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Volumn 13, Issue 4, 2016, Pages 685-701

Astrocytes: Integrative Regulators of Neuroinflammation in Stroke and Other Neurological Diseases

Author keywords

Astrocyte; Brain injury; Glial scar; Neuroinflammation; Stroke

Indexed keywords

ADAPTIVE IMMUNITY; ASTROCYTE; BRAIN FUNCTION; BRAIN INJURY; CELL FUNCTION; CELL INTERACTION; CELL SURVIVAL; CENTRAL NERVOUS SYSTEM; CEREBROVASCULAR ACCIDENT; HUMAN; IMMUNOREGULATION; INNATE IMMUNITY; INTRACELLULAR SIGNALING; MOLECULAR BIOLOGY; NERVOUS SYSTEM INFLAMMATION; NEUROLOGIC DISEASE; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; ANIMAL; BLOOD BRAIN BARRIER; COMPLICATION; INFLAMMATION; METABOLISM; PATHOLOGY;

EID: 84988714406     PISSN: 19337213     EISSN: 18787479     Source Type: Journal    
DOI: 10.1007/s13311-016-0477-8     Document Type: Review
Times cited : (158)

References (167)
  • 1
    • 0033779559 scopus 로고    scopus 로고
    • Astrocyte glutamate transport: review of properties, regulation, and physiological functions
    • COI: 1:STN:280:DC%2BD3M%2FivVGmtA%3D%3D
    • Anderson CM, Swanson RA. Astrocyte glutamate transport: review of properties, regulation, and physiological functions. Glia 2000;32:1-14.
    • (2000) Glia , vol.32 , pp. 1-14
    • Anderson, C.M.1    Swanson, R.A.2
  • 2
    • 55049084760 scopus 로고    scopus 로고
    • The mystery and magic of glia: a perspective on their roles in health and disease
    • COI: 1:CAS:528:DC%2BD1cXhsVahsr7J
    • Barres BA. The mystery and magic of glia: a perspective on their roles in health and disease. Neuron 2008;60:430-440.
    • (2008) Neuron , vol.60 , pp. 430-440
    • Barres, B.A.1
  • 4
    • 84864464545 scopus 로고    scopus 로고
    • Immune surveillance in the central nervous system
    • COI: 1:CAS:528:DC%2BC38XhtV2hsr3I
    • Ousman SS, Kubes P. Immune surveillance in the central nervous system. Nat Neurosci 2012;15:1096-1101.
    • (2012) Nat Neurosci , vol.15 , pp. 1096-1101
    • Ousman, S.S.1    Kubes, P.2
  • 5
    • 77957021581 scopus 로고    scopus 로고
    • Astrocyte heterogeneity: an underappreciated topic in neurobiology
    • COI: 1:CAS:528:DC%2BC3cXht1WlsL7I
    • Zhang Y, Barres BA. Astrocyte heterogeneity: an underappreciated topic in neurobiology. Curr Opin Neurobiol 2010;20:588-594.
    • (2010) Curr Opin Neurobiol , vol.20 , pp. 588-594
    • Zhang, Y.1    Barres, B.A.2
  • 6
    • 33847634789 scopus 로고    scopus 로고
    • Astroglial heterogeneity closely reflects the neuronal-defined anatomy of the adult murine CNS
    • Emsley JG, Macklis JD. Astroglial heterogeneity closely reflects the neuronal-defined anatomy of the adult murine CNS. Neuron Glia Biol 2006;2:175-186.
    • (2006) Neuron Glia Biol , vol.2 , pp. 175-186
    • Emsley, J.G.1    Macklis, J.D.2
  • 7
    • 55449103144 scopus 로고    scopus 로고
    • Application of a translational profiling approach for the comparative analysis of CNS cell types
    • COI: 1:CAS:528:DC%2BD1cXhsVCls7vL
    • Doyle JP, Dougherty JD, Heiman M, et al. Application of a translational profiling approach for the comparative analysis of CNS cell types. Cell 2008;135:749-762.
    • (2008) Cell , vol.135 , pp. 749-762
    • Doyle, J.P.1    Dougherty, J.D.2    Heiman, M.3
  • 8
    • 0027410649 scopus 로고
    • Astrocyte subtypes in the rat olfactory bulb: morphological heterogeneity and differential laminar distribution
    • COI: 1:STN:280:DyaK3s7lsFelsw%3D%3D
    • Bailey MS, Shipley MT. Astrocyte subtypes in the rat olfactory bulb: morphological heterogeneity and differential laminar distribution. J Comp Neurol 1993;328:501-526.
    • (1993) J Comp Neurol , vol.328 , pp. 501-526
    • Bailey, M.S.1    Shipley, M.T.2
  • 9
    • 42949175821 scopus 로고    scopus 로고
    • Identification of positionally distinct astrocyte subtypes whose identities are specified by a homeodomain code
    • COI: 1:CAS:528:DC%2BD1cXmt1Smur4%3D
    • Hochstim C, Deneen B, Lukaszewicz A, Zhou Q, Anderson DJ. Identification of positionally distinct astrocyte subtypes whose identities are specified by a homeodomain code. Cell 2008;133:510-522.
    • (2008) Cell , vol.133 , pp. 510-522
    • Hochstim, C.1    Deneen, B.2    Lukaszewicz, A.3    Zhou, Q.4    Anderson, D.J.5
  • 10
    • 27844606461 scopus 로고    scopus 로고
    • Specification of astrocytes by bHLH protein SCL in a restricted region of the neural tube
    • COI: 1:CAS:528:DC%2BD2MXht1WksbbI
    • Muroyama Y, Fujiwara Y, Orkin SH, Rowitch DH. Specification of astrocytes by bHLH protein SCL in a restricted region of the neural tube. Nature 2005;438:360-363.
    • (2005) Nature , vol.438 , pp. 360-363
    • Muroyama, Y.1    Fujiwara, Y.2    Orkin, S.H.3    Rowitch, D.H.4
  • 11
    • 26444552361 scopus 로고    scopus 로고
    • Astrocytic purinergic signaling coordinates synaptic networks
    • COI: 1:CAS:528:DC%2BD2MXhtVOjsr7F
    • Pascual O, Casper KB, Kubera C, et al. Astrocytic purinergic signaling coordinates synaptic networks. Science 2005;310:113-116.
    • (2005) Science , vol.310 , pp. 113-116
    • Pascual, O.1    Casper, K.B.2    Kubera, C.3
  • 12
    • 13544273916 scopus 로고    scopus 로고
    • Thrombospondins are astrocyte-secreted proteins that promote CNS synaptogenesis
    • COI: 1:CAS:528:DC%2BD2MXhs1Krt7g%3D
    • Christopherson KS, Ullian EM, Stokes CC, et al. Thrombospondins are astrocyte-secreted proteins that promote CNS synaptogenesis. Cell 2005;120:421-433.
    • (2005) Cell , vol.120 , pp. 421-433
    • Christopherson, K.S.1    Ullian, E.M.2    Stokes, C.C.3
  • 13
    • 84888348687 scopus 로고    scopus 로고
    • TGF-beta signaling regulates neuronal C1q expression and developmental synaptic refinement
    • COI: 1:CAS:528:DC%2BC3sXhs1yhsb3E
    • Bialas AR, Stevens B. TGF-beta signaling regulates neuronal C1q expression and developmental synaptic refinement. Nat Neurosci 2013;16:1773-1782.
    • (2013) Nat Neurosci , vol.16 , pp. 1773-1782
    • Bialas, A.R.1    Stevens, B.2
  • 14
    • 79952305803 scopus 로고    scopus 로고
    • Astrocyte-neuron lactate transport is required for long-term memory formation
    • COI: 1:CAS:528:DC%2BC3MXjsFeqt7Y%3D
    • Suzuki A, Stern SA, Bozdagi O, et al. Astrocyte-neuron lactate transport is required for long-term memory formation. Cell 2011;144:810-823.
    • (2011) Cell , vol.144 , pp. 810-823
    • Suzuki, A.1    Stern, S.A.2    Bozdagi, O.3
  • 15
    • 34250870091 scopus 로고    scopus 로고
    • Variations in promoter activity reveal a differential expression and physiology of glutamate transporters by glia in the developing and mature CNS
    • COI: 1:CAS:528:DC%2BD2sXnsVWqsr0%3D
    • Regan MR, Huang YH, Kim YS, et al. Variations in promoter activity reveal a differential expression and physiology of glutamate transporters by glia in the developing and mature CNS. J Neurosci 2007;27:6607-6619.
    • (2007) J Neurosci , vol.27 , pp. 6607-6619
    • Regan, M.R.1    Huang, Y.H.2    Kim, Y.S.3
  • 16
    • 75649138386 scopus 로고    scopus 로고
    • Astroglial networks: a step further in neuroglial and gliovascular interactions
    • COI: 1:CAS:528:DC%2BC3cXnsVajug%3D%3D
    • Giaume C, Koulakoff A, Roux L, Holcman D, Rouach N. Astroglial networks: a step further in neuroglial and gliovascular interactions. Nat Rev Neurosci 2010;11:87-99.
    • (2010) Nat Rev Neurosci , vol.11 , pp. 87-99
    • Giaume, C.1    Koulakoff, A.2    Roux, L.3    Holcman, D.4    Rouach, N.5
  • 17
    • 45549083671 scopus 로고    scopus 로고
    • Gap junction-mediated astrocytic networks in the mouse barrel cortex
    • COI: 1:CAS:528:DC%2BD1cXmt1Slt7o%3D
    • Houades V, Koulakoff A, Ezan P, Seif I, Giaume C. Gap junction-mediated astrocytic networks in the mouse barrel cortex. J Neurosci 2008;28:5207-5217.
