 84891736162 scopus 로고    scopus 로고
    • Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis
    • Johansson, M. E. et al. Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis. Gut 63, 281-291 (2014).
    • (2014) Gut , vol.63 , pp. 281-291
    • Johansson, M.E.1
  • 7
    • 33745746660 scopus 로고    scopus 로고
    • Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection
    • Van der Sluis, M. et al. Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection. Gastroenterology 131, 117-129 (2006).
    • (2006) Gastroenterology , vol.131 , pp. 117-129
    • Van Der Sluis, M.1
  • 9
    • 0000752197 scopus 로고
    • Junctional complexes in various epithelia
    • Farquhar, M. & Palade, G. Junctional complexes in various epithelia. J. Cell Biol. 17, 375-412 (1963).
    • (1963) J. Cell Biol. , vol.17 , pp. 375-412
    • Farquhar, M.1    Palade, G.2
  • 10
    • 0023176321 scopus 로고
    • Intestinal absorptive cell tight junctions are linked to cytoskeleton
    • Madara, J. L. Intestinal absorptive cell tight junctions are linked to cytoskeleton. Am. J. Physiol. 253, C171-C175 (1987).
    • (1987) Am. J. Physiol. , vol.253 , pp. C171-C175
    • Madara, J.L.1
  • 11
    • 0021228377 scopus 로고
    • Brush border cytoskeleton and integration of cellular functions
    • Mooseker, M. S. et al. Brush border cytoskeleton and integration of cellular functions. J. Cell Biol. 99, 104s-112s (1984).
    • (1984) J. Cell Biol. , vol.99 , pp. 104s-112s
    • Mooseker, M.S.1
  • 12
    • 84901491471 scopus 로고    scopus 로고
    • Dynamic contacts: Rearranging adherens junctions to drive epithelial remodelling
    • Takeichi, M. Dynamic contacts: rearranging adherens junctions to drive epithelial remodelling. Nat. Rev. Mol. Cell Biol. 15, 397-410 (2014).
    • (2014) Nat. Rev. Mol. Cell Biol. , vol.15 , pp. 397-410
    • Takeichi, M.1
  • 13
    • 39849100440 scopus 로고    scopus 로고
    • Adherens and tight junctions: Structure, function and connections to the actin cytoskeleton
    • Hartsock, A. & Nelson, W. J. Adherens and tight junctions: structure, function and connections to the actin cytoskeleton. Biochim. Biophys. Acta 1778, 660-669 (2008).
    • (2008) Biochim. Biophys. Acta , vol.1778 , pp. 660-669
    • Hartsock, A.1    Nelson, W.J.2
  • 14
    • 28344439885 scopus 로고    scopus 로고
    • A-catenin is a molecular switch that binds E-cadherin-β-catenin and regulates actin-filament assembly
    • Drees, F., Pokutta, S., Yamada, S., Nelson, W. J. & Weis, W. I. a-catenin is a molecular switch that binds E-cadherin-β-catenin and regulates actin-filament assembly. Cell 123, 903-915 (2005).
    • (2005) Cell , vol.123 , pp. 903-915
    • Drees, F.1    Pokutta, S.2    Yamada, S.3    Nelson, W.J.4    Weis, W.I.5
  • 15
    • 81355138558 scopus 로고    scopus 로고
    • The secret life of a-catenin: Moonlighting in morphogenesis
    • Maiden, S. L. & Hardin, J. The secret life of a-catenin: moonlighting in morphogenesis. J. Cell Biol. 195, 543-552 (2011).
    • (2011) J. Cell Biol. , vol.195 , pp. 543-552
    • Maiden, S.L.1    Hardin, J.2
  • 16
    • 33846065117 scopus 로고    scopus 로고
    • Depletion of E-cadherin disrupts establishment but not maintenance of cell junctions in Madin-Darby canine kidney epithelial cells
    • Capaldo, C. T. & Macara, I. G. Depletion of E-cadherin disrupts establishment but not maintenance of cell junctions in Madin-Darby canine kidney epithelial cells. Mol. Biol. Cell 18, 189-200 (2007).
    • (2007) Mol. Biol. Cell , vol.18 , pp. 189-200
    • Capaldo, C.T.1    Macara, I.G.2
  • 17
    • 84883301688 scopus 로고    scopus 로고
    • ZO-1 recruitment to a-catenin -a novel mechanism for coupling the assembly of tight junctions to adherens junctions
    • Maiers, J. L., Peng, X., Fanning, A. S. & DeMali, K. A. ZO-1 recruitment to a-catenin -a novel mechanism for coupling the assembly of tight junctions to adherens junctions. J. Cell Sci. 126, 3904-3915 (2013).
    • (2013) J. Cell Sci. , vol.126 , pp. 3904-3915
    • Maiers, J.L.1    Peng, X.2    Fanning, A.S.3    DeMali, K.A.4
  • 18
    • 0014782467 scopus 로고
    • A fine structural analysis of intercellular junctions in the mouse liver
    • Goodenough, D. A. & Revel, J. P. A fine structural analysis of intercellular junctions in the mouse liver. J. Cell Biol. 45, 272-290 (1970).
    • (1970) J. Cell Biol. , vol.45 , pp. 272-290
    • Goodenough, D.A.1    Revel, J.P.2
  • 19
    • 0020058236 scopus 로고
    • Evidence for the lipidic nature of tight junction strands
    • Kachar, B. & Reese, T. S. Evidence for the lipidic nature of tight junction strands. Nature 296, 464-466 (1982).
    • (1982) Nature , vol.296 , pp. 464-466
    • Kachar, B.1    Reese, T.S.2
  • 20
    • 84940894920 scopus 로고    scopus 로고
    • Conceptual barriers to understanding physical barriers
    • Lingaraju, A. et al. Conceptual barriers to understanding physical barriers. Semin. Cell Dev. Biol. 42, 13-21 (2015).
    • (2015) Semin. Cell Dev. Biol. , vol.42 , pp. 13-21
    • Lingaraju, A.1
  • 21
    • 0027744129 scopus 로고
    • Occludin: A novel integral membrane protein localizing at tight junctions
    • Furuse, M. et al. Occludin: a novel integral membrane protein localizing at tight junctions. J. Cell Biol. 123, 1777-1788 (1993).
    • (1993) J. Cell Biol. , vol.123 , pp. 1777-1788
    • Furuse, M.1
  • 22
    • 0029811688 scopus 로고    scopus 로고
    • Alterations in cell cholesterol content modulate Ca2+-induced tight junction assembly by MDCK cells
    • Stankewich, M. C., Francis, S. A., Vu, Q. U., Schneeberger, E. E. & Lynch, R. D. Alterations in cell cholesterol content modulate Ca2+-induced tight junction assembly by MDCK cells. Lipids 31, 817-828 (1996).
    • (1996) Lipids , vol.31 , pp. 817-828
    • Stankewich, M.C.1    Francis, S.A.2    Vu, Q.U.3    Schneeberger, E.E.4    Lynch, R.D.5
  • 23
    • 0032840311 scopus 로고    scopus 로고
    • Rapid reduction of MDCK cell cholesterol by methyl-cyclodextrin alters steady state transepithelial electrical resistance
    • Francis, S. A. et al. Rapid reduction of MDCK cell cholesterol by methyl-cyclodextrin alters steady state transepithelial electrical resistance. Eur. J. Cell Biol. 78, 473-484 (1999).
    • (1999) Eur. J. Cell Biol. , vol.78 , pp. 473-484
    • Francis, S.A.1
  • 24
    • 33745193296 scopus 로고    scopus 로고
    • Myosin light chain phosphorylation regulates barrier function by remodeling tight junction structure
    • Shen, L. et al. Myosin light chain phosphorylation regulates barrier function by remodeling tight junction structure. J. Cell Sci. 119, 2095-2106 (2006).
    • (2006) J. Cell Sci. , vol.119 , pp. 2095-2106
    • Shen, L.1
  • 25
    • 33645963995 scopus 로고    scopus 로고
    • Claudins and epithelial paracellular transport
    • Van Itallie, C. M. & Anderson, J. M. Claudins and epithelial paracellular transport. Annu. Rev. Physiol. 68, 403-429 (2006).
    • (2006) Annu. Rev. Physiol. , vol.68 , pp. 403-429
    • Van Itallie, C.M.1    Anderson, J.M.2
  • 26
    • 0035897412 scopus 로고    scopus 로고
    • Conversion of zonulae occludentes from tight to leaky strand type by introducing claudin-2 into Madin-Darby canine kidney i cells
    • Furuse, M., Furuse, K., Sasaki, H. & Tsukita, S. Conversion of zonulae occludentes from tight to leaky strand type by introducing claudin-2 into Madin-Darby canine kidney I cells. J. Cell Biol. 153, 263-272 (2001).
    • (2001) J. Cell Biol. , vol.153 , pp. 263-272
    • Furuse, M.1    Furuse, K.2    Sasaki, H.3    Tsukita, S.4
  • 27
    • 0037115724 scopus 로고    scopus 로고
    • Claudin-2 expression induces cation-selective channels in tight junctions of epithelial cells
    • Amasheh, S. et al. Claudin-2 expression induces cation-selective channels in tight junctions of epithelial cells. J. Cell Sci. 115, 4969-4976 (2002).
    • (2002) J. Cell Sci. , vol.115 , pp. 4969-4976
    • Amasheh, S.1
  • 28
    • 84957922490 scopus 로고    scopus 로고
    • Claudin-2-dependent paracellular channels are dynamically gated
    • Weber, C. R. et al. Claudin-2-dependent paracellular channels are dynamically gated. eLife 4, e09906 (2015).
    • (2015) ELife , vol.4 , pp. e09906
    • Weber, C.R.1
  • 29
    • 77950588683 scopus 로고    scopus 로고
    • Epithelial myosin light chain kinase activation induces mucosal interleukin-13 expression to alter tight junction ion selectivity
    • Weber, C. R. et al. Epithelial myosin light chain kinase activation induces mucosal interleukin-13 expression to alter tight junction ion selectivity. J. Biol. Chem. 285, 12037-12046 (2010).
    • (2010) J. Biol. Chem. , vol.285 , pp. 12037-12046
    • Weber, C.R.1
  • 30
    • 79956202699 scopus 로고    scopus 로고
    • Occludin S408 phosphorylation regulates tight junction protein interactions and barrier function
    • Raleigh, D. R. et al. Occludin S408 phosphorylation regulates tight junction protein interactions and barrier function. J. Cell Biol. 193, 565-582 (2011).
    • (2011) J. Cell Biol. , vol.193 , pp. 565-582
    • Raleigh, D.R.1
  • 31
    • 84881534032 scopus 로고    scopus 로고
    • Loss of claudins 2 and 15 from mice causes defects in paracellular Na+ flow and nutrient transport in gut and leads to death from malnutrition
    • Wada, M., Tamura, A., Takahashi, N. & Tsukita, S. Loss of claudins 2 and 15 from mice causes defects in paracellular Na+ flow and nutrient transport in gut and leads to death from malnutrition. Gastroenterology 144, 369-380 (2013).
    • (2013) Gastroenterology , vol.144 , pp. 369-380
    • Wada, M.1    Tamura, A.2    Takahashi, N.3    Tsukita, S.4
  • 32
    • 79952286129 scopus 로고    scopus 로고
    • Loss of claudin-15, but not claudin-2, causes Na+ deficiency and glucose malabsorption in mouse small intestine
    • Tamura, A. et al. Loss of claudin-15, but not claudin-2, causes Na+ deficiency and glucose malabsorption in mouse small intestine. Gastroenterology 140, 913-923 (2011).
    • (2011) Gastroenterology , vol.140 , pp. 913-923
    • Tamura, A.1
  • 33
    • 84912106825 scopus 로고    scopus 로고
    • The role of molecular remodeling in differential regulation of tight junction permeability
    • Turner, J. R., Buschmann, M. M., Romero-Calvo, I., Sailer, A. & Shen, L. The role of molecular remodeling in differential regulation of tight junction permeability. Semin. Cell Dev. Biol. 36, 204-212 (2014).
    • (2014) Semin. Cell Dev. Biol. , vol.36 , pp. 204-212
    • Turner, J.R.1    Buschmann, M.M.2    Romero-Calvo, I.3    Sailer, A.4    Shen, L.5
  • 34
    • 77950663681 scopus 로고    scopus 로고
    • Tight junction-associated MARVEL proteins marveld3, tricellulin, and occludin have distinct but overlapping functions
    • Raleigh, D. R. et al. Tight junction-associated MARVEL proteins marveld3, tricellulin, and occludin have distinct but overlapping functions. Mol. Biol. Cell 21, 1200-1213 (2010).
