CR6-interacting factor 1 is a key regulator in Aβ-induced mitochondrial disruption and pathogenesis of Alzheimer's disease

Cell Death and Differentiation

Volumn 22, Issue 6, 2015, Pages 959-973

  Byun, J ^a   Son, S M ^a   Cha, M Y ^a   Shong, M ^b   Hwang, Y J ^c   Kim, Y ^c   Ryu, H ^c,d   Moon, M ^e   Kim, K S ^e   Mook Jung, I ^a  

^a Seoul National University College of Medicine   (South Korea)

^b Chungnam National University   (South Korea)

^c Korea Institute of Science and Technology   (South Korea)

^d BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e MCLEAN HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; CELL CYCLE PROTEIN; CRIF1 PROTEIN, MOUSE; GADD45GIP1 PROTEIN, HUMAN; NUCLEAR PROTEIN; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR SP1;

ALZHEIMER DISEASE; ANIMAL; BRAIN; CELL SURVIVAL; GENETICS; HUMAN; METABOLISM; MITOCHONDRION; MOUSE; PATHOLOGY; TUMOR CELL LINE;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; BRAIN; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CELL SURVIVAL; HUMANS; MICE; MITOCHONDRIA; NUCLEAR PROTEINS; REACTIVE OXYGEN SPECIES; SP1 TRANSCRIPTION FACTOR;

EID: 84939985504     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2014.184     Document Type: Article

References (59)

