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Volumn 24, Issue 10, 2013, Pages 481-487

AMPK: Mediating the metabolic effects of salicylate-based drugs?

Author keywords

AMPK; Aspirin; Cancer; Diabetes; Inflammation; Salicylate

Indexed keywords

6,7 DIHYDRO 4 HYDROXY 3 (2' HYDROXY 1,1' BIPHENYL 4 YL) 6 OXOTHIENO[2,3 B]PYRIDINE 5 CARBONITRILE; ACETYLSALICYLIC ACID; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROSTAGLANDIN SYNTHASE; SALICYLIC ACID; SALSALATE;

EID: 84884414016     PISSN: 10432760     EISSN: 18793061     Source Type: Journal    
DOI: 10.1016/j.tem.2013.06.002     Document Type: Review
Times cited : (68)

References (60)
  • 1
    • 69949097909 scopus 로고    scopus 로고
    • Salicylic acid, a multifaceted hormone to combat disease
    • Vlot A.C., et al. Salicylic acid, a multifaceted hormone to combat disease. Annu. Rev. Phytopathol. 2009, 47:177-206.
    • (2009) Annu. Rev. Phytopathol. , vol.47 , pp. 177-206
    • Vlot, A.C.1
  • 2
    • 2542425151 scopus 로고
    • Pharmacokinetics of aspirin and salicylate in relation to inhibition of arachidonate cyclooxygenase and antiinflammatory activity
    • Higgs G.A., et al. Pharmacokinetics of aspirin and salicylate in relation to inhibition of arachidonate cyclooxygenase and antiinflammatory activity. Proc. Natl. Acad. Sci. U.S.A. 1987, 84:1417-1420.
    • (1987) Proc. Natl. Acad. Sci. U.S.A. , vol.84 , pp. 1417-1420
    • Higgs, G.A.1
  • 3
    • 84861222690 scopus 로고    scopus 로고
    • The ancient drug salicylate directly activates AMP-activated protein kinase
    • Hawley S.A., et al. The ancient drug salicylate directly activates AMP-activated protein kinase. Science 2012, 336:918-922.
    • (2012) Science , vol.336 , pp. 918-922
    • Hawley, S.A.1
  • 4
    • 84861648941 scopus 로고    scopus 로고
    • Aspirin inhibits mTOR signaling, activates AMP-activated protein kinase, and induces autophagy in colorectal cancer cells
    • Din F.V., et al. Aspirin inhibits mTOR signaling, activates AMP-activated protein kinase, and induces autophagy in colorectal cancer cells. Gastroenterology 2012, 142:1504-1515.
    • (2012) Gastroenterology , vol.142 , pp. 1504-1515
    • Din, F.V.1
  • 5
    • 0015237292 scopus 로고
    • Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs
    • Vane J.R. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nat. New Biol. 1971, 231:232-235.
    • (1971) Nat. New Biol. , vol.231 , pp. 232-235
    • Vane, J.R.1
  • 6
    • 0031777185 scopus 로고    scopus 로고
    • Cyclooxygenases 1 and 2
    • Vane J.R., et al. Cyclooxygenases 1 and 2. Ann. Rev. Pharm. Toxicol. 1998, 38:97-120.
    • (1998) Ann. Rev. Pharm. Toxicol. , vol.38 , pp. 97-120
    • Vane, J.R.1
  • 7
    • 0024381125 scopus 로고
    • Comparative analgesic and anti-inflammatory properties of sodium salicylate and acetylsalicylic acid (aspirin) in rheumatoid arthritis
    • Preston S.J., et al. Comparative analgesic and anti-inflammatory properties of sodium salicylate and acetylsalicylic acid (aspirin) in rheumatoid arthritis. Br. J. Clin. Pharmacol. 1989, 27:607-611.
    • (1989) Br. J. Clin. Pharmacol. , vol.27 , pp. 607-611
    • Preston, S.J.1
  • 8
    • 0032992467 scopus 로고    scopus 로고
    • Salicylates and sulfasalazine, but not glucocorticoids, inhibit leukocyte accumulation by an adenosine-dependent mechanism that is independent of inhibition of prostaglandin synthesis and p105 of NFkappaB
    • Cronstein B.N., et al. Salicylates and sulfasalazine, but not glucocorticoids, inhibit leukocyte accumulation by an adenosine-dependent mechanism that is independent of inhibition of prostaglandin synthesis and p105 of NFkappaB. Proc. Natl. Acad. Sci. U.S.A. 1999, 96:6377-6381.
