Larazotide acetate regulates epithelial tight junctions in vitro and in vivo

Peptides

Volumn 35, Issue 1, 2012, Pages 86-94

  Gopalakrishnan, Shobha ^a   Durai, Malarvizhi ^a   Kitchens, Kelly ^a,d   Tamiz, Amir P ^a   Somerville, Robert ^a,e   Ginski, Mark ^a,f   Paterson, Blake M ^a,g   Murray, Joseph A ^b   Verdu, Elena F ^c   Alkan, Sefik S ^a,h   Pandey, Niranjan B ^a  

^a ALBA Therapeutics   (United States)

^b MAYO CLINIC   (United States)

^c MCMASTER UNIVERSITY   (Canada)

^d MPN1   (United States)

^e NATIONAL CANCER INSTITUTE   (United States)

^f Johns Hopkins University School of Medicine ^*  (United States)

^g JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^h Alkan Consulting LLC   (Switzerland)

Author keywords

Actin; Celiac disease; Gliadin; Permeability inducer; Tight junction; ZO 1

Indexed keywords

ACTIN; AT 1002; AT 4067; CYTOKINE; GLIADIN; LARAZOTIDE; PEPTIDE DERIVATIVE; PROTEIN ZO1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELIAC DISEASE; CELL STRAIN; CELL STRAIN CACO 2; CONTROLLED STUDY; DRUG MECHANISM; ELECTRIC RESISTANCE; ENTERITIS; EPITHELIUM CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MACROPHAGE MIGRATION INHIBITION; MEMBRANE PERMEABILITY; MEMBRANE STRUCTURE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; REGULATORY MECHANISM; TIGHT JUNCTION; TRANSEPITHELIAL ELECTRICAL RESISTANCE; TRANSGENIC MOUSE;

MUS MUSCULUS; VIBRIO CHOLERAE;

EID: 84859805588     PISSN: 01969781     EISSN: 18735169     Source Type: Journal    
DOI: 10.1016/j.peptides.2012.02.015     Document Type: Article

References (46)

