-
1
-
-
84892179075
-
Global effects of smoking, of quitting, and of taxing tobacco
-
Jha, P. & Peto, R. Global effects of smoking, of quitting, and of taxing tobacco. N Engl J Med 370, 60-68 (2014).
-
(2014)
N Engl J Med
, vol.370
, pp. 60-68
-
-
Jha, P.1
Peto, R.2
-
2
-
-
33745905620
-
Role of apoptosis in the pathogenesis of COPD and pulmonary emphysema
-
Demedts, I. K., Demoor, T., Bracke, K. R., Joos, G. F. & Brusselle, G. G. Role of apoptosis in the pathogenesis of COPD and pulmonary emphysema. Respir Res 7, 53 (2006).
-
(2006)
Respir Res
, vol.7
, pp. 53
-
-
Demedts, I.K.1
Demoor, T.2
Bracke, K.R.3
Joos, G.F.4
Brusselle, G.G.5
-
3
-
-
45049083557
-
Induction of apoptosis by cigarette smoke via ROS-dependent endoplasmic reticulum stress and CCAAT/enhancerbinding protein-homologous protein (CHOP)
-
Tagawa, Y., et al. Induction of apoptosis by cigarette smoke via ROS-dependent endoplasmic reticulum stress and CCAAT/enhancerbinding protein-homologous protein (CHOP). Free Radic Biol Med 45, 50-59 (2008).
-
(2008)
Free Radic Biol Med
, vol.45
, pp. 50-59
-
-
Tagawa, Y.1
-
4
-
-
34447556991
-
Pathobiology of cigarette smoke-induced chronic obstructive pulmonary disease
-
Yoshida, T. & Tuder, R. M. Pathobiology of cigarette smoke-induced chronic obstructive pulmonary disease. Physiol Rev 87, 1047-1082 (2007).
-
(2007)
Physiol Rev
, vol.87
, pp. 1047-1082
-
-
Yoshida, T.1
Tuder, R.M.2
-
5
-
-
13544275539
-
Enhanced bronchial expression of vascular endothelial growth factor and receptors (Flk-1 and Flt-1) in patients with chronic obstructive pulmonary disease
-
Kranenburg, A. R., de Boer, W. I., Alagappan, V. K., Sterk, P. J. & Sharma, H. S. Enhanced bronchial expression of vascular endothelial growth factor and receptors (Flk-1 and Flt-1) in patients with chronic obstructive pulmonary disease. Thorax 60, 106-113 (2005).
-
(2005)
Thorax
, vol.60
, pp. 106-113
-
-
Kranenburg, A.R.1
De Boer, W.I.2
Alagappan, V.K.3
Sterk, P.J.4
Sharma, H.S.5
-
6
-
-
77954470662
-
Rtp801, a suppressor of mTOR signaling, is an essential mediator of cigarette smoke-induced pulmonary injury and emphysema
-
Yoshida, T., et al. Rtp801, a suppressor of mTOR signaling, is an essential mediator of cigarette smoke-induced pulmonary injury and emphysema. Nat Med 16, 767-773 (2010).
-
(2010)
Nat Med
, vol.16
, pp. 767-773
-
-
Yoshida, T.1
-
7
-
-
0036118562
-
Identification of a novel hypoxia-inducible factor 1-responsive gene, RTP801, involved in apoptosis
-
Shoshani, T., et al. Identification of a novel hypoxia-inducible factor 1-responsive gene, RTP801, involved in apoptosis. Mol Cell Biol 22, 2283-2293 (2002).
-
(2002)
Mol Cell Biol
, vol.22
, pp. 2283-2293
-
-
Shoshani, T.1
-
9
-
-
34247247221
-
Cigarette smoke stimulates matrix metalloproteinase-2 activity via EGR-1 in human lung fibroblasts
-
Ning, W., et al. Cigarette smoke stimulates matrix metalloproteinase-2 activity via EGR-1 in human lung fibroblasts. Am J Respir Cell Mol Biol 36, 480-490 (2007).
