메뉴 건너뛰기




Volumn 8, Issue 12, 2013, Pages

COH-SR4 reduces body weight, improves glycemic control and prevents hepatic steatosis in high fat diet-induced obese mice

Author keywords

[No Author keywords available]

Indexed keywords

1,3 BIS(3,5 DICHLOROPHENYL)UREA; ACETYL COENZYME A CARBOXYLASE; ACYL COENZYME A DESATURASE 1; ADIPONECTIN; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE KINASE; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE KINASE BETA; CARNITINE PALMITOYLTRANSFERASE 1A; CARNITINE PALMITOYLTRANSFERASE I; FATTY ACID SYNTHASE; GLUCOSE 6 PHOSPHATASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; LEPTIN; LIVER ENZYME; LIVER KINASE B1; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); PHOSPHOENOLPYRUVATE CARBOXYKINASE 1; PHOSPHOTRANSFERASE; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; UREA DERIVATIVE; 1,3-BIS(3,5-DICHLOROPHENYL)UREA; ADIPOCYTOKINE; CARBANILAMIDE DERIVATIVE; GLUCOSE BLOOD LEVEL;

EID: 84893431857     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0083801     Document Type: Article
Times cited : (23)

References (51)
  • 2
    • 2942675088 scopus 로고    scopus 로고
    • Obesity, metabolic syndrome, and cardiovascular disease
    • Grundy SM (2004) Obesity, metabolic syndrome, and cardiovascular disease. J Clin Endocrinol Metab 89:2595-2600.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 2595-2600
    • Grundy, S.M.1
  • 3
    • 84892476014 scopus 로고    scopus 로고
    • Diabetes and cancer: Two diseases with obesity as a common risk factor
    • DOI:10.1111/dom.12124 [Epub ahead of print]
    • Garg SK, Maurer H, Reed K, Selagamsetty R (2013) Diabetes and cancer: two diseases with obesity as a common risk factor. Diabetes Obes Metab DOI:10.1111/dom.12124 [Epub ahead of print].
    • (2013) Diabetes Obes Metab
    • Garg, S.K.1    Maurer, H.2    Reed, K.3    Selagamsetty, R.4
  • 4
    • 63549114784 scopus 로고    scopus 로고
    • Hypertrophy and/or hyperplasia: Dynamics of adipose tissue growth
    • Jo J, Gavrilova O, Pack S, Jou W, Mullen S, et al. (2009) Hypertrophy and/or hyperplasia: dynamics of adipose tissue growth. PLoS Comput Biol 5:e1000324.
    • (2009) PLoS Comput Biol , vol.5
    • Jo, J.1    Gavrilova, O.2    Pack, S.3    Jou, W.4    Mullen, S.5
  • 6
    • 79960820132 scopus 로고    scopus 로고
    • The growing challenge of obesity and cancer: An inflammatory issue
    • Harvey AE, Lashinger LM, Hursting SD (2011) The growing challenge of obesity and cancer: an inflammatory issue. Ann N Y Acad Sc 1229:45-52.
    • (2011) Ann N Y Acad Sc , vol.1229 , pp. 45-52
    • Harvey, A.E.1    Lashinger, L.M.2    Hursting, S.D.3
  • 7
    • 79953193036 scopus 로고    scopus 로고
    • Sensing of energy and nutrients by AMP-activated protein kinase
    • Hardie DG (2011) Sensing of energy and nutrients by AMP-activated protein kinase. Am J Clin Nutr 93:891S-896S.
    • (2011) Am J Clin Nutr , vol.93
    • Hardie, D.G.1
  • 9
    • 0029005507 scopus 로고
    • Inhibition of fatty acid and cholesterol synthesis by stimulation of AMP-activated protein kinase
    • Henin N, Vincent MF, Gruber HE, Van den Berghe G (1995) Inhibition of fatty acid and cholesterol synthesis by stimulation of AMP-activated protein kinase. FASEB J 9:541-546.