    • (2010) Mol. Biol. Cell , vol.21 , pp. 1200-1213
    • Raleigh, D.R.1
  • 35
    • 0028110309 scopus 로고
    • Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctions
    • Furuse, M. et al. Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctions. J. Cell Biol. 127, 1617-1626 (1994).
    • (1994) J. Cell Biol. , vol.127 , pp. 1617-1626
    • Furuse, M.1
  • 36
    • 84876075035 scopus 로고    scopus 로고
    • In tight junctions, claudins regulate the interactions between occludin, tricellulin and marvelD3, which, inversely, modulate claudin oligomerization
    • Cording, J. et al. In tight junctions, claudins regulate the interactions between occludin, tricellulin and marvelD3, which, inversely, modulate claudin oligomerization. J. Cell Sci. 126, 554-564 (2013).
    • (2013) J. Cell Sci. , vol.126 , pp. 554-564
    • Cording, J.1
  • 37
    • 67249084776 scopus 로고    scopus 로고
    • Zonula occludens-1 and -2 are cytosolic scaffolds that regulate the assembly of cellular junctions
    • Fanning, A. S. & Anderson, J. M. Zonula occludens-1 and -2 are cytosolic scaffolds that regulate the assembly of cellular junctions. Ann. N. Y. Acad. Sci. 1165, 113-120 (2009).
    • (2009) Ann. N. Y. Acad. Sci. , vol.1165 , pp. 113-120
    • Fanning, A.S.1    Anderson, J.M.2
  • 38
    • 0029095287 scopus 로고
    • Zonula occludens (ZO)-1 and ZO-2: Membrane-associated guanylate kinase homologues (MAGuKs) of the tight junction
    • Anderson, J. M., Fanning, A. S., Lapierre, L. & Van Itallie, C. M. Zonula occludens (ZO)-1 and ZO-2: membrane-associated guanylate kinase homologues (MAGuKs) of the tight junction. Biochem. Soc. Trans. 23, 470-475 (1995).
    • (1995) Biochem. Soc. Trans. , vol.23 , pp. 470-475
    • Anderson, J.M.1    Fanning, A.S.2    Lapierre, L.3    Van Itallie, C.M.4
  • 39
    • 48649096603 scopus 로고    scopus 로고
    • Deficiency of zonula occludens-1 causes embryonic lethal phenotype associated with defected yolk sac angiogenesis and apoptosis of embryonic cells
    • Katsuno, T. et al. Deficiency of zonula occludens-1 causes embryonic lethal phenotype associated with defected yolk sac angiogenesis and apoptosis of embryonic cells. Mol. Biol. Cell 19, 2465-2475 (2008).
    • (2008) Mol. Biol. Cell , vol.19 , pp. 2465-2475
    • Katsuno, T.1
  • 40
    • 40749084863 scopus 로고    scopus 로고
    • Early embryonic lethality of mice lacking ZO-2, but not ZO-3, reveals critical and nonredundant roles for individual zonula occludens proteins in mammalian development
    • Xu, J. et al. Early embryonic lethality of mice lacking ZO-2, but not ZO-3, reveals critical and nonredundant roles for individual zonula occludens proteins in mammalian development. Mol. Cell. Biol. 28, 1669-1678 (2008).
    • (2008) Mol. Cell. Biol. , vol.28 , pp. 1669-1678
    • Xu, J.1
  • 41
    • 0037994064 scopus 로고    scopus 로고
    • Complex inheritance of familial hypercholanemia with associated mutations in TJP2 and BAAT
    • Carlton, V. E. et al. Complex inheritance of familial hypercholanemia with associated mutations in TJP2 and BAAT. Nat. Genet. 34, 91-96 (2003).
    • (2003) Nat. Genet. , vol.34 , pp. 91-96
    • Carlton, V.E.1
  • 42
    • 84898057518 scopus 로고    scopus 로고
    • Mutations in TJP2 cause progressive cholestatic liver disease
    • Sambrotta, M. et al. Mutations in TJP2 cause progressive cholestatic liver disease. Nat. Genet. 46, 326-328 (2014).
    • (2014) Nat. Genet. , vol.46 , pp. 326-328
    • Sambrotta, M.1
  • 43
    • 84908279831 scopus 로고    scopus 로고
    • Claudin 2 deficiency reduces bile flow and increases susceptibility to cholesterol gallstone disease in mice
    • Matsumoto, K. et al. Claudin 2 deficiency reduces bile flow and increases susceptibility to cholesterol gallstone disease in mice. Gastroenterology 147, 1134-1145.e10 (2014).
    • (2014) Gastroenterology , vol.147 , pp. 1134-1134e10
    • Matsumoto, K.1
  • 44
    • 84928969190 scopus 로고    scopus 로고
    • Hepatic injury in nonalcoholic steatohepatitis contributes to altered intestinal permeability
    • Luther, J. et al. Hepatic injury in nonalcoholic steatohepatitis contributes to altered intestinal permeability. Cell. Mol. Gastroenterol. Hepatol. 1, 222-232 (2015).
    • (2015) Cell. Mol. Gastroenterol. Hepatol. , vol.1 , pp. 222-232
    • Luther, J.1
  • 46
    • 70349317350 scopus 로고    scopus 로고
    • ZO-1 stabilizes the tight junction solute barrier through coupling to the perijunctional cytoskeleton
    • Van Itallie, C. M., Fanning, A. S., Bridges, A. & Anderson, J. M. ZO-1 stabilizes the tight junction solute barrier through coupling to the perijunctional cytoskeleton. Mol. Biol. Cell 20, 3930-3940 (2009).
    • (2009) Mol. Biol. Cell , vol.20 , pp. 3930-3940
    • Van Itallie, C.M.1    Fanning, A.S.2    Bridges, A.3    Anderson, J.M.4
  • 47
    • 84932608065 scopus 로고    scopus 로고
    • Intestinal barrier loss as a critical pathogenic link between inflammatory bowel disease and graft-versus-host disease
    • Nalle, S. C. & Turner, J. R. Intestinal barrier loss as a critical pathogenic link between inflammatory bowel disease and graft-versus-host disease. Mucosal Immunol. 8, 720-730 (2015).
    • (2015) Mucosal Immunol. , vol.8 , pp. 720-730
    • Nalle, S.C.1    Turner, J.R.2
  • 48
    • 84880611949 scopus 로고    scopus 로고
    • TNFR2 activates MLCK-dependent tight junction dysregulation to cause apoptosismediated barrier loss and experimental colitis
    • Su, L. et al. TNFR2 activates MLCK-dependent tight junction dysregulation to cause apoptosismediated barrier loss and experimental colitis. Gastroenterology 145, 407-415 (2013).
    • (2013) Gastroenterology , vol.145 , pp. 407-415
    • Su, L.1
  • 50
    • 0035210487 scopus 로고    scopus 로고
    • Epithelial barrier defects in ulcerative colitis: Characterization and quantification by electrophysiological imaging
    • Gitter, A. H., Wullstein, F., Fromm, M. & Schulzke, J. D. Epithelial barrier defects in ulcerative colitis: characterization and quantification by electrophysiological imaging. Gastroenterology 121, 1320-1328 (2001).
    • (2001) Gastroenterology , vol.121 , pp. 1320-1328
    • Gitter, A.H.1    Wullstein, F.2    Fromm, M.3    Schulzke, J.D.4
  • 51
    • 77957223906 scopus 로고    scopus 로고
    • Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells
    • Snippert, H. J. et al. Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells. Cell 143, 134-144 (2010).
    • (2010) Cell , vol.143 , pp. 134-144
    • Snippert, H.J.1
  • 52
    • 67651159312 scopus 로고    scopus 로고
    • Stem cells, selfrenewal, and differentiation in the intestinal epithelium
    • van der Flier, L. G. & Clevers, H. Stem cells, selfrenewal, and differentiation in the intestinal epithelium. Annu. Rev. Physiol. 71, 241-260 (2009).
    • (2009) Annu. Rev. Physiol. , vol.71 , pp. 241-260
    • Van Der Flier, L.G.1    Clevers, H.2
  • 53
    • 84975748266 scopus 로고    scopus 로고
    • Foxl1-expressing mesenchymal cells constitute the intestinal stem cell niche
    • Aoki, R. et al. Foxl1-expressing mesenchymal cells constitute the intestinal stem cell niche. Cell. Mol. Gastroenterol. Hepatol. 2, 175-188 (2016).
    • (2016) Cell. Mol. Gastroenterol. Hepatol. , vol.2 , pp. 175-188
    • Aoki, R.1
  • 54
    • 17144428522 scopus 로고    scopus 로고
    • Distinct temporal-spatial roles for rho kinase and myosin light chain kinase in epithelial purse-string wound closure
    • Russo, J. M. et al. Distinct temporal-spatial roles for rho kinase and myosin light chain kinase in epithelial purse-string wound closure. Gastroenterology 128, 987-1001 (2005).
    • (2005) Gastroenterology , vol.128 , pp. 987-1001
    • Russo, J.M.1
  • 55
    • 79953174256 scopus 로고    scopus 로고
    • The epithelial barrier is maintained by in vivo tight junction expansion during pathologic intestinal epithelial shedding
    • Marchiando, A. M. et al. The epithelial barrier is maintained by in vivo tight junction expansion during pathologic intestinal epithelial shedding. Gastroenterology 140, 1208-1218.e2 (2011).
    • (2011) Gastroenterology , vol.140 , pp. 1208-1208e2
    • Marchiando, A.M.1
  • 56
    • 0035960736 scopus 로고    scopus 로고
    • An epithelial cell destined for apoptosis signals its neighbors to extrude it by an actin-and myosindependent mechanism
    • Rosenblatt, J., Raff, M. C. & Cramer, L. P. An epithelial cell destined for apoptosis signals its neighbors to extrude it by an actin-and myosindependent mechanism. Curr. Biol. 11, 1847-1857 (2001).
    • (2001) Curr. Biol. , vol.11 , pp. 1847-1857
    • Rosenblatt, J.1    Raff, M.C.2    Cramer, L.P.3
  • 57
    • 0023510866 scopus 로고
    • Structural basis for physiological regulation of paracellular pathways in intestinal epithelia
    • Madara, J. L. & Pappenheimer, J. R. Structural basis for physiological regulation of paracellular pathways in intestinal epithelia. J. Membr. Biol. 100, 149-164 (1987).
    • (1987) J. Membr. Biol. , vol.100 , pp. 149-164
    • Madara, J.L.1    Pappenheimer, J.R.2
  • 58
    • 0023520885 scopus 로고
    • Physiological regulation of transepithelial impedance in the intestinal mucosa of rats and hamsters
    • Pappenheimer, J. R. Physiological regulation of transepithelial impedance in the intestinal mucosa of rats and hamsters. J. Membr. Biol. 100, 137-148 (1987).
    • (1987) J. Membr. Biol. , vol.100 , pp. 137-148
    • Pappenheimer, J.R.1
  • 59
    • 0023521841 scopus 로고
    • Contribution of solvent drag through intercellular junctions to absorption of nutrients by the small intestine of the rat
    • Pappenheimer, J. R. & Reiss, K. Z. Contribution of solvent drag through intercellular junctions to absorption of nutrients by the small intestine of the rat. J. Membr. Biol. 100, 123-136 (1987).
    • (1987) J. Membr. Biol. , vol.100 , pp. 123-136
    • Pappenheimer, J.R.1    Reiss, K.Z.2
  • 60
    • 0030669302 scopus 로고    scopus 로고
    • Physiological regulation of epithelial tight junctions is associated with myosin light-chain phosphorylation
    • Turner, J. R. et al. Physiological regulation of epithelial tight junctions is associated with myosin light-chain phosphorylation. Am. J. Physiol. 273, C1378-C1385 (1997).
    • (1997) Am. J. Physiol. , vol.273 , pp. C1378-C1385
    • Turner, J.R.1
  • 61
    • 0034733881 scopus 로고    scopus 로고
    • Show me the pathway! Regulation of paracellular permeability by Na+-glucose cotransport
    • Turner, J. R. Show me the pathway! Regulation of paracellular permeability by Na+-glucose cotransport. Adv. Drug Deliv. Rev. 41, 265-281 (2000).