    • (2008) J Neurosci , vol.28 , pp. 5207-5217
    • Houades, V.1    Koulakoff, A.2    Ezan, P.3    Seif, I.4    Giaume, C.5
  • 18
    • 0034067910 scopus 로고    scopus 로고
    • Connexins and gap junctions of astrocytes and oligodendrocytes in the CNS
    • COI: 1:CAS:528:DC%2BD3cXit1WhtL0%3D
    • Nagy JI, Rash JE. Connexins and gap junctions of astrocytes and oligodendrocytes in the CNS. Brain Res Brain Res Rev 2000;32:29-44.
    • (2000) Brain Res Brain Res Rev , vol.32 , pp. 29-44
    • Nagy, J.I.1    Rash, J.E.2
  • 20
    • 0027373799 scopus 로고
    • Human fetal astrocytes induce the expression of blood-brain barrier specific proteins by autologous endothelial cells
    • COI: 1:CAS:528:DyaK3sXms1Grsb0%3D
    • Hurwitz AA, Berman JW, Rashbaum WK, Lyman WD. Human fetal astrocytes induce the expression of blood-brain barrier specific proteins by autologous endothelial cells. Brain Res 1993;625:238-243.
    • (1993) Brain Res , vol.625 , pp. 238-243
    • Hurwitz, A.A.1    Berman, J.W.2    Rashbaum, W.K.3    Lyman, W.D.4
  • 21
    • 79960141471 scopus 로고    scopus 로고
    • The immunology of stroke: from mechanisms to translation
    • COI: 1:CAS:528:DC%2BC3MXos1Srsrw%3D
    • Iadecola C, Anrather J. The immunology of stroke: from mechanisms to translation. Nat Med 2011;17:796-808.
    • (2011) Nat Med , vol.17 , pp. 796-808
    • Iadecola, C.1    Anrather, J.2
  • 22
    • 84864558012 scopus 로고    scopus 로고
    • CD36 is involved in astrocyte activation and astroglial scar formation
    • COI: 1:CAS:528:DC%2BC38XhtFCrsrbF
    • Bao Y, Qin L, Kim E, et al. CD36 is involved in astrocyte activation and astroglial scar formation. J Cereb Blood Flow Metab 2012;32:1567-1577.
    • (2012) J Cereb Blood Flow Metab , vol.32 , pp. 1567-1577
    • Bao, Y.1    Qin, L.2    Kim, E.3
  • 24
    • 51649115123 scopus 로고    scopus 로고
    • Glutamate activates GFAP gene promoter from cultured astrocytes through TGF-beta1 pathways
    • COI: 1:CAS:528:DC%2BD1cXovFWgtbw%3D
    • Romao LF, Sousa Vde O, Neto VM, Gomes FC. Glutamate activates GFAP gene promoter from cultured astrocytes through TGF-beta1 pathways. J Neurochem 2008;106:746-756.
    • (2008) J Neurochem , vol.106 , pp. 746-756
    • Romao, L.F.1    Sousa Vde, O.2    Neto, V.M.3    Gomes, F.C.4
  • 25
    • 0037444676 scopus 로고    scopus 로고
    • Activation of extracellular signal-regulated kinase by stretch-induced injury in astrocytes involves extracellular ATP and P2 purinergic receptors
    • COI: 1:CAS:528:DC%2BD3sXlsV2qt7Y%3D
    • Neary JT, Kang Y, Willoughby KA, Ellis EF. Activation of extracellular signal-regulated kinase by stretch-induced injury in astrocytes involves extracellular ATP and P2 purinergic receptors. J Neurosci 2003;23:2348-2356.
    • (2003) J Neurosci , vol.23 , pp. 2348-2356
    • Neary, J.T.1    Kang, Y.2    Willoughby, K.A.3    Ellis, E.F.4
  • 26
    • 36448939414 scopus 로고    scopus 로고
    • Activation of CysLT receptors induces astrocyte proliferation and death after oxygen-glucose deprivation
    • Huang XJ, Zhang WP, Li CT, et al. Activation of CysLT receptors induces astrocyte proliferation and death after oxygen-glucose deprivation. Glia 2008;56:27-37.
    • (2008) Glia , vol.56 , pp. 27-37
    • Huang, X.J.1    Zhang, W.P.2    Li, C.T.3
  • 27
    • 33847099936 scopus 로고    scopus 로고
    • Astrocytes are active players in cerebral innate immunity
    • COI: 1:CAS:528:DC%2BD2sXit1GrtLs%3D
    • Farina C, Aloisi F, Meinl E. Astrocytes are active players in cerebral innate immunity. Trends Immunol 2007;28:138-145.
    • (2007) Trends Immunol , vol.28 , pp. 138-145
    • Farina, C.1    Aloisi, F.2    Meinl, E.3
  • 28
    • 1842454626 scopus 로고    scopus 로고
    • The role of astrocytes in the immunopathogenesis of toxoplasmic encephalitis
    • COI: 1:CAS:528:DC%2BD2cXivVCku78%3D
    • Wilson EH, Hunter CA. The role of astrocytes in the immunopathogenesis of toxoplasmic encephalitis. Int J Parasitol 2004;34:543-548.
    • (2004) Int J Parasitol , vol.34 , pp. 543-548
    • Wilson, E.H.1    Hunter, C.A.2
  • 29
    • 80054978638 scopus 로고    scopus 로고
    • Proliferating reactive astrocytes are regulated by Notch-1 in the peri-infarct area after stroke
    • Shimada IS, Borders A, Aronshtam A, Spees JL. Proliferating reactive astrocytes are regulated by Notch-1 in the peri-infarct area after stroke. Stroke 2011;42:3231-3237.
    • (2011) Stroke , vol.42 , pp. 3231-3237
    • Shimada, I.S.1    Borders, A.2    Aronshtam, A.3    Spees, J.L.4
  • 30
    • 39749132193 scopus 로고    scopus 로고
    • Protective role of reactive astrocytes in brain ischemia
    • Li L, Lundkvist A, Andersson D, et al. Protective role of reactive astrocytes in brain ischemia. J Cereb Blood Flow Metab 2008;28:468-481.
    • (2008) J Cereb Blood Flow Metab , vol.28 , pp. 468-481
    • Li, L.1    Lundkvist, A.2    Andersson, D.3
  • 31
    • 67651148406 scopus 로고    scopus 로고
    • Inactivation of astroglial NF-kappa B promotes survival of retinal neurons following ischemic injury
    • Dvoriantchikova G, Barakat D, Brambilla R, et al. Inactivation of astroglial NF-kappa B promotes survival of retinal neurons following ischemic injury. Eur J Neurosci 2009;30:175-185.
    • (2009) Eur J Neurosci , vol.30 , pp. 175-185
    • Dvoriantchikova, G.1    Barakat, D.2    Brambilla, R.3
  • 32
    • 22344431751 scopus 로고    scopus 로고
    • Inhibition of astroglial nuclear factor kappaB reduces inflammation and improves functional recovery after spinal cord injury
    • COI: 1:CAS:528:DC%2BD2MXmtVaqtr4%3D
    • Brambilla R, Bracchi-Ricard V, Hu WH, et al. Inhibition of astroglial nuclear factor kappaB reduces inflammation and improves functional recovery after spinal cord injury. J Exp Med 2005;202:145-156.
    • (2005) J Exp Med , vol.202 , pp. 145-156
    • Brambilla, R.1    Bracchi-Ricard, V.2    Hu, W.H.3
  • 33
    • 67649506550 scopus 로고    scopus 로고
    • Transgenic inhibition of astroglial NF-kappa B leads to increased axonal sparing and sprouting following spinal cord injury
    • COI: 1:CAS:528:DC%2BD1MXovV2mur8%3D
    • Brambilla R, Hurtado A, Persaud T, et al. Transgenic inhibition of astroglial NF-kappa B leads to increased axonal sparing and sprouting following spinal cord injury. J Neurochem 2009;110:765-778.
    • (2009) J Neurochem , vol.110 , pp. 765-778
    • Brambilla, R.1    Hurtado, A.2    Persaud, T.3
  • 34
    • 84880851472 scopus 로고    scopus 로고
    • Glial scar borders are formed by newly proliferated, elongated astrocytes that interact to corral inflammatory and fibrotic cells via STAT3-dependent mechanisms after spinal cord injury
    • COI: 1:CAS:528:DC%2BC3sXht1Cltr7F
    • Wanner IB, Anderson MA, Song B, et al. Glial scar borders are formed by newly proliferated, elongated astrocytes that interact to corral inflammatory and fibrotic cells via STAT3-dependent mechanisms after spinal cord injury. J Neurosci 2013;33:12870-12886.
    • (2013) J Neurosci , vol.33 , pp. 12870-12886
    • Wanner, I.B.1    Anderson, M.A.2    Song, B.3
  • 35
    • 33745919498 scopus 로고    scopus 로고
    • Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury
    • COI: 1:CAS:528:DC%2BD28Xms1eksL0%3D
    • Okada S, Nakamura M, Katoh H, et al. Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury. Nat Med 2006;12:829-834.