    • (1995) FASEB J , vol.9 , pp. 541-546
    • Henin, N.1    Vincent, M.F.2    Gruber, H.E.3    Van Den Berghe, G.4
  • 10
    • 63849206613 scopus 로고    scopus 로고
    • AMP-activated protein kinase in the regulation of hepatic energy metabolism: From physiology to therapeutic perspectives
    • Oxf
    • Viollet B, Guigas B, Leclerc J, Hébrard S, Lantier L, et al. (2009) AMP-activated protein kinase in the regulation of hepatic energy metabolism: from physiology to therapeutic perspectives. Acta Physiol (Oxf) 196:81-98.
    • (2009) Acta Physiol , vol.196 , pp. 81-98
    • Viollet, B.1    Guigas, B.2    Leclerc, J.3    Hébrard, S.4    Lantier, L.5
  • 11
    • 84869021501 scopus 로고    scopus 로고
    • AMP-activated protein kinase: An emerging drug target to regulate imbalances in lipid and carbohydrate metabolism to treat cardio-metabolic diseases
    • Srivastava RA, Pinkosky SL, Filippov S, Hanselman JC, Cramer CT, et al. (2012) AMP-activated protein kinase: an emerging drug target to regulate imbalances in lipid and carbohydrate metabolism to treat cardio-metabolic diseases. J Lipid Res 53:2490-2514.
    • (2012) J Lipid Res , vol.53 , pp. 2490-2514
    • Srivastava, R.A.1    Pinkosky, S.L.2    Filippov, S.3    Hanselman, J.C.4    Cramer, C.T.5
  • 12
    • 79953755370 scopus 로고    scopus 로고
    • AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice
    • Li Y, Xu S, Mihaylova MM, Zheng B, Hou X, et al. (2011) AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice. Cell Metab 13:376-388.
    • (2011) Cell Metab , vol.13 , pp. 376-388
    • Li, Y.1    Xu, S.2    Mihaylova, M.M.3    Zheng, B.4    Hou, X.5
  • 13
    • 0037040185 scopus 로고    scopus 로고
    • Mechanism for fatty acid "sparing" effect on glucose-induced transcription: Regulation of carbohydrate-responsive element-binding protein by AMP-activated protein kinase
    • DOI 10.1074/jbc.M107895200
    • Kawaguchi T, Osatomi K, Yamashita H, Kabashima T, Uyeda K (2002) Mechanism for fatty acid "sparing" effect on glucose-induced transcription: regulation of carbohydrate-responsive element-binding protein by AMP-activated protein kinase. J Biol Chem 2776:3829-3835. (Pubitemid 34968632)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.6 , pp. 3829-3835
    • Kawaguchi, T.1    Osatomi, K.2    Yamashita, H.3    Kabashima, T.4    Uyeda, K.5
  • 14
    • 4344714725 scopus 로고    scopus 로고
    • Induced adiposity and adipocyte hypertrophy in mice lacking the AMP-activated protein kinase-alpha 2 subunit
    • DOI 10.2337/diabetes.53.9.2242
    • Villena JA, Viollet B, Andreelli F, Kahn A, Vaulont S, et al. (2004) Induced adiposity and adipocyte hypertrophy in mice lacking the AMP-activated protein kinase-alpha2 subunit. Diabetes 53:2242-2249. (Pubitemid 39145577)
    • (2004) Diabetes , vol.53 , Issue.9 , pp. 2242-2249
    • Villena, J.A.1    Viollet, B.2    Andreelli, F.3    Kahn, A.4    Vaulont, S.5    Sul, H.S.6
  • 15
    • 84870349122 scopus 로고    scopus 로고
    • AMP-activated protein kinase a1 protects against diet-induced insulin resistance and obesity
    • Zhang W, Zhang X, Wang H, Guo X, Li H, et al. (2012) AMP-activated protein kinase a1 protects against diet-induced insulin resistance and obesity. Diabetes 61:3114-3125.
    • (2012) Diabetes , vol.61 , pp. 3114-3125
    • Zhang, W.1    Zhang, X.2    Wang, H.3    Guo, X.4    Li, H.5
  • 16
    • 75349099919 scopus 로고    scopus 로고
    • Development of protein kinase activators: AMPK as a target in metabolic disorders and cancer
    • Fogarty S, Hardie DG (2009) Development of protein kinase activators: AMPK as a target in metabolic disorders and cancer. Biochim Biophys Acta 1804:581-591.