-
(2007)
Am J Respir Cell Mol Biol
, vol.36
, pp. 480-490
-
-
Ning, W.1
-
10
-
-
79851481837
-
Hypoxia inducible factor-1alpha in human emphysema lung tissue
-
Yasuo, M., et al. Hypoxia inducible factor-1alpha in human emphysema lung tissue. Eur Respir J 37, 775-783 (2011).
-
(2011)
Eur Respir J
, vol.37
, pp. 775-783
-
-
Yasuo, M.1
-
11
-
-
0029051439
-
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
-
Wang, G. L., Jiang, B. H., Rue, E. A. & Semenza, G. L. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci USA 92, 5510-5514 (1995).
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 5510-5514
-
-
Wang, G.L.1
Jiang, B.H.2
Rue, E.A.3
Semenza, G.L.4
-
12
-
-
0036304634
-
Hypoxia-inducible factor 1, a master transcription factor of cellular hypoxic gene expression
-
Hirota, K. Hypoxia-inducible factor 1, a master transcription factor of cellular hypoxic gene expression. J Anesth 16, 150-159 (2002).
-
(2002)
J Anesth
, vol.16
, pp. 150-159
-
-
Hirota, K.1
-
13
-
-
17944375360
-
C. Elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
-
Epstein, A. C., et al. C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell 107, 43-54 (2001).
-
(2001)
Cell
, vol.107
, pp. 43-54
-
-
Epstein, A.C.1
-
14
-
-
0035834409
-
A conserved family of prolyl-4-hydroxylases that modify HIF
-
Bruick, R. K. & McKnight, S. L. A conserved family of prolyl-4-hydroxylases that modify HIF. Science 294, 1337-1340 (2001).
-
(2001)
Science
, vol.294
, pp. 1337-1340
-
-
Bruick, R.K.1
McKnight, S.L.2
-
15
-
-
0035887011
-
FIH-1: A novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity
-
Mahon, P. C., Hirota, K. & Semenza, G. L. FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity. Genes Dev 15, 2675-2686 (2001).
-
(2001)
Genes Dev
, vol.15
, pp. 2675-2686
-
-
Mahon, P.C.1
Hirota, K.2
Semenza, G.L.3
-
16
-
-
33745686086
-
Activation of hypoxia-inducible factor 1 during macrophage differentiation
-
Oda, T., et al. Activation of hypoxia-inducible factor 1 during macrophage differentiation. Am J Physiol Cell Physiol 291, C104-113 (2006).
-
(2006)
Am J Physiol Cell Physiol
, vol.291
, pp. C104-C113
-
-
Oda, T.1
-
17
-
-
0035012605
-
HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: Novel mechanism for HIF-1-mediated vascular endothelial growth factor expression
-
Laughner, E., Taghavi, P., Chiles, K., Mahon, P. C. & Semenza, G. L. HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression. Mol Cell Biol 21, 3995-4004 (2001).
-
(2001)
Mol Cell Biol
, vol.21
, pp. 3995-4004
-
-
Laughner, E.1
Taghavi, P.2
Chiles, K.3
Mahon, P.C.4
Semenza, G.L.5
-
18
-
-
0027136260
-
Desferrioxamine induces erythropoietin gene expression and hypoxia-inducible factor 1 DNAbinding activity: Implications for models of hypoxia signal transduction
-
Wang, G. L. & Semenza, G. L. Desferrioxamine induces erythropoietin gene expression and hypoxia-inducible factor 1 DNAbinding activity: implications for models of hypoxia signal transduction. Blood 82, 3610-3615 (1993).
-
(1993)
Blood
, vol.82
, pp. 3610-3615
-
-
Wang, G.L.1
Semenza, G.L.2
-
19
-
-
0030659531
-
V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: Involvement of HIF-1 in tumor progression
-
Jiang, B. H., Agani, F., Passaniti, A. & Semenza, G. L. V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: involvement of HIF-1 in tumor progression. Cancer Res 57, 5328-5335 (1997).