    • (2006) Nat Med , vol.12 , pp. 829-834
    • Okada, S.1    Nakamura, M.2    Katoh, H.3
  • 36
    • 49049091210 scopus 로고    scopus 로고
    • STAT3 is a critical regulator of astrogliosis and scar formation after spinal cord injury
    • COI: 1:CAS:528:DC%2BD1cXovVSgtbo%3D
    • Herrmann JE, Imura T, Song B, et al. STAT3 is a critical regulator of astrogliosis and scar formation after spinal cord injury. J Neurosci 2008;28:7231-7243.
    • (2008) J Neurosci , vol.28 , pp. 7231-7243
    • Herrmann, J.E.1    Imura, T.2    Song, B.3
  • 37
    • 84964324589 scopus 로고    scopus 로고
    • Astrocyte scar formation aids central nervous system axon regeneration
    • COI: 1:CAS:528:DC%2BC28XltFKhsL0%3D
    • Anderson MA, Burda JE, Ren Y, et al. Astrocyte scar formation aids central nervous system axon regeneration. Nature 2016;532:195-200.
    • (2016) Nature , vol.532 , pp. 195-200
    • Anderson, M.A.1    Burda, J.E.2    Ren, Y.3
  • 38
    • 84871291657 scopus 로고    scopus 로고
    • Conditional Sox9 ablation reduces chondroitin sulfate proteoglycan levels and improves motor function following spinal cord injury
    • McKillop WM, Dragan M, Schedl A, Brown A. Conditional Sox9 ablation reduces chondroitin sulfate proteoglycan levels and improves motor function following spinal cord injury. Glia 2013;61:164-177.
    • (2013) Glia , vol.61 , pp. 164-177
    • McKillop, W.M.1    Dragan, M.2    Schedl, A.3    Brown, A.4
  • 39
    • 58149379612 scopus 로고    scopus 로고
    • Matrix metalloproteinase-9 facilitates glial scar formation in the injured spinal cord
    • COI: 1:CAS:528:DC%2BD1cXhsFCqsLfN
    • Hsu JY, Bourguignon LY, Adams CM, et al. Matrix metalloproteinase-9 facilitates glial scar formation in the injured spinal cord. J Neurosci 2008;28:13467-13477.
    • (2008) J Neurosci , vol.28 , pp. 13467-13477
    • Hsu, J.Y.1    Bourguignon, L.Y.2    Adams, C.M.3
  • 40
    • 1542317072 scopus 로고    scopus 로고
    • Reactive astrocytes protect tissue and preserve function after spinal cord injury
    • COI: 1:CAS:528:DC%2BD2cXitlCrtLk%3D
    • Faulkner JR, Herrmann JE, Woo MJ, Tansey KE, Doan NB, Sofroniew MV. Reactive astrocytes protect tissue and preserve function after spinal cord injury. J Neurosci 2004;24:2143-2155.
    • (2004) J Neurosci , vol.24 , pp. 2143-2155
    • Faulkner, J.R.1    Herrmann, J.E.2    Woo, M.J.3    Tansey, K.E.4    Doan, N.B.5    Sofroniew, M.V.6
  • 41
    • 77951664911 scopus 로고    scopus 로고
    • Fibrinogen triggers astrocyte scar formation by promoting the availability of active TGF-beta after vascular damage
    • COI: 1:CAS:528:DC%2BC3cXosFeqs74%3D
    • Schachtrup C, Ryu JK, Helmrick MJ, et al. Fibrinogen triggers astrocyte scar formation by promoting the availability of active TGF-beta after vascular damage. J Neurosci 2010;30:5843-5854.
    • (2010) J Neurosci , vol.30 , pp. 5843-5854
    • Schachtrup, C.1    Ryu, J.K.2    Helmrick, M.J.3
  • 42
    • 0031439210 scopus 로고    scopus 로고
    • Macrophage/Microglia regulation of astrocytic tenascin: synergistic action of transforming growth factor-beta and basic fibroblast growth factor
    • COI: 1:CAS:528:DyaK2sXotVWgsb0%3D
    • Smith GM, Hale JH. Macrophage/Microglia regulation of astrocytic tenascin: synergistic action of transforming growth factor-beta and basic fibroblast growth factor. J Neurosci 1997;17:9624-9633.
    • (1997) J Neurosci , vol.17 , pp. 9624-9633
    • Smith, G.M.1    Hale, J.H.2
  • 43
    • 33751398742 scopus 로고    scopus 로고
    • Smad3 null mice display more rapid wound closure and reduced scar formation after a stab wound to the cerebral cortex
    • COI: 1:CAS:528:DC%2BD28Xht1Krt7zL
    • Wang Y, Moges H, Bharucha Y, Symes A. Smad3 null mice display more rapid wound closure and reduced scar formation after a stab wound to the cerebral cortex. Exp Neurol 2007;203:168-184.
    • (2007) Exp Neurol , vol.203 , pp. 168-184
    • Wang, Y.1    Moges, H.2    Bharucha, Y.3    Symes, A.4
  • 44
    • 0033152442 scopus 로고    scopus 로고
    • Leukocyte infiltration, neuronal degeneration, and neurite outgrowth after ablation of scar-forming, reactive astrocytes in adult transgenic mice
    • COI: 1:CAS:528:DyaK1MXks1Wrsrs%3D
    • Bush TG, Puvanachandra N, Horner CH, et al. Leukocyte infiltration, neuronal degeneration, and neurite outgrowth after ablation of scar-forming, reactive astrocytes in adult transgenic mice. Neuron 1999;23:297-308.
    • (1999) Neuron , vol.23 , pp. 297-308
    • Bush, T.G.1    Puvanachandra, N.2    Horner, C.H.3
  • 45
    • 33749508895 scopus 로고    scopus 로고
    • Essential protective roles of reactive astrocytes in traumatic brain injury
    • COI: 1:STN:280:DC%2BD28rntVKntA%3D%3D
    • Myer DJ, Gurkoff GG, Lee SM, Hovda DA, Sofroniew MV. Essential protective roles of reactive astrocytes in traumatic brain injury. Brain 2006;129:2761-2772.
    • (2006) Brain , vol.129 , pp. 2761-2772
    • Myer, D.J.1    Gurkoff, G.G.2    Lee, S.M.3    Hovda, D.A.4    Sofroniew, M.V.5
  • 46
    • 0034810795 scopus 로고    scopus 로고
    • Interleukin-1 beta is required for the early evolution of reactive astrogliosis following CNS lesion
    • COI: 1:CAS:528:DC%2BD3MXns1yrsr4%3D
    • Herx LM, Yong VW. Interleukin-1 beta is required for the early evolution of reactive astrogliosis following CNS lesion. J Neuropathol Exp Neurol 2001;60:961-971.
    • (2001) J Neuropathol Exp Neurol , vol.60 , pp. 961-971
    • Herx, L.M.1    Yong, V.W.2
  • 47
    • 84876933529 scopus 로고    scopus 로고
    • Live imaging of astrocyte responses to acute injury reveals selective juxtavascular proliferation
    • COI: 1:CAS:528:DC%2BC3sXkvFOqs74%3D
    • Bardehle S, Kruger M, Buggenthin F, et al. Live imaging of astrocyte responses to acute injury reveals selective juxtavascular proliferation. Nat Neurosci 2013;16:580-586.
    • (2013) Nat Neurosci , vol.16 , pp. 580-586
    • Bardehle, S.1    Kruger, M.2    Buggenthin, F.3
  • 48
    • 0028012270 scopus 로고
    • Reactive astrogliosis in the neonatal mouse brain and its modulation by cytokines
    • COI: 1:CAS:528:DyaK2cXhvV2gtbo%3D
    • Balasingam V, Tejada-Berges T, Wright E, Bouckova R, Yong VW. Reactive astrogliosis in the neonatal mouse brain and its modulation by cytokines. J Neurosci 1994;14:846-856.
    • (1994) J Neurosci , vol.14 , pp. 846-856
    • Balasingam, V.1    Tejada-Berges, T.2    Wright, E.3    Bouckova, R.4    Yong, V.W.5
  • 49
    • 40449101837 scopus 로고    scopus 로고
    • Endothelin-1 regulates astrocyte proliferation and reactive gliosis via a JNK/c-Jun signaling pathway
    • COI: 1:CAS:528:DC%2BD1cXjt1Ghur0%3D
    • Gadea A, Schinelli S, Gallo V. Endothelin-1 regulates astrocyte proliferation and reactive gliosis via a JNK/c-Jun signaling pathway. J Neurosci 2008;28:2394-2408.
    • (2008) J Neurosci , vol.28 , pp. 2394-2408
    • Gadea, A.1    Schinelli, S.2    Gallo, V.3
  • 50
    • 70349103383 scopus 로고    scopus 로고
    • Reactive astrocytes form scar-like perivascular barriers to leukocytes during adaptive immune inflammation of the CNS
    • COI: 1:CAS:528:DC%2BD1MXht1SrtbbF
    • Voskuhl RR, Peterson RS, Song B, et al. Reactive astrocytes form scar-like perivascular barriers to leukocytes during adaptive immune inflammation of the CNS. J Neurosci 2009;29:11511-11522.
    • (2009) J Neurosci , vol.29 , pp. 11511-11522
    • Voskuhl, R.R.1    Peterson, R.S.2    Song, B.3
  • 51
    • 2442547563 scopus 로고    scopus 로고
    • TNFR1-dependent VCAM-1 expression by astrocytes exposes the CNS to destructive inflammation
    • COI: 1:CAS:528:DC%2BD2cXktVOmt7Y%3D
    • Gimenez MA, Sim JE, Russell JH. TNFR1-dependent VCAM-1 expression by astrocytes exposes the CNS to destructive inflammation. J Neuroimmunol 2004;151:116-125.