    • (2000) Adv. Drug Deliv. Rev. , vol.41 , pp. 265-281
    • Turner, J.R.1
  • 62
    • 0024525147 scopus 로고
    • Intestinal glucose transport using perfused rat jejunum in vivo: Model analysis and derivation of corrected kinetic constants
    • Meddings, J. B. & Westergaard, H. Intestinal glucose transport using perfused rat jejunum in vivo: model analysis and derivation of corrected kinetic constants. Clin. Sci. (Lond.) 76, 403-413 (1989).
    • (1989) Clin. Sci. (Lond.) , vol.76 , pp. 403-413
    • Meddings, J.B.1    Westergaard, H.2
  • 63
    • 0027763397 scopus 로고
    • Luminal nutrients alter tight-junction permeability in the rat jejunum: An in vivo perfusion model
    • Sadowski, D. C. & Meddings, J. B. Luminal nutrients alter tight-junction permeability in the rat jejunum: an in vivo perfusion model. Can. J. Physiol. Pharmacol. 71, 835-839 (1993).
    • (1993) Can. J. Physiol. Pharmacol. , vol.71 , pp. 835-839
    • Sadowski, D.C.1    Meddings, J.B.2
  • 64
    • 0034527745 scopus 로고    scopus 로고
    • Noninvasive in vivo analysis of human small intestinal paracellular absorption: Regulation by Na+-glucose cotransport
    • Turner, J. R., Cohen, D. E., Mrsny, R. J. & Madara, J. L. Noninvasive in vivo analysis of human small intestinal paracellular absorption: regulation by Na+-glucose cotransport. Dig. Dis. Sci. 45, 2122-2126 (2000).
    • (2000) Dig. Dis. Sci. , vol.45 , pp. 2122-2126
    • Turner, J.R.1    Cohen, D.E.2    Mrsny, R.J.3    Madara, J.L.4
  • 65
    • 23244455992 scopus 로고    scopus 로고
    • Interleukin-13 is the key effector Th2 cytokine in ulcerative colitis that affects epithelial tight junctions, apoptosis, and cell restitution
    • Heller, F. et al. Interleukin-13 is the key effector Th2 cytokine in ulcerative colitis that affects epithelial tight junctions, apoptosis, and cell restitution. Gastroenterology 129, 550-564 (2005).
    • (2005) Gastroenterology , vol.129 , pp. 550-564
    • Heller, F.1
  • 66
    • 80052400212 scopus 로고    scopus 로고
    • Interleukin-6 (IL-6) regulates claudin-2 expression and tight junction permeability in intestinal epithelium
    • Suzuki, T., Yoshinaga, N. & Tanabe, S. Interleukin-6 (IL-6) regulates claudin-2 expression and tight junction permeability in intestinal epithelium. J. Biol. Chem. 286, 31263-31271 (2011).
    • (2011) J. Biol. Chem. , vol.286 , pp. 31263-31271
    • Suzuki, T.1    Yoshinaga, N.2    Tanabe, S.3
  • 67
    • 36849042673 scopus 로고    scopus 로고
    • Opposing regulation of the tight junction protein claudin-2 by interferon- and interleukin-4
    • Wisner, D. M., Harris, L. R. III, Green, C. L. & Poritz, L. S. Opposing regulation of the tight junction protein claudin-2 by interferon- and interleukin-4. J. Surg. Res. 144, 1-7 (2008).
    • (2008) J. Surg. Res. , vol.144 , pp. 1-7
    • Wisner, D.M.1    Harris, L.R.2    Green, C.L.3    Poritz, L.S.4
  • 68
    • 77954655235 scopus 로고    scopus 로고
    • TNFa up-regulates claudin-2 expression in epithelial HT-29/B6 cells via phosphatidylinositol-3-kinase signaling
    • Mankertz, J. et al. TNFa up-regulates claudin-2 expression in epithelial HT-29/B6 cells via phosphatidylinositol-3-kinase signaling. Cell Tissue Res. 336, 67-77 (2009).
    • (2009) Cell Tissue Res. , vol.336 , pp. 67-77
    • Mankertz, J.1
  • 69
    • 84902653958 scopus 로고    scopus 로고
    • TH9 cells that express the transcription factor PU.1 drive T cell-mediated colitis via IL-9 receptor signaling in intestinal epithelial cells
    • Gerlach, K. et al. TH9 cells that express the transcription factor PU.1 drive T cell-mediated colitis via IL-9 receptor signaling in intestinal epithelial cells. Nat. Immunol. 15, 676-686 (2014).
    • (2014) Nat. Immunol. , vol.15 , pp. 676-686
    • Gerlach, K.1
  • 70
    • 33845995125 scopus 로고    scopus 로고
    • Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohns disease
    • Zeissig, S. et al. Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohns disease. Gut 56, 61-72 (2007).
    • (2007) Gut , vol.56 , pp. 61-72
    • Zeissig, S.1
  • 71
    • 27744551342 scopus 로고    scopus 로고
    • Inflammatory processes have differential effects on claudins 2, 3 and 4 in colonic epithelial cells
    • Prasad, S. et al. Inflammatory processes have differential effects on claudins 2, 3 and 4 in colonic epithelial cells. Lab. Invest. 85, 1139-1162 (2005).
    • (2005) Lab. Invest. , vol.85 , pp. 1139-1162
    • Prasad, S.1
  • 72
    • 60549090106 scopus 로고    scopus 로고
    • Molecular basis for cation selectivity in claudin-2-based paracellular pores: Identification of an electrostatic interaction site
    • Yu, A. S. et al. Molecular basis for cation selectivity in claudin-2-based paracellular pores: identification of an electrostatic interaction site. J. Gen. Physiol. 133, 111-127 (2009).
    • (2009) J. Gen. Physiol. , vol.133 , pp. 111-127
    • Yu, A.S.1
  • 73
    • 84881256884 scopus 로고    scopus 로고
    • Conserved aromatic residue confers cation selectivity in claudin-2 and claudin-10b
    • Li, J., Zhuo, M., Pei, L. & Yu, A. S. Conserved aromatic residue confers cation selectivity in claudin-2 and claudin-10b. J. Biol. Chem. 288, 22790-22797 (2013).
    • (2013) J. Biol. Chem. , vol.288 , pp. 22790-22797
    • Li, J.1    Zhuo, M.2    Pei, L.3    Yu, A.S.4
  • 74
    • 84896797690 scopus 로고    scopus 로고
    • Comprehensive cysteine-scanning mutagenesis reveals claudin-2 pore-lining residues with different intrapore locations
    • Li, J., Zhuo, M., Pei, L., Rajagopal, M. & Yu, A. S. Comprehensive cysteine-scanning mutagenesis reveals claudin-2 pore-lining residues with different intrapore locations. J. Biol. Chem. 289, 6475-6484 (2014).
    • (2014) J. Biol. Chem. , vol.289 , pp. 6475-6484
    • Li, J.1    Zhuo, M.2    Pei, L.3    Rajagopal, M.4    Yu, A.S.5
  • 75
    • 0021251275 scopus 로고
    • Partitioning of paracellular conductance along the ileal crypt-villus axis: A hypothesis based on structural analysis with detailed consideration of tight junction structure-function relationships
    • Marcial, M. A., Carlson, S. L. & Madara, J. L. Partitioning of paracellular conductance along the ileal crypt-villus axis: a hypothesis based on structural analysis with detailed consideration of tight junction structure-function relationships. J. Membr. Biol. 80, 59-70 (1984).
    • (1984) J. Membr. Biol. , vol.80 , pp. 59-70
    • Marcial, M.A.1    Carlson, S.L.2    Madara, J.L.3
  • 76
    • 0033774567 scopus 로고    scopus 로고
    • Permeability of the rat small intestinal epithelium along the villus-crypt axis: Effects of glucose transport
    • Fihn, B. M., Sjoqvist, A. & Jodal, M. Permeability of the rat small intestinal epithelium along the villus-crypt axis: effects of glucose transport. Gastroenterology 119, 1029-1036 (2000).
    • (2000) Gastroenterology , vol.119 , pp. 1029-1036
    • Fihn, B.M.1    Sjoqvist, A.2    Jodal, M.3
  • 77
    • 0022877339 scopus 로고
    • Maturation of tight junctions in Guinea-pig cecal epithelium
    • Mora-Galindo, J. Maturation of tight junctions in guinea-pig cecal epithelium. Cell Tissue Res. 246, 169-175 (1986).
    • (1986) Cell Tissue Res. , vol.246 , pp. 169-175
    • Mora-Galindo, J.1
  • 78
    • 0036678630 scopus 로고    scopus 로고
    • Anti-tumor necrosis factor treatment restores the gut barrier in Crohns disease
    • Suenaert, P. et al. Anti-tumor necrosis factor treatment restores the gut barrier in Crohns disease. Am. J. Gastroenterol. 97, 2000-2004 (2002).
    • (2002) Am. J. Gastroenterol. , vol.97 , pp. 2000-2004
    • Suenaert, P.1
  • 79
    • 0032923705 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha antibody (infliximab) therapy profoundly down-regulates the inflammation in Crohns ileocolitis
    • Baert, F. J. et al. Tumor necrosis factor alpha antibody (infliximab) therapy profoundly down-regulates the inflammation in Crohns ileocolitis. Gastroenterology 116, 22-28 (1999).
    • (1999) Gastroenterology , vol.116 , pp. 22-28
    • Baert, F.J.1
  • 80
    • 0036305854 scopus 로고    scopus 로고
    • A membrane-permeant peptide that inhibits MLC kinase restores barrier function in in vitro models of intestinal disease
    • Zolotarevsky, Y. et al. A membrane-permeant peptide that inhibits MLC kinase restores barrier function in in vitro models of intestinal disease. Gastroenterology 123, 163-172 (2002).
    • (2002) Gastroenterology , vol.123 , pp. 163-172
    • Zolotarevsky, Y.1
  • 81
    • 13244298599 scopus 로고    scopus 로고
    • Interferon and tumor necrosis factor-a synergize to induce intestinal epithelial barrier dysfunction by up-regulating myosin light chain kinase expression
    • Wang, F. et al. Interferon and tumor necrosis factor-a synergize to induce intestinal epithelial barrier dysfunction by up-regulating myosin light chain kinase expression. Am. J. Pathol. 166, 409-419 (2005).
    • (2005) Am. J. Pathol. , vol.166 , pp. 409-419
    • Wang, F.1
  • 82
    • 33749428028 scopus 로고    scopus 로고
    • Coordinated epithelial NHE3 inhibition and barrier dysfunction are required for TNF-mediated diarrhea in vivo
    • Clayburgh, D. R., Musch, M. W., Leitges, M., Fu, Y. X. & Turner, J. R. Coordinated epithelial NHE3 inhibition and barrier dysfunction are required for TNF-mediated diarrhea in vivo. J. Clin. Invest. 116, 2682-2694 (2006).
    • (2006) J. Clin. Invest. , vol.116 , pp. 2682-2694
    • Clayburgh, D.R.1    Musch, M.W.2    Leitges, M.3    Fu, Y.X.4    Turner, J.R.5
  • 83
    • 33749466490 scopus 로고    scopus 로고
    • IFN-induced TNFR2 expression is required for TNF-dependent intestinal epithelial barrier dysfunction
    • Wang, F. et al. IFN-induced TNFR2 expression is required for TNF-dependent intestinal epithelial barrier dysfunction. Gastroenterology 131, 1153-1163 (2006).
    • (2006) Gastroenterology , vol.131 , pp. 1153-1163
    • Wang, F.1
  • 84
    • 26444577545 scopus 로고    scopus 로고
    • Epithelial myosin light chain kinase-dependent barrier dysfunction mediates T cell activation-induced diarrhea in vivo
    • Clayburgh, D. R. et al. Epithelial myosin light chain kinase-dependent barrier dysfunction mediates T cell activation-induced diarrhea in vivo. J. Clin. Invest. 115, 2702-2715 (2005).
    • (2005) J. Clin. Invest. , vol.115 , pp. 2702-2715
    • Clayburgh, D.R.1
  • 85
    • 33748747620 scopus 로고    scopus 로고
    • Tumor necrosis factor-induced long myosin light chain kinase transcription is regulated by differentiation-dependent signaling events. Characterization of the human long myosin light chain kinase promoter
    • Graham, W. V. et al. Tumor necrosis factor-induced long myosin light chain kinase transcription is regulated by differentiation-dependent signaling events. Characterization of the human long myosin light chain kinase promoter. J. Biol. Chem. 281, 26205-26215 (2006).