-
(1997)
Cancer Res
, vol.57
, pp. 5328-5335
-
-
Jiang, B.H.1
Agani, F.2
Passaniti, A.3
Semenza, G.L.4
-
20
-
-
1642453685
-
Nitric oxide induces hypoxia-inducible factor 1 activation that is dependent on MAPK and phosphatidylinositol 3-kinase signaling
-
Kasuno, K., et al. Nitric oxide induces hypoxia-inducible factor 1 activation that is dependent on MAPK and phosphatidylinositol 3-kinase signaling. J Biol Chem 279, 2550-2558 (2004).
-
(2004)
J Biol Chem
, vol.279
, pp. 2550-2558
-
-
Kasuno, K.1
-
21
-
-
72449143164
-
Cigarette smoke extract induces COX-2 expression via a PKCalpha/c-Src/EGFR, PDGFR/PI3K/Akt/NF-kappaB pathway and p300 in tracheal smooth muscle cells
-
Yang, C. M., et al. Cigarette smoke extract induces COX-2 expression via a PKCalpha/c-Src/EGFR, PDGFR/PI3K/Akt/NF-kappaB pathway and p300 in tracheal smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 297, L892-902 (2009).
-
(2009)
Am J Physiol Lung Cell Mol Physiol
, vol.297
, pp. L892-L902
-
-
Yang, C.M.1
-
22
-
-
61449087199
-
Cigarette smoke extract induces cytosolic phospholipase A2 expression via NADPH oxidase, MAPKs, AP-1, and NF-kappaB in human tracheal smooth muscle cells
-
Cheng, S. E., et al. Cigarette smoke extract induces cytosolic phospholipase A2 expression via NADPH oxidase, MAPKs, AP-1, and NF-kappaB in human tracheal smooth muscle cells. Free Radic Biol Med 46, 948-960 (2009).
-
(2009)
Free Radic Biol Med
, vol.46
, pp. 948-960
-
-
Cheng, S.E.1
-
23
-
-
0037064010
-
Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells
-
Fukuda, R., et al. Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells. J Biol Chem 277, 38205-38211 (2002).
-
(2002)
J Biol Chem
, vol.277
, pp. 38205-38211
-
-
Fukuda, R.1
-
24
-
-
0034885922
-
Cytotoxic effects of cigarette smoke extract on an alveolar type II cell-derived cell line
-
Hoshino, Y., et al. Cytotoxic effects of cigarette smoke extract on an alveolar type II cell-derived cell line. Am J Physiol Lung Cell Mol Physiol 281, L509-516 (2001).
-
(2001)
Am J Physiol Lung Cell Mol Physiol
, vol.281
, pp. L509-L516
-
-
Hoshino, Y.1
-
25
-
-
84858983379
-
Mitochondrial reactive oxygen species mediates nicotine-induced hypoxia-inducible factor-1alpha expression in human non-small cell lung cancer cells
-
Guo, L., et al. Mitochondrial reactive oxygen species mediates nicotine-induced hypoxia-inducible factor-1alpha expression in human non-small cell lung cancer cells. Biochim Biophys Acta 1822, 852-861 (2012).
-
(2012)
Biochim Biophys Acta
, vol.1822
, pp. 852-861
-
-
Guo, L.1
-
26
-
-
0034901463
-
Hypoxia-inducible factor 1: Oxygen homeostasis and disease pathophysiology
-
Semenza, G. L. Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology. Trends Mol Med 7, 345-350 (2001).
-
(2001)
Trends Mol Med
, vol.7
, pp. 345-350
-
-
Semenza, G.L.1
-
27
-
-
0036789574
-
Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin
-
Hudson, C. C., et al. Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin. Mol Cell Biol 22, 7004-7014 (2002).