    • (2009) Biochim Biophys Acta , vol.1804 , pp. 581-591
    • Fogarty, S.1    Hardie, D.G.2
  • 17
    • 84884565721 scopus 로고    scopus 로고
    • AMP-activated protein kinase: A target for old drugs against diabetes and cancer
    • Russo GL, Russo M, Ungaro P (2013) AMP-activated protein kinase: A target for old drugs against diabetes and cancer. Biochem Pharmacol 86:339-350.
    • (2013) Biochem Pharmacol , vol.86 , pp. 339-350
    • Russo, G.L.1    Russo, M.2    Ungaro, P.3
  • 18
    • 84883709817 scopus 로고    scopus 로고
    • AMPK: A target for drugs and natural products with effects on both diabetes and cancer
    • Hardie DG (2013) AMPK: A target for drugs and natural products with effects on both diabetes and cancer. Diabetes 62:2164-2172.
    • (2013) Diabetes , vol.62 , pp. 2164-2172
    • Hardie, D.G.1
  • 20
    • 61449222837 scopus 로고    scopus 로고
    • Pioglitazone stimulates AMP-activated protein kinase signalling and increases the expression of genes involved in adiponectin signalling, mitochondrial function and fat oxidation in human skeletal muscle in vivo: A randomised trial
    • Coletta DK, Sriwijitkamol A, Wajcberg E, Tantiwong P, Li M, et al. (2009) Pioglitazone stimulates AMP-activated protein kinase signalling and increases the expression of genes involved in adiponectin signalling, mitochondrial function and fat oxidation in human skeletal muscle in vivo: a randomised trial. Diabetologia 52:723-732.
    • (2009) Diabetologia , vol.52 , pp. 723-732
    • Coletta, D.K.1    Sriwijitkamol, A.2    Wajcberg, E.3    Tantiwong, P.4    Li, M.5
  • 21
    • 84865130936 scopus 로고    scopus 로고
    • Resveratrol ameliorates diabetes-related metabolic changes via activation of AMP-activated protein kinase and its downstream targets in db/db mice
    • Do GM, Jung UJ, Park HJ, Kwon EY, Jeon SM, et al. (2012) Resveratrol ameliorates diabetes-related metabolic changes via activation of AMP-activated protein kinase and its downstream targets in db/db mice. Mol Nutr Food Res 6:1282-1291.
    • (2012) Mol Nutr Food Res , vol.6 , pp. 1282-1291
    • Do, G.M.1    Jung, U.J.2    Park, H.J.3    Kwon, E.Y.4    Jeon, S.M.5
  • 22
    • 84880702294 scopus 로고    scopus 로고
    • Curcumin attenuates diet-induced hepatic steatosis by activating AMP-activated protein kinase
    • Um MY, Hwang KH, Ahn J, Ha TY (2013) Curcumin attenuates diet-induced hepatic steatosis by activating AMP-activated protein kinase. Basic Clin Pharmacol Toxicol 113:152-157.
    • (2013) Basic Clin Pharmacol Toxicol , vol.113 , pp. 152-157
    • Um, M.Y.1    Hwang, K.H.2    Ahn, J.3    Ha, T.Y.4
  • 23
    • 65649089100 scopus 로고    scopus 로고
    • Berberine improves lipid dysregulation in obesity by controlling central and peripheral AMPK activity
    • Kim WS, Lee YS, Cha SH, Jeong HW, Choe SS, et al. (2009) Berberine improves lipid dysregulation in obesity by controlling central and peripheral AMPK activity. Am J Physiol Endocrinol Metab 296:E812-E819.
    • (2009) Am J Physiol Endocrinol Metab , vol.296
    • Kim, W.S.1    Lee, Y.S.2    Cha, S.H.3    Jeong, H.W.4    Choe, S.S.5
  • 24
    • 84862314784 scopus 로고    scopus 로고
    • AMPK activation with glabridin ameliorates adiposity and lipid dysregulation in obesity
    • Lee JW, Choe SS, Jang H, Kim J, Jeong HW, et al. (2012) AMPK activation with glabridin ameliorates adiposity and lipid dysregulation in obesity. J Lipid Res 53:1277-1286.