    • (2006) J. Biol. Chem. , vol.281 , pp. 26205-26215
    • Graham, W.V.1
  • 86
    • 58649090901 scopus 로고    scopus 로고
    • Targeted epithelial tight junction dysfunction causes immune activation and contributes to development of experimental colitis
    • Su, L. et al. Targeted epithelial tight junction dysfunction causes immune activation and contributes to development of experimental colitis. Gastroenterology 136, 551-563 (2009).
    • (2009) Gastroenterology , vol.136 , pp. 551-563
    • Su, L.1
  • 87
    • 77950585581 scopus 로고    scopus 로고
    • Caveolin-1-dependent occludin endocytosis is required for TNF-induced tight junction regulation in vivo
    • Marchiando, A. M. et al. Caveolin-1-dependent occludin endocytosis is required for TNF-induced tight junction regulation in vivo. J. Cell Biol. 189, 111-126 (2010).
    • (2010) J. Cell Biol. , vol.189 , pp. 111-126
    • Marchiando, A.M.1
  • 88
    • 84884738779 scopus 로고    scopus 로고
    • Occludin OCEL-domain interactions are required for maintenance and regulation of the tight junction barrier to macromolecular flux
    • Buschmann, M. M. et al. Occludin OCEL-domain interactions are required for maintenance and regulation of the tight junction barrier to macromolecular flux. Mol. Biol. Cell 24, 3056-3068 (2013).
    • (2013) Mol. Biol. Cell , vol.24 , pp. 3056-3068
    • Buschmann, M.M.1
  • 89
    • 77955992054 scopus 로고    scopus 로고
    • Occludin is required for cytokine-induced regulation of tight junction barriers
    • Van Itallie, C. M., Fanning, A. S., Holmes, J. & Anderson, J. M. Occludin is required for cytokine-induced regulation of tight junction barriers. J. Cell Sci. 123, 2844-2852 (2010).
    • (2010) J. Cell Sci. , vol.123 , pp. 2844-2852
    • Van Itallie, C.M.1    Fanning, A.S.2    Holmes, J.3    Anderson, J.M.4
  • 90
    • 77953020085 scopus 로고    scopus 로고
    • Tricellulin forms homomeric and heteromeric tight junctional complexes
    • Westphal, J. K. et al. Tricellulin forms homomeric and heteromeric tight junctional complexes. Cell. Mol. Life Sci. 67, 2057-2068 (2010).
    • (2010) Cell. Mol. Life Sci. , vol.67 , pp. 2057-2068
    • Westphal, J.K.1
  • 91
    • 69949110857 scopus 로고    scopus 로고
    • Tricellulin forms a barrier to macromolecules in tricellular tight junctions without affecting ion permeability
    • Krug, S. M. et al. Tricellulin forms a barrier to macromolecules in tricellular tight junctions without affecting ion permeability. Mol. Biol. Cell 20, 3713-3724 (2009).
    • (2009) Mol. Biol. Cell , vol.20 , pp. 3713-3724
    • Krug, S.M.1
  • 92
    • 58149279832 scopus 로고    scopus 로고
    • Loss of occludin affects tricellular localization of tricellulin
    • Ikenouchi, J., Sasaki, H., Tsukita, S., Furuse, M. & Tsukita, S. Loss of occludin affects tricellular localization of tricellulin. Mol. Biol. Cell 19, 4687-4693 (2008).
    • (2008) Mol. Biol. Cell , vol.19 , pp. 4687-4693
    • Ikenouchi, J.1    Sasaki, H.2    Tsukita, S.3    Furuse, M.4    Tsukita, S.5
  • 93
    • 77957748045 scopus 로고    scopus 로고
    • C-Jun N-terminal kinase is largely involved in the regulation of tricellular tight junctions via tricellulin in human pancreatic duct epithelial cells
    • Kojima, T. et al. c-Jun N-terminal kinase is largely involved in the regulation of tricellular tight junctions via tricellulin in human pancreatic duct epithelial cells. J. Cell. Physiol. 225, 720-733 (2010).
    • (2010) J. Cell. Physiol. , vol.225 , pp. 720-733
    • Kojima, T.1
  • 94
    • 84883509402 scopus 로고    scopus 로고
    • Tricellulin deficiency affects tight junction architecture and cochlear hair cells
    • Nayak, G. et al. Tricellulin deficiency affects tight junction architecture and cochlear hair cells. J. Clin. Invest. 123, 4036-4049 (2013).
    • (2013) J. Clin. Invest. , vol.123 , pp. 4036-4049
    • Nayak, G.1
  • 95
    • 33845190613 scopus 로고    scopus 로고
    • Tricellulin is a tight-junction protein necessary for hearing
    • Riazuddin, S. et al. Tricellulin is a tight-junction protein necessary for hearing. Am. J. Hum. Genet. 79, 1040-1051 (2006).
    • (2006) Am. J. Hum. Genet. , vol.79 , pp. 1040-1051
    • Riazuddin, S.1
  • 96
    • 38949172779 scopus 로고    scopus 로고
    • Splice-site mutations in the TRIC gene underlie autosomal recessive nonsyndromic hearing impairment in Pakistani families
    • Chishti, M. S. et al. Splice-site mutations in the TRIC gene underlie autosomal recessive nonsyndromic hearing impairment in Pakistani families. J. Hum. Genet. 53, 101-105 (2008).
    • (2008) J. Hum. Genet. , vol.53 , pp. 101-105
    • Chishti, M.S.1
  • 97
    • 84979036476 scopus 로고    scopus 로고
    • Deafness in occludin-deficient mice with dislocation of tricellulin and progressive apoptosis of the hair cells
    • Kitajiri, S. I. et al. Deafness in occludin-deficient mice with dislocation of tricellulin and progressive apoptosis of the hair cells. Biol. Open 3, 759-766 (2014).
    • (2014) Biol. Open , vol.3 , pp. 759-766
    • Kitajiri, S.I.1
  • 98
    • 0033635344 scopus 로고    scopus 로고
    • Complex phenotype of mice lacking occludin, a component of tight junction strands
    • Saitou, M. et al. Complex phenotype of mice lacking occludin, a component of tight junction strands. Mol. Biol. Cell 11, 4131-4142 (2000).
    • (2000) Mol. Biol. Cell , vol.11 , pp. 4131-4142
    • Saitou, M.1
  • 99
    • 17444392533 scopus 로고    scopus 로고
    • Epithelial transport and barrier function in occludin-deficient mice
    • Schulzke, J. D. et al. Epithelial transport and barrier function in occludin-deficient mice. Biochim. Biophys. Acta 1669, 34-42 (2005).
    • (2005) Biochim. Biophys. Acta , vol.1669 , pp. 34-42
    • Schulzke, J.D.1
  • 100
    • 33645049332 scopus 로고    scopus 로고
    • The primary defect in experimental ileitis originates from a nonhematopoietic source
    • Olson, T. S. et al. The primary defect in experimental ileitis originates from a nonhematopoietic source. J. Exp. Med. 203, 541-552 (2006).
    • (2006) J. Exp. Med. , vol.203 , pp. 541-552
    • Olson, T.S.1
  • 101
    • 59849104578 scopus 로고    scopus 로고
    • Normalization of leaky gut in chronic fatigue syndrome (CFS) is accompanied by a clinical improvement: Effects of age, duration of illness and the translocation of LPS from gram-negative bacteria
    • Maes, M. & Leunis, J. C. Normalization of leaky gut in chronic fatigue syndrome (CFS) is accompanied by a clinical improvement: effects of age, duration of illness and the translocation of LPS from gram-negative bacteria. Neuro Endocrinol. Lett. 29, 902-910 (2008).
    • (2008) Neuro Endocrinol. Lett. , vol.29 , pp. 902-910
    • Maes, M.1    Leunis, J.C.2
  • 102
    • 84956911098 scopus 로고    scopus 로고
    • Leaky gut -concept or clinical entity? Curr
    • Quigley, E. M. Leaky gut -concept or clinical entity? Curr. Opin. Gastroenterol. 32, 74-79 (2016).
    • (2016) Opin. Gastroenterol. , vol.32 , pp. 74-79
    • Quigley, E.M.1
  • 103
    • 84882797836 scopus 로고    scopus 로고
    • Intestinal permeability defects: Is it time to treat? Clin
    • Odenwald, M. A. & Turner, J. R. Intestinal permeability defects: is it time to treat? Clin. Gastroenterol. Hepatol. 11, 1075-1083 (2013).
    • (2013) Gastroenterol. Hepatol. , vol.11 , pp. 1075-1083
    • Odenwald, M.A.1    Turner, J.R.2
  • 104
    • 84951296372 scopus 로고    scopus 로고
    • Enterohemorrhagic Escherichia coli reduces mucus and intermicrovillar bridges in human stem cell-derived colonoids
    • In, J. et al. Enterohemorrhagic Escherichia coli reduces mucus and intermicrovillar bridges in human stem cell-derived colonoids. Cell. Mol. Gastroenterol. Hepatol. 2, 48-62.e3 (2016).
    • (2016) Cell. Mol. Gastroenterol. Hepatol. , vol.2 , pp. 48-48e3
    • In, J.1
  • 105
    • 0030775148 scopus 로고    scopus 로고
    • Enteropathogenic Escherichia coli-induced myosin light chain phosphorylation alters intestinal epithelial permeability
    • Yuhan, R., Koutsouris, A., Savkovic, S. D. & Hecht, G. Enteropathogenic Escherichia coli-induced myosin light chain phosphorylation alters intestinal epithelial permeability. Gastroenterology 113, 1873-1882 (1997).
    • (1997) Gastroenterology , vol.113 , pp. 1873-1882
    • Yuhan, R.1    Koutsouris, A.2    Savkovic, S.D.3    Hecht, G.4
  • 106
    • 0033523773 scopus 로고    scopus 로고
    • Clostridium perfringens enterotoxin fragment removes specific claudins from tight junction strands: Evidence for direct involvement of claudins in tight junction barrier
    • Sonoda, N. et al. Clostridium perfringens enterotoxin fragment removes specific claudins from tight junction strands: evidence for direct involvement of claudins in tight junction barrier. J. Cell Biol. 147, 195-204 (1999).
    • (1999) J. Cell Biol. , vol.147 , pp. 195-204
    • Sonoda, N.1
  • 107
    • 84922879446 scopus 로고    scopus 로고
    • Tight junctions. Structural insight into tight junction disassembly by Clostridium perfringens enterotoxin
    • Saitoh, Y. et al. Tight junctions. Structural insight into tight junction disassembly by Clostridium perfringens enterotoxin. Science 347, 775-778 (2015).
    • (2015) Science , vol.347 , pp. 775-778
    • Saitoh, Y.1
  • 108
    • 0026577118 scopus 로고
    • Clostridium difficile toxin B disrupts the barrier function of T84 monolayers
    • Hecht, G., Koutsouris, A., Pothoulakis, C., LaMont, J. T. & Madara, J. L. Clostridium difficile toxin B disrupts the barrier function of T84 monolayers. Gastroenterology 102, 416-423 (1992).
    • (1992) Gastroenterology , vol.102 , pp. 416-423
    • Hecht, G.1    Koutsouris, A.2    Pothoulakis, C.3    LaMont, J.T.4    Madara, J.L.5
  • 109
    • 0029054398 scopus 로고
    • Glucosylation of Rho proteins by Clostridium difficile toxin B
    • Just, I. et al. Glucosylation of Rho proteins by Clostridium difficile toxin B. Nature 375, 500-503 (1995).
    • (1995) Nature , vol.375 , pp. 500-503
    • Just, I.1
  • 110
    • 0024267211 scopus 로고
    • Crohns disease -a permeability disorder of the tight junction?
    • Hollander, D. Crohns disease -a permeability disorder of the tight junction? Gut 29, 1621-1624 (1988).
    • (1988) Gut , vol.29 , pp. 1621-1624
    • Hollander, D.1
  • 112
    • 0020643629 scopus 로고
    • Abnormal small intestinal permeability to sugars in patients with Crohns disease of the terminal ileum and colon
    • Ukabam, S. O., Clamp, J. R. & Cooper, B. T. Abnormal small intestinal permeability to sugars in patients with Crohns disease of the terminal ileum and colon. Digestion 27, 70-74 (1983).
