Identification of a novel malonyl-CoA IC50for CPT-I: Implications for predicting in vivo fatty acid oxidation rates

Biochemical Journal

Volumn 448, Issue 1, 2012, Pages 13-20

  Smith, Brennan K ^a   Perry, Christopher G R ^a,e   Koves, Timothy R ^b   Wright, David C ^a   Smith, Jeffrey C ^c   Neufer, P Darrell ^d   Muoio, Deborah M ^b   Holloway, Graham P ^a  

^a UNIVERSITY OF GUELPH   (Canada)

^b DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c CARLETON UNIVERSITY   (Canada)

^d EAST CAROLINA UNIVERSITY   (United States)

^e YORK UNIVERSITY   (Canada)

Author keywords

Carnitine palmitoyltransferase I (CPT I); Isolated mitochondrion; Malonyl CoA; Palmitoyl CoA; Permeabilized muscle fibre; Skeletal muscle

Indexed keywords

CARNITINE PALMITOYLTRANSFERASE I; MALONYL COENZYME A; PALMITOYL COENZYME A;

ANIMAL CELL; ARTICLE; CELL MEMBRANE PERMEABILITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SUBSTRATE; EXERCISE; FATTY ACID OXIDATION; IC 50; IN VIVO STUDY; INHIBITION KINETICS; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; MUSCLE CELL; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PREDICTIVE VALUE; PRIORITY JOURNAL; RAT; SKELETAL MUSCLE;

ANIMALS; CARNITINE; CARNITINE O-PALMITOYLTRANSFERASE; CELL MEMBRANE PERMEABILITY; DOSE-RESPONSE RELATIONSHIP, DRUG; FATTY ACIDS; INHIBITORY CONCENTRATION 50; KINETICS; MALONYL COENZYME A; MITOCHONDRIA, MUSCLE; MUSCLE FIBERS, SLOW-TWITCH; MUSCLE, SKELETAL; OXIDATION-REDUCTION; OXYGEN CONSUMPTION; PALMITOYL COENZYME A; PHYSICAL CONDITIONING, ANIMAL; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84867801249     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20121110     Document Type: Article

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