1. Katzman R. Alzheimer's disease. N Engl J Med 1986; 314: 964-973.
2. Walsh DM, Selkoe DJ. Deciphering the molecular basis of memory failure in Alzheimer's disease. Neuron 2004; 44: 181-193.
3. Querfurth HW, LaFerla FM. Alzheimer's disease. N Engl J Med 2010; 362: 329-344.
4. Baloyannis SJ, Costa V, Michmizos D. Mitochondrial alterations in Alzheimer's disease. Am J Alzheimers Dis Other Demen 2004; 19: 89-93.
5. Cha MY, Han SH, Son SM, Hong HS, Choi YJ, Byun J et al. Mitochondria-specific accumulation of amyloid beta induces mitochondrial dysfunction leading to apoptotic cell death. PLoS One 2012; 7: e34929.
6. Lin MT, Beal MF. Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature 2006; 443: 787-795.
7. Chacinska A, Koehler CM, Milenkovic D, Lithgow T, Pfanner N. Importing mitochondrial proteins: machineries and mechanisms. Cell 2009; 138: 628-644.
8. Youle RJ, Karbowski M. Mitochondrial fission in apoptosis. Nat Rev Mol Cell Biol 2005; 6: 657-663.
9. Knott AB, Perkins G, Schwarzenbacher R, Bossy-Wetzel E. Mitochondrial fragmentation in neurodegeneration. Nat Rev Neurosci 2008; 9: 505-518.
10. Wang X, Su B, Siedlak SL, Moreira PI, Fujioka H, Wang Y et al. Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins. Proc Natl Acad Sci USA 2008; 105: 19318-19323.
11. Perry G, Nunomura A, Hirai K, Zhu X, Prez M, Avila J et al. Is oxidative damage the fundamental pathogenic mechanism of Alzheimer's and other neurodegenerative diseases? Free Radic Biol Med 2002; 33: 1475-1479.
12. de la Monte SM, Luong T, Neely TR, Robinson D, Wands JR. Mitochondrial DNA damage as a mechanism of cell loss in Alzheimer's disease. Lab Invest 2000; 80: 1323-1335.
13. Oh NS, Yoon SH, Lee WK, Choi JY, Min do S, Bae YS. Phosphorylation of CKBBP2/CRIF1 by protein kinase CKII promotes cell proliferation. Gene 2007; 386: 147-153.
14. Zhang X, Ran Q, Li Z, Liu Y, Liang X, Chen X. Cell cycle arrest of Jurkat cells by leukemic bone marrow stromal cells: possible mechanisms and involvement of CRIF1. Transplant Proc 2011; 43: 2770-2773.
15. Kang HJ, Hong YB, Kim HJ, Bae I. CR6-interacting factor 1 (CRIF1) regulates NF-E2-related factor 2 (NRF2) protein stability by proteasome-mediated degradation. J Biol Chem 2010; 285: 21258-21268.
16. Kim SJ, Kwon MC, Ryu MJ, Chung HK, Tadi S, Kim YK et al. CRIF1 is essential for the synthesis and insertion of oxidative phosphorylation polypeptides in the mammalian mitochondrial membrane. Cell Metab 2012; 16: 274-283.
17. Son SM, Jung ES, Shin HJ, Byun J, Mook-Jung I. Abeta-induced formation of autophagosomes is mediated by RAGE-CaMKKbeta-AMPK signaling. Neurobiol Aging 2012; 33: 1006 e1011-1006 e1023.
18. Lee DH, Goldberg AL. Proteasome inhibitors: valuable new tools for cell biologists. Trends Cell Biol 1998; 8: 397-403.
19. Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 2012; 8: 445-544.
20. Zorov DB, Juhaszova M, Sollott SJ. Mitochondrial ROS-induced ROS release: an update and review. Biochim Biophys Acta 2006; 1757: 509-517.
21. Shelat PB, Chalimoniuk M, Wang JH, Strosznajder JB, Lee JC, Sun AY et al. Amyloid beta peptide and NMDA induce ROS from NADPH oxidase and AA release from cytosolic phospholipase A2 in cortical neurons. J Neurochem 2008; 106: 45-55.
22. t Hart BA, Simons JM, Knaan-Shanzer S, Bakker NP, Labadie RP. Antiarthritic activity of the newly developed neutrophil oxidative burst antagonist apocynin. Free Radic Biol Med 1990; 9: 127-131.
23. Cross AR, Jones OT. The effect of the inhibitor diphenylene iodonium on the superoxidegenerating system of neutrophils. Specific labelling of a component polypeptide of the oxidase. Biochem J 1986; 237: 111-116.
24. Sang J, Yang K, Sun Y, Han Y, Cang H, Chen Y et al. SUMO2 and SUMO3 transcription is differentially regulated by oxidative stress in an Sp1-dependent manner. Biochem J 2011; 435: 489-498.
25. Hsin IL, Sheu GT, Chen HH, Chiu LY, Wang HD, Chan HW et al. N-Acetyl cysteine mitigates curcumin-mediated telomerase inhibition through rescuing of Sp1 reduction in A549 cells. Mutat Res 2010; 688: 72-77.
26. Spengler ML, Brattain MG. Sumoylation inhibits cleavage of Sp1 N-terminal negative regulatory domain and inhibits Sp1-dependent transcription. J Biol Chem 2006; 281: 5567-5574.
27. Wang YT, Yang WB, Chang WC, Hung JJ. Interplay of posttranslational modifications in Sp1 mediates Sp1 stability during cell cycle progression. J Mol Biol 2011; 414: 1-14.
28. Knott AB, Perkins G, Schwarzenbacher R, Bossy-Wetzel E. Mitochondrial fragmentation in neurodegeneration. Nat Rev Neurosci 2008; 9: 505-518.
29. Tillement L, Lecanu L, Papadopoulos V. Alzheimer's disease: Effects of ?-Amyloid on mitochondria. Mitochondrion 2011; 11: 13-21.
30. Youle RJ, Karbowski M. Mitochondrial fission in apoptosis. Nat Rev Mol Cell Biol 2005; 6: 657-663.
31. Aliev G, Smith MA, de la Torre JC, Perry G. Mitochondria as a primary target for vascular hypoperfusion and oxidative stress in Alzheimer's disease. Mitochondrion 2004; 4: 649-663.
32. Wang X, Su B, Siedlak SL, Moreira PI, Fujioka H, Wang Y et al. Amyloid-? overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins. Proc Natl Acad Sci 2008; 105: 19318-19323.
33. Darshi M, Mendiola VL, Mackey MR, Murphy AN, Koller A, Perkins GA et al. ChChd3, an inner mitochondrial membrane protein, is essential for maintaining crista integrity and mitochondrial function. J Biol Chem 2011; 286: 2918-2932.