-
(2002)
Mol Cell Biol
, vol.22
, pp. 7004-7014
-
-
Hudson, C.C.1
-
28
-
-
0034654174
-
Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: Implications for tumor angiogenesis and therapeutics
-
Zhong, H., et al. Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Cancer Res 60, 1541-1545 (2000).
-
(2000)
Cancer Res
, vol.60
, pp. 1541-1545
-
-
Zhong, H.1
-
29
-
-
0038375038
-
Vascular endothelial growth factor gene expression in colon cancer cells exposed to prostaglandin E2 is mediated by hypoxia-inducible factor 1
-
Fukuda, R., Kelly, B. & Semenza, G. L. Vascular endothelial growth factor gene expression in colon cancer cells exposed to prostaglandin E2 is mediated by hypoxia-inducible factor 1. Cancer Res 63, 2330-2334 (2003).
-
(2003)
Cancer Res
, vol.63
, pp. 2330-2334
-
-
Fukuda, R.1
Kelly, B.2
Semenza, G.L.3
-
30
-
-
10844284695
-
Functional integrity of nuclear factor kappaB, phosphatidylinositol 3′-kinase, and mitogen-activated protein kinase signaling allows tumor necrosis factor alpha-evoked Bcl-2 expression to provoke internal ribosome entry site-dependent translation of hypoxia-inducible factor 1alpha
-
Zhou, J., Callapina, M., Goodall, G. J. & Brune, B. Functional integrity of nuclear factor kappaB, phosphatidylinositol 3′-kinase, and mitogen-activated protein kinase signaling allows tumor necrosis factor alpha-evoked Bcl-2 expression to provoke internal ribosome entry site-dependent translation of hypoxia-inducible factor 1alpha. Cancer Res 64, 9041-9048 (2004).
-
(2004)
Cancer Res
, vol.64
, pp. 9041-9048
-
-
Zhou, J.1
Callapina, M.2
Goodall, G.J.3
Brune, B.4
-
31
-
-
60749102389
-
Cigarette smoke induces cellular senescence via Werners syndrome protein down-regulation
-
Nyunoya, T., et al. Cigarette smoke induces cellular senescence via Werners syndrome protein down-regulation. Am J Respir Crit Care Med 179, 279-287 (2009).
-
(2009)
Am J Respir Crit Care Med
, vol.179
, pp. 279-287
-
-
Nyunoya, T.1
-
32
-
-
0037835443
-
Cigarette smoke extract induces oxidative stress and apoptosis in human lung fibroblasts
-
Carnevali, S., et al. Cigarette smoke extract induces oxidative stress and apoptosis in human lung fibroblasts. Am J Physiol Lung Cell Mol Physiol 284, L955-963 (2003).
-
(2003)
Am J Physiol Lung Cell Mol Physiol
, vol.284
, pp. L955-L963
-
-
Carnevali, S.1
-
33
-
-
33745700377
-
Differential induction of apoptosis by cigarette smoke extract in primary human lung fibroblast strains: Implications for emphysema
-
Baglole, C. J., et al. Differential induction of apoptosis by cigarette smoke extract in primary human lung fibroblast strains: implications for emphysema. Am J Physiol Lung Cell Mol Physiol 291, L19-29 (2006).
-
(2006)
Am J Physiol Lung Cell Mol Physiol
, vol.291
, pp. L19-L29
-
-
Baglole, C.J.1
-
34
-
-
44449159236
-
Reactive oxygen species and HIF-1 signalling in cancer
-
Galanis, A., et al. Reactive oxygen species and HIF-1 signalling in cancer. Cancer Lett 266, 12-20 (2008).
-
(2008)
Cancer Lett
, vol.266
, pp. 12-20
-
-
Galanis, A.1
-
35
-
-
84946606829
-
Cigarette smoke-mediated oxidative stress induces apoptosis via the MAPKs/STAT1 pathway in mouse lung fibroblasts
-
Lee, H., et al. Cigarette smoke-mediated oxidative stress induces apoptosis via the MAPKs/STAT1 pathway in mouse lung fibroblasts. Toxicol Lett 240, 140-148 (2016).