    • (2004) J Neuroimmunol , vol.151 , pp. 116-125
    • Gimenez, M.A.1    Sim, J.E.2    Russell, J.H.3
  • 52
    • 79958042327 scopus 로고    scopus 로고
    • Gp130-dependent astrocytic survival is critical for the control of autoimmune central nervous system inflammation
    • COI: 1:CAS:528:DC%2BC3MXmtlyktb0%3D
    • Haroon F, Drogemuller K, Handel U, et al. Gp130-dependent astrocytic survival is critical for the control of autoimmune central nervous system inflammation. J Immunol 2011;186:6521-6531.
    • (2011) J Immunol , vol.186 , pp. 6521-6531
    • Haroon, F.1    Drogemuller, K.2    Handel, U.3
  • 53
    • 52949085996 scopus 로고    scopus 로고
    • Astrocyte gp130 expression is critical for the control of Toxoplasma encephalitis
    • Drogemuller K, Helmuth U, Brunn A, et al. Astrocyte gp130 expression is critical for the control of Toxoplasma encephalitis. J Immunol 2008;18:2683-2693.
    • (2008) J Immunol , vol.18 , pp. 2683-2693
    • Drogemuller, K.1    Helmuth, U.2    Brunn, A.3
  • 54
    • 2942538162 scopus 로고    scopus 로고
    • The intermediate filament GFAP is important for the control of experimental murine Staphylococcus aureus-induced brain abscess and Toxoplasma encephalitis
    • Stenzel W, Soltek S, Schluter D, Deckert M. The intermediate filament GFAP is important for the control of experimental murine Staphylococcus aureus-induced brain abscess and Toxoplasma encephalitis. J Neuropathol Exp Neurol 2004;63:631-640.
    • (2004) J Neuropathol Exp Neurol , vol.63 , pp. 631-640
    • Stenzel, W.1    Soltek, S.2    Schluter, D.3    Deckert, M.4
  • 55
    • 84860322835 scopus 로고    scopus 로고
    • Genomic analysis of reactive astrogliosis
    • COI: 1:CAS:528:DC%2BC38XmvFehs70%3D
    • Zamanian JL, Xu L, Foo LC, et al. Genomic analysis of reactive astrogliosis. J Neurosci 2012;32:6391-6410.
    • (2012) J Neurosci , vol.32 , pp. 6391-6410
    • Zamanian, J.L.1    Xu, L.2    Foo, L.C.3
  • 56
    • 77950521720 scopus 로고    scopus 로고
    • Astrocytes initiate inflammation in the injured mouse spinal cord by promoting the entry of neutrophils and inflammatory monocytes in an IL-1 receptor/MyD88-dependent fashion
    • COI: 1:CAS:528:DC%2BC3cXkvFKlsrY%3D
    • Pineau I, Sun L, Bastien D, Lacroix S. Astrocytes initiate inflammation in the injured mouse spinal cord by promoting the entry of neutrophils and inflammatory monocytes in an IL-1 receptor/MyD88-dependent fashion. Brain Behav Immun 2010;24:540-553.
    • (2010) Brain Behav Immun , vol.24 , pp. 540-553
    • Pineau, I.1    Sun, L.2    Bastien, D.3    Lacroix, S.4
  • 57
    • 0041319041 scopus 로고    scopus 로고
    • Chemokine expression by glial cells directs leukocytes to sites of axonal injury in the CNS
    • COI: 1:CAS:528:DC%2BD3sXmvFGhu78%3D
    • Babcock AA, Kuziel WA, Rivest S, Owens T. Chemokine expression by glial cells directs leukocytes to sites of axonal injury in the CNS. J Neurosci 2003;23:7922-7930.
    • (2003) J Neurosci , vol.23 , pp. 7922-7930
    • Babcock, A.A.1    Kuziel, W.A.2    Rivest, S.3    Owens, T.4
  • 58
    • 0029931236 scopus 로고    scopus 로고
    • Chemokine monocyte chemoattractant protein-1 is expressed by astrocytes after mechanical injury to the brain
    • COI: 1:CAS:528:DyaK28XjtFCnu7c%3D
    • Glabinski AR, Balasingam V, Tani M, et al. Chemokine monocyte chemoattractant protein-1 is expressed by astrocytes after mechanical injury to the brain. J Immunol 1996;156:4363-4368.
    • (1996) J Immunol , vol.156 , pp. 4363-4368
    • Glabinski, A.R.1    Balasingam, V.2    Tani, M.3
  • 59
    • 37049003280 scopus 로고    scopus 로고
    • Analysis of the cerebral transcriptome in mice subjected to traumatic brain injury: importance of IL-6
    • COI: 1:CAS:528:DC%2BD2sXhsVagsLvL
    • Quintana A, Giralt M, Molinero A, Campbell IL, Penkowa M, Hidalgo J. Analysis of the cerebral transcriptome in mice subjected to traumatic brain injury: importance of IL-6. Neuroimmunomodulation 2007;14:139-143.
    • (2007) Neuroimmunomodulation , vol.14 , pp. 139-143
    • Quintana, A.1    Giralt, M.2    Molinero, A.3    Campbell, I.L.4    Penkowa, M.5    Hidalgo, J.6
  • 60
    • 68149148572 scopus 로고    scopus 로고
    • Site-specific production of IL-6 in the central nervous system retargets and enhances the inflammatory response in experimental autoimmune encephalomyelitis
    • COI: 1:CAS:528:DC%2BD1MXoslCrsbk%3D
    • Quintana A, Muller M, Frausto RF, et al. Site-specific production of IL-6 in the central nervous system retargets and enhances the inflammatory response in experimental autoimmune encephalomyelitis. J Immunol 2009;183:2079-2088.
    • (2009) J Immunol , vol.183 , pp. 2079-2088
    • Quintana, A.1    Muller, M.2    Frausto, R.F.3
  • 61
    • 0032878430 scopus 로고    scopus 로고
    • Transgenic expression of interleukin-6 in the central nervous system confers protection against acute herpes simplex virus type-1 infection
    • COI: 1:CAS:528:DyaK1MXntlSksL0%3D
    • Carr DJ, Campbell IL. Transgenic expression of interleukin-6 in the central nervous system confers protection against acute herpes simplex virus type-1 infection. J Neurovirol 1999;5:449-457.
    • (1999) J Neurovirol , vol.5 , pp. 449-457
    • Carr, D.J.1    Campbell, I.L.2
  • 62
    • 0037114162 scopus 로고    scopus 로고
    • The role of the MHC class II transactivator in class II expression and antigen presentation by astrocytes and in susceptibility to central nervous system autoimmune disease
    • COI: 1:CAS:528:DC%2BD38XpsFCqu7Y%3D
    • Stuve O, Youssef S, Slavin AJ, et al. The role of the MHC class II transactivator in class II expression and antigen presentation by astrocytes and in susceptibility to central nervous system autoimmune disease. J Immunol 2002;169:6720-6732.
    • (2002) J Immunol , vol.169 , pp. 6720-6732
    • Stuve, O.1    Youssef, S.2    Slavin, A.J.3
  • 63
    • 84864414689 scopus 로고    scopus 로고
    • IFN-gamma signaling to astrocytes protects from autoimmune mediated neurological disability
    • COI: 1:CAS:528:DC%2BC38XhtFCgur7I
    • Hindinger C, Bergmann CC, Hinton DR, et al. IFN-gamma signaling to astrocytes protects from autoimmune mediated neurological disability. PLoS One 2012;7:e42088.
    • (2012) PLoS One , vol.7
    • Hindinger, C.1    Bergmann, C.C.2    Hinton, D.R.3
  • 64
    • 79957723865 scopus 로고    scopus 로고
    • Neuroprotection mediated through estrogen receptor-alpha in astrocytes
    • COI: 1:CAS:528:DC%2BC3MXntVegu7k%3D
    • Spence RD, Hamby ME, Umeda E, et al. Neuroprotection mediated through estrogen receptor-alpha in astrocytes. Proc Natl Acad Sci U S A 2011;108:8867-8872.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 8867-8872
    • Spence, R.D.1    Hamby, M.E.2    Umeda, E.3
  • 65
    • 77949973725 scopus 로고    scopus 로고
    • Astrocyte-restricted ablation of interleukin-17-induced Act1-mediated signaling ameliorates autoimmune encephalomyelitis
    • COI: 1:CAS:528:DC%2BC3cXlsVSntrc%3D
    • Kang Z, Altuntas CZ, Gulen MF, et al. Astrocyte-restricted ablation of interleukin-17-induced Act1-mediated signaling ameliorates autoimmune encephalomyelitis. Immunity 2010;32:414-425.
    • (2010) Immunity , vol.32 , pp. 414-425
    • Kang, Z.1    Altuntas, C.Z.2    Gulen, M.F.3
  • 66
    • 84872497437 scopus 로고    scopus 로고
    • Astrocytic Fas ligand expression is required to induce T-cell apoptosis and recovery from experimental autoimmune encephalomyelitis
    • COI: 1:CAS:528:DC%2BC38Xhs12rtr3P
    • Wang X, Haroon F, Karray S, Martina D, Schluter D. Astrocytic Fas ligand expression is required to induce T-cell apoptosis and recovery from experimental autoimmune encephalomyelitis. Eur J Immunol 2013;43:115-124.
