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Volumn 1, Issue 2, 2015, Pages 222-232.e2

Hepatic Injury in Nonalcoholic Steatohepatitis Contributes to Altered Intestinal Permeability

Author keywords

Meta Analysis; Myosin Light Chain Kinase; Steatosis; Tight Junctions

Indexed keywords

ALANINE AMINOTRANSFERASE; CHOLINE; METHIONINE; MYOSIN LIGHT CHAIN KINASE; TUMOR NECROSIS FACTOR ALPHA;

EID: 84928969190     PISSN: None     EISSN: 2352345X     Source Type: Journal    
DOI: 10.1016/j.jcmgh.2015.01.001     Document Type: Article
Times cited : (209)

References (48)
  • 1
    • 12144259379 scopus 로고    scopus 로고
    • Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population
    • Szczepaniak L.S., Nurenberg P., Leonard D., et al. Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population. Am J Physiol Endocrinol Metab 2005, 288:E462-E468.
    • (2005) Am J Physiol Endocrinol Metab , vol.288 , pp. E462-E468
    • Szczepaniak, L.S.1    Nurenberg, P.2    Leonard, D.3
  • 2
    • 0034950652 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: predictors of nonalcoholic steatohepatitis and liver fibrosis in the severely obese
    • Dixon J.B., Bhathal P.S., O'Brien P.E. Nonalcoholic fatty liver disease: predictors of nonalcoholic steatohepatitis and liver fibrosis in the severely obese. Gastroenterology 2001, 121:91-100.
    • (2001) Gastroenterology , vol.121 , pp. 91-100
    • Dixon, J.B.1    Bhathal, P.S.2    O'Brien, P.E.3
  • 3
    • 80052477222 scopus 로고    scopus 로고
    • DSS induced colitis increases portal LPS levels and enhances hepatic inflammation and fibrogenesis in experimental NASH
    • Gabele E., Dostert K., Hofmann C., et al. DSS induced colitis increases portal LPS levels and enhances hepatic inflammation and fibrogenesis in experimental NASH. JHepatol 2011, 55:1391-1399.
    • (2011) JHepatol , vol.55 , pp. 1391-1399
    • Gabele, E.1    Dostert, K.2    Hofmann, C.3
  • 4
    • 84856957894 scopus 로고    scopus 로고
    • Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity
    • Henao-Mejia J., Elinav E., Jin C., et al. Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature 2012, 482:179-185.
    • (2012) Nature , vol.482 , pp. 179-185
    • Henao-Mejia, J.1    Elinav, E.2    Jin, C.3
  • 5
    • 79251479402 scopus 로고    scopus 로고
    • Diet-induced weight loss reduces colorectal inflammation: implications for colorectal carcinogenesis
    • Pendyala S., Neff L.M., Suarez-Farinas M., Holt P.R. Diet-induced weight loss reduces colorectal inflammation: implications for colorectal carcinogenesis. Am J Clin Nutr 2011, 93:234-242.
    • (2011) Am J Clin Nutr , vol.93 , pp. 234-242
    • Pendyala, S.1    Neff, L.M.2    Suarez-Farinas, M.3    Holt, P.R.4
  • 6
    • 84873296091 scopus 로고    scopus 로고
    • Characterization of gut microbiome in nonalcoholic steatohepatitis (NASH) patients: a connection between endogenous alcohol and NASH
    • Zhu L., Baker S.S., Gill C., et al. Characterization of gut microbiome in nonalcoholic steatohepatitis (NASH) patients: a connection between endogenous alcohol and NASH. Hepatology 2013, 57:601-609.
    • (2013) Hepatology , vol.57 , pp. 601-609
    • Zhu, L.1    Baker, S.S.2    Gill, C.3
  • 8
    • 0041876133 scopus 로고    scopus 로고
    • Measuring inconsistency in meta-analysis
    • Higgins J.P., Thompson S.G., Deeks J.J. Measuring inconsistency in meta-analysis. BMJ 2003, 327:557-560.
    • (2003) BMJ , vol.327 , pp. 557-560
    • Higgins, J.P.1    Thompson, S.G.2    Deeks, J.J.3
  • 9
    • 84875557018 scopus 로고    scopus 로고
    • The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses
    • nd. Available at
    • Wells GA, Shea B, O'Connell D, etal. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. Ottawa: Ottawa Health Research Institute, nd. Available at:. http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp.