-
(2016)
Toxicol Lett
, vol.240
, pp. 140-148
-
-
Lee, H.1
-
36
-
-
0032578458
-
Mitochondrial reactive oxygen species trigger hypoxia-induced transcription
-
Chandel, N. S., et al. Mitochondrial reactive oxygen species trigger hypoxia-induced transcription. Proc Natl Acad Sci USA 95, 11715-11720 (1998).
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 11715-11720
-
-
Chandel, N.S.1
-
37
-
-
0034682786
-
Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: A mechanism of O2 sensing
-
Chandel, N. S., et al. Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing. J Biol Chem 275, 25130-25138 (2000).
-
(2000)
J Biol Chem
, vol.275
, pp. 25130-25138
-
-
Chandel, N.S.1
-
38
-
-
77956713136
-
Hypoxia-inducible factor-1 activation in nonhypoxic conditions: The essential role of mitochondrial-derived reactive oxygen species
-
Patten, D. A., et al. Hypoxia-inducible factor-1 activation in nonhypoxic conditions: the essential role of mitochondrial-derived reactive oxygen species. Mol Biol Cell 21, 3247-3257 (2010).
-
(2010)
Mol Biol Cell
, vol.21
, pp. 3247-3257
-
-
Patten, D.A.1
-
39
-
-
84870461608
-
The role of hypoxia-inducible factors in oxygen sensing by the carotid body
-
Semenza, G. L. & Prabhakar, N. R. The role of hypoxia-inducible factors in oxygen sensing by the carotid body. Adv Exp Med Biol 758, 1-5 (2012).
-
(2012)
Adv Exp Med Biol
, vol.758
, pp. 1-5
-
-
Semenza, G.L.1
Prabhakar, N.R.2
-
40
-
-
39749196227
-
LPS induces hypoxia-inducible factor 1 activation in macrophage-differentiated cells in a reactive oxygen speciesdependent manner
-
Nishi, K., et al. LPS induces hypoxia-inducible factor 1 activation in macrophage-differentiated cells in a reactive oxygen speciesdependent manner. Antioxid Redox Signal 10, 983-995 (2008).
-
(2008)
Antioxid Redox Signal
, vol.10
, pp. 983-995
-
-
Nishi, K.1
-
41
-
-
0038380432
-
Inhibition of hypoxia-induced angiogenesis by cigarette smoke exposure: Impairment of the HIF-1alpha/VEGF pathway
-
Michaud, S. E., Menard, C., Guy, L. G., Gennaro, G. & Rivard, A. Inhibition of hypoxia-induced angiogenesis by cigarette smoke exposure: impairment of the HIF-1alpha/VEGF pathway. FASEB J 17, 1150-1152 (2003).
-
(2003)
FASEB J
, vol.17
, pp. 1150-1152
-
-
Michaud, S.E.1
Menard, C.2
Guy, L.G.3
Gennaro, G.4
Rivard, A.5
-
42
-
-
34548102391
-
Nicotine induces hypoxia-inducible factor-1alpha expression in human lung cancer cells via nicotinic acetylcholine receptor-mediated signaling pathways
-
Zhang, Q., et al. Nicotine induces hypoxia-inducible factor-1alpha expression in human lung cancer cells via nicotinic acetylcholine receptor-mediated signaling pathways. Clin Cancer Res 13, 4686-4694 (2007).
-
(2007)
Clin Cancer Res
, vol.13
, pp. 4686-4694
-
-
Zhang, Q.1
-
43
-
-
79251646875
-
Chronic CSE treatment induces the growth of normal oral keratinocytes via PDK2 upregulation, increased glycolysis and HIF1alpha stabilization
-
Sun, W., Chang, S. S., Fu, Y., Liu, Y. & Califano, J. A. Chronic CSE treatment induces the growth of normal oral keratinocytes via PDK2 upregulation, increased glycolysis and HIF1alpha stabilization. PLoS One 6, e16207 (2011).