    • (2013) Eur J Immunol , vol.43 , pp. 115-124
    • Wang, X.1    Haroon, F.2    Karray, S.3    Martina, D.4    Schluter, D.5
  • 67
    • 0034193032 scopus 로고    scopus 로고
    • Astrocyte-targeted expression of IL-12 induces active cellular immune responses in the central nervous system and modulates experimental allergic encephalomyelitis
    • COI: 1:CAS:528:DC%2BD3cXivFWmtrk%3D
    • Pagenstecher A, Lassmann S, Carson MJ, Kincaid CL, Stalder AK, Campbell IL. Astrocyte-targeted expression of IL-12 induces active cellular immune responses in the central nervous system and modulates experimental allergic encephalomyelitis. J Immunol 2000;164:4481-4492.
    • (2000) J Immunol , vol.164 , pp. 4481-4492
    • Pagenstecher, A.1    Lassmann, S.2    Carson, M.J.3    Kincaid, C.L.4    Stalder, A.K.5    Campbell, I.L.6
  • 68
    • 0030793527 scopus 로고    scopus 로고
    • Astroglial overproduction of TGF-beta 1 enhances inflammatory central nervous system disease in transgenic mice
    • COI: 1:CAS:528:DyaK2sXjsVKmsLo%3D
    • Wyss-Coray T, Borrow P, Brooker MJ, Mucke L. Astroglial overproduction of TGF-beta 1 enhances inflammatory central nervous system disease in transgenic mice. J Neuroimmunol 1997;77:45-50.
    • (1997) J Neuroimmunol , vol.77 , pp. 45-50
    • Wyss-Coray, T.1    Borrow, P.2    Brooker, M.J.3    Mucke, L.4
  • 69
    • 84902345621 scopus 로고    scopus 로고
    • Astrocytic transforming growth factor-beta signaling reduces subacute neuroinflammation after stroke in mice
    • Cekanaviciute E, Fathali N, Doyle KP, Williams AM, Han J, Buckwalter MS. Astrocytic transforming growth factor-beta signaling reduces subacute neuroinflammation after stroke in mice. Glia 2014;62:1227-1240.
    • (2014) Glia , vol.62 , pp. 1227-1240
    • Cekanaviciute, E.1    Fathali, N.2    Doyle, K.P.3    Williams, A.M.4    Han, J.5    Buckwalter, M.S.6
  • 70
    • 84903610889 scopus 로고    scopus 로고
    • Astrocytic TGF-beta signaling limits inflammation and reduces neuronal damage during central nervous system Toxoplasma infection
    • COI: 1:CAS:528:DC%2BC2cXhtVWmsLfL
    • Cekanaviciute E, Dietrich HK, Axtell RC, et al. Astrocytic TGF-beta signaling limits inflammation and reduces neuronal damage during central nervous system Toxoplasma infection. J Immunol 2014;193:139-149.
    • (2014) J Immunol , vol.193 , pp. 139-149
    • Cekanaviciute, E.1    Dietrich, H.K.2    Axtell, R.C.3
  • 71
    • 0036942730 scopus 로고    scopus 로고
    • Chemokines are differentially expressed by astrocytes, microglia and inflammatory leukocytes in Toxoplasma encephalitis and critically regulated by interferon-gamma
    • COI: 1:CAS:528:DC%2BD38XisFWmsbY%3D
    • Strack A, Asensio VC, Campbell IL, Schluter D, Deckert M. Chemokines are differentially expressed by astrocytes, microglia and inflammatory leukocytes in Toxoplasma encephalitis and critically regulated by interferon-gamma. Acta Neuropathol 2002;103:458-468.
    • (2002) Acta Neuropathol , vol.103 , pp. 458-468
    • Strack, A.1    Asensio, V.C.2    Campbell, I.L.3    Schluter, D.4    Deckert, M.5
  • 72
    • 47249162826 scopus 로고    scopus 로고
    • Analysis of the neuroinflammatory response to TLR7 stimulation in the brain: comparison of multiple TLR7 and/or TLR8 agonists
    • COI: 1:CAS:528:DC%2BD1cXmtVams70%3D
    • Butchi NB, Pourciau S, Du M, Morgan TW, Peterson KE. Analysis of the neuroinflammatory response to TLR7 stimulation in the brain: comparison of multiple TLR7 and/or TLR8 agonists. J Immunol 2008;180:7604-7612.
    • (2008) J Immunol , vol.180 , pp. 7604-7612
    • Butchi, N.B.1    Pourciau, S.2    Du, M.3    Morgan, T.W.4    Peterson, K.E.5
  • 73
    • 0035795072 scopus 로고    scopus 로고
    • Enhanced expression of fractalkine in HIV-1 associated dementia
    • COI: 1:CAS:528:DC%2BD3MXitF2rsro%3D
    • Pereira CF, Middel J, Jansen G, Verhoef J, Nottet HS. Enhanced expression of fractalkine in HIV-1 associated dementia. J Neuroimmunol 2001;115:168-175.
    • (2001) J Neuroimmunol , vol.115 , pp. 168-175
    • Pereira, C.F.1    Middel, J.2    Jansen, G.3    Verhoef, J.4    Nottet, H.S.5
  • 74
    • 0033799211 scopus 로고    scopus 로고
    • Chemokine gene expression in astrocytes of Borna disease virus-infected rats and mice in the absence of inflammation
    • COI: 1:CAS:528:DC%2BD3cXmslymtLY%3D
    • Sauder C, Hallensleben W, Pagenstecher A, et al. Chemokine gene expression in astrocytes of Borna disease virus-infected rats and mice in the absence of inflammation. J Virol 2000;74:9267-9280.
    • (2000) J Virol , vol.74 , pp. 9267-9280
    • Sauder, C.1    Hallensleben, W.2    Pagenstecher, A.3
  • 75
    • 1642443931 scopus 로고    scopus 로고
    • Induction of C chemokine XCL1 (lymphotactin/single C motif-1 alpha/activation-induced, T cell-derived and chemokine-related cytokine) expression by HIV-1 Tat protein
    • COI: 1:CAS:528:DC%2BD2cXptl2gsQ%3D%3D
    • Kim BO, Liu Y, Zhou BY, He JJ. Induction of C chemokine XCL1 (lymphotactin/single C motif-1 alpha/activation-induced, T cell-derived and chemokine-related cytokine) expression by HIV-1 Tat protein. J Immunol 2004;172:1888-1895.
    • (2004) J Immunol , vol.172 , pp. 1888-1895
    • Kim, B.O.1    Liu, Y.2    Zhou, B.Y.3    He, J.J.4
  • 76
    • 0028826296 scopus 로고
    • Activation of astrocytes in the spinal cord of mice chronically infected with a neurotropic coronavirus
    • COI: 1:CAS:528:DyaK2MXpsVGhsrw%3D
    • Sun N, Grzybicki D, Castro RF, Murphy S, Perlman S. Activation of astrocytes in the spinal cord of mice chronically infected with a neurotropic coronavirus. Virology 1995;213:482-493.
    • (1995) Virology , vol.213 , pp. 482-493
    • Sun, N.1    Grzybicki, D.2    Castro, R.F.3    Murphy, S.4    Perlman, S.5
  • 77
    • 32344437590 scopus 로고    scopus 로고
    • TLR3-mediated signal induces proinflammatory cytokine and chemokine gene expression in astrocytes: differential signaling mechanisms of TLR3-induced IP-10 and IL-8 gene expression
    • Park C, Lee S, Cho IH, et al. TLR3-mediated signal induces proinflammatory cytokine and chemokine gene expression in astrocytes: differential signaling mechanisms of TLR3-induced IP-10 and IL-8 gene expression. Glia 2006;53:248-256.
    • (2006) Glia , vol.53 , pp. 248-256
    • Park, C.1    Lee, S.2    Cho, I.H.3
  • 78
    • 68349160698 scopus 로고    scopus 로고
    • Pivotal role of cerebral interleukin-17-producing gammadeltaT cells in the delayed phase of ischemic brain injury
    • COI: 1:CAS:528:DC%2BD1MXpt1Ons74%3D
    • Shichita T, Sugiyama Y, Ooboshi H, et al. Pivotal role of cerebral interleukin-17-producing gammadeltaT cells in the delayed phase of ischemic brain injury. Nat Med 2009;15:946-950.
    • (2009) Nat Med , vol.15 , pp. 946-950
    • Shichita, T.1    Sugiyama, Y.2    Ooboshi, H.3
  • 79
    • 0033216123 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of glial scarring and progressive cavitation: in vivo and in vitro analysis of inflammation-induced secondary injury after CNS trauma
    • COI: 1:CAS:528:DyaK1MXmt1aquro%3D
    • Fitch MT, Doller C, Combs CK, Landreth GE, Silver J. Cellular and molecular mechanisms of glial scarring and progressive cavitation: in vivo and in vitro analysis of inflammation-induced secondary injury after CNS trauma. J Neurosci 1999;19:8182-8198.
    • (1999) J Neurosci , vol.19 , pp. 8182-8198
    • Fitch, M.T.1    Doller, C.2    Combs, C.K.3    Landreth, G.E.4    Silver, J.5
  • 80
    • 77953221160 scopus 로고    scopus 로고
    • Chronic cortical and subcortical pathology with associated neurological deficits ensuing experimental herpes encephalitis
    • Armien AG, Hu S, Little MR, et al. Chronic cortical and subcortical pathology with associated neurological deficits ensuing experimental herpes encephalitis. Brain Pathol 2010;20:738-750.