    • (2012) J Lipid Res , vol.53 , pp. 1277-1286
    • Lee, J.W.1    Choe, S.S.2    Jang, H.3    Kim, J.4    Jeong, H.W.5
  • 25
    • 84866742125 scopus 로고    scopus 로고
    • Novel dichlorophenyl urea compounds inhibit proliferation of human leukemia HL-60 cells by inducing cell cycle arrest, differentiation and apoptosis
    • Figarola JL, Weng Y, Lincoln C, Horne D, Rahbar S (2012) Novel dichlorophenyl urea compounds inhibit proliferation of human leukemia HL-60 cells by inducing cell cycle arrest, differentiation and apoptosis. Invest New Drugs 30:1413-1425.
    • (2012) Invest New Drugs , vol.30 , pp. 1413-1425
    • Figarola, J.L.1    Weng, Y.2    Lincoln, C.3    Horne, D.4    Rahbar, S.5
  • 26
    • 84868507133 scopus 로고    scopus 로고
    • 1,3-Bis(3,5-dichlorophenyl) urea compound 'COH-SR4' inhibits proliferation and activates apoptosis in melanoma
    • Singhal SS, Figarola J, Singhal J, Leake K, Nagaprashantha L, et al. (2012) 1,3-Bis(3,5-dichlorophenyl) urea compound 'COH-SR4' inhibits proliferation and activates apoptosis in melanoma. Biochem Pharmacol 84:1419-1427.
    • (2012) Biochem Pharmacol , vol.84 , pp. 1419-1427
    • Singhal, S.S.1    Figarola, J.2    Singhal, J.3    Leake, K.4    Nagaprashantha, L.5
  • 27
    • 84876141146 scopus 로고    scopus 로고
    • Small molecule COH-SR4 inhibits adipocyte differentiation via AMPK activation
    • Figarola JL, Rahbar S (2013) Small molecule COH-SR4 inhibits adipocyte differentiation via AMPK activation. Int J Mol Med 31:1166-1176.
    • (2013) Int J Mol Med , vol.31 , pp. 1166-1176
    • Figarola, J.L.1    Rahbar, S.2
  • 28
    • 0035710746 scopus 로고    scopus 로고
    • -delta deltaCT method
    • DOI 10.1006/meth.2001.1262
    • Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta deltaC(T)) method. Methods 25:402-408. (Pubitemid 34164012)
    • (2001) Methods , vol.25 , Issue.4 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 30
    • 2442710044 scopus 로고    scopus 로고
    • Genetic vulnerability to diet-induced obesity in the C57BL/6J mouse: Physiological and molecular characteristics
    • DOI 10.1016/j.physbeh.2004.02.006, PII S0031938404000460
    • Collins S, Martin TL, Surwit RS, Robidoux J (2004) Genetic vulnerability to diet-induced obesity in the C57BL/6J mouse: physiological and molecular characteristics. Physiol Behav 81:243-248. (Pubitemid 38670090)
    • (2004) Physiology and Behavior , vol.81 , Issue.2 , pp. 243-248
    • Collins, S.1    Martin, T.L.2    Surwit, R.S.3    Robidoux, J.4
  • 31
    • 3543009434 scopus 로고    scopus 로고
    • The high-fat diet-fed mouse: A model for studying mechanisms and treatment of impaired glucose tolerance and type 2 diabetes
    • Winzell MS, Ahrén B (2004) The high-fat diet-fed mouse: a model for studying mechanisms and treatment of impaired glucose tolerance and type 2 diabetes. Diabetes 53:S215-S219.
    • (2004) Diabetes , vol.53
    • Winzell, M.S.1    Ahrén, B.2
  • 32
    • 4444344507 scopus 로고    scopus 로고
    • Lipids and glucose in type 2 diabetes: What is the cause and effect?