34. Alkhaja AK, Jans DC, Nikolov M, Vukotic M, Lytovchenko O, Ludewig F et al. MINOS1 is a conserved component of mitofilin complexes and required for mitochondrial function and cristae organization. Mol Biol Cell 2012; 23: 247-257.
35. Merkwirth C, Langer T. Prohibitin function within mitochondria: essential roles for cell proliferation and cristae morphogenesis. Biochim Biophys Acta 2009; 1793: 27-32.
36. NUNOMURA A, PERRY G, ALIEV G, HIRAI K, TAKEDA A, BALRAJ EK et al. Oxidative Damage Is the Earliest Event in Alzheimer Disease. J Neuropathol Exp Neurol 2001; 60: 759-767.
37. Resende R, Moreira PI, Proena T, Deshpande A, Busciglio J, Pereira C et al. Brain oxidative stress in a triple-transgenic mouse model of Alzheimer disease. Free Radic Biol Med 2008; 44: 2051-2057.
38. Ryu H, Lee J, Zaman K, Kubilis J, Ferrante RJ, Ross BD et al. Sp1 and Sp3 are oxidative stress-inducible, antideath transcription factors in cortical neurons. J Neurosci 2003; 23: 3597-3606.
39. Citron BA, Dennis JS, Zeitlin RS, Echeverria V. Transcription factor Sp1 dysregulation in Alzheimer's disease. J Neurosci Res 2008; 86: 2499-2504.
40. Cho HJ, Son SM, Jin SM, Hong HS, Shin DH, Kim SJ et al. RAGE regulates BACE1 and Abeta generation via NFAT1 activation in Alzheimer's disease animal model. FASEB J 2009; 23: 2639-2649.
41. Xie H, Hou S, Jiang J, Sekutowicz M, Kelly J, Bacskai BJ. Rapid cell death is preceded by amyloid plaque-mediated oxidative stress. Proc Natl Acad Sci USA 2013; 110: 7904-7909.
42. Oakley H, Cole SL, Logan S, Maus E, Shao P, Craft J et al. Intraneuronal beta-Amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation. J Neurosci 2006; 26: 10129-10140.
43. Rojas S, Herance JR, Gispert JD, Abad S, Torrent E, Jimenez X et al. In vivo evaluation of amyloid deposition and brain glucose metabolism of 5XFAD mice using positron emission tomography. Neurobiol Aging 2013; 34: 1790-1798.
44. Du H, Guo L, Fang F, Chen D, Sosunov AA, McKhann GM et al. Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease. Nat Med 2008; 14: 1097-1105.
45. Schmidt C, Lepsverdize E, Chi SL, Das AM, Pizzo SV, Dityatev A et al. Amyloid precursor protein and amyloid beta-peptide bind to ATP synthase and regulate its activity at the surface of neural cells. Mol Psychiatry 2008; 13: 953-969.
46. Hansson Petersen CA, Alikhani N, Behbahani H, Wiehager B, Pavlov PF, Alafuzoff I et al. The amyloid beta-peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae. Proc Natl Acad Sci USA 2008; 105: 13145-13150.
47. Cali T, Ottolini D, Brini M. Mitochondrial Ca(2+) and neurodegeneration. Cell Calcium 2012; 52: 73-85.
48. Kannurpatti SS, Biswal BB. Mitochondrial Ca2+ uniporter blockers influence activationinduced CBF response in the rat somatosensory cortex. J Cereb Blood Flow Metab 2008; 28: 772-785.
49. Paumard P, Vaillier J, Coulary B, Schaeffer J, Soubannier V, Mueller DM et al. The ATP synthase is involved in generating mitochondrial cristae morphology. EMBO J 2002; 21: 221-230.
50. Goyon V, Fronzes R, Salin B, di-Rago JP, Velours J, Brethes D. Yeast cells depleted in Atp14p fail to assemble Atp6p within the ATP synthase and exhibit altered mitochondrial cristae morphology. J Biol Chem 2008; 283: 9749-9758.
51. Schleicher M, Shepherd BR, Suarez Y, Fernandez-Hernando C, Yu J, Pan Y et al. Prohibitin-1 maintains the angiogenic capacity of endothelial cells by regulating mitochondrial function and senescence. J Cell Biol 2008; 180: 101-112.
52. Hsiao K, Chapman P, Nilsen S, Eckman C, Harigaya Y, Younkin S et al. Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice. Science 1996; 274: 99-102.
53. Jankowsky JL, Fadale DJ, Anderson J, Xu GM, Gonzales V, Jenkins NA et al. Mutant presenilins specifically elevate the levels of the 42 residue beta-Amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase. Hum Mol Genetics 2004; 13: 159-170.
54. Oakley H, Cole SL, Logan S, Maus E, Shao P, Craft J et al. Intraneuronal beta-Amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation. J Neurosci 2006; 26: 10129-10140.
55. Son SM, Song H, Byun J, Park KS, Jang HC, Park YJ et al. Altered APP processing in insulin-resistant conditions is mediated by autophagosome accumulation via the inhibition of mammalian target of rapamycin pathway. Diabetes 2012; 61: 3126-3138.
56. Moon M, Hong HS, Nam DW, Baik SH, Song H, Kook SY et al. Intracellular amyloid-beta accumulation in calcium-binding protein-deficient neurons leads to amyloidbeta plaque formation in animal model of Alzheimer's disease. J Alzheimers Dis 2012; 29: 615-628.
57. Lee J, Hwang YJ, Shin JY, Lee WC, Wie J, Kim KY et al. Epigenetic regulation of cholinergic receptor M1 (CHRM1) by histone H3K9me3 impairs Ca(2+) signaling in Huntington's disease. Acta Neuropathol 2013; 125: 727-739.
58. Son SM, Byun J, Roh SE, Kim SJ, Mook-Jung I. Reduced IRE1alpha mediates apoptotic cell death by disrupting calcium homeostasis via the InsP3 receptor. Cell Death Dis 2014; 5: e1188.
59. Pantazopoulos H, Boyer-Boiteau A, Holbrook EH, Jang W, Hahn CG, Arnold SE et al. Proteoglycan abnormalities in olfactory epithelium tissue from subjects diagnosed with schizophrenia. Schizophr Res 2013; 150: 366-372.