Salsalate (salicylate) uncouples mitochondria, improves glucose homeostasis, and reduces liver lipids independent of ampk-β1

Diabetes

Volumn 65, Issue 11, 2016, Pages 3352-3361

  Smith, Brennan K ^a   Ford, Rebecca J ^a   Desjardins, Eric M ^a   Green, Alex E ^a   Hughes, Meghan C ^b   Houde, Vanessa P ^a   Day, Emily A ^a   Marcinko, Katarina ^a   Crane, Justin D ^a   Mottillo, Emilio P ^a   Perry, Christopher G R ^b   Kemp, Bruce E ^c,d   Tarnopolsky, Mark A ^a   Steinberg, Gregory R ^a  

^a MCMASTER UNIVERSITY   (Canada)

^b YORK UNIVERSITY   (Canada)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d AUSTRALIAN CATHOLIC UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CYCLODEXTRIN; GLUCOSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE BETA 1; INSULIN; INTERLEUKIN 1BETA; LIPID; MONOCYTE CHEMOTACTIC PROTEIN 1; OLIGOMYCIN; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; SALICYLIC ACID; SALSALATE; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN 1; SALICYLIC ACID DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BROWN ADIPOSE TISSUE; CONCENTRATION RESPONSE; CONDUCTANCE; CONTROLLED STUDY; DIET RESTRICTION; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG MECHANISM; ENERGY EXPENDITURE; GLUCOSE HOMEOSTASIS; GLUCOSE TOLERANCE; KNOCKOUT MOUSE; LIPID LIVER LEVEL; LIPOGENESIS; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONALCOHOLIC FATTY LIVER; NONHUMAN; OXIDATIVE PHOSPHORYLATION UNCOUPLING; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; WILD TYPE MOUSE; ADVERSE EFFECTS; ANIMAL; DRUG EFFECTS; GENETICS; HOMEOSTASIS; LIPID DIET; LIPID METABOLISM; LIVER; LIVER CELL; METABOLISM; MITOCHONDRIAL MEMBRANE POTENTIAL;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; DIET, HIGH-FAT; HEPATOCYTES; HOMEOSTASIS; LIPID METABOLISM; LIPOGENESIS; LIVER; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICE, KNOCKOUT; MITOCHONDRIA; SALICYLATES;

EID: 84994218522     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db16-0564     Document Type: Article

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