    • (1999) Proc. Natl. Acad. Sci. U.S.A. , vol.96 , pp. 6377-6381
    • Cronstein, B.N.1
  • 9
    • 0028167846 scopus 로고
    • Inhibition of NF-kappa B by sodium salicylate and aspirin
    • Kopp E., Ghosh S. Inhibition of NF-kappa B by sodium salicylate and aspirin. Science 1994, 265:956-959.
    • (1994) Science , vol.265 , pp. 956-959
    • Kopp, E.1    Ghosh, S.2
  • 10
    • 0032487857 scopus 로고    scopus 로고
    • The anti-inflammatory agents aspirin and salicylate inhibit the activity of IκB kinase-beta
    • Yin M.J., et al. The anti-inflammatory agents aspirin and salicylate inhibit the activity of IκB kinase-beta. Nature 1998, 396:77-80.
    • (1998) Nature , vol.396 , pp. 77-80
    • Yin, M.J.1
  • 11
    • 84884416079 scopus 로고    scopus 로고
    • International Centre for Kinase Profiling, MRC Protein Phosphorylation and Ubiquitylation Unit
    • International Centre for Kinase Profiling Kinase Inhibitor Database 2013, MRC Protein Phosphorylation and Ubiquitylation Unit. http://www.kinase-screen.mrc.ac.uk/kinase-inhibitors.
    • (2013) Kinase Inhibitor Database
  • 12
    • 33745861300 scopus 로고    scopus 로고
    • Inflammation and insulin resistance
    • Shoelson S.E., et al. Inflammation and insulin resistance. J. Clin. Invest. 2006, 116:1793-1801.
    • (2006) J. Clin. Invest. , vol.116 , pp. 1793-1801
    • Shoelson, S.E.1
  • 13
    • 0035979775 scopus 로고    scopus 로고
    • Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta
    • Yuan M., et al. Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta. Science 2001, 293:1673-1677.
    • (2001) Science , vol.293 , pp. 1673-1677
    • Yuan, M.1
  • 14
    • 0036099857 scopus 로고    scopus 로고
    • Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes
    • Hundal R.S., et al. Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes. J. Clin. Invest. 2002, 109:1321-1326.
    • (2002) J. Clin. Invest. , vol.109 , pp. 1321-1326
    • Hundal, R.S.1
  • 15
    • 20044387026 scopus 로고    scopus 로고
    • IKK-beta links inflammation to obesity-induced insulin resistance
    • Arkan M.C., et al. IKK-beta links inflammation to obesity-induced insulin resistance. Nat. Med. 2005, 11:191-198.
    • (2005) Nat. Med. , vol.11 , pp. 191-198
    • Arkan, M.C.1
  • 16
    • 84876485218 scopus 로고    scopus 로고
    • A randomised trial of salsalate for insulin resistance and cardiovascular risk factors in persons with abnormal glucose tolerance
    • Goldfine A.B., et al. A randomised trial of salsalate for insulin resistance and cardiovascular risk factors in persons with abnormal glucose tolerance. Diabetologia 2013, 56:714-723.
    • (2013) Diabetologia , vol.56 , pp. 714-723
    • Goldfine, A.B.1
  • 17
    • 38949119419 scopus 로고    scopus 로고
    • Salsalate improves glycemia and inflammatory parameters in obese young adults
    • Fleischman A., et al. Salsalate improves glycemia and inflammatory parameters in obese young adults. Diabetes Care 2008, 31:289-294.
    • (2008) Diabetes Care , vol.31 , pp. 289-294
    • Fleischman, A.1
  • 18
    • 79955662435 scopus 로고    scopus 로고
    • Stimulation of human whole-body energy expenditure by salsalate is fueled by higher lipid oxidation under fasting conditions and by higher oxidative glucose disposal under insulin-stimulated conditions
    • Meex R.C., et al. Stimulation of human whole-body energy expenditure by salsalate is fueled by higher lipid oxidation under fasting conditions and by higher oxidative glucose disposal under insulin-stimulated conditions. J. Clin. Endocrinol. Metab. 2011, 96:1415-1423.