    • DOI 10.2337/diacare.27.9.2253
    • Boden G, Laakso M (2004) Lipids and glucose in type 2 diabetes: what is the cause and effect? Diabetes Care 27:2253-2259. (Pubitemid 39167198)
    • (2004) Diabetes Care , vol.27 , Issue.9 , pp. 2253-2259
    • Boden, G.1    Laakso, M.2
  • 33
    • 34247863931 scopus 로고    scopus 로고
    • Abnormal Lipid and Glucose Metabolism in Obesity: Implications for Nonalcoholic Fatty Liver Disease
    • DOI 10.1053/j.gastro.2007.03.055, PII S0016508507005811
    • Parekh S, Anania A (2007) Abnormal lipid and glucose metabolism in obesity: implications for nonalcoholic fatty liver disease. Gastroenterology 132:2191-2207. (Pubitemid 46693752)
    • (2007) Gastroenterology , vol.132 , Issue.6 , pp. 2191-2207
    • Parekh, S.1    Anania, F.A.2
  • 34
    • 66349099340 scopus 로고    scopus 로고
    • Fatty acid metabolism: Target for metabolic syndrome
    • Wakil SJ, Abu-Elheiga LA (2009) Fatty acid metabolism: target for metabolic syndrome. J Lipid Res 50:S138-S143.
    • (2009) J Lipid Res , vol.50
    • Wakil, S.J.1    Abu-Elheiga, L.A.2
  • 36
    • 40549135297 scopus 로고    scopus 로고
    • Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: Lessons from genetically engineered mice
    • DOI 10.1172/JCI34275
    • Postic C, Girard J (2008) Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice. J Clin Invest 118: 829-838. (Pubitemid 351364588)
    • (2008) Journal of Clinical Investigation , vol.118 , Issue.3 , pp. 829-838
    • Postic, C.1    Girard, J.2
  • 37
    • 0035029874 scopus 로고    scopus 로고
    • Effect of 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside infusion on in vivo glucose and lipid metabolism in lean and obese zucker rats
    • Bergeron R, Previs SF, Cline GW, Perret P, Russell RR, et al. (2001) Effect of 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside infusion on in vivo glucose and lipid metabolism in lean and obese Zucker rats. Diabetes 50:1076-1082. (Pubitemid 32374538)
    • (2001) Diabetes , vol.50 , Issue.5 , pp. 1076-1082
    • Bergeron, R.1    Previs, S.F.2    Cline, G.W.3    Perret, P.4    Russell III, R.R.5    Young, L.H.6    Shulman, G.I.7
  • 38
    • 44849131936 scopus 로고    scopus 로고
    • Resveratrol improves non-alcoholic fatty liver disease by activating AMP-activated protein kinase
    • DOI 10.1111/j.1745-7254.2008.00807.x
    • Shang J, Chen LL, Xiao FX, Sun H, Ding HC, et al. (2008) Resveratrol improves non-alcoholic fatty liver disease by activating AMP-activated protein kinase. Acta Pharmacol Sin 29:698-706. (Pubitemid 351799479)
    • (2008) Acta Pharmacologica Sinica , vol.29 , Issue.6 , pp. 698-706
    • Shang, J.1    Chen, L.-L.2    Xiao, F.-X.3    Sun, H.4    Ding, H.-C.5    Xiao, H.6
  • 39
    • 54849431380 scopus 로고    scopus 로고
    • Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respiration
    • Polak P, Cybulski N, Feige JN, Auwerx J, Rüegg MA, et al. (2008) Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respiration. Cell Metab 8:399-410.
    • (2008) Cell Metab , vol.8 , pp. 399-410
    • Polak, P.1    Cybulski, N.2    Feige, J.N.3    Auwerx, J.4    Rüegg, M.A.5
  • 40
    • 66249088672 scopus 로고    scopus 로고
    • Rapamycin protects against high fat diet-induced obesity in C57BL/6J mice
    • Chang GR, Chiu YS, Wu YY, Chen WY, Liao JW, et al. (2009) Rapamycin protects against high fat diet-induced obesity in C57BL/6J mice. J Pharmacol Sci 109:496-503.
    • (2009) J Pharmacol Sci , vol.109 , pp. 496-503
    • Chang, G.R.1    Chiu, Y.S.2    Wu, Y.Y.3    Chen, W.Y.4    Liao, J.W.5
  • 41
    • 33645884425 scopus 로고    scopus 로고
    • Liver adenosine monophosphate-activated kinase-alpha2 catalytic subunit is a key target for the control of hepatic glucose production by adiponectin and leptin but not insulin
    • Andreelli F, Foretz M, Knauf C, Cani PD, Perrin C, et al. (2006) Liver adenosine monophosphate-activated kinase-alpha2 catalytic subunit is a key target for the control of hepatic glucose production by adiponectin and leptin but not insulin. Endocrinology 147:2432-2441.