    • (1983) Digestion , vol.27 , pp. 70-74
    • Ukabam, S.O.1    Clamp, J.R.2    Cooper, B.T.3
  • 113
    • 0032958705 scopus 로고    scopus 로고
    • Altered tight junction structure contributes to the impaired epithelial barrier function in ulcerative colitis
    • Schmitz, H. et al. Altered tight junction structure contributes to the impaired epithelial barrier function in ulcerative colitis. Gastroenterology 116, 301-309 (1999).
    • (1999) Gastroenterology , vol.116 , pp. 301-309
    • Schmitz, H.1
  • 114
    • 52649123158 scopus 로고    scopus 로고
    • Claudin-1 and claudin-2 expression is elevated in inflammatory bowel disease and may contribute to early neoplastic transformation
    • Weber, C. R., Nalle, S. C., Tretiakova, M., Rubin, D. T. & Turner, J. R. Claudin-1 and claudin-2 expression is elevated in inflammatory bowel disease and may contribute to early neoplastic transformation. Lab. Invest. 88, 1110-1120 (2008).
    • (2008) Lab. Invest. , vol.88 , pp. 1110-1120
    • Weber, C.R.1    Nalle, S.C.2    Tretiakova, M.3    Rubin, D.T.4    Turner, J.R.5
  • 115
    • 30944443377 scopus 로고    scopus 로고
    • Epithelial myosin light chain kinase expression and activity are upregulated in inflammatory bowel disease
    • Blair, S. A., Kane, S. V., Clayburgh, D. R. & Turner, J. R. Epithelial myosin light chain kinase expression and activity are upregulated in inflammatory bowel disease. Lab. Invest. 86, 191-201 (2006).
    • (2006) Lab. Invest. , vol.86 , pp. 191-201
    • Blair, S.A.1    Kane, S.V.2    Clayburgh, D.R.3    Turner, J.R.4
  • 116
    • 0027217379 scopus 로고
    • Intestinal permeability and the prediction of relapse in Crohns disease
    • Wyatt, J., Vogelsang, H., Hubl, W., Waldhoer, T. & Lochs, H. Intestinal permeability and the prediction of relapse in Crohns disease. Lancet 341, 1437-1439 (1993).
    • (1993) Lancet , vol.341 , pp. 1437-1439
    • Wyatt, J.1    Vogelsang, H.2    Hubl, W.3    Waldhoer, T.4    Lochs, H.5
  • 117
    • 0032871326 scopus 로고    scopus 로고
    • Intestinal permeability test as a predictor of clinical course in Crohns disease
    • DInca, R. et al. Intestinal permeability test as a predictor of clinical course in Crohns disease. Am. J. Gastroenterol. 94, 2956-2960 (1999).
    • (1999) Am. J. Gastroenterol. , vol.94 , pp. 2956-2960
    • Dinca, R.1
  • 118
    • 0034234796 scopus 로고    scopus 로고
    • Surrogate markers of intestinal inflammation are predictive of relapse in patients with inflammatory bowel disease
    • Tibble, J. A., Sigthorsson, G., Bridger, S., Fagerhol, M. K. & Bjarnason, I. Surrogate markers of intestinal inflammation are predictive of relapse in patients with inflammatory bowel disease. Gastroenterology 119, 15-22 (2000).
    • (2000) Gastroenterology , vol.119 , pp. 15-22
    • Tibble, J.A.1    Sigthorsson, G.2    Bridger, S.3    Fagerhol, M.K.4    Bjarnason, I.5
  • 119
    • 84862880940 scopus 로고    scopus 로고
    • Local barrier dysfunction identified by confocal laser endomicroscopy predicts relapse in inflammatory bowel disease
    • Kiesslich, R. et al. Local barrier dysfunction identified by confocal laser endomicroscopy predicts relapse in inflammatory bowel disease. Gut 61, 1146-1153 (2012).
    • (2012) Gut , vol.61 , pp. 1146-1153
    • Kiesslich, R.1
  • 120
    • 0025286406 scopus 로고
    • Maintenance of the macromolecular barrier at cell extrusion sites in intestinal epithelium: Physiological rearrangement of tight junctions
    • Madara, J. L. Maintenance of the macromolecular barrier at cell extrusion sites in intestinal epithelium: physiological rearrangement of tight junctions. J. Membr. Biol. 116, 177-184 (1990).
    • (1990) J. Membr. Biol. , vol.116 , pp. 177-184
    • Madara, J.L.1
  • 121
    • 0022970442 scopus 로고
    • Increased intestinal permeability in patients with Crohns disease and their relatives. A possible etiologic factor
    • Hollander, D. et al. Increased intestinal permeability in patients with Crohns disease and their relatives. A possible etiologic factor. Ann. Intern. Med. 105, 883-885 (1986).
    • (1986) Ann. Intern. Med. , vol.105 , pp. 883-885
    • Hollander, D.1
  • 122
    • 84992648249 scopus 로고    scopus 로고
    • A disease-associated microbial and metabolomics state in relatives of pediatric inflammatory bowel disease patients
    • Jacobs, J. P. et al. A disease-associated microbial and metabolomics state in relatives of pediatric inflammatory bowel disease patients. Cell. Mol. Gastroenterol. Hepatol. 2, 750-766 (2016).
    • (2016) Cell. Mol. Gastroenterol. Hepatol. , vol.2 , pp. 750-766
    • Jacobs, J.P.1
  • 123
    • 84999751792 scopus 로고    scopus 로고
    • Microgeographic proteomic networks of the human colonic mucosa and their association with inflammatory bowel disease
    • Li, X. et al. Microgeographic proteomic networks of the human colonic mucosa and their association with inflammatory bowel disease. Cell. Mol. Gastroenterol. Hepatol. 2, 567-583 (2016).
    • (2016) Cell. Mol. Gastroenterol. Hepatol. , vol.2 , pp. 567-583
    • Li, X.1
  • 124
    • 33144473772 scopus 로고    scopus 로고
    • Genetic basis for increased intestinal permeability in families with Crohns disease: Role of CARD15 3020insC mutation?
    • Buhner, S. et al. Genetic basis for increased intestinal permeability in families with Crohns disease: role of CARD15 3020insC mutation? Gut 55, 342-347 (2006).
    • (2006) Gut , vol.55 , pp. 342-347
    • Buhner, S.1
  • 126
    • 0034465898 scopus 로고    scopus 로고
    • Increased intestinal permeability precedes the onset of Crohns disease in a subject with familial risk
    • Irvine, E. J. & Marshall, J. K. Increased intestinal permeability precedes the onset of Crohns disease in a subject with familial risk. Gastroenterology 119, 1740-1744 (2000).
    • (2000) Gastroenterology , vol.119 , pp. 1740-1744
    • Irvine, E.J.1    Marshall, J.K.2
  • 127
    • 46049083963 scopus 로고    scopus 로고
    • Unique role of junctional adhesion molecule-A in maintaining mucosal homeostasis in inflammatory bowel disease
    • Vetrano, S. et al. Unique role of junctional adhesion molecule-A in maintaining mucosal homeostasis in inflammatory bowel disease. Gastroenterology 135, 173-184 (2008).
    • (2008) Gastroenterology , vol.135 , pp. 173-184
    • Vetrano, S.1
  • 129
    • 0020060944 scopus 로고
    • Intestinal permeability in coeliac disease: The response to gluten withdrawal and single-dose gluten challenge
    • Hamilton, I., Cobden, I., Rothwell, J. & Axon, A. T. Intestinal permeability in coeliac disease: the response to gluten withdrawal and single-dose gluten challenge. Gut 23, 202-210 (1982).
    • (1982) Gut , vol.23 , pp. 202-210
    • Hamilton, I.1    Cobden, I.2    Rothwell, J.3    Axon, A.T.4
  • 130
    • 0030915523 scopus 로고    scopus 로고
    • Gastrointestinal permeability in celiac disease
    • Smecuol, E. et al. Gastrointestinal permeability in celiac disease. Gastroenterology 112, 1129-1136 (1997).
    • (1997) Gastroenterology , vol.112 , pp. 1129-1136
    • Smecuol, E.1
  • 131
    • 0027409890 scopus 로고
    • Intestinal permeability in patients with coeliac disease and relatives of patients with coeliac disease
    • van Elburg, R. M., Uil, J. J., Mulder, C. J. & Heymans, H. S. Intestinal permeability in patients with coeliac disease and relatives of patients with coeliac disease. Gut 34, 354-357 (1993).
    • (1993) Gut , vol.34 , pp. 354-357
    • Van Elburg, R.M.1    Uil, J.J.2    Mulder, C.J.3    Heymans, H.S.4
  • 132
    • 0035058421 scopus 로고    scopus 로고
    • Improvement in intestinal permeability precedes morphometric recovery of the small intestine in coeliac disease
    • Cummins, A. G. et al. Improvement in intestinal permeability precedes morphometric recovery of the small intestine in coeliac disease. Clin. Sci. (Lond.) 100, 379-386 (2001).
    • (2001) Clin. Sci. (Lond.) , vol.100 , pp. 379-386
    • Cummins, A.G.1
  • 133
    • 84876481254 scopus 로고    scopus 로고
    • A controlled trial of glutenfree diet in patients with irritable bowel syndromediarrhea: Effects on bowel frequency and intestinal function
    • Vazquez-Roque, M. I. et al. A controlled trial of glutenfree diet in patients with irritable bowel syndromediarrhea: effects on bowel frequency and intestinal function. Gastroenterology 144, 903-911.e3 (2013).
    • (2013) Gastroenterology , vol.144 , pp. 903-903e3
    • Vazquez-Roque, M.I.1
  • 134
    • 0025768190 scopus 로고
    • Abnormal permeability precedes the development of a gluten sensitive enteropathy in Irish setter dogs
    • Hall, E. J. & Batt, R. M. Abnormal permeability precedes the development of a gluten sensitive enteropathy in Irish setter dogs. Gut 32, 749-753 (1991).
    • (1991) Gut , vol.32 , pp. 749-753
    • Hall, E.J.1    Batt, R.M.2
  • 135
    • 38349112856 scopus 로고    scopus 로고
    • Gliadin-dependent neuromuscular and epithelial secretory responses in gluten-sensitive HLA-DQ8 transgenic mice
    • Verdu, E. F. et al. Gliadin-dependent neuromuscular and epithelial secretory responses in gluten-sensitive HLA-DQ8 transgenic mice. Am. J. Physiol. Gastrointest. Liver Physiol. 294, G217-G225 (2008).
    • (2008) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.294 , pp. G217-G225
    • Verdu, E.F.1
  • 136
    • 68149094492 scopus 로고    scopus 로고
    • Host responses to intestinal microbial antigens in gluten-sensitive mice
    • Natividad, J. M. et al. Host responses to intestinal microbial antigens in gluten-sensitive mice. PLoS ONE 4, e6472 (2009).
    • (2009) PLoS ONE , vol.4 , pp. e6472
    • Natividad, J.M.1
  • 137
    • 0037302604 scopus 로고    scopus 로고
    • Early effects of gliadin on enterocyte intracellular signalling involved in intestinal barrier function
    • Clemente, M. G. et al. Early effects of gliadin on enterocyte intracellular signalling involved in intestinal barrier function. Gut 52, 218-223 (2003).
    • (2003) Gut , vol.52 , pp. 218-223
    • Clemente, M.G.1
  • 138
    • 24044493977 scopus 로고    scopus 로고
    • Rapid disruption of intestinal barrier function by gliadin involves altered expression of apical junctional proteins
    • Sander, G. R., Cummins, A. G., Henshall, T. & Powell, B. C. Rapid disruption of intestinal barrier function by gliadin involves altered expression of apical junctional proteins. FEBS Lett. 579, 4851-4855 (2005).
    • (2005) FEBS Lett. , vol.579 , pp. 4851-4855
    • Sander, G.R.1    Cummins, A.G.2    Henshall, T.3    Powell, B.C.4
  • 139
    • 0034728821 scopus 로고    scopus 로고
    • Zonulin, a newly discovered modulator of intestinal permeability, and its expression in coeliac disease
    • Fasano, A. et al. Zonulin, a newly discovered modulator of intestinal permeability, and its expression in coeliac disease. Lancet 355, 1518-1519 (2000).
