The landscape of somatic mutations in protein coding genes in apparently benign human tissues carries signatures of relaxed purifying selection

Nucleic Acids Research

Volumn 44, Issue 5, 2016, Pages 2075-2084

  Yadav, Vinod Kumar ^a   Degregori, James ^a,b   De, Subhajyoti ^a,b,c  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF COLORADO CANCER CENTER   (United States)

^c Food Science and Human Nutrition   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGE; ARTICLE; BLADDER TISSUE; BLOOD DONOR; BREAST; DNA DAMAGE; DNA TRANSCRIPTION; GENETIC CODE; HEMATOPOIETIC STEM CELL; HETEROZYGOTE; HUMAN; HUMAN TISSUE; LIVER PARENCHYMA; LUNG PARENCHYMA; MALIGNANT NEOPLASTIC DISEASE; MISSENSE MUTATION; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; PROSTATE; PURIFYING SELECTION; SILENT MUTATION; SMOKING; SOMATIC MUTATION; STOMACH; THYROID GLAND TISSUE; TISSUE LEVEL; AGING; ANTIBODY SPECIFICITY; BIOLOGICAL MODEL; EXOME; FEMALE; GENETIC SELECTION; GENETICS; HIGH THROUGHPUT SEQUENCING; HUMAN GENOME; MALE; METABOLISM; MUTATION RATE; NEOPLASM; OPEN READING FRAME; PATHOLOGY; TUMOR MICROENVIRONMENT;

AGING; EXOME; FEMALE; GENOME, HUMAN; HEMATOPOIETIC STEM CELLS; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; MALE; MODELS, GENETIC; MUTATION RATE; MUTATION, MISSENSE; NEOPLASMS; OPEN READING FRAMES; ORGAN SPECIFICITY; SELECTION, GENETIC; TUMOR MICROENVIRONMENT;

EID: 84963819060     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkw086     Document Type: Article

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