1. Aijaz S, Balda MS, Matter K. Tight junctions: molecular architecture and function. Int Rev Cytol 2006;248:261-98. (Pubitemid 43238173)
2. Al-Sadi R, Ye D, Dokladny K, Ma TY. Mechanism of IL-1beta-induced increase in intestinal epithelial tight junction permeability. J Immunol 2008;180:5653-61.
3. Arrieta MC, Bistritz L, Meddings JB. Alterations in intestinal permeability. Gut 2006;55:1512-20. (Pubitemid 44476799)
4. Artursson P, Magnusson C. Epithelial transport of drugs in cell culture. II: Effect of extracellular calcium concentration on the paracellular transport of drugs of different lipophilicities across monolayers of intestinal epithelial (Caco-2) cells. J Pharm Sci 1990;79:595-600. (Pubitemid 20222724)
5. Black KE, Murray JA, David CS. HLA-DQ determines the response to exogenous wheat proteins: a model of gluten sensitivity in transgenic knockout mice. J Immunol 2002;169:5595-600. (Pubitemid 35291659)
6. Bodinier M, Legoux MA, Pineau F, Triballeau S, Segain JP, Brossard C, et al. Intestinal translocation capabilities of wheat allergens using the Caco-2 cell line. J Agric Food Chem 2007;55:4576-83. (Pubitemid 46938087)
7. Ciccocioppo R, Finamore A, Ara C, Di Sabatino A, Mengheri E, Corazza GR. Altered expression, localization, and phosphorylation of epithelial junctional proteins in celiac disease. Am J Clin Pathol 2006;125:502-11.
8. Clayburgh DR, Shen L, Turner JR. A porous defense: the leaky epithelial barrier in intestinal disease. Lab Invest 2004;84:282-91. (Pubitemid 41656483)
9. Clemente MG, De Virgiliis S, Kang JS, Macatagney R, Musu MP, Di Pierro MR, et al. Early effects of gliadin on enterocyte intracellular signalling involved in intestinal barrier function. Gut 2003;52:218-23. (Pubitemid 36115062)
10. Crespo Perez L, Castillejo de Villasante G, Cano Ruiz A, Leon F. Non-dietary therapeutic clinical trials in coeliac disease. Eur J Intern Med 2012;23:9-14.
11. Dolfini E, Roncoroni L, Elli L, Fumagalli C, Colombo R, Ramponi S, et al. Cytoskeleton reorganization and ultrastructural damage induced by gliadin in a three-dimensional in vitro model. World J Gastroenterol 2005;11:7597-601. (Pubitemid 43168422)
12. Elli L, Roncoroni L, Doneda L, Ciulla MM, Colombo R, Braidotti P, et al. Imaging analysis of the gliadin direct effect on tight junctions in an in vitro three-dimensional Lovo cell line culture system. Toxicol In Vitro 2011;25:45-50.
13. Ellis HJ, Rosen-Bronson S, O'Reilly N, Ciclitira PJ. Measurement of gluten using a monoclonal antibody to a coeliac toxic peptide of A-gliadin. Gut 1998;43:190-5. (Pubitemid 28348320)
14. Fasano A, Shea-Donohue T. Mechanisms of disease: the role of intestinal barrier function in the pathogenesis of gastrointestinal autoimmune diseases. Nat Clin Pract Gastroenterol Hepatol 2005;2:416-22. (Pubitemid 41486094)
15. Fink MP, Delude RL. Epithelial barrier dysfunction: a unifying theme to explain the pathogenesis of multiple organ dysfunction at the cellular level. Crit Care Clin 2005;21:177-96. (Pubitemid 40386748)
16. Furuse M. Molecular basis of the core structure of tight junctions. Cold Spring Harb Perspect Biol 2010;2:a002907.
17. Garrote JA, Gomez-Gonzalez E, Bernardo D, Arranz E, Chirdo F. Celiac disease pathogenesis: the proinflammatory cytokine network. J Pediatr Gastroenterol Nutr 2008;47(Suppl. 1):S27-32.
18. Ginski MJ, Taneja R, Polli JE. Prediction of dissolution-absorption relationships from a continuous dissolution/Caco-2 system. AAPS Pharm Sci 1999;1:E3.
19. Gopalakrishnan S, Pandey N, Tamiz AP, Vere J, Carrasco R, Somerville R, et al. Mechanism of action of ZOT-derived peptide AT-1002, a tight junction regulator and absorption enhancer. Int J Pharm 2009;365:121-30.
20. Kagnoff MF. Celiac disease: pathogenesis of a model immunogenetic disease. J Clin Invest 2007;117:41-9. (Pubitemid 46048448)
21. Madara JL, Barenberg D, Carlson S. Effects of cytochalasin D on occluding junctions of intestinal absorptive cells: further evidence that the cytoskeleton may influence paracellular permeability and junctional charge selectivity. J Cell Biol 1986;102:2125-36.
22. Marinaro M, Fasano A, De Magistris MT. Zonula occludens toxin acts as an adjuvant through different mucosal routes and induces protective immune responses. Infect Immun 2003;71:1897-902. (Pubitemid 36368721)
23. Matysiak-Budnik T, Moura IC, Arcos-Fajardo M, Lebreton C, Menard S, Candalh C, et al. Secretory IgA mediates retrotranscytosis of intact gliadin peptides via the transferrin receptor in celiac disease. J Exp Med 2008;205:143-54. (Pubitemid 351185722)
24. Montalto M, Cuoco L, Ricci R, Maggiano N, Vecchio FM, Gasbarrini G. Immunohistochemical analysis of ZO-1 in the duodenal mucosa of patients with untreated and treated celiac disease. Digestion 2002;65:227-33.
