Mitochondrial DNA damage Is associated with reduced mitochondrial bioenergetics in Huntington's disease

Free Radical Biology and Medicine

Volumn 53, Issue 7, 2012, Pages 1478-1488

  Siddiqui, Almas ^a   Rivera Sánchez, Sulay ^b   Castro, María Del R ^c   Acevedo Torres, Karina ^b   Rane, Anand ^a   Torres Ramos, Carlos A ^b   Nicholls, David G ^a   Andersen, Julie K ^a   Ayala Torres, Sylvette ^c  

^a BUCK INSTITUTE FOR RESEARCH ON AGING   (United States)

^b UNIVERSITY OF PUERTO RICO   (Puerto Rico)

^c UNIVERSITY OF PUERTO RICO SCHOOL OF MEDICINE   (Puerto Rico)

Author keywords

AP endonuclease; Base excision repair; Huntington's disease; Mitochondrial DNA; Mitochondrial dysfunction; Mitochondrial respiration

Indexed keywords

CARBONYL CYANIDE 4 (TRIFLUOROMETHOXY)PHENYLHYDRAZONE; ENDONUCLEASE; HUNTINGTIN; HYDROGEN PEROXIDE; MITOCHONDRIAL DNA; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BIOENERGY; CELL FUNCTION; CONTROLLED STUDY; DISEASE ASSOCIATION; DNA DAMAGE; EXCISION REPAIR; GENE SILENCING; HUMAN; HUMAN CELL; HUNTINGTON CHOREA; HYPOTHESIS; IN VITRO STUDY; MITOCHONDRIAL DNA DEPLETION; MITOCHONDRION; MOUSE; MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SKIN FIBROBLAST;

ANIMALS; AUTOPSY; CELL NUCLEUS; DNA DAMAGE; DNA, MITOCHONDRIAL; DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE; FIBROBLASTS; GENE EXPRESSION; HUMANS; HUNTINGTON DISEASE; HYDROGEN PEROXIDE; MICE; MITOCHONDRIA; MITOCHONDRIAL TURNOVER; MUTATION; NEOSTRIATUM; NERVE TISSUE PROTEINS; OXIDATION-REDUCTION; OXIDATIVE STRESS; PRIMARY CELL CULTURE;

MAMMALIA;

EID: 84866395321     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2012.06.008     Document Type: Article

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