Autophagy flux in CA1 neurons of Alzheimer hippocampus: Increased induction overburdens failing lysosomes to propel neuritic dystrophy

Autophagy

Volumn 12, Issue 12, 2016, Pages 2467-2483

  Bordi, Matteo ^a,b   Berg, Martin J ^a   Mohan, Panaiyur S ^a,b   Peterhoff, Corrinne M ^a   Alldred, Melissa J ^a,b   Che, Shaoli ^a,b   Ginsberg, Stephen D ^a,b   Nixon, Ralph A ^a,b,c  

^a NATHAN S KLINE INSTITUTE FOR PSYCHIATRIC RESEARCH   (United States)

^b NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

^c NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alzheimer disease; autophagosomes; autophagy; CA1 pyramidal neurons; dystrophic neurites; hippocampus; lysosomes; MTOR; TFE3; TFEB

Indexed keywords

AUTOPHAGY PROTEIN 12; AUTOPHAGY PROTEIN 3; AUTOPHAGY PROTEIN 5; AUTOPHAGY PROTEIN 8; CATHEPSIN D; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; MESSENGER RNA; MICROPHTHALMIA ASSOCIATED TRANSCRIPTION FACTOR; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN P62; RAB PROTEIN; RAB4A PROTEIN; RAB5A PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR BINDING TO IGHM ENHANCER 3 PROTEIN; TRANSCRIPTION FACTOR EB; TRANSCRIPTION FACTOR FKHR; TRANSCRIPTION FACTOR FKHRL1; UNCLASSIFIED DRUG; BASIC HELIX LOOP HELIX LEUCINE ZIPPER TRANSCRIPTION FACTOR; LIGHT CHAIN 3, HUMAN; MICROTUBULE ASSOCIATED PROTEIN; TFE3 PROTEIN, HUMAN; TFEB PROTEIN, HUMAN;

ALZHEIMER DISEASE; ARTICLE; AUTOLYSOSOME; AUTOPHAGOSOME; AUTOPHAGY; CELL VACUOLE; CELLULAR DISTRIBUTION; CLINICAL ARTICLE; CONTROLLED STUDY; GENE EXPRESSION PROFILING; GENE ONTOLOGY; GLIA; HIPPOCAMPAL CA1 REGION; HUMAN; HUMAN CELL; HUMAN TISSUE; LASER CAPTURE MICRODISSECTION; LYSOSOME; PROTEIN EXPRESSION; PYRAMIDAL NERVE CELL; TRANSCRIPTION REGULATION; UPREGULATION; AGED; DEMOGRAPHY; FEMALE; GENE EXPRESSION REGULATION; GENETICS; MALE; METABOLISM; MIDDLE AGED; NEURITE; PATHOLOGY; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; AUTOPHAGOSOMES; AUTOPHAGY; BASIC HELIX-LOOP-HELIX LEUCINE ZIPPER TRANSCRIPTION FACTORS; CA1 REGION, HIPPOCAMPAL; CATHEPSIN D; DEMOGRAPHY; FEMALE; GENE EXPRESSION REGULATION; HUMANS; LYSOSOMES; MALE; MICROTUBULE-ASSOCIATED PROTEINS; MIDDLE AGED; NEURITES;

EID: 84994128006     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.1080/15548627.2016.1239003     Document Type: Article

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