    • (2000) Lancet , vol.355 , pp. 1518-1519
    • Fasano, A.1
  • 140
    • 84859805588 scopus 로고    scopus 로고
    • Larazotide acetate regulates epithelial tight junctions in vitro and in vivo
    • Gopalakrishnan, S. et al. Larazotide acetate regulates epithelial tight junctions in vitro and in vivo. Peptides 35, 86-94 (2012).
    • (2012) Peptides , vol.35 , pp. 86-94
    • Gopalakrishnan, S.1
  • 141
    • 84872717725 scopus 로고    scopus 로고
    • Larazotide acetate in patients with coeliac disease undergoing a gluten challenge: A randomised placebo-controlled study
    • Kelly, C. P. et al. Larazotide acetate in patients with coeliac disease undergoing a gluten challenge: a randomised placebo-controlled study. Aliment. Pharmacol. Ther. 37, 252-262 (2013).
    • (2013) Aliment. Pharmacol. Ther. , vol.37 , pp. 252-262
    • Kelly, C.P.1
  • 142
    • 28444452580 scopus 로고    scopus 로고
    • Myosin IXB variant increases the risk of celiac disease and points toward a primary intestinal barrier defect
    • Monsuur, A. J. et al. Myosin IXB variant increases the risk of celiac disease and points toward a primary intestinal barrier defect. Nat. Genet. 37, 1341-1344 (2005).
    • (2005) Nat. Genet. , vol.37 , pp. 1341-1344
    • Monsuur, A.J.1
  • 143
    • 0141817736 scopus 로고    scopus 로고
    • A major non-HLA locus in celiac disease maps to chromosome 19
    • Van Belzen, M. J. et al. A major non-HLA locus in celiac disease maps to chromosome 19. Gastroenterology 125, 1032-1041 (2003).
    • (2003) Gastroenterology , vol.125 , pp. 1032-1041
    • Van Belzen, M.J.1
  • 144
    • 0029991890 scopus 로고    scopus 로고
    • Human myosin-IXb, an unconventional myosin with a chimerin-like rho/rac GTPase-activating protein domain in its tail
    • Wirth, J. A., Jensen, K. A., Post, P. L., Bement, W. M. & Mooseker, M. S. Human myosin-IXb, an unconventional myosin with a chimerin-like rho/rac GTPase-activating protein domain in its tail. J. Cell Sci. 109, 653-661 (1996).
    • (1996) J. Cell Sci. , vol.109 , pp. 653-661
    • Wirth, J.A.1    Jensen, K.A.2    Post, P.L.3    Bement, W.M.4    Mooseker, M.S.5
  • 145
    • 0031977198 scopus 로고    scopus 로고
    • Human myosin-IXb is a mechanochemically active motor and a GAP for rho
    • Post, P. L., Bokoch, G. M. & Mooseker, M. S. Human myosin-IXb is a mechanochemically active motor and a GAP for rho. J. Cell Sci. 111, 941-950 (1998).
    • (1998) J. Cell Sci. , vol.111 , pp. 941-950
    • Post, P.L.1    Bokoch, G.M.2    Mooseker, M.S.3
  • 146
    • 33646574535 scopus 로고    scopus 로고
    • Lack of association of MYO9B genetic variants with coeliac disease in a British cohort
    • Hunt, K. A. et al. Lack of association of MYO9B genetic variants with coeliac disease in a British cohort. Gut 55, 969-972 (2006).
    • (2006) Gut , vol.55 , pp. 969-972
    • Hunt, K.A.1
  • 147
    • 33646552094 scopus 로고    scopus 로고
    • Association analysis of MYO9B gene polymorphisms with celiac disease in a Swedish/Norwegian cohort
    • Amundsen, S. S. et al. Association analysis of MYO9B gene polymorphisms with celiac disease in a Swedish/Norwegian cohort. Hum. Immunol. 67, 341-345 (2006).
    • (2006) Hum. Immunol. , vol.67 , pp. 341-345
    • Amundsen, S.S.1
  • 148
    • 79958265603 scopus 로고    scopus 로고
    • Replication of genetic variation in the MYO9B gene in Crohns disease
    • Wolters, V. M. et al. Replication of genetic variation in the MYO9B gene in Crohns disease. Hum. Immunol. 72, 592-597 (2011).
    • (2011) Hum. Immunol. , vol.72 , pp. 592-597
    • Wolters, V.M.1
  • 149
    • 33845622964 scopus 로고    scopus 로고
    • Genetic variation in myosin IXB is associated with ulcerative colitis
    • van Bodegraven, A. A. et al. Genetic variation in myosin IXB is associated with ulcerative colitis. Gastroenterology 131, 1768-1774 (2006).
    • (2006) Gastroenterology , vol.131 , pp. 1768-1774
    • Van Bodegraven, A.A.1
  • 150
    • 69449092789 scopus 로고    scopus 로고
    • Association between genetic variants in myosin IXB and Crohns disease
    • Cooney, R. et al. Association between genetic variants in myosin IXB and Crohns disease. Inflamm. Bowel Dis. 15, 1014-1021 (2009).
    • (2009) Inflamm. Bowel Dis. , vol.15 , pp. 1014-1021
    • Cooney, R.1
  • 151
    • 84863516735 scopus 로고    scopus 로고
    • A role for myosin IXb, a motor-RhoGAP chimera, in epithelial wound healing and tight junction regulation
    • Chandhoke, S. K. & Mooseker, M. S. A role for myosin IXb, a motor-RhoGAP chimera, in epithelial wound healing and tight junction regulation. Mol. Biol. Cell 23, 2468-2480 (2012).
    • (2012) Mol. Biol. Cell , vol.23 , pp. 2468-2480
    • Chandhoke, S.K.1    Mooseker, M.S.2
  • 152
    • 84962892930 scopus 로고    scopus 로고
    • Mice lacking myosin IXb, an inflammatory bowel disease susceptibility gene, have impaired intestinal barrier function and superficial ulceration in the ileum
    • Hegan, P. S. et al. Mice lacking myosin IXb, an inflammatory bowel disease susceptibility gene, have impaired intestinal barrier function and superficial ulceration in the ileum. Cytoskeleton (Hoboken) 73, 163-179 (2016).
    • (2016) Cytoskeleton (Hoboken) , vol.73 , pp. 163-179
    • Hegan, P.S.1
  • 153
    • 85028094075 scopus 로고    scopus 로고
    • Cell polarity-determining proteins Par-3 and PP-1 are involved in epithelial tight junction defects in coeliac disease
    • Schumann, M. et al. Cell polarity-determining proteins Par-3 and PP-1 are involved in epithelial tight junction defects in coeliac disease. Gut 61, 220-228 (2012).
    • (2012) Gut , vol.61 , pp. 220-228
    • Schumann, M.1
  • 154
    • 77949720519 scopus 로고    scopus 로고
    • Mucosal expression of claudins 2, 3 and 4 in proximal and distal part of duodenum in children with coeliac disease
    • Szakal, D. N. et al. Mucosal expression of claudins 2, 3 and 4 in proximal and distal part of duodenum in children with coeliac disease. Virchows Arch. 456, 245-250 (2010).
    • (2010) Virchows Arch. , vol.456 , pp. 245-250
    • Szakal, D.N.1
  • 155
    • 0018724826 scopus 로고
    • Abnormal intestinal permeability to sugars in villous atrophy
    • Menzies, I. S. et al. Abnormal intestinal permeability to sugars in villous atrophy. Lancet 2, 1107-1109 (1979).
    • (1979) Lancet , vol.2 , pp. 1107-1109
    • Menzies, I.S.1
  • 156
    • 0028879979 scopus 로고
    • Intestinal absorptive capacity, intestinal permeability and jejunal histology in HIV and their relation to diarrhoea
    • Keating, J. et al. Intestinal absorptive capacity, intestinal permeability and jejunal histology in HIV and their relation to diarrhoea. Gut 37, 623-629 (1995).
    • (1995) Gut , vol.37 , pp. 623-629
    • Keating, J.1
  • 157
    • 0028972499 scopus 로고
    • Inflammatory bowel disease and adenomas in mice expressing a dominant negative N-cadherin
    • Hermiston, M. L. & Gordon, J. I. Inflammatory bowel disease and adenomas in mice expressing a dominant negative N-cadherin. Science 270, 1203-1207 (1995).
    • (1995) Science , vol.270 , pp. 1203-1207
    • Hermiston, M.L.1    Gordon, J.I.2
  • 158
    • 0031710227 scopus 로고    scopus 로고
    • Alterations in classical cadherins associated with progression in ulcerative and Crohns colitis
    • Jankowski, J. A. et al. Alterations in classical cadherins associated with progression in ulcerative and Crohns colitis. Lab. Invest. 78, 1155-1167 (1998).
    • (1998) Lab. Invest. , vol.78 , pp. 1155-1167
    • Jankowski, J.A.1
  • 159
    • 77953221408 scopus 로고    scopus 로고
    • P120-catenin is essential for maintenance of barrier function and intestinal homeostasis in mice
    • Smalley-Freed, W. G. et al. p120-catenin is essential for maintenance of barrier function and intestinal homeostasis in mice. J. Clin. Invest. 120, 1824-1835 (2010).
    • (2010) J. Clin. Invest. , vol.120 , pp. 1824-1835
    • Smalley-Freed, W.G.1
  • 160
    • 78650775249 scopus 로고    scopus 로고
    • A key role for E-cadherin in intestinal homeostasis and Paneth cell maturation
    • Schneider, M. R. et al. A key role for E-cadherin in intestinal homeostasis and Paneth cell maturation. PLoS ONE 5, e14325 (2010).
    • (2010) PLoS ONE , vol.5 , pp. e14325
    • Schneider, M.R.1
  • 161
    • 70649103789 scopus 로고    scopus 로고
    • Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region
    • Barrett, J. C. et al. Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region. Nat. Genet. 41, 1330-1334 (2009).
    • (2009) Nat. Genet. , vol.41 , pp. 1330-1334
    • Barrett, J.C.1
  • 162
    • 84873733916 scopus 로고    scopus 로고
    • IL-10R polymorphisms are associated with very-early-onset ulcerative colitis
    • Moran, C. J. et al. IL-10R polymorphisms are associated with very-early-onset ulcerative colitis. Inflamm. Bowel Dis. 19, 115-123 (2013).
    • (2013) Inflamm. Bowel Dis. , vol.19 , pp. 115-123
    • Moran, C.J.1
  • 163
    • 70949087383 scopus 로고    scopus 로고
    • Inflammatory bowel disease and mutations affecting the interleukin-10 receptor
    • Glocker, E. O. et al. Inflammatory bowel disease and mutations affecting the interleukin-10 receptor. N. Engl. J. Med. 361, 2033-2045 (2009).
    • (2009) N. Engl. J. Med. , vol.361 , pp. 2033-2045
    • Glocker, E.O.1
  • 164
    • 84876361518 scopus 로고    scopus 로고
    • Genetic susceptibility in IBD: Overlap between ulcerative colitis and Crohns disease
    • Doecke, J. D. et al. Genetic susceptibility in IBD: overlap between ulcerative colitis and Crohns disease. Inflamm. Bowel Dis. 19, 240-245 (2013).
    • (2013) Inflamm. Bowel Dis. , vol.19 , pp. 240-245
    • Doecke, J.D.1
  • 165
    • 0035192380 scopus 로고    scopus 로고
    • Inflammatory bowel disease: Lessons from the IL-10 gene-deficient mouse
    • Madsen, K. L. Inflammatory bowel disease: lessons from the IL-10 gene-deficient mouse. Clin. Invest. Med. 24, 250-257 (2001).
    • (2001) Clin. Invest. Med. , vol.24 , pp. 250-257
    • Madsen, K.L.1
  • 166
    • 0027521572 scopus 로고
    • Interleukin-10-deficient mice develop chronic enterocolitis
    • Kuhn, R., Lohler, J., Rennick, D., Rajewsky, K. & Muller, W. Interleukin-10-deficient mice develop chronic enterocolitis. Cell 75, 263-274 (1993).
    • (1993) Cell , vol.75 , pp. 263-274
    • Kuhn, R.1    Lohler, J.2    Rennick, D.3    Rajewsky, K.4    Muller, W.5
  • 167
    • 70349427086 scopus 로고    scopus 로고
    • Toll-like receptor 4-mediated regulation of spontaneous Helicobacter-dependent colitis in IL-10-deficient mice
    • Matharu, K. S. et al. Toll-like receptor 4-mediated regulation of spontaneous Helicobacter-dependent colitis in IL-10-deficient mice. Gastroenterology 137, 1380-1390.e3 (2009).
