The Impact of Environmental and Endogenous Damage on Somatic Mutation Load in Human Skin Fibroblasts

PLoS Genetics

Volumn 12, Issue 10, 2016, Pages

  Saini, Natalie ^a   Roberts, Steven A ^b   Klimczak, Leszek J ^a   Chan, Kin ^a   Grimm, Sara A ^a   Dai, Shuangshuang ^a   Fargo, David C ^a   Boyer, Jayne C ^c   Kaufmann, William K ^d   Taylor, Jack A ^a   Lee, Eunjung ^e,f   Cortes Ciriano, Isidro ^e   Park, Peter J ^e,f   Schurman, Shepherd H ^a   Malc, Ewa P ^d   Mieczkowski, Piotr A ^d   Gordenin, Dmitry A ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b WASHINGTON STATE UNIVERSITY   (United States)

^c UNIVERSITY OF NORTH CAROLINA   (United States)

^d UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^e HARVARD MEDICAL SCHOOL   (United States)

^f BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA;

ADULT; ARTICLE; CANCER PREVENTION; CANCER PROGNOSIS; CARCINOGENESIS; CHROMOSOME REARRANGEMENT; CONTROLLED STUDY; DNA EXTRACTION; DNA REPAIR; DNA REPLICATION; ENVIRONMENTAL FACTOR; ENVIRONMENTAL IMPACT; EPIGENETICS; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC DISORDER; GENOMIC INSTABILITY; HUMAN; HUMAN CELL; HUMAN GENOME; HUMAN TISSUE; MUTAGENESIS; MUTATIONAL LOAD; NEXT GENERATION SEQUENCING; NUCLEIC ACID BASE SUBSTITUTION; PLURIPOTENT STEM CELL; SKIN CELL; SKIN FIBROBLAST; SOMATIC MUTATION; SUN EXPOSURE; ULTRAVIOLET RADIATION; ADVERSE EFFECTS; BIOPSY; CELL CLONE; CLINICAL TRIAL; DNA DAMAGE; FIBROBLAST; GENETICS; HIGH THROUGHPUT SEQUENCING; MALE; MIDDLE AGED; MUTATION; MUTATION RATE; NEOPLASMS; PATHOLOGY; RADIATION RESPONSE; SINGLE CELL ANALYSIS; SKIN; SUNLIGHT;

BIOPSY; CLONE CELLS; DNA DAMAGE; FIBROBLASTS; GENOME, HUMAN; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; MALE; MIDDLE AGED; MUTAGENESIS; MUTATION; MUTATION RATE; NEOPLASMS; SINGLE-CELL ANALYSIS; SKIN; SUNLIGHT;

EID: 84994275805     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1006385     Document Type: Article

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