    • (2010) Brain Pathol , vol.20 , pp. 738-750
    • Armien, A.G.1    Hu, S.2    Little, M.R.3
  • 81
    • 50949084200 scopus 로고    scopus 로고
    • Two faces of chondroitin sulfate proteoglycan in spinal cord repair: a role in microglia/macrophage activation
    • Rolls A, Shechter R, London A, et al. Two faces of chondroitin sulfate proteoglycan in spinal cord repair: a role in microglia/macrophage activation. PLoS Med 2008;5:e171.
    • (2008) PLoS Med , vol.5
    • Rolls, A.1    Shechter, R.2    London, A.3
  • 82
    • 0033519334 scopus 로고    scopus 로고
    • Abnormal reaction to central nervous system injury in mice lacking glial fibrillary acidic protein and vimentin
    • COI: 1:CAS:528:DyaK1MXivFKnsbc%3D
    • Pekny M, Johansson CB, Eliasson C, et al. Abnormal reaction to central nervous system injury in mice lacking glial fibrillary acidic protein and vimentin. J Cell Biol 1999;145:503-514.
    • (1999) J Cell Biol , vol.145 , pp. 503-514
    • Pekny, M.1    Johansson, C.B.2    Eliasson, C.3
  • 83
    • 84880700718 scopus 로고    scopus 로고
    • Reversible reactivity by optic nerve astrocytes
    • Sun D, Qu J, Jakobs TC. Reversible reactivity by optic nerve astrocytes. Glia 2013;61:1218-1235.
    • (2013) Glia , vol.61 , pp. 1218-1235
    • Sun, D.1    Qu, J.2    Jakobs, T.C.3
  • 84
    • 33751251695 scopus 로고    scopus 로고
    • Redefining the concept of reactive astrocytes as cells that remain within their unique domains upon reaction to injury
    • COI: 1:CAS:528:DC%2BD28Xht1Ojs77E
    • Wilhelmsson U, Bushong EA, Price DL, et al. Redefining the concept of reactive astrocytes as cells that remain within their unique domains upon reaction to injury. Proc Natl Acad Sci U S A 2006;103:17513-17518.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 17513-17518
    • Wilhelmsson, U.1    Bushong, E.A.2    Price, D.L.3
  • 85
    • 34247377375 scopus 로고    scopus 로고
    • Up-regulation of Connexin43 in the glial scar following photothrombotic ischemic injury
    • COI: 1:CAS:528:DC%2BD2sXkslCnsbc%3D
    • Haupt C, Witte OW, Frahm C. Up-regulation of Connexin43 in the glial scar following photothrombotic ischemic injury. Mol Cell Neurosci 2007;35:89-99.
    • (2007) Mol Cell Neurosci , vol.35 , pp. 89-99
    • Haupt, C.1    Witte, O.W.2    Frahm, C.3
  • 86
    • 0042665641 scopus 로고    scopus 로고
    • The chondroitin sulfate proteoglycans neurocan, brevican, phosphacan, and versican are differentially regulated following spinal cord injury
    • COI: 1:CAS:528:DC%2BD3sXlvVCrtbY%3D
    • Jones LL, Margolis RU, Tuszynski MH. The chondroitin sulfate proteoglycans neurocan, brevican, phosphacan, and versican are differentially regulated following spinal cord injury. Exp Neurol 2003;182:399-411.
    • (2003) Exp Neurol , vol.182 , pp. 399-411
    • Jones, L.L.1    Margolis, R.U.2    Tuszynski, M.H.3
  • 87
    • 0031471718 scopus 로고    scopus 로고
    • Regeneration of adult axons in white matter tracts of the central nervous system
    • COI: 1:CAS:528:DyaK1cXhtVWisw%3D%3D
    • Davies SJ, Fitch MT, Memberg SP, Hall AK, Raisman G, Silver J. Regeneration of adult axons in white matter tracts of the central nervous system. Nature 1997;390:680-683.
    • (1997) Nature , vol.390 , pp. 680-683
    • Davies, S.J.1    Fitch, M.T.2    Memberg, S.P.3    Hall, A.K.4    Raisman, G.5    Silver, J.6
  • 88
    • 0033573386 scopus 로고    scopus 로고
    • The chondroitin sulfate proteoglycans neurocan and phosphacan are expressed by reactive astrocytes in the chronic CNS glial scar
    • COI: 1:CAS:528:DyaK1MXotVyjsLg%3D
    • McKeon RJ, Jurynec MJ, Buck CR. The chondroitin sulfate proteoglycans neurocan and phosphacan are expressed by reactive astrocytes in the chronic CNS glial scar. J Neurosci 1999;19:10778-10788.
    • (1999) J Neurosci , vol.19 , pp. 10778-10788
    • McKeon, R.J.1    Jurynec, M.J.2    Buck, C.R.3
  • 89
    • 61349151640 scopus 로고    scopus 로고
    • The immune response in Taenia solium neurocysticercosis in pigs is associated with astrogliosis, axonal degeneration and altered blood-brain barrier permeability
    • COI: 1:CAS:528:DC%2BD1MXisFGls7s%3D
    • Sikasunge CS, Johansen MV, Phiri IK, Willingham AL, 3rd, Leifsson PS. The immune response in Taenia solium neurocysticercosis in pigs is associated with astrogliosis, axonal degeneration and altered blood-brain barrier permeability. Vet Parasitol 2009;160:242-250.
    • (2009) Vet Parasitol , vol.160 , pp. 242-250
    • Sikasunge, C.S.1    Johansen, M.V.2    Phiri, I.K.3    Willingham, A.L.4    Leifsson, P.S.5
  • 90
    • 2942615005 scopus 로고    scopus 로고
    • Neuroregulatory events follow adaptive immune-mediated elimination of HIV-1-infected macrophages: studies in a murine model of viral encephalitis
    • COI: 1:CAS:528:DC%2BD2cXks1agsro%3D
    • Poluektova L, Gorantla S, Faraci J, Birusingh K, Dou H, Gendelman HE. Neuroregulatory events follow adaptive immune-mediated elimination of HIV-1-infected macrophages: studies in a murine model of viral encephalitis. J Immunol 2004;172:7610-7617.
    • (2004) J Immunol , vol.172 , pp. 7610-7617
    • Poluektova, L.1    Gorantla, S.2    Faraci, J.3    Birusingh, K.4    Dou, H.5    Gendelman, H.E.6
  • 91
    • 84864387229 scopus 로고    scopus 로고
    • Activation of innate immune responses in the central nervous system during reovirus myelitis
    • COI: 1:CAS:528:DC%2BC38XhtV2hu7nM
    • Schittone SA, Dionne KR, Tyler KL, Clarke P. Activation of innate immune responses in the central nervous system during reovirus myelitis. J Virol 2012;86:8107-8118.
    • (2012) J Virol , vol.86 , pp. 8107-8118
    • Schittone, S.A.1    Dionne, K.R.2    Tyler, K.L.3    Clarke, P.4
  • 92
    • 0037356722 scopus 로고    scopus 로고
    • The Rho/ROCK pathway mediates neurite growth-inhibitory activity associated with the chondroitin sulfate proteoglycans of the CNS glial scar
    • COI: 1:CAS:528:DC%2BD3sXis1yqt7s%3D
    • Monnier PP, Sierra A, Schwab JM, Henke-Fahle S, Mueller BK. The Rho/ROCK pathway mediates neurite growth-inhibitory activity associated with the chondroitin sulfate proteoglycans of the CNS glial scar. Mol Cell Neurosci 2003;22:319-330.
    • (2003) Mol Cell Neurosci , vol.22 , pp. 319-330
    • Monnier, P.P.1    Sierra, A.2    Schwab, J.M.3    Henke-Fahle, S.4    Mueller, B.K.5
  • 93
    • 22144460104 scopus 로고    scopus 로고
    • CS-4,6 is differentially upregulated in glial scar and is a potent inhibitor of neurite extension
    • COI: 1:CAS:528:DC%2BD2MXlvFKmtLc%3D
    • Gilbert RJ, McKeon RJ, Darr A, Calabro A, Hascall VC, Bellamkonda RV. CS-4,6 is differentially upregulated in glial scar and is a potent inhibitor of neurite extension. Mol Cell Neurosci 2005;29:545-558.
    • (2005) Mol Cell Neurosci , vol.29 , pp. 545-558
    • Gilbert, R.J.1    McKeon, R.J.2    Darr, A.3    Calabro, A.4    Hascall, V.C.5    Bellamkonda, R.V.6
  • 94
    • 0029826713 scopus 로고    scopus 로고
    • Chondroitin sulfate proteoglycan and tenascin in the wounded adult mouse neostriatum in vitro: dopamine neuron attachment and process outgrowth
    • COI: 1:CAS:528:DyaK28Xns1Sisrg%3D
    • Gates MA, Fillmore H, Steindler DA. Chondroitin sulfate proteoglycan and tenascin in the wounded adult mouse neostriatum in vitro: dopamine neuron attachment and process outgrowth. J Neurosci 1996;16:8005-8018.