-
(2011)
PLoS One
, vol.6
, pp. e16207
-
-
Sun, W.1
Chang, S.S.2
Fu, Y.3
Liu, Y.4
Califano, J.A.5
-
44
-
-
83255176101
-
Hydrogen sulfide inhibits hypoxia- but not anoxia-induced hypoxia-inducible factor 1 activation in a von hippel-lindauand mitochondria-dependent manner
-
Kai, S., et al. Hydrogen sulfide inhibits hypoxia- but not anoxia-induced hypoxia-inducible factor 1 activation in a von hippel-lindauand mitochondria-dependent manner. Antioxidants & redox signaling 16, 203-216 (2012).
-
(2012)
Antioxidants & Redox Signaling
, vol.16
, pp. 203-216
-
-
Kai, S.1
-
45
-
-
84891506888
-
Differential roles of prostaglandin E-type receptors in activation of hypoxia-inducible factor 1 by prostaglandin E1 in vascular-derived cells under non-hypoxic conditions
-
Suzuki, K., et al. Differential roles of prostaglandin E-type receptors in activation of hypoxia-inducible factor 1 by prostaglandin E1 in vascular-derived cells under non-hypoxic conditions. PeerJ 1, e220 (2013).
-
(2013)
PeerJ
, vol.1
, pp. e220
-
-
Suzuki, K.1
-
46
-
-
64149112403
-
The Akt/mTOR pathway assures the synthesis of HIF-1alpha protein in a glucose- and reoxygenation-dependent manner in irradiated tumors
-
Harada, H., et al. The Akt/mTOR pathway assures the synthesis of HIF-1alpha protein in a glucose- and reoxygenation-dependent manner in irradiated tumors. J Biol Chem 284, 5332-5342 (2009).
-
(2009)
J Biol Chem
, vol.284
, pp. 5332-5342
-
-
Harada, H.1
-
47
-
-
48249137727
-
Macrophage migration inhibitory factor activates hypoxia-inducible factor in a p53-dependent manner
-
Oda, S., et al. Macrophage migration inhibitory factor activates hypoxia-inducible factor in a p53-dependent manner. PLoS One 3, e2215 (2008).
-
(2008)
PLoS One
, vol.3
, pp. e2215
-
-
Oda, S.1
-
48
-
-
84897361584
-
The volatile anesthetic isoflurane differentially suppresses the induction of erythropoietin synthesis elicited by acute anemia and systemic hypoxemia in mice in an hypoxia-inducible factor-2-dependent manner
-
Kai, S., Tanaka, T., Matsuyama, T., Suzuki, K. & Hirota, K. The volatile anesthetic isoflurane differentially suppresses the induction of erythropoietin synthesis elicited by acute anemia and systemic hypoxemia in mice in an hypoxia-inducible factor-2-dependent manner. Eur J Pharmacol 732C, 43-49 (2014).
-
(2014)
Eur J Pharmacol
, vol.732
, pp. 43-49
-
-
Kai, S.1
Tanaka, T.2
Matsuyama, T.3
Suzuki, K.4
Hirota, K.5
-
49
-
-
27244433455
-
Optical imaging of tumor hypoxia and evaluation of efficacy of a hypoxia-targeting drug in living animals
-
Harada, H., Kizaka-Kondoh, S. & Hiraoka, M. Optical imaging of tumor hypoxia and evaluation of efficacy of a hypoxia-targeting drug in living animals. Mol Imaging 4, 182-193 (2005).
-
(2005)
Mol Imaging
, vol.4
, pp. 182-193
-
-
Harada, H.1
Kizaka-Kondoh, S.2
Hiraoka, M.3
-
50
-
-
34447565882
-
The combination of hypoxia-response enhancers and an oxygen-dependent proteolytic motif enables real-time imaging of absolute HIF-1 activity in tumor xenografts
-
Harada, H., et al. The combination of hypoxia-response enhancers and an oxygen-dependent proteolytic motif enables real-time imaging of absolute HIF-1 activity in tumor xenografts. Biochem Biophys Res Commun 360, 791-796 (2007).