    • (2011) J. Clin. Endocrinol. Metab. , vol.96 , pp. 1415-1423
    • Meex, R.C.1
  • 19
    • 0018095368 scopus 로고
    • Mechanisms for inhibition of free fatty acid mobilization by nicotinic acid and sodium salicylate in canine subcutaneous adipose tissue in situ
    • Vik-Mo H., Mjos O.D. Mechanisms for inhibition of free fatty acid mobilization by nicotinic acid and sodium salicylate in canine subcutaneous adipose tissue in situ. Scand. J. Clin. Lab. Invest. 1978, 38:209-216.
    • (1978) Scand. J. Clin. Lab. Invest. , vol.38 , pp. 209-216
    • Vik-Mo, H.1    Mjos, O.D.2
  • 20
    • 0019950582 scopus 로고
    • Inhibition of hepatic lipogenesis by salicylate
    • Beynen A.C., et al. Inhibition of hepatic lipogenesis by salicylate. Toxicology 1982, 24:33-43.
    • (1982) Toxicology , vol.24 , pp. 33-43
    • Beynen, A.C.1
  • 21
    • 67650914230 scopus 로고    scopus 로고
    • AMPK in health and disease
    • Steinberg G.R., Kemp B.E. AMPK in health and disease. Physiol. Rev. 2009, 89:1025-1078.
    • (2009) Physiol. Rev. , vol.89 , pp. 1025-1078
    • Steinberg, G.R.1    Kemp, B.E.2
  • 22
    • 84868005485 scopus 로고    scopus 로고
    • AMP-activated protein kinase: a target for drugs both ancient and modern
    • Hardie D.G., et al. AMP-activated protein kinase: a target for drugs both ancient and modern. Chem. Biol. 2012, 19:1222-1236.
    • (2012) Chem. Biol. , vol.19 , pp. 1222-1236
    • Hardie, D.G.1
  • 23
    • 0345107247 scopus 로고    scopus 로고
    • Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade
    • Hawley S.A., et al. Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade. J. Biol. 2003, 2:28.
    • (2003) J. Biol. , vol.2 , pp. 28
    • Hawley, S.A.1
  • 24
    • 17144474893 scopus 로고    scopus 로고
    • Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICAR
    • Sakamoto K., et al. Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICAR. Am. J. Physiol. Endocrinol. Metab. 2004, 287:E310-E317.
    • (2004) Am. J. Physiol. Endocrinol. Metab. , vol.287
    • Sakamoto, K.1
  • 25
    • 12144287284 scopus 로고    scopus 로고
    • LKB1 is a master kinase that activates 13 protein kinases of the AMPK subfamily, including the MARK/PAR-1 kinases
    • Lizcano J.M., et al. LKB1 is a master kinase that activates 13 protein kinases of the AMPK subfamily, including the MARK/PAR-1 kinases. EMBO J. 2004, 23:833-843.
    • (2004) EMBO J. , vol.23 , pp. 833-843
    • Lizcano, J.M.1
  • 26
    • 79959338922 scopus 로고    scopus 로고
    • AMPK is a direct adenylate charge-regulated protein kinase
    • Oakhill J.S., et al. AMPK is a direct adenylate charge-regulated protein kinase. Science 2011, 332:1433-1435.
    • (2011) Science , vol.332 , pp. 1433-1435
    • Oakhill, J.S.1
  • 27
    • 79954517977 scopus 로고    scopus 로고
    • Structure of mammalian AMPK and its regulation by ADP
    • Xiao B., et al. Structure of mammalian AMPK and its regulation by ADP. Nature 2011, 472:230-233.
    • (2011) Nature , vol.472 , pp. 230-233
    • Xiao, B.1
  • 28
    • 77956410464 scopus 로고    scopus 로고
    • Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activation
    • Hawley S.A., et al. Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activation. Cell Metab. 2010, 11:554-565.
    • (2010) Cell Metab. , vol.11 , pp. 554-565
    • Hawley, S.A.1
  • 29
    • 36348998521 scopus 로고    scopus 로고
    • Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase
    • Goransson O., et al. Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase. J. Biol. Chem. 2007, 282:32549-32560.
