Chronic CSE treatment induces the growth of normal oral keratinocytes via PDK2 upregulation, increased glycolysis and HIF1α stabilization

PLoS ONE

Volumn 6, Issue 1, 2011, Pages

  Sun, Wenyue ^a   Chang, Steven S ^a   Fu, Yumei ^a   Liu, Yan ^a   Califano, Joseph A ^a,b  

^a DEPARTMENT OF PATHOLOGY   (United States)

^b GREATER BALTIMORE MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ADENOSINE TRIPHOSPHATE; CIGARETTE SMOKE; DICHLOROACETIC ACID; GLUCOSE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; LACTIC ACID; PYRUVATE DEHYDROGENASE; PYRUVATE DEHYDROGENASE ALPHA; PYRUVATE DEHYDROGENASE KINASE 2; PYRUVIC ACID; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; PROTEIN SERINE THREONINE KINASE; PYRUVATE DEHYDROGENASE (ACETYL TRANSFERRING) KINASE; PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING) KINASE;

AMINO ACID SYNTHESIS; ARTICLE; BIOACCUMULATION; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; GLUCOSE INTAKE; GLYCOLYSIS; GROWTH INHIBITION; HEAD AND NECK CARCINOMA; HUMAN; HUMAN CELL; KERATINOCYTE; LONG TERM EXPOSURE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; SQUAMOUS CELL CARCINOMA; UPREGULATION; CELL LINE; CHEMISTRY; CYTOLOGY; GENETICS; HEAD AND NECK TUMOR; MOUTH; SMOKE; TOBACCO;

NICOTIANA TABACUM;

CARCINOMA, SQUAMOUS CELL; CELL LINE; CELL PROLIFERATION; GLYCOLYSIS; HEAD AND NECK NEOPLASMS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; KERATINOCYTES; MOUTH; PROTEIN STABILITY; PROTEIN-SERINE-THREONINE KINASES; REACTIVE OXYGEN SPECIES; SMOKE; TOBACCO; UP-REGULATION;

EID: 79251646875     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0016207     Document Type: Article

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