    • Ottawa: Ottawa Health Research Institute
    • Wells, G.A.1    Shea, B.2    O'Connell, D.3
  • 10
    • 0033667445 scopus 로고    scopus 로고
    • Publication and related bias in meta-analysis: power of statistical tests and prevalence in the literature
    • Sterne J.A., Gavaghan D., Egger M. Publication and related bias in meta-analysis: power of statistical tests and prevalence in the literature. JClin Epidemiol 2000, 53:1119-1129.
    • (2000) JClin Epidemiol , vol.53 , pp. 1119-1129
    • Sterne, J.A.1    Gavaghan, D.2    Egger, M.3
  • 11
    • 20044374023 scopus 로고    scopus 로고
    • Design and validation of a histological scoring system for nonalocholic fatty liver disease
    • Kleiner D.E., Brunt E.M., Van Natta M., et al. Design and validation of a histological scoring system for nonalocholic fatty liver disease. Hepatology 2005, 41:1313-1321.
    • (2005) Hepatology , vol.41 , pp. 1313-1321
    • Kleiner, D.E.1    Brunt, E.M.2    Van Natta, M.3
  • 12
    • 0030103346 scopus 로고    scopus 로고
    • The impact of femur fracture with associated soft tissue injury on immune function and intestinal permeability
    • Napolitano L.M., Koruda M.J., Meyer A.A., Baker C.C. The impact of femur fracture with associated soft tissue injury on immune function and intestinal permeability. Shock 1996, 5:202-507.
    • (1996) Shock , vol.5 , pp. 202-507
    • Napolitano, L.M.1    Koruda, M.J.2    Meyer, A.A.3    Baker, C.C.4
  • 13
    • 26444577545 scopus 로고    scopus 로고
    • Epithelial myosin light chain kinase-dependent barrier dysfunction mediates T cell-activation-induced diarrhea invivo
    • Clayburgh D.R., Barrett T.A., Tang Y., et al. Epithelial myosin light chain kinase-dependent barrier dysfunction mediates T cell-activation-induced diarrhea invivo. JClin Invest 2005, 115:2702-2715.
    • (2005) JClin Invest , vol.115 , pp. 2702-2715
    • Clayburgh, D.R.1    Barrett, T.A.2    Tang, Y.3
  • 14
    • 33845761551 scopus 로고    scopus 로고
    • Ahigh-throughput microfluidic real-time gene expression living cell array
    • King K.R., Wang S., Irimia D., et al. Ahigh-throughput microfluidic real-time gene expression living cell array. Lab Chip 2007, 7:77-85.
    • (2007) Lab Chip , vol.7 , pp. 77-85
    • King, K.R.1    Wang, S.2    Irimia, D.3
  • 15
    • 84934444252 scopus 로고    scopus 로고
    • Isolation of Kupffer cells from rates fed chronic ethanol
    • Humana Press, Totowa, NJ, L.E. Nagy (Ed.)
    • McMullen M., Pritchard M., Nagy L. Isolation of Kupffer cells from rates fed chronic ethanol. Alcohol: methods and protocols 2008, 199-212. Humana Press, Totowa, NJ. L.E. Nagy (Ed.).
    • (2008) Alcohol: methods and protocols , pp. 199-212
    • McMullen, M.1    Pritchard, M.2    Nagy, L.3
  • 16
    • 33745802227 scopus 로고    scopus 로고
    • Roles of phosphatidylinositol 3-kinase and osteopontin in steatosis and aminotransferase release by hepatocytes treated with methionine-choline-deficient medium
    • Sahai A., Pan X., Paul R., et al. Roles of phosphatidylinositol 3-kinase and osteopontin in steatosis and aminotransferase release by hepatocytes treated with methionine-choline-deficient medium. Am J Physiol Gastrointest Liver Physiol 2006, 291:G55-G62.