    • (1996) J Neurosci , vol.16 , pp. 8005-8018
    • Gates, M.A.1    Fillmore, H.2    Steindler, D.A.3
  • 95
    • 3042798646 scopus 로고    scopus 로고
    • Dual-gene, dual-cell type therapy against an excitotoxic insult by bolstering neuroenergetics
    • COI: 1:CAS:528:DC%2BD2cXlvFKrur8%3D
    • Bliss TM, Ip M, Cheng E, et al. Dual-gene, dual-cell type therapy against an excitotoxic insult by bolstering neuroenergetics. J Neurosci 2004;24:6202-6208.
    • (2004) J Neurosci , vol.24 , pp. 6202-6208
    • Bliss, T.M.1    Ip, M.2    Cheng, E.3
  • 96
    • 51349122248 scopus 로고    scopus 로고
    • Modulation of astrocytic metabolic phenotype by proinflammatory cytokines
    • Gavillet M, Allaman I, Magistretti PJ. Modulation of astrocytic metabolic phenotype by proinflammatory cytokines. Glia 2008;56:975-989.
    • (2008) Glia , vol.56 , pp. 975-989
    • Gavillet, M.1    Allaman, I.2    Magistretti, P.J.3
  • 97
    • 84877940219 scopus 로고    scopus 로고
    • Multiple sclerosis and glutamate excitotoxicity
    • COI: 1:CAS:528:DC%2BC2cXms1ChtLc%3D
    • Kostic M, Zivkovic N, Stojanovic I. Multiple sclerosis and glutamate excitotoxicity. Rev in Neurosci 2013;24:71-88.
    • (2013) Rev in Neurosci , vol.24 , pp. 71-88
    • Kostic, M.1    Zivkovic, N.2    Stojanovic, I.3
  • 98
    • 34547435817 scopus 로고    scopus 로고
    • Neuroinflammation and regulation of glial glutamate uptake in neurological disorders
    • COI: 1:CAS:528:DC%2BD2sXovFanurc%3D
    • Tilleux S, Hermans E. Neuroinflammation and regulation of glial glutamate uptake in neurological disorders. J Neurosci Res 2007;85:2059-2070.
    • (2007) J Neurosci Res , vol.85 , pp. 2059-2070
    • Tilleux, S.1    Hermans, E.2
  • 100
    • 42549107361 scopus 로고    scopus 로고
    • The inflammatory cytokine, interleukin-1 beta, mediates loss of astroglial glutamate transport and drives excitotoxic motor neuron injury in the spinal cord during acute viral encephalomyelitis
    • COI: 1:CAS:528:DC%2BD1cXmsVOlsLw%3D
    • Prow NA, Irani DN. The inflammatory cytokine, interleukin-1 beta, mediates loss of astroglial glutamate transport and drives excitotoxic motor neuron injury in the spinal cord during acute viral encephalomyelitis. J Neurochem 2008;105:1276-1286.
    • (2008) J Neurochem , vol.105 , pp. 1276-1286
    • Prow, N.A.1    Irani, D.N.2
  • 101
    • 0036662772 scopus 로고    scopus 로고
    • Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures
    • COI: 1:CAS:528:DC%2BD38XltF2msbw%3D
    • Besong G, Battaglia G, D'Onofrio M, et al. Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. J Neurosci 2002;22:5403-5411.
    • (2002) J Neurosci , vol.22 , pp. 5403-5411
    • Besong, G.1    Battaglia, G.2    D'Onofrio, M.3
  • 102
    • 0034960228 scopus 로고    scopus 로고
    • CXCR4-activated astrocyte glutamate release via TNFalpha: amplification by microglia triggers neurotoxicity
    • COI: 1:CAS:528:DC%2BD3MXltVSrsb4%3D
    • Bezzi P, Domercq M, Brambilla L, et al. CXCR4-activated astrocyte glutamate release via TNFalpha: amplification by microglia triggers neurotoxicity. Nat Neurosci 2001;4:702-710.
    • (2001) Nat Neurosci , vol.4 , pp. 702-710
    • Bezzi, P.1    Domercq, M.2    Brambilla, L.3
  • 103
    • 20344366326 scopus 로고    scopus 로고
    • Astrocytes in cerebral ischemic injury: morphological and general considerations
    • Panickar KS, Norenberg MD. Astrocytes in cerebral ischemic injury: morphological and general considerations. Glia 2005;50:287-298.
    • (2005) Glia , vol.50 , pp. 287-298
    • Panickar, K.S.1    Norenberg, M.D.2
  • 104
    • 36549071601 scopus 로고    scopus 로고
    • Innate and adaptive immunity during epileptogenesis and spontaneous seizures: evidence from experimental models and human temporal lobe epilepsy
    • COI: 1:CAS:528:DC%2BD2sXhsVSnsL7I
    • Ravizza T, Gagliardi B, Noe F, Boer K, Aronica E, Vezzani A. Innate and adaptive immunity during epileptogenesis and spontaneous seizures: evidence from experimental models and human temporal lobe epilepsy. Neurobiol Dis 2008;29:142-160.
    • (2008) Neurobiol Dis , vol.29 , pp. 142-160
    • Ravizza, T.1    Gagliardi, B.2    Noe, F.3    Boer, K.4    Aronica, E.5    Vezzani, A.6
  • 105
    • 0037131063 scopus 로고    scopus 로고
    • Inflammatory reactions in human medial temporal lobe epilepsy with hippocampal sclerosis
    • COI: 1:CAS:528:DC%2BD38Xns1ahsLs%3D
    • Crespel A, Coubes P, Rousset MC, et al. Inflammatory reactions in human medial temporal lobe epilepsy with hippocampal sclerosis. Brain Res 2002;952:159-169.
    • (2002) Brain Res , vol.952 , pp. 159-169
    • Crespel, A.1    Coubes, P.2    Rousset, M.C.3
  • 106
    • 67650546999 scopus 로고    scopus 로고
    • The pannexin 1 channel activates the inflammasome in neurons and astrocytes
    • COI: 1:CAS:528:DC%2BD1MXnslegt7s%3D
    • Silverman WR, de Rivero Vaccari JP, et al. The pannexin 1 channel activates the inflammasome in neurons and astrocytes. J Biol Chem 2009;284:18143-18151.
    • (2009) J Biol Chem , vol.284 , pp. 18143-18151
    • Silverman, W.R.1    de Rivero Vaccari, J.P.2
  • 107
    • 84879577117 scopus 로고    scopus 로고
    • Human astrocytes express a novel NLRP2 inflammasome
    • Minkiewicz J, de Rivero Vaccari JP, Keane RW. Human astrocytes express a novel NLRP2 inflammasome. Glia 2013;61:1113-1121.
    • (2013) Glia , vol.61 , pp. 1113-1121
    • Minkiewicz, J.1    de Rivero Vaccari, J.P.2    Keane, R.W.3
  • 108
    • 84885959981 scopus 로고    scopus 로고
    • FOXO3a involvement in the release of TNF-alpha stimulated by ATP in spinal cord astrocytes
    • COI: 1:CAS:528:DC%2BC3sXhtFaju7vN
    • Xia M, Zhu Y. FOXO3a involvement in the release of TNF-alpha stimulated by ATP in spinal cord astrocytes. J Mol Neurosci 2013;51:792-804.
    • (2013) J Mol Neurosci , vol.51 , pp. 792-804
    • Xia, M.1    Zhu, Y.2
  • 109
    • 0035884937 scopus 로고    scopus 로고
    • P2X7-like receptor activation in astrocytes increases chemokine monocyte chemoattractant protein-1 expression via mitogen-activated protein kinase
    • COI: 1:CAS:528:DC%2BD3MXmvFWhtbY%3D
    • Panenka W, Jijon H, Herx LM, et al. P2X7-like receptor activation in astrocytes increases chemokine monocyte chemoattractant protein-1 expression via mitogen-activated protein kinase. J Neurosci 2001;21:7135-7142.
    • (2001) J Neurosci , vol.21 , pp. 7135-7142
    • Panenka, W.1    Jijon, H.2    Herx, L.M.3
  • 110
    • 84856384517 scopus 로고    scopus 로고
    • Microglia activation triggers astrocyte-mediated modulation of excitatory neurotransmission
    • COI: 1:CAS:528:DC%2BC38Xis1yrtLw%3D
    • Pascual O, Ben Achour S, Rostaing P, Triller A, Bessis A. Microglia activation triggers astrocyte-mediated modulation of excitatory neurotransmission. Proc Natl Acad Sci U S A 2012;109:E197-E205.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. E197-E205
    • Pascual, O.1    Ben Achour, S.2    Rostaing, P.3    Triller, A.4    Bessis, A.5
  • 111
    • 65549130913 scopus 로고    scopus 로고
    • Temporal and spatial dynamics of cerebral immune cell accumulation in stroke
    • Gelderblom M, Leypoldt F, Steinbach K, et al. Temporal and spatial dynamics of cerebral immune cell accumulation in stroke. Stroke 2009;40:1849-1857.
    • (2009) Stroke , vol.40 , pp. 1849-1857
    • Gelderblom, M.1    Leypoldt, F.2    Steinbach, K.3
  • 112
    • 84876784407 scopus 로고    scopus 로고
    • Innate immunity in the CNS: redefining the relationship between the CNS and Its environment
    • COI: 1:CAS:528:DC%2BC3sXmsFCltLY%3D
    • Lampron A, Elali A, Rivest S. Innate immunity in the CNS: redefining the relationship between the CNS and Its environment. Neuron 2013;78:214-232.