25. Natividad JM, Huang X, Slack E, Jury J, Sanz Y, David C, et al. Host responses to intestinal microbial antigens in gluten-sensitive mice. PLoS One 2009;4:e6472.
26. Paterson BM, Lammers KM, Arrieta MC, Fasano A, Meddings JB. The safety, tolerance, pharmacokinetic and pharmacodynamic effects of single doses of AT- 1001 in coeliac disease subjects: a proof of concept study. Aliment Pharmacol Ther 2007;26:757-66. (Pubitemid 47246202)
27. Picarelli A, Di Tola M, Sabbatella L, Anania MC, Di Cello T, Greco R, et al. 31-43 amino acid sequence of the alpha-gliadin induces anti-endomysial antibody production during in vitro challenge. Scand J Gastroenterol 1999;34:1099-102. (Pubitemid 29533768)
28. Pinier M, Verdu EF, Nasser-Eddine M, David CS, Vezina A, Rivard N, et al. Polymeric binders suppress gliadin-induced toxicity in the intestinal epithelium. Gastroenterology 2009;136:288-98.
29. Rubio-Tapia A, Murray JA. Celiac disease. Curr Opin Gastroenterol 2010;26:116-22.
30. Sander GR, Cummins AG, Henshall T, Powell BC. Rapid disruption of intestinal barrier function by gliadin involves altered expression of apical junctional proteins. FEBS Lett 2005;579:4851-5. (Pubitemid 41218674)
31. Sawada N, Murata M, Kikuchi K, Osanai M, Tobioka H, Kojima T, et al. Tight junctions and human diseases. Med Electron Microsc 2003;36:147-56. (Pubitemid 37288275)
32. Schmitz H, Fromm M, Bentzel CJ, Scholz P, Detjen K, Mankertz J, et al. Tumor necrosis factor-alpha (TNFalpha) regulates the epithelial barrier in the human intestinal cell line HT-29/B6. J Cell Sci 1999;112(Pt 1):137-46. (Pubitemid 29043841)
33. Schneeberger EE, Lynch RD. The tight junction: a multifunctional complex. Am J Physiol Cell Physiol 2004;286:C1213-28. (Pubitemid 38649971)
34. Schulzke JD, Bentzel CJ, Schulzke I, Riecken EO, Fromm M. Epithelial tight junction structure in the jejunum of children with acute and treated celiac sprue. Pediatr Res 1998;43:435-41. (Pubitemid 28157949)
35. Schumann M, Richter JF, Wedell I, Moos V, Zimmermann-Kordmann M, Schneider T, et al. Mechanisms of epithelial translocation of the alpha(2)-gliadin-33mer in coeliac sprue. Gut 2008;57:747-54. (Pubitemid 351716965)
36. Shan L, Molberg O, Parrot I, Hausch F, Filiz F, Gray GM, et al. Structural basis for gluten intolerance in celiac sprue. Science 2002;297:2275-9.
37. Silva MA, Jury J, Sanz Y, Wiepjes M, Huang X, Murray JA, et al. Increased bacterial translocation in gluten-sensitive mice is independent of small intestinal paracellular permeability defect. Dig Dis Sci 2012.
38. Song KH, Fasano A, Eddington ND. Enhanced nasal absorption of hydrophilic markers after dosing with AT1002, a tight junction modulator. Eur J Pharm Biopharm 2008;69:231-7. (Pubitemid 351467172)
39. Thomas KE, Sapone A, Fasano A, Vogel SN. Gliadin stimulation of murine macrophage inflammatory gene expression and intestinal permeability are MyD88-dependent: role of the innate immune response in Celiac disease. J Immunol 2006;176:2512-21. (Pubitemid 43201702)
40. Tsukita S, Furuse M, Itoh M. Multifunctional strands in tight junctions. Nat Rev Mol Cell Biol 2001;2:285-93. (Pubitemid 33676971)
41. Turner JR, Rill BK, Carlson SL, Carnes D, Kerner R, Mrsny RJ, et al. Physiological regulation of epithelial tight junctions is associated with myosin light-chain phosphorylation. Am J Physiol 1997;273:C1378-85.
42. Ukabam SO, Clamp JR, Cooper BT. Abnormal small intestinal permeability to sugars in patients with Crohn's disease of the terminal ileum and colon. Digestion 1983;27:70-4. (Pubitemid 13041629)
43. Van Driessche W, Kreindler JL, Malik AB, Margulies S, Lewis SA, Kim KJ. Interrelations/cross talk between transcellular transport function and paracellular tight junctional properties in lung epithelial and endothelial barriers. Am J Physiol Lung Cell Mol Physiol 2007;293:L520-4. (Pubitemid 47358809)
44. Verdu EF, Huang X, Natividad J, Lu J, Blennerhassett PA, David CS, et al. Gliadin-dependent neuromuscular and epithelial secretory responses in gluten-sensitive HLA-DQ8 transgenic mice. Am J Physiol Gastrointest Liver Physiol 2008;294:G217-25.
45. Wang F, Schwarz BT, Graham WV, Wang Y, Su L, Clayburgh DR, et al. IFNgamma-induced TNFR2 expression is required for TNF-dependent intestinal epithelial barrier dysfunction. Gastroenterology 2006;131:1153-63. (Pubitemid 44515106)
46. Watts T, Berti I, Sapone A, Gerarduzzi T, Not T, Zielke R, et al. Role of the intestinal tight junction modulator zonulin in the pathogenesis of type I diabetes in BB diabetic-prone rats. Proc Natl Acad Sci U S A 2005;102:2916-21. (Pubitemid 40299891)