    • (2006) Am J Physiol Gastrointest Liver Physiol , vol.291 , pp. G55-G62
    • Sahai, A.1    Pan, X.2    Paul, R.3
  • 17
    • 0035125052 scopus 로고    scopus 로고
    • The role of small intestinal bacterial overgrowth, intestinal permeability, endotoxaemia, and tumour necrosis factor α in the pathogenesis of non-alcoholic steatohepatitis
    • Wigg A.J., Roberts-Thomson I.C., Dymock R.B., et al. The role of small intestinal bacterial overgrowth, intestinal permeability, endotoxaemia, and tumour necrosis factor α in the pathogenesis of non-alcoholic steatohepatitis. Gut 2001, 48:206-211.
    • (2001) Gut , vol.48 , pp. 206-211
    • Wigg, A.J.1    Roberts-Thomson, I.C.2    Dymock, R.B.3
  • 18
    • 47949095562 scopus 로고    scopus 로고
    • Susceptibility togut leakiness: a possible mechanism for endotoxaemia in non-alcoholic steatohepatitis
    • Farhadi A., Gundlapalli S., Shaikh M., et al. Susceptibility togut leakiness: a possible mechanism for endotoxaemia in non-alcoholic steatohepatitis. Liver Int 2008, 28:1026-1033.
    • (2008) Liver Int , vol.28 , pp. 1026-1033
    • Farhadi, A.1    Gundlapalli, S.2    Shaikh, M.3
  • 19
    • 68949148889 scopus 로고    scopus 로고
    • Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease
    • Miele L., Valenza V., La Torre G., et al. Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease. Hepatology 2009, 49:1877-1887.
    • (2009) Hepatology , vol.49 , pp. 1877-1887
    • Miele, L.1    Valenza, V.2    La Torre, G.3
  • 20
    • 84864193026 scopus 로고    scopus 로고
    • Nutrition, intestinal permeability, and blood ethanol levels are altered in patients with nonalcoholic fatty liver disease
    • Volynets V., Kuper M.A., Strahl S., et al. Nutrition, intestinal permeability, and blood ethanol levels are altered in patients with nonalcoholic fatty liver disease. Dig Dis Sci 2012, 57:1932-1941.
    • (2012) Dig Dis Sci , vol.57 , pp. 1932-1941
    • Volynets, V.1    Kuper, M.A.2    Strahl, S.3
  • 21
    • 84902550631 scopus 로고    scopus 로고
    • Intestinal permeability is increased in children with non-alcoholic fatty liver disease, and correlates with liver disease severity
    • Giorgio V., Miele L., Principessa L., et al. Intestinal permeability is increased in children with non-alcoholic fatty liver disease, and correlates with liver disease severity. Dig Liver Dis 2014, 46:556-560.
    • (2014) Dig Liver Dis , vol.46 , pp. 556-560
    • Giorgio, V.1    Miele, L.2    Principessa, L.3
  • 22
    • 84930477870 scopus 로고    scopus 로고
    • Polyethylene glycol versus dual sugar assay for gastrointestinal permeability analysis: is it time to choose?
    • van Wijck K., Bessems B.A., van Eijk H.M., et al. Polyethylene glycol versus dual sugar assay for gastrointestinal permeability analysis: is it time to choose?. Clin Exp Gastroenterol 2012, 5:139-150.
    • (2012) Clin Exp Gastroenterol , vol.5 , pp. 139-150
    • van Wijck, K.1    Bessems, B.A.2    van Eijk, H.M.3
  • 23
    • 77953891627 scopus 로고    scopus 로고
    • Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1β in mice
    • Miura K., Kodama Y., Inokucki S., et al. Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1β in mice. Gastroenterology 2010, 139:323-334.
    • (2010) Gastroenterology , vol.139 , pp. 323-334
    • Miura, K.1    Kodama, Y.2    Inokucki, S.3
  • 24
    • 70949094933 scopus 로고    scopus 로고
    • IL-6 deficiency attenuates murine diet-induced non-alcoholic steatohepatitis
    • Mas E., Danjoux M., Garcia V., et al. IL-6 deficiency attenuates murine diet-induced non-alcoholic steatohepatitis. PLoS ONE 2009, 4:e7929.
    • (2009) PLoS ONE , vol.4 , pp. e7929
    • Mas, E.1    Danjoux, M.2    Garcia, V.3
  • 25
    • 77950585581 scopus 로고    scopus 로고
    • Caveolin-1-dependent occludin endocytosis is required for TNF-induced tight junction regulation invivo
    • Marchiando A.M., Shen L., Graham W.V., et al. Caveolin-1-dependent occludin endocytosis is required for TNF-induced tight junction regulation invivo. JCell Biol 2010, 189:111-126.