    • (2006) Endocrinology , vol.147 , pp. 2432-2441
    • Andreelli, F.1    Foretz, M.2    Knauf, C.3    Cani, P.D.4    Perrin, C.5
  • 43
    • 17844368938 scopus 로고    scopus 로고
    • Short-term overexpression of a constitutively active form of AMP-activated protein kinase in the liver leads to mild hypoglycemia and fatty liver
    • DOI 10.2337/diabetes.54.5.1331
    • Foretz M, Ancellin N, Andreelli F, Saintillan Y, Grondin P, et al. (2005) Shortterm overexpression of a constitutively active form of AMP-activated protein kinase in the liver leads to mild hypoglycemia and fatty liver. Diabetes 54:1331-1339. (Pubitemid 40586661)
    • (2005) Diabetes , vol.54 , Issue.5 , pp. 1331-1339
    • Foretz, M.1    Ancellin, N.2    Andreelli, F.3    Saintillan, Y.4    Grondin, P.5    Kahn, A.6    Thorens, B.7    Vaulont, S.8    Viollet, B.9
  • 44
    • 80054841617 scopus 로고    scopus 로고
    • AICAR response element binding protein (AREBP), a key modulator of hepatic glucose production regulated by AMPK in vivo
    • Shirai T, Inoue E, Ishimi Y, Yamauchi J (2011) AICAR response element binding protein (AREBP), a key modulator of hepatic glucose production regulated by AMPK in vivo. Biochem Biophys Res Commun 414:287-291.
    • (2011) Biochem Biophys Res Commun , vol.414 , pp. 287-291
    • Shirai, T.1    Inoue, E.2    Ishimi, Y.3    Yamauchi, J.4
  • 45
    • 77956410464 scopus 로고    scopus 로고
    • Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activation
    • Hawley SA, Ross FA, Chevtzoff C, Green KA, Evans A, et al. (2010) Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activation. Cell Metab 11:554-565.
    • (2010) Cell Metab , vol.11 , pp. 554-565
    • Hawley, S.A.1    Ross, F.A.2    Chevtzoff, C.3    Green, K.A.4    Evans, A.5
  • 47
    • 84888439282 scopus 로고    scopus 로고
    • Metabolic roles of AMPK and metformin in cancer cells
    • Choi YK, Park KG (2013) Metabolic roles of AMPK and metformin in cancer cells. Mol Cells 36:279-287.
    • (2013) Mol Cells , vol.36 , pp. 279-287
    • Choi, Y.K.1    Park, K.G.2
  • 48
    • 76449110705 scopus 로고    scopus 로고
    • Resveratrol modulates tumor cell proliferation and protein translation via SIRT1-dependent AMPK activation
    • Lin JN, Lin VC, Rau KM, Shieh PC, Kuo DH, et al. (2010) Resveratrol modulates tumor cell proliferation and protein translation via SIRT1-dependent AMPK activation. J Agric Food Chem 58:1584-1592.
    • (2010) J Agric Food Chem , vol.58 , pp. 1584-1592
    • Lin, J.N.1    Lin, V.C.2    Rau, K.M.3    Shieh, P.C.4    Kuo, D.H.5
  • 49
    • 84455208086 scopus 로고    scopus 로고
    • Berberine-induced AMPK activation inhibits the metastatic potential of melanoma cells via reduction of ERK activity and COX-2 protein expression
    • Kim HS, Kim MJ, Kim EJ, Yang Y, Lee MS, et al. (2012) Berberine-induced AMPK activation inhibits the metastatic potential of melanoma cells via reduction of ERK activity and COX-2 protein expression. Biochem Pharmacol 83:385-394.
    • (2012) Biochem Pharmacol , vol.83 , pp. 385-394
    • Kim, H.S.1    Kim, M.J.2    Kim, E.J.3    Yang, Y.4    Lee, M.S.5
  • 50
    • 84893455835 scopus 로고    scopus 로고
    • The dark face of AMPK as an essential tumor promoter
    • Jeon SM, Hay N (2012) The dark face of AMPK as an essential tumor promoter. Cell Logist 2:197-202.
    • (2012) Cell Logist , vol.2 , pp. 197-202
    • Jeon, S.M.1    Hay, N.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.