    • (2007) J. Biol. Chem. , vol.282 , pp. 32549-32560
    • Goransson, O.1
  • 30
    • 36348978499 scopus 로고    scopus 로고
    • Defining the mechanism of activation of AMP-activated protein kinase by the small molecule A-769662, a member of the thienopyridone family
    • Sanders M.J., et al. Defining the mechanism of activation of AMP-activated protein kinase by the small molecule A-769662, a member of the thienopyridone family. J. Biol. Chem. 2007, 282:32539-32548.
    • (2007) J. Biol. Chem. , vol.282 , pp. 32539-32548
    • Sanders, M.J.1
  • 31
    • 56049112796 scopus 로고    scopus 로고
    • Thienopyridone drugs are selective activators of AMP-activated protein kinase beta1-containing complexes
    • Scott J.W., et al. Thienopyridone drugs are selective activators of AMP-activated protein kinase beta1-containing complexes. Chem. Biol. 2008, 15:1220-1230.
    • (2008) Chem. Biol. , vol.15 , pp. 1220-1230
    • Scott, J.W.1
  • 32
    • 84872159532 scopus 로고    scopus 로고
    • AMPK is a negative regulator of the Warburg effect and suppresses tumor growth in vivo
    • Faubert B., et al. AMPK is a negative regulator of the Warburg effect and suppresses tumor growth in vivo. Cell Metab. 2012, 17:113-124.
    • (2012) Cell Metab. , vol.17 , pp. 113-124
    • Faubert, B.1
  • 33
    • 21644455008 scopus 로고    scopus 로고
    • Anti-lipolytic action of AMP-activated protein kinase in rodent adipocytes
    • Daval M., et al. Anti-lipolytic action of AMP-activated protein kinase in rodent adipocytes. J. Biol. Chem. 2005, 280:25250-25257.
    • (2005) J. Biol. Chem. , vol.280 , pp. 25250-25257
    • Daval, M.1
  • 34
    • 0024516569 scopus 로고
    • Phosphorylation of bovine hormone-sensitive lipase by the AMP-activated protein kinase. A possible antilipolytic mechanism
    • Garton A.J., et al. Phosphorylation of bovine hormone-sensitive lipase by the AMP-activated protein kinase. A possible antilipolytic mechanism. Eur. J. Biochem. 1989, 179:249-254.
    • (1989) Eur. J. Biochem. , vol.179 , pp. 249-254
    • Garton, A.J.1
  • 35
    • 79959956336 scopus 로고    scopus 로고
    • AMP-activated protein kinase inhibits NF-kappaB signaling and inflammation: impact on healthspan and lifespan
    • Salminen A., et al. AMP-activated protein kinase inhibits NF-kappaB signaling and inflammation: impact on healthspan and lifespan. J. Mol. Med. 2011, 89:667-676.
    • (2011) J. Mol. Med. , vol.89 , pp. 667-676
    • Salminen, A.1
  • 36
    • 79953221811 scopus 로고    scopus 로고
    • Counter-modulation of fatty acid-induced pro-inflammatory nuclear factor kappaB signalling in rat skeletal muscle cells by AMP-activated protein kinase
    • Green C.J., et al. Counter-modulation of fatty acid-induced pro-inflammatory nuclear factor kappaB signalling in rat skeletal muscle cells by AMP-activated protein kinase. Biochem. J. 2011, 435:463-474.
    • (2011) Biochem. J. , vol.435 , pp. 463-474
    • Green, C.J.1
  • 37
    • 84872576236 scopus 로고    scopus 로고
    • Metabolism of inflammation limited by AMPK and pseudo-starvation
    • O'Neill L.A., Hardie D.G. Metabolism of inflammation limited by AMPK and pseudo-starvation. Nature 2013, 493:346-355.
    • (2013) Nature , vol.493 , pp. 346-355
    • O'Neill, L.A.1    Hardie, D.G.2
  • 38
    • 84865197492 scopus 로고    scopus 로고
    • Commitment to glycolysis sustains survival of NO-producing inflammatory dendritic cells
    • Everts B., et al. Commitment to glycolysis sustains survival of NO-producing inflammatory dendritic cells. Blood 2012, 120:1422-1431.