    • (2010) JCell Biol , vol.189 , pp. 111-126
    • Marchiando, A.M.1    Shen, L.2    Graham, W.V.3
  • 26
    • 84880611949 scopus 로고    scopus 로고
    • TNFR2 activates MLCK-dependent tight junction dysregulation to cause apoptosis-mediated barrier loss and experimental colitis
    • Su L., Nalle S.C., Shen L., et al. TNFR2 activates MLCK-dependent tight junction dysregulation to cause apoptosis-mediated barrier loss and experimental colitis. Gastroenterology 2013, 145:407-415.
    • (2013) Gastroenterology , vol.145 , pp. 407-415
    • Su, L.1    Nalle, S.C.2    Shen, L.3
  • 27
    • 4544358290 scopus 로고    scopus 로고
    • Searching for coeliac disease in patients with non-alcoholic fatty liver disease
    • Bardella M.T., Valenti L., Pagliari C., et al. Searching for coeliac disease in patients with non-alcoholic fatty liver disease. Dig Liver Dis 2004, 36:333-336.
    • (2004) Dig Liver Dis , vol.36 , pp. 333-336
    • Bardella, M.T.1    Valenti, L.2    Pagliari, C.3
  • 28
    • 83555163743 scopus 로고    scopus 로고
    • Changing shape of disease: nonalcoholic fatty liver disease in Crohn's disease-a case series and review of the literature
    • McGowan C.E., Jones P., Long M.D., Barritt A.S. Changing shape of disease: nonalcoholic fatty liver disease in Crohn's disease-a case series and review of the literature. Inflamm Bowel Dis 2012, 18:49-54.
    • (2012) Inflamm Bowel Dis , vol.18 , pp. 49-54
    • McGowan, C.E.1    Jones, P.2    Long, M.D.3    Barritt, A.S.4
  • 29
    • 84889576841 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease is associated with benign gastrointestinal disorders
    • Reddy S.K., Zhan M., Alexander H.R., El-Kamary S.S. Nonalcoholic fatty liver disease is associated with benign gastrointestinal disorders. World J Gastroenterol 2013, 19:8301-8311.
    • (2013) World J Gastroenterol , vol.19 , pp. 8301-8311
    • Reddy, S.K.1    Zhan, M.2    Alexander, H.R.3    El-Kamary, S.S.4
  • 30
    • 84886999533 scopus 로고    scopus 로고
    • Effects of probiotics on nonalcoholic fatty liver disease: a meta-analysis
    • Ma Y.Y., Li L., Yu C.H. Effects of probiotics on nonalcoholic fatty liver disease: a meta-analysis. World J Gastroenterol 2013, 19:6911-6918.
    • (2013) World J Gastroenterol , vol.19 , pp. 6911-6918
    • Ma, Y.Y.1    Li, L.2    Yu, C.H.3
  • 31
    • 84877924539 scopus 로고    scopus 로고
    • Activated intestinal macrophages in patients with cirrhosis release NO and IL-6 that may disrupt intestinal barrier function
    • Du Plessis J., Vanheel H., Janssen C.E., et al. Activated intestinal macrophages in patients with cirrhosis release NO and IL-6 that may disrupt intestinal barrier function. JHepatol 2013, 58:1125-1132.
    • (2013) JHepatol , vol.58 , pp. 1125-1132
    • Du Plessis, J.1    Vanheel, H.2    Janssen, C.E.3
  • 32
    • 84856350648 scopus 로고    scopus 로고
    • Role of innate immunity and the microbiota in liver fibrosis: crosstalk between the liver and gut
    • Seki E., Schanbl B. Role of innate immunity and the microbiota in liver fibrosis: crosstalk between the liver and gut. JPhysiol 2012, 590:447-458.
    • (2012) JPhysiol , vol.590 , pp. 447-458
    • Seki, E.1    Schanbl, B.2
  • 33
    • 0035183475 scopus 로고    scopus 로고
    • Gene expression of tumor necrosis factor alpha and TNF-receptors, p55 and p75, in nonalcoholic steatohepatitis patients
    • Crespo J., Cayon A., Fernandez-Gil P., et al. Gene expression of tumor necrosis factor alpha and TNF-receptors, p55 and p75, in nonalcoholic steatohepatitis patients. Hepatology 2001, 34:1158-1163.