    • (2009) Gastroenterology , vol.137 , pp. 1380-1380e3
    • Matharu, K.S.1
  • 168
    • 0033228442 scopus 로고    scopus 로고
    • Interleukin-10 gene-deficient mice develop a primary intestinal permeability defect in response to enteric microflora
    • Madsen, K. L. et al. Interleukin-10 gene-deficient mice develop a primary intestinal permeability defect in response to enteric microflora. Inflamm. Bowel Dis. 5, 262-270 (1999).
    • (1999) Inflamm. Bowel Dis. , vol.5 , pp. 262-270
    • Madsen, K.L.1
  • 169
    • 0034116557 scopus 로고    scopus 로고
    • Antibiotic therapy attenuates colitis in interleukin 10 gene-deficient mice
    • Madsen, K. L. et al. Antibiotic therapy attenuates colitis in interleukin 10 gene-deficient mice. Gastroenterology 118, 1094-1105 (2000).
    • (2000) Gastroenterology , vol.118 , pp. 1094-1105
    • Madsen, K.L.1
  • 170
    • 84898809123 scopus 로고    scopus 로고
    • The microbiome in inflammatory bowel disease: Current status and the future ahead
    • Kostic, A. D., Xavier, R. J. & Gevers, D. The microbiome in inflammatory bowel disease: current status and the future ahead. Gastroenterology 146, 1489-1499 (2014).
    • (2014) Gastroenterology , vol.146 , pp. 1489-1499
    • Kostic, A.D.1    Xavier, R.J.2    Gevers, D.3
  • 171
    • 0036829094 scopus 로고    scopus 로고
    • Rapid development of colitis in NSAID-treated IL-10-deficient mice
    • Berg, D. J. et al. Rapid development of colitis in NSAID-treated IL-10-deficient mice. Gastroenterology 123, 1527-1542 (2002).
    • (2002) Gastroenterology , vol.123 , pp. 1527-1542
    • Berg, D.J.1
  • 172
    • 84925709065 scopus 로고    scopus 로고
    • Increasing small intestinal permeability worsens colitis in the IL-10-/-mouse and prevents the induction of oral tolerance to ovalbumin
    • Arrieta, M. C., Madsen, K. L., Field, C. J. & Meddings, J. B. Increasing small intestinal permeability worsens colitis in the IL-10-/-mouse and prevents the induction of oral tolerance to ovalbumin. Inflamm. Bowel Dis. 21, 8-18 (2015).
    • (2015) Inflamm. Bowel Dis. , vol.21 , pp. 8-18
    • Arrieta, M.C.1    Madsen, K.L.2    Field, C.J.3    Meddings, J.B.4
  • 173
    • 58249085436 scopus 로고    scopus 로고
    • Reducing small intestinal permeability attenuates colitis in the IL10 gene-deficient mouse
    • Arrieta, M. C., Madsen, K., Doyle, J. & Meddings, J. Reducing small intestinal permeability attenuates colitis in the IL10 gene-deficient mouse. Gut 58, 41-48 (2009).
    • (2009) Gut , vol.58 , pp. 41-48
    • Arrieta, M.C.1    Madsen, K.2    Doyle, J.3    Meddings, J.4
  • 174
    • 0020694110 scopus 로고
    • Graft-versus-host disease and survival in patients with aplastic anemia treated by marrow grafts from HLA-identical siblings -beneficial effect of a protective environment
    • Storb, R. et al. Graft-versus-host disease and survival in patients with aplastic anemia treated by marrow grafts from HLA-identical siblings -beneficial effect of a protective environment. N. Engl. J. Med. 308, 302-307 (1983).
    • (1983) N. Engl. J. Med. , vol.308 , pp. 302-307
    • Storb, R.1
  • 175
    • 0033011210 scopus 로고    scopus 로고
    • Tumor necrosis factor inhibitor ameliorates murine intestinal graft-versus-host disease
    • Brown, G. R. et al. Tumor necrosis factor inhibitor ameliorates murine intestinal graft-versus-host disease. Gastroenterology 116, 593-601 (1999).
    • (1999) Gastroenterology , vol.116 , pp. 593-601
    • Brown, G.R.1
  • 176
    • 0032533897 scopus 로고    scopus 로고
    • Tumor necrosis factor-a production to lipopolysaccharide stimulation by donor cells predicts the severity of experimental acute graftversus-host disease
    • Cooke, K. R. et al. Tumor necrosis factor-a production to lipopolysaccharide stimulation by donor cells predicts the severity of experimental acute graftversus-host disease. J. Clin. Invest. 102, 1882-1891 (1998).
    • (1998) J. Clin. Invest. , vol.102 , pp. 1882-1891
    • Cooke, K.R.1
  • 177
    • 84904512053 scopus 로고    scopus 로고
    • Recipient NK cell inactivation and intestinal barrier loss are required for MHC-matched graft-versus-host disease
    • Nalle, S. C. et al. Recipient NK cell inactivation and intestinal barrier loss are required for MHC-matched graft-versus-host disease. Sci. Transl Med. 6, 243ra87 (2014).
    • (2014) Sci. Transl Med. , vol.6 , pp. 243ra87
    • Nalle, S.C.1
  • 178
    • 33750906233 scopus 로고    scopus 로고
    • Increased intestinal permeability precedes clinical onset of type 1 diabetes
    • Bosi, E. et al. Increased intestinal permeability precedes clinical onset of type 1 diabetes. Diabetologia 49, 2824-2827 (2006).
    • (2006) Diabetologia , vol.49 , pp. 2824-2827
    • Bosi, E.1
  • 179
    • 0032937027 scopus 로고    scopus 로고
    • Increased gastrointestinal permeability is an early lesion in the spontaneously diabetic BB rat
    • Meddings, J. B., Jarand, J., Urbanski, S. J., Hardin, J. & Gall, D. G. Increased gastrointestinal permeability is an early lesion in the spontaneously diabetic BB rat. Am. J. Physiol. 276, G951-G957 (1999).
    • (1999) Am. J. Physiol. , vol.276 , pp. G951-G957
    • Meddings, J.B.1    Jarand, J.2    Urbanski, S.J.3    Hardin, J.4    Gall, D.G.5
  • 181
    • 84962190977 scopus 로고    scopus 로고
    • Cathelicidin antimicrobial peptide: A novel regulator of islet function, islet regeneration, and selected gut bacteria
    • Pound, L. D. et al. Cathelicidin antimicrobial peptide: a novel regulator of islet function, islet regeneration, and selected gut bacteria. Diabetes 64, 4135-4147 (2015).
    • (2015) Diabetes , vol.64 , pp. 4135-4147
    • Pound, L.D.1
  • 182
    • 84938965221 scopus 로고    scopus 로고
    • Role of the gastrointestinal ecosystem in the development of Type 1 diabetes
    • Daft, J. G. & Lorenz, R. G. Role of the gastrointestinal ecosystem in the development of Type 1 diabetes. Pediatr. Diabetes 16, 407-418 (2015).
    • (2015) Pediatr. Diabetes , vol.16 , pp. 407-418
    • Daft, J.G.1    Lorenz, R.G.2
  • 183
    • 54549122338 scopus 로고    scopus 로고
    • Innate immunity and intestinal microbiota in the development of Type 1 diabetes
    • Wen, L. et al. Innate immunity and intestinal microbiota in the development of Type 1 diabetes. Nature 455, 1109-1113 (2008).
    • (2008) Nature , vol.455 , pp. 1109-1113
    • Wen, L.1
  • 184
    • 0027166934 scopus 로고
    • NOD mouse colonies around the world -recent facts and figures
    • Pozzilli, P., Signore, A., Williams, A. J. & Beales, P. E. NOD mouse colonies around the world -recent facts and figures. Immunol. Today 14, 193-196 (1993).
    • (1993) Immunol. Today , vol.14 , pp. 193-196
    • Pozzilli, P.1    Signore, A.2    Williams, A.J.3    Beales, P.E.4
  • 185
    • 14544277099 scopus 로고    scopus 로고
    • Role of the intestinal tight junction modulator zonulin in the pathogenesis of type i diabetes in BB diabetic-prone rats
    • Watts, T. et al. Role of the intestinal tight junction modulator zonulin in the pathogenesis of type I diabetes in BB diabetic-prone rats. Proc. Natl Acad. Sci. USA 102, 2916-2921 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 2916-2921
    • Watts, T.1
  • 186
    • 33745311630 scopus 로고    scopus 로고
    • Zonulin upregulation is associated with increased gut permeability in subjects with type 1 diabetes and their relatives
    • Sapone, A. et al. Zonulin upregulation is associated with increased gut permeability in subjects with type 1 diabetes and their relatives. Diabetes 55, 1443-1449 (2006).
    • (2006) Diabetes , vol.55 , pp. 1443-1449
    • Sapone, A.1
  • 187
    • 84867101199 scopus 로고    scopus 로고
    • A randomized, double-blind study of larazotide acetate to prevent the activation of celiac disease during gluten challenge
    • Leffler, D. A. et al. A randomized, double-blind study of larazotide acetate to prevent the activation of celiac disease during gluten challenge. Am. J. Gastroenterol. 107, 1554-1562 (2012).
    • (2012) Am. J. Gastroenterol. , vol.107 , pp. 1554-1562
    • Leffler, D.A.1
  • 188
    • 33645985802 scopus 로고    scopus 로고
    • Engraftment of mucosal stem cells into murine jejunum is dependent on optimal dose of cells
    • Avansino, J. R., Chen, D. C., Woolman, J. D., Hoagland, V. D. & Stelzner, M. Engraftment of mucosal stem cells into murine jejunum is dependent on optimal dose of cells. J. Surg. Res. 132, 74-79 (2006).
    • (2006) J. Surg. Res. , vol.132 , pp. 74-79
    • Avansino, J.R.1    Chen, D.C.2    Woolman, J.D.3    Hoagland, V.D.4    Stelzner, M.5
  • 189
    • 0028070612 scopus 로고
    • Colonic mucosal replacement by syngeneic small intestinal stem cell transplantation
    • Tait, I. S., Evans, G. S., Flint, N. & Campbell, F. C. Colonic mucosal replacement by syngeneic small intestinal stem cell transplantation. Am. J. Surg. 167, 67-72 (1994).
    • (1994) Am. J. Surg. , vol.167 , pp. 67-72
    • Tait, I.S.1    Evans, G.S.2    Flint, N.3    Campbell, F.C.4
  • 190
    • 67349123408 scopus 로고    scopus 로고
    • Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
    • Sato, T. et al. Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature 459, 262-265 (2009).
    • (2009) Nature , vol.459 , pp. 262-265
    • Sato, T.1
  • 191
    • 84997106969 scopus 로고    scopus 로고
    • Epithelial regeneration after gastric ulceration causes prolonged cell-type alterations
    • Aihara, E. et al. Epithelial regeneration after gastric ulceration causes prolonged cell-type alterations. Cell. Mol. Gastroenterol. Hepatol. 2, 625-647 (2016).
    • (2016) Cell. Mol. Gastroenterol. Hepatol. , vol.2 , pp. 625-647
    • Aihara, E.1
  • 192
    • 84997419129 scopus 로고    scopus 로고
    • The development of spasmolytic polypeptide/TFF2-expressing metaplasia (SPEM) during gastric repair is absent in the aged stomach
    • Engevik, A. C. et al. The development of spasmolytic polypeptide/TFF2-expressing metaplasia (SPEM) during gastric repair is absent in the aged stomach. Cell. Mol. Gastroenterol. Hepatol. 2, 605-624 (2016).
    • (2016) Cell. Mol. Gastroenterol. Hepatol. , vol.2 , pp. 605-624
    • Engevik, A.C.1
  • 193
    • 84862777784 scopus 로고    scopus 로고
    • Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5+ stem cell
    • Yui, S. et al. Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5+ stem cell. Nat. Med. 18, 618-623 (2012).
    • (2012) Nat. Med. , vol.18 , pp. 618-623
    • Yui, S.1
  • 194
    • 84864854371 scopus 로고    scopus 로고
    • Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas
    • Schepers, A. G. et al. Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas. Science 337, 730-735 (2012).