    • (2012) Blood , vol.120 , pp. 1422-1431
    • Everts, B.1
  • 39
    • 77954735369 scopus 로고    scopus 로고
    • Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation
    • Krawczyk C.M., et al. Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation. Blood 2010, 115:4742-4749.
    • (2010) Blood , vol.115 , pp. 4742-4749
    • Krawczyk, C.M.1
  • 40
    • 84862016400 scopus 로고    scopus 로고
    • The sedoheptulose kinase CARKL directs macrophage polarization through control of glucose metabolism
    • Haschemi A., et al. The sedoheptulose kinase CARKL directs macrophage polarization through control of glucose metabolism. Cell Metab. 2012, 15:813-826.
    • (2012) Cell Metab. , vol.15 , pp. 813-826
    • Haschemi, A.1
  • 41
    • 58849115949 scopus 로고    scopus 로고
    • Adenosine 5'-monophosphate-activated protein kinase promotes macrophage polarization to an anti-inflammatory functional phenotype
    • Sag D., et al. Adenosine 5'-monophosphate-activated protein kinase promotes macrophage polarization to an anti-inflammatory functional phenotype. J. Immunol. 2008, 181:8633-8641.
    • (2008) J. Immunol. , vol.181 , pp. 8633-8641
    • Sag, D.1
  • 42
    • 77953517927 scopus 로고    scopus 로고
    • Macrophage α1-AMP-activated protein kinase (α1AMPK) antagonizes fatty acid-induced inflammation through SIRT1
    • Yang Z., et al. Macrophage α1-AMP-activated protein kinase (α1AMPK) antagonizes fatty acid-induced inflammation through SIRT1. J. Biol. Chem. 2010, 285:19051-19059.
    • (2010) J. Biol. Chem. , vol.285 , pp. 19051-19059
    • Yang, Z.1
  • 43
    • 84055190798 scopus 로고    scopus 로고
    • Hematopoietic AMPK beta1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity
    • Galic S., et al. Hematopoietic AMPK beta1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity. J. Clin. Invest. 2011, 121:4903-4915.
    • (2011) J. Clin. Invest. , vol.121 , pp. 4903-4915
    • Galic, S.1
  • 44
    • 33745823168 scopus 로고    scopus 로고
    • 2+ in T lymphocytes
    • 2+ in T lymphocytes. J. Exp. Med. 2006, 203:1665-1670.
    • (2006) J. Exp. Med. , vol.203 , pp. 1665-1670
    • Tamas, P.1
  • 45
    • 80054726323 scopus 로고    scopus 로고
    • The liver kinase B1 is a central regulator of T cell development, activation, and metabolism
    • MacIver N.J., et al. The liver kinase B1 is a central regulator of T cell development, activation, and metabolism. J. Immunol. 2011, 187:4187-4198.
    • (2011) J. Immunol. , vol.187 , pp. 4187-4198
    • MacIver, N.J.1
  • 46
    • 84876454059 scopus 로고    scopus 로고
    • AMPKalpha1: a glucose sensor that controls CD8 T-cell memory
    • Rolf J., et al. AMPKalpha1: a glucose sensor that controls CD8 T-cell memory. Eur. J. Immunol. 2013, 43:889-896.
    • (2013) Eur. J. Immunol. , vol.43 , pp. 889-896
    • Rolf, J.1
  • 47
    • 67650096912 scopus 로고    scopus 로고
    • Enhancing CD8 T-cell memory by modulating fatty acid metabolism
    • Pearce E.L., et al. Enhancing CD8 T-cell memory by modulating fatty acid metabolism. Nature 2009, 460:103-107.
    • (2009) Nature , vol.460 , pp. 103-107
    • Pearce, E.L.1
  • 48
    • 65349152488 scopus 로고    scopus 로고
    • Aspirin and non-steroidal anti-inflammatory drugs for cancer prevention: an international consensus statement
    • Cuzick J., et al. Aspirin and non-steroidal anti-inflammatory drugs for cancer prevention: an international consensus statement. Lancet Oncol. 2009, 10:501-507.