    • (2001) Hepatology , vol.34 , pp. 1158-1163
    • Crespo, J.1    Cayon, A.2    Fernandez-Gil, P.3
  • 34
    • 84868124411 scopus 로고    scopus 로고
    • TNF-α messenger ribonucleic acid (mRNA) in patients with nonalcoholic steatohepatitis
    • Alaaeddine N., Sidaoui J., Hilal G., et al. TNF-α messenger ribonucleic acid (mRNA) in patients with nonalcoholic steatohepatitis. Eur Cytokine Netw 2012, 23:107-111.
    • (2012) Eur Cytokine Netw , vol.23 , pp. 107-111
    • Alaaeddine, N.1    Sidaoui, J.2    Hilal, G.3
  • 35
    • 25844508967 scopus 로고    scopus 로고
    • Levels of serum hyaluronic acid, TNF-alpha and IL-8 in patients with nonalcoholic steatohepatitis
    • Bahccioglu I.H., Yalniz M., Ataseven H., et al. Levels of serum hyaluronic acid, TNF-alpha and IL-8 in patients with nonalcoholic steatohepatitis. Hepatogastroenterology 2005, 52:1549-1553.
    • (2005) Hepatogastroenterology , vol.52 , pp. 1549-1553
    • Bahccioglu, I.H.1    Yalniz, M.2    Ataseven, H.3
  • 36
    • 0036305854 scopus 로고    scopus 로고
    • Amembrane-permeant peptide that inhibits mlc kinase restores barrier function in invitro models of intestinal disease
    • Zolotarevsky Y., Hecht G., Koutsouris A., et al. Amembrane-permeant peptide that inhibits mlc kinase restores barrier function in invitro models of intestinal disease. Gastroenterology 2002, 123:163-172.
    • (2002) Gastroenterology , vol.123 , pp. 163-172
    • Zolotarevsky, Y.1    Hecht, G.2    Koutsouris, A.3
  • 37
    • 13244298599 scopus 로고    scopus 로고
    • Interferon-gamma and tumor necrosis factor-alpha synergize to induce intestinal epithelial barrier dysfunction by up-regulating myosin light chain kinase expression
    • Wang F., Graham W.V., Wang Y., et al. Interferon-gamma and tumor necrosis factor-alpha synergize to induce intestinal epithelial barrier dysfunction by up-regulating myosin light chain kinase expression. Am J Pathol 2005, 166:409-419.
    • (2005) Am J Pathol , vol.166 , pp. 409-419
    • Wang, F.1    Graham, W.V.2    Wang, Y.3
  • 38
    • 84879114381 scopus 로고    scopus 로고
    • Mechanism of IL-1β modulation of intestinal epithelial barrier involves p38 kinase and activating transcription factor-2 activation
    • Al-Sadi R., Guo S., Ye D., et al. Mechanism of IL-1β modulation of intestinal epithelial barrier involves p38 kinase and activating transcription factor-2 activation. JImmunol 2013, 190:6596-6606.
    • (2013) JImmunol , vol.190 , pp. 6596-6606
    • Al-Sadi, R.1    Guo, S.2    Ye, D.3
  • 39
    • 84859735371 scopus 로고    scopus 로고
    • Association between serum interleukin-6 concentrations and mortality in older adults: the Rancho Bernardo study
    • Lee J.K., Bettencourt R., Brenner D., et al. Association between serum interleukin-6 concentrations and mortality in older adults: the Rancho Bernardo study. PLoS ONE 2012, 7:e34218.
    • (2012) PLoS ONE , vol.7 , pp. e34218
    • Lee, J.K.1    Bettencourt, R.2    Brenner, D.3
  • 40
    • 80052400212 scopus 로고    scopus 로고
    • Interleukin-6 (IL-6) regulates claudin-2 expression and tight junction permeability in intestinal epithelium
    • Suzuki T., Yoshinaga N., Tanabe S. Interleukin-6 (IL-6) regulates claudin-2 expression and tight junction permeability in intestinal epithelium. JBiol Chem 2011, 286:31263-31271.
