MicroRNA-455 regulates brown adipogenesis via a novel HIF1an-AMPK-PGC1α signaling network

EMBO Reports

Volumn 16, Issue 10, 2015, Pages 1378-1393

  Zhang, Hongbin ^a,b   Guan, Meiping ^a,c   Townsend, Kristy L ^a   Huang, Tian Lian ^a   An, Ding ^a   Yan, Xu ^a   Xue, Ruidan ^a   Schulz, Tim J ^a,d   Winnay, Jonathon ^a   Mori, Marcelo ^a,e   Hirshman, Michael F ^a   Kristiansen, Karsten ^b   Tsang, John S ^f   White, Andrew P ^a   Cypess, Aaron M ^a   Goodyear, Laurie J ^a   Tseng, Yu Hua ^a,g  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c SOUTHERN MEDICAL UNIVERSITY   (China)

^d GERMAN INSTITUTE OF HUMAN NUTRITION   (Germany)

^e FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^f NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^g HARVARD STEM CELL INSTITUTE   (United States)

Author keywords

brown adipogenesis; differentiation; metabolism; microRNA; UCP1

Indexed keywords

AMP ACTIVATED KINASE ALPHA 1 SUBUNIT; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; HYPOXIA INDUCIBLE FACTOR 1ALPHA INHIBITOR; MICRORNA; MICRORNA 455; NECDIN; OSTEOGENIC PROTEIN 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PROTEIN INHIBITOR; TRANSCRIPTION FACTOR RUNX1; TRANSCRIPTION FACTOR RUNX1T1; UNCLASSIFIED DRUG; FACTOR INHIBITING HYPOXIA-INDUCIBLE FACTOR 1, MOUSE; HIF1AN PROTEIN, HUMAN; MIRN455 MICRORNA, HUMAN; MIRN455 MICRORNA, MOUSE; MIXED FUNCTION OXIDASE; NERVE PROTEIN; NUCLEAR PROTEIN; PPARGC1A PROTEIN, MOUSE; REPRESSOR PROTEIN; TRANSCRIPTION FACTOR;

ADIPOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BIOGENESIS; BROWN ADIPOCYTE; BROWN ADIPOSE TISSUE; CELL DIFFERENTIATION; COLD EXPOSURE; CONTROLLED STUDY; GENE EXPRESSION; GENE FUNCTION; HUMAN; HUMAN TISSUE; IN VITRO STUDY; MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SUBCUTANEOUS FAT; THERMOGENESIS; WHITE ADIPOSE TISSUE; ANIMAL; CELL CULTURE; COLD; GENETICS; METABOLISM; ORGANELLE BIOGENESIS; TRANSGENIC MOUSE;

ADIPOCYTES, BROWN; ADIPOGENESIS; ADIPOSE TISSUE, WHITE; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; CELL DIFFERENTIATION; CELLS, CULTURED; COLD TEMPERATURE; HUMANS; MICE; MICE, TRANSGENIC; MICRORNAS; MIXED FUNCTION OXYGENASES; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; ORGANELLE BIOGENESIS; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA COACTIVATOR 1-ALPHA; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; THERMOGENESIS; TRANSCRIPTION FACTORS;

EID: 84942819409     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.15252/embr.201540837     Document Type: Article

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