    • (2009) Lancet Oncol. , vol.10 , pp. 501-507
    • Cuzick, J.1
  • 49
    • 78650825618 scopus 로고    scopus 로고
    • Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials
    • Rothwell P.M., et al. Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials. Lancet 2011, 377:31-41.
    • (2011) Lancet , vol.377 , pp. 31-41
    • Rothwell, P.M.1
  • 50
    • 0030606299 scopus 로고    scopus 로고
    • Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2)
    • Oshima M., et al. Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2). Cell 1996, 87:803-809.
    • (1996) Cell , vol.87 , pp. 803-809
    • Oshima, M.1
  • 51
    • 84876032294 scopus 로고    scopus 로고
    • Aspirin is associated with lower melanoma risk among postmenopausal Caucasian women: the Women's Health Initiative
    • Gamba C.A., et al. Aspirin is associated with lower melanoma risk among postmenopausal Caucasian women: the Women's Health Initiative. Cancer 2013, 119:1562-1569.
    • (2013) Cancer , vol.119 , pp. 1562-1569
    • Gamba, C.A.1
  • 52
    • 21444450527 scopus 로고    scopus 로고
    • Low-dose aspirin in the primary prevention of cancer: the Women's Health Study: a randomized controlled trial
    • Cook N.R., et al. Low-dose aspirin in the primary prevention of cancer: the Women's Health Study: a randomized controlled trial. JAMA 2005, 294:47-55.
    • (2005) JAMA , vol.294 , pp. 47-55
    • Cook, N.R.1
  • 53
    • 84873719461 scopus 로고    scopus 로고
    • Use of aspirin, but not other non-steroidal anti-inflammatory drugs is associated with decreased prostate cancer risk at the population level
    • Veitonmaki T., et al. Use of aspirin, but not other non-steroidal anti-inflammatory drugs is associated with decreased prostate cancer risk at the population level. Eur. J. Cancer 2013, 49:938-945.
    • (2013) Eur. J. Cancer , vol.49 , pp. 938-945
    • Veitonmaki, T.1
  • 54
    • 84862989872 scopus 로고    scopus 로고
    • Aspirin but not ibuprofen use is associated with reduced risk of prostate cancer: a PLCO study
    • Shebl F.M., et al. Aspirin but not ibuprofen use is associated with reduced risk of prostate cancer: a PLCO study. Br. J. Cancer 2012, 107:207-214.
    • (2012) Br. J. Cancer , vol.107 , pp. 207-214
    • Shebl, F.M.1
  • 55
    • 84862848716 scopus 로고    scopus 로고
    • Cancer risk associated with use of metformin and sulfonylurea in type 2 diabetes: a meta-analysis
    • Soranna D., et al. Cancer risk associated with use of metformin and sulfonylurea in type 2 diabetes: a meta-analysis. Oncologist 2012, 17:813-822.
    • (2012) Oncologist , vol.17 , pp. 813-822
    • Soranna, D.1
  • 56
    • 55449124298 scopus 로고    scopus 로고
    • Min/+ mice
    • Min/+ mice. Cancer Sci. 2008, 99:2136-2141.
    • (2008) Cancer Sci. , vol.99 , pp. 2136-2141
    • Tomimoto, A.1
  • 58
    • 0000459772 scopus 로고
    • Uber den Stoffwechsel der Tumoren
    • Warburg O., et al. Uber den Stoffwechsel der Tumoren. Biochem. Z 1924, 152:319-344.
    • (1924) Biochem. Z , vol.152 , pp. 319-344
    • Warburg, O.1
  • 59
    • 26444570010 scopus 로고    scopus 로고
    • Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations
    • Pollard P.J., et al. Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations. Hum. Mol. Genet. 2005, 14:2231-2239.
    • (2005) Hum. Mol. Genet. , vol.14 , pp. 2231-2239
    • Pollard, P.J.1
  • 60
    • 0038506725 scopus 로고    scopus 로고
    • Multiple pathways are co-regulated by the protein kinase Snf1 and the transcription factors Adr1 and Cat8
    • Young E.T., et al. Multiple pathways are co-regulated by the protein kinase Snf1 and the transcription factors Adr1 and Cat8. J. Biol. Chem. 2003, 278:26146-26158.
    • (2003) J. Biol. Chem. , vol.278 , pp. 26146-26158
    • Young, E.T.1


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