    • (2011) JBiol Chem , vol.286 , pp. 31263-31271
    • Suzuki, T.1    Yoshinaga, N.2    Tanabe, S.3
  • 41
    • 84908238878 scopus 로고    scopus 로고
    • Both bone marrow-derived and non-bone marrow-derived cells contribute to AIM2 and NLRP3 inflammasome activation in a MyD88-dependent manner in dietary steatohepatitis
    • Csak T., Pillai A., Ganz M., et al. Both bone marrow-derived and non-bone marrow-derived cells contribute to AIM2 and NLRP3 inflammasome activation in a MyD88-dependent manner in dietary steatohepatitis. Liver Int 2014, 34:1402-1413.
    • (2014) Liver Int , vol.34 , pp. 1402-1413
    • Csak, T.1    Pillai, A.2    Ganz, M.3
  • 42
    • 27744458510 scopus 로고    scopus 로고
    • NF-κB activation, rather than TNF, mediates hepatic inflammation in a murine dietary model of steatohepatitis
    • Pena A.D., Leclercq I., Field J., et al. NF-κB activation, rather than TNF, mediates hepatic inflammation in a murine dietary model of steatohepatitis. Gastroenterology 2005, 129:1663-1674.
    • (2005) Gastroenterology , vol.129 , pp. 1663-1674
    • Pena, A.D.1    Leclercq, I.2    Field, J.3
  • 43
    • 33144463511 scopus 로고    scopus 로고
    • Tumour necrosis factor signalling through activation of Kupffer cells plays an essential role in liver fibrosis of nonalcoholic steatohepatitis in mice
    • Tomita K., Tamiya G., Ando S., et al. Tumour necrosis factor signalling through activation of Kupffer cells plays an essential role in liver fibrosis of nonalcoholic steatohepatitis in mice. Gut 2006, 55:415-424.
    • (2006) Gut , vol.55 , pp. 415-424
    • Tomita, K.1    Tamiya, G.2    Ando, S.3
  • 44
    • 40849106735 scopus 로고    scopus 로고
    • The treatment with antibody to TNF-alpha reduces the inflammation, necrosis, and fibrosis in the non-alcoholic steatohepatitis induced by the methionine-and choline-deficient diet
    • Koca S.S., Bahcecioglu I.H., Poyrazoglu O.K., et al. The treatment with antibody to TNF-alpha reduces the inflammation, necrosis, and fibrosis in the non-alcoholic steatohepatitis induced by the methionine-and choline-deficient diet. Inflammation 2008, 31:91-98.
    • (2008) Inflammation , vol.31 , pp. 91-98
    • Koca, S.S.1    Bahcecioglu, I.H.2    Poyrazoglu, O.K.3
  • 45
    • 77950617221 scopus 로고    scopus 로고
    • The immunosuppressant drug, thalidomide, improves hepatic alterations induced by a high-fat diet in mice
    • Pinto Lde F., Compri C.M., Fornari J.V., et al. The immunosuppressant drug, thalidomide, improves hepatic alterations induced by a high-fat diet in mice. Liver Int 2010, 30:603-610.
    • (2010) Liver Int , vol.30 , pp. 603-610
    • Pinto Lde, F.1    Compri, C.M.2    Fornari, J.V.3
  • 46
    • 84880798525 scopus 로고    scopus 로고
    • The effect of etanercept on hepatic fibrosis risk in patients with non-alcoholic fatty liver disease, metabolic syndrome, and psoriasis
    • Campanati A., Ganzetti G., Di Sario A., et al. The effect of etanercept on hepatic fibrosis risk in patients with non-alcoholic fatty liver disease, metabolic syndrome, and psoriasis. JGastroenterol 2013, 48:839-846.
    • (2013) JGastroenterol , vol.48 , pp. 839-846
    • Campanati, A.1    Ganzetti, G.2    Di Sario, A.3
  • 47
    • 84923468701 scopus 로고    scopus 로고
    • Dysbiosis-induced intestinal inflammation activates TNFRI and mediates alcoholic liver disease in mice
    • Published online
    • Chen P., Starkel P., Turner J.R., et al. Dysbiosis-induced intestinal inflammation activates TNFRI and mediates alcoholic liver disease in mice. Hepatology 2014, Published online. http://dx.doi.org/10.1002/hep.27489.
    • (2014) Hepatology
    • Chen, P.1    Starkel, P.2    Turner, J.R.3


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