    • (2012) Science , vol.337 , pp. 730-735
    • Schepers, A.G.1
  • 195
    • 59049106578 scopus 로고    scopus 로고
    • Crypt stem cells as the cells-of-origin of intestinal cancer
    • Barker, N. et al. Crypt stem cells as the cells-of-origin of intestinal cancer. Nature 457, 608-611 (2009).
    • (2009) Nature , vol.457 , pp. 608-611
    • Barker, N.1
  • 196
    • 84992535817 scopus 로고    scopus 로고
    • The RNA polymerase III subunit Polr3b is required for the maintenance of small intestinal crypts in mice
    • Kieckhaefer, J. et al. The RNA polymerase III subunit Polr3b is required for the maintenance of small intestinal crypts in mice. Cell. Mol. Gastroenterol. Hepatol. 2, 783-795 (2016).
    • (2016) Cell. Mol. Gastroenterol. Hepatol. , vol.2 , pp. 783-795
    • Kieckhaefer, J.1
  • 197
    • 84992655949 scopus 로고    scopus 로고
    • Requirement of Gaq/Ga11 signaling in the preservation of mouse intestinal epithelial homeostasis
    • Watanabe, N. et al. Requirement of Gaq/Ga11 signaling in the preservation of mouse intestinal epithelial homeostasis. Cell. Mol. Gastroenterol. Hepatol. 2, 767-782 (2016).
    • (2016) Cell. Mol. Gastroenterol. Hepatol. , vol.2 , pp. 767-782
    • Watanabe, N.1
  • 198
    • 50149105621 scopus 로고    scopus 로고
    • Transactivation of EGF receptor and ErbB2 protects intestinal epithelial cells from TNF-induced apoptosis
    • Yamaoka, T. et al. Transactivation of EGF receptor and ErbB2 protects intestinal epithelial cells from TNF-induced apoptosis. Proc. Natl Acad. Sci. USA 105, 11772-11777 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 11772-11777
    • Yamaoka, T.1
  • 199
    • 34247193001 scopus 로고    scopus 로고
    • R-spondin1, a novel intestinotrophic mitogen, ameliorates experimental colitis in mice
    • Zhao, J. et al. R-spondin1, a novel intestinotrophic mitogen, ameliorates experimental colitis in mice. Gastroenterology 132, 1331-1343 (2007).
    • (2007) Gastroenterology , vol.132 , pp. 1331-1343
    • Zhao, J.1
  • 200
    • 14944357138 scopus 로고    scopus 로고
    • Wnt, stem cells and cancer in the intestine
    • Pinto, D. & Clevers, H. Wnt, stem cells and cancer in the intestine. Biol. Cell 97, 185-196 (2005).
    • (2005) Biol. Cell , vol.97 , pp. 185-196
    • Pinto, D.1    Clevers, H.2
  • 201
    • 2942668475 scopus 로고    scopus 로고
    • Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration
    • Sansom, O. J. et al. Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration. Genes Dev. 18, 1385-1390 (2004).
    • (2004) Genes Dev. , vol.18 , pp. 1385-1390
    • Sansom, O.J.1
  • 202
    • 84859196824 scopus 로고    scopus 로고
    • The pan-ErbB negative regulator Lrig1 is an intestinal stem cell marker that functions as a tumor suppressor
    • Powell, A. E. et al. The pan-ErbB negative regulator Lrig1 is an intestinal stem cell marker that functions as a tumor suppressor. Cell 149, 146-158 (2012).
    • (2012) Cell , vol.149 , pp. 146-158
    • Powell, A.E.1
  • 203
    • 84859430024 scopus 로고    scopus 로고
    • Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling
    • Wong, V. W. et al. Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling. Nat. Cell Biol. 14, 401-408 (2012).
    • (2012) Nat. Cell Biol. , vol.14 , pp. 401-408
    • Wong, V.W.1
  • 204
    • 84864750939 scopus 로고    scopus 로고
    • Epidermal growth factor receptor inhibits colitis-associated cancer in mice
    • Dube, P. E. et al. Epidermal growth factor receptor inhibits colitis-associated cancer in mice. J. Clin. Invest. 122, 2780-2792 (2012).
    • (2012) J. Clin. Invest. , vol.122 , pp. 2780-2792
    • Dube, P.E.1
  • 205
    • 79961045642 scopus 로고    scopus 로고
    • Role of myosin light chain kinase in regulation of basal blood pressure and maintenance of salt-induced hypertension
    • He, W. Q. et al. Role of myosin light chain kinase in regulation of basal blood pressure and maintenance of salt-induced hypertension. Am. J. Physiol. Heart Circ. Physiol. 301, H584-H591 (2011).
    • (2011) Am. J. Physiol. Heart Circ. Physiol. , vol.301 , pp. H584-H591
    • He, W.Q.1
  • 206
    • 48549089459 scopus 로고    scopus 로고
    • Myosin light chain kinase is central to smooth muscle contraction and required for gastrointestinal motility in mice
    • He, W. Q. et al. Myosin light chain kinase is central to smooth muscle contraction and required for gastrointestinal motility in mice. Gastroenterology 135, 610-620 (2008).
    • (2008) Gastroenterology , vol.135 , pp. 610-620
    • He, W.Q.1
  • 207
    • 77949333284 scopus 로고    scopus 로고
    • Myosin light chain kinase is necessary for tonic airway smooth muscle contraction
    • Zhang, W. C. et al. Myosin light chain kinase is necessary for tonic airway smooth muscle contraction. J. Biol. Chem. 285, 5522-5531 (2010).
    • (2010) J. Biol. Chem. , vol.285 , pp. 5522-5531
    • Zhang, W.C.1
  • 208
    • 84862871048 scopus 로고    scopus 로고
    • Defective tight junctions in refractory celiac disease
    • Schumann, M. et al. Defective tight junctions in refractory celiac disease. Ann. N. Y. Acad. Sci. 1258, 43-51 (2012).
    • (2012) Ann. N. Y. Acad. Sci. , vol.1258 , pp. 43-51
    • Schumann, M.1
  • 209
    • 80053521469 scopus 로고    scopus 로고
    • Increased intestinal permeability and tight junction disruption by altered expression and localization of occludin in a murine graft versus host disease model
    • Noth, R. et al. Increased intestinal permeability and tight junction disruption by altered expression and localization of occludin in a murine graft versus host disease model. BMC Gastroenterol. 11, 109 (2011).
    • (2011) BMC Gastroenterol. , vol.11 , pp. 109
    • Noth, R.1
  • 210
    • 84881030277 scopus 로고    scopus 로고
    • Complex roles of caspases in the pathogenesis of inflammatory bowel disease
    • Becker, C., Watson, A. J. & Neurath, M. F. Complex roles of caspases in the pathogenesis of inflammatory bowel disease. Gastroenterology 144, 283-293 (2013).
    • (2013) Gastroenterology , vol.144 , pp. 283-293
    • Becker, C.1    Watson, A.J.2    Neurath, M.F.3
  • 211
    • 66549112120 scopus 로고    scopus 로고
    • Pathology of graftversus-host disease in the gastrointestinal tract
    • Washington, K. & Jagasia, M. Pathology of graftversus-host disease in the gastrointestinal tract. Hum. Pathol. 40, 909-917 (2009).
    • (2009) Hum. Pathol. , vol.40 , pp. 909-917
    • Washington, K.1    Jagasia, M.2
  • 212
    • 0023927304 scopus 로고
    • Assessment of the lactulose-mannitol test in Crohns disease
    • Andre, F. et al. Assessment of the lactulose-mannitol test in Crohns disease. Gut 29, 511-515 (1988).
    • (1988) Gut , vol.29 , pp. 511-515
    • Andre, F.1
  • 213
    • 0028125084 scopus 로고
    • Increased permeability of macroscopically normal small bowel in Crohns disease
    • Peeters, M. et al. Increased permeability of macroscopically normal small bowel in Crohns disease. Dig. Dis. Sci. 39, 2170-2176 (1994).
    • (1994) Dig. Dis. Sci. , vol.39 , pp. 2170-2176
    • Peeters, M.1
  • 214
    • 0018894692 scopus 로고
    • Passage of molecules through the wall of the gastrointestinal tract. II. Application of low-molecular weight polyethyleneglycol and a deterministic mathematical model for determining intestinal permeability in man
    • Sundqvist, T., Magnusson, K. E., Sjodahl, R., Stjernstrom, I. & Tagesson, C. Passage of molecules through the wall of the gastrointestinal tract. II. Application of low-molecular weight polyethyleneglycol and a deterministic mathematical model for determining intestinal permeability in man. Gut 21, 208-214 (1980).
    • (1980) Gut , vol.21 , pp. 208-214
    • Sundqvist, T.1    Magnusson, K.E.2    Sjodahl, R.3    Stjernstrom, I.4    Tagesson, C.5
  • 215
    • 0033635128 scopus 로고    scopus 로고
    • Abnormal intestinal permeability predicts relapse in inactive Crohn disease
    • Arnott, I. D., Kingstone, K. & Ghosh, S. Abnormal intestinal permeability predicts relapse in inactive Crohn disease. Scand. J. Gastroenterol. 35, 1163-1169 (2000).
    • (2000) Scand. J. Gastroenterol. , vol.35 , pp. 1163-1169
    • Arnott, I.D.1    Kingstone, K.2    Ghosh, S.3
  • 216
    • 23544454108 scopus 로고
    • Lactulose/mannitol permeability is increased in relatives of patients with Crohns disease
    • May, G. R., Sutherland, L. M. & Meddings, J. B. Lactulose/mannitol permeability is increased in relatives of patients with Crohns disease. Gastroenterology 102, A934 (1992).
    • (1992) Gastroenterology , vol.102 , pp. A934
    • May, G.R.1    Sutherland, L.M.2    Meddings, J.B.3
  • 217
    • 0032763736 scopus 로고    scopus 로고
    • Sugar tests detect celiac disease among first-degree relatives
    • Smecuol, E. et al. Sugar tests detect celiac disease among first-degree relatives. Am. J. Gastroenterol. 94, 3547-3552 (1999).
    • (1999) Am. J. Gastroenterol. , vol.94 , pp. 3547-3552
    • Smecuol, E.1
  • 218
    • 11144353743 scopus 로고    scopus 로고
    • Ultrastructural mucosal alterations and increased intestinal permeability in non-celiac, type i diabetic patients
    • Secondulfo, M. et al. Ultrastructural mucosal alterations and increased intestinal permeability in non-celiac, type I diabetic patients. Dig. Liver Dis. 36, 35-45 (2004).
    • (2004) Dig. Liver Dis. , vol.36 , pp. 35-45
    • Secondulfo, M.1
  • 219
    • 34247598857 scopus 로고    scopus 로고
    • Loss of the tight junction protein ZO-1 in dextran sulfate sodium induced colitis
    • Poritz, L. S. et al. Loss of the tight junction protein ZO-1 in dextran sulfate sodium induced colitis. J. Surg. Res. 140, 12-19 (2007).
    • (2007) J. Surg. Res. , vol.140 , pp. 12-19
    • Poritz, L.S.1
  • 220
    • 67650667753 scopus 로고    scopus 로고
    • Temporal and spatial analysis of clinical and molecular parameters in dextran sodium sulfate induced colitis
    • Yan, Y. et al. Temporal and spatial analysis of clinical and molecular parameters in dextran sodium sulfate induced colitis. PLoS ONE 4, e6073 (2009).
    • (2009) PLoS ONE , vol.4 , pp. e6073
    • Yan, Y.1
  • 221
    • 34547830319 scopus 로고    scopus 로고
    • Gut toxicity during hemopoietic stem cell transplantation may predict acute graft-versus-host disease severity in patients
    • Johansson, J. E. & Ekman, T. Gut toxicity during hemopoietic stem cell transplantation may predict acute graft-versus-host disease severity in patients. Dig. Dis. Sci. 52, 2340-2345 (2007).
    • (2007) Dig. Dis. Sci. , vol.52 , pp. 2340-2345
    • Johansson, J.E.1    Ekman, T.2
  • 222
    • 77949272755 scopus 로고    scopus 로고
    • Gut barrier disruption by an enteric bacterial pathogen accelerates insulitis in NOD mice
    • Lee, A. S. et al. Gut barrier disruption by an enteric bacterial pathogen accelerates insulitis in NOD mice. Diabetologia 53, 741-748 (2010).
    • (2010) Diabetologia , vol.53 , pp. 741-748
    • Lee, A.S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.