-
(2007)
Biochem Biophys Res Commun
, vol.360
, pp. 791-796
-
-
Harada, H.1
-
51
-
-
0346503159
-
Comparative subchronic inhalation study of smoke from the 1R4F and 2R4F reference cigarettes
-
Higuchi, M. A., Sagartz, J., Shreve, W. K. & Ayres, P. H. Comparative subchronic inhalation study of smoke from the 1R4F and 2R4F reference cigarettes. Inhal Toxicol 16, 1-20 (2004).
-
(2004)
Inhal Toxicol
, vol.16
, pp. 1-20
-
-
Higuchi, M.A.1
Sagartz, J.2
Shreve, W.K.3
Ayres, P.H.4
-
52
-
-
33750904409
-
Thioredoxin-1 suppresses systemic inflammatory responses against cigarette smoking
-
Sato, A., et al. Thioredoxin-1 suppresses systemic inflammatory responses against cigarette smoking. Antioxid Redox Signal 8, 1891-1896 (2006).
-
(2006)
Antioxid Redox Signal
, vol.8
, pp. 1891-1896
-
-
Sato, A.1
-
53
-
-
42449089433
-
Thioredoxin-1 ameliorates cigarette smoke-induced lung inflammation and emphysema in mice
-
Sato, A., et al. Thioredoxin-1 ameliorates cigarette smoke-induced lung inflammation and emphysema in mice. J Pharmacol Exp Ther 325, 380-388 (2008).
-
(2008)
J Pharmacol Exp Ther
, vol.325
, pp. 380-388
-
-
Sato, A.1
-
54
-
-
46449129334
-
Anticancer photodynamic and non-photodynamic effects of pterin derivatives on a pancreatic cancer cell line
-
Miyoshi, T., et al. Anticancer photodynamic and non-photodynamic effects of pterin derivatives on a pancreatic cancer cell line. J Pharmacol Sci 107, 221-225 (2008).
-
(2008)
J Pharmacol Sci
, vol.107
, pp. 221-225
-
-
Miyoshi, T.1
-
55
-
-
77952670768
-
Edaravone directly reacts with singlet oxygen and protects cells from attack
-
Nishinaka, Y., et al. Edaravone directly reacts with singlet oxygen and protects cells from attack. Life Sci 86, 808-813 (2010).
-
(2010)
Life Sci
, vol.86
, pp. 808-813
-
-
Nishinaka, Y.1
-
56
-
-
84455192443
-
General anesthetics inhibit erythropoietin induction under hypoxic conditions in the mouse brain
-
Tanaka, T., et al. General anesthetics inhibit erythropoietin induction under hypoxic conditions in the mouse brain. PLoS One 6, e29378 (2011).
-
(2011)
PLoS One
, vol.6
, pp. e29378
-
-
Tanaka, T.1
-
57
-
-
84900846903
-
P38 mitogen-activated protein kinase determines the susceptibility to cigarette smoke-induced emphysema in mice
-
Marumo, S., et al. p38 mitogen-activated protein kinase determines the susceptibility to cigarette smoke-induced emphysema in mice. BMC Pulm Med 14, 79 (2014).
-
(2014)
BMC Pulm Med
, vol.14
, pp. 79
-
-
Marumo, S.1
-
58
-
-
84875215709
-
Investigation of the freely available easy-to-use software EZR for medical statistics
-
Kanda, Y. Investigation of the freely available easy-to-use software EZR for medical statistics. Bone marrow transplantation 48, 452-458 (2013).
-
(2013)
Bone Marrow Transplantation
, vol.48
, pp. 452-458
-
-
Kanda, Y.1
|