    • (2013) Neuron , vol.78 , pp. 214-232
    • Lampron, A.1    Elali, A.2    Rivest, S.3
  • 113
    • 84922363034 scopus 로고    scopus 로고
    • B-Lymphocyte mediated delayed cognitive impairment following stroke
    • COI: 1:CAS:528:DC%2BC2MXpvFGlsLc%3D
    • Doyle KP, Quach L, Solé M, et al. B-Lymphocyte mediated delayed cognitive impairment following stroke. J Neurosci 2015;35:2133-2145.
    • (2015) J Neurosci , vol.35 , pp. 2133-2145
    • Doyle, K.P.1    Quach, L.2    Solé, M.3
  • 114
    • 84866364390 scopus 로고    scopus 로고
    • The anatomical and cellular basis of immune surveillance in the central nervous system
    • COI: 1:CAS:528:DC%2BC38Xht1Wkt7fN
    • Ransohoff RM, Engelhardt B. The anatomical and cellular basis of immune surveillance in the central nervous system. Nat Rev Immunol 2012;12:623-635.
    • (2012) Nat Rev Immunol , vol.12 , pp. 623-635
    • Ransohoff, R.M.1    Engelhardt, B.2
  • 115
    • 84859716425 scopus 로고    scopus 로고
    • The adaptive immune system in diseases of the central nervous system
    • COI: 1:CAS:528:DC%2BC38Xlt1egtL4%3D
    • Wraith DC, Nicholson LB. The adaptive immune system in diseases of the central nervous system. J Clin Invest 2012;122:1172-1179.
    • (2012) J Clin Invest , vol.122 , pp. 1172-1179
    • Wraith, D.C.1    Nicholson, L.B.2
  • 116
    • 84863857952 scopus 로고    scopus 로고
    • Central nervous system: a modified immune surveillance circuit?
    • COI: 1:CAS:528:DC%2BC38XhtVCltb%2FI
    • Romo-Gonzalez T, Chavarria A, Perez HJ. Central nervous system: a modified immune surveillance circuit? Brain Behav Immun 2012;26:823-829.
    • (2012) Brain Behav Immun , vol.26 , pp. 823-829
    • Romo-Gonzalez, T.1    Chavarria, A.2    Perez, H.J.3
  • 117
    • 84862752109 scopus 로고    scopus 로고
    • An autoimmunity odyssey: how autoreactive T cells infiltrate into the CNS
    • Kawakami N, Bartholomaus I, Pesic M, Mues M. An autoimmunity odyssey: how autoreactive T cells infiltrate into the CNS. Immunol Rev 2012;248:140-155.
    • (2012) Immunol Rev , vol.248 , pp. 140-155
    • Kawakami, N.1    Bartholomaus, I.2    Pesic, M.3    Mues, M.4
  • 118
    • 80555149758 scopus 로고    scopus 로고
    • Innate-adaptive crosstalk: how dendritic cells shape immune responses in the CNS
    • COI: 1:CAS:528:DC%2BC38Xhs1GrtLnN
    • Clarkson BD, Heninger E, Harris MG, Lee J, Sandor M, Fabry Z. Innate-adaptive crosstalk: how dendritic cells shape immune responses in the CNS. Adv Exp Med Biol 2012;946:309-333.
    • (2012) Adv Exp Med Biol , vol.946 , pp. 309-333
    • Clarkson, B.D.1    Heninger, E.2    Harris, M.G.3    Lee, J.4    Sandor, M.5    Fabry, Z.6
  • 120
    • 0037085719 scopus 로고    scopus 로고
    • Expression of fractalkine (CX3CL1) and its receptor, CX3CR1, during acute and chronic inflammation in the rodent CNS
    • Hughes PM, Botham MS, Frentzel S, Mir A, Perry VH. Expression of fractalkine (CX3CL1) and its receptor, CX3CR1, during acute and chronic inflammation in the rodent CNS. Glia 2002;37:314-327.
    • (2002) Glia , vol.37 , pp. 314-327
    • Hughes, P.M.1    Botham, M.S.2    Frentzel, S.3    Mir, A.4    Perry, V.H.5
  • 121
    • 84982840449 scopus 로고    scopus 로고
    • Kim E, Cho S. Microglia and monocyte-derived macrophages in stroke. Neurotherapeutics 2016 Aug 2 [Epub ahead of print].
    • Kim E, Cho S. Microglia and monocyte-derived macrophages in stroke. Neurotherapeutics 2016 Aug 2 [Epub ahead of print].
  • 122
    • 84941314571 scopus 로고    scopus 로고
    • Complexity of the cell-cell interactions in the innate immune response after cerebral ischemia
    • COI: 1:CAS:528:DC%2BC2MXot1Wgurc%3D
    • Cuartero MI, Ballesteros I, Lizasoain I, Moro MA. Complexity of the cell-cell interactions in the innate immune response after cerebral ischemia. Brain Res 2015;1623:53-62.
    • (2015) Brain Res , vol.1623 , pp. 53-62
    • Cuartero, M.I.1    Ballesteros, I.2    Lizasoain, I.3    Moro, M.A.4
  • 123
    • 70350558453 scopus 로고    scopus 로고
    • Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord
    • COI: 1:CAS:528:DC%2BD1MXhsVSmtrnJ
    • Kigerl KA, Gensel JC, Ankeny DP, Alexander JK, Donnelly DJ, Popovich PG. Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord. J Neurosci 2009;29:13435-13444.
    • (2009) J Neurosci , vol.29 , pp. 13435-13444
    • Kigerl, K.A.1    Gensel, J.C.2    Ankeny, D.P.3    Alexander, J.K.4    Donnelly, D.J.5    Popovich, P.G.6
  • 124
    • 77956012154 scopus 로고    scopus 로고
    • Nitric oxide and neuronal death
    • COI: 1:CAS:528:DC%2BC3cXhtVKgsrnP
    • Brown GC. Nitric oxide and neuronal death. Nitric oxide 2010;23:153-165.
    • (2010) Nitric oxide , vol.23 , pp. 153-165
    • Brown, G.C.1
  • 125
    • 80052561392 scopus 로고    scopus 로고
    • Microglial cells contribute to endogenous brain defenses after acute neonatal focal stroke
    • COI: 1:CAS:528:DC%2BC3MXhtFOhtrrI
    • Faustino JV, Wang X, Johnson CE, et al. Microglial cells contribute to endogenous brain defenses after acute neonatal focal stroke. J Neurosci 2011;31:12992-13001.
    • (2011) J Neurosci , vol.31 , pp. 12992-13001
    • Faustino, J.V.1    Wang, X.2    Johnson, C.E.3
  • 127
    • 0032519925 scopus 로고    scopus 로고
    • Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-b, PGE2, and PAF
    • COI: 1:CAS:528:DyaK1cXht1Wrt70%3D
    • Fadok VA, Bratton DL, Konowal A, Freed PW, Westcott JY, Henson PM. Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-b, PGE2, and PAF. J Clin Invest 1998;101:890-898.
    • (1998) J Clin Invest , vol.101 , pp. 890-898
    • Fadok, V.A.1    Bratton, D.L.2    Konowal, A.3    Freed, P.W.4    Westcott, J.Y.5    Henson, P.M.6
  • 128
    • 67650485985 scopus 로고    scopus 로고
    • Alternative activation of macrophages: an immunologic functional perspective
    • COI: 1:CAS:528:DC%2BD1MXlsFSltrk%3D
    • Martinez FO, Helming L, Gordon S. Alternative activation of macrophages: an immunologic functional perspective. Annu Rev Immunol 2009;27:451-483.
    • (2009) Annu Rev Immunol , vol.27 , pp. 451-483
    • Martinez, F.O.1    Helming, L.2    Gordon, S.3
  • 129
    • 79959999864 scopus 로고    scopus 로고
    • Increased brain injury and worsened neurological outcome in interleukin-4 knockout mice after transient focal cerebral ischemia
    • Xiong X, Barreto GE, Xu L, Ouyang YB, Xie X, Giffard RG. Increased brain injury and worsened neurological outcome in interleukin-4 knockout mice after transient focal cerebral ischemia. Stroke 2011;42:2026-2032.
    • (2011) Stroke , vol.42 , pp. 2026-2032
    • Xiong, X.1    Barreto, G.E.2    Xu, L.3    Ouyang, Y.B.4    Xie, X.5    Giffard, R.G.6
  • 130
    • 0032584685 scopus 로고    scopus 로고
    • IL-10 reduces rat brain injury following focal stroke
    • COI: 1:CAS:528:DyaK1cXkslyltbk%3D
    • Spera PA, Ellison JA, Feuerstein GZ, Barone FC. IL-10 reduces rat brain injury following focal stroke. Neurosci Lett 1998;251:189-192.
    • (1998) Neurosci Lett , vol.251 , pp. 189-192
    • Spera, P.A.1    Ellison, J.A.2    Feuerstein, G.Z.3    Barone, F.C.4
  • 131
    • 17544366612 scopus 로고    scopus 로고
    • A transforming growth factor-beta antagonist unmasks the neuroprotective role of this endogenous cytokine in excitotoxic and ischemic brain injury
    • COI: 1:CAS:528:DC%2BD3cXks1Snu74%3D
    • Ruocco A, Nicole O, Docagne F, et al. A transforming growth factor-beta antagonist unmasks the neuroprotective role of this endogenous cytokine in excitotoxic and ischemic brain injury. J Cereb Blood Flow Metab 1999;19:1345-1353.
    • (1999) J Cereb Blood Flow Metab , vol.19 , pp. 1345-1353
    • Ruocco, A.1    Nicole, O.2    Docagne, F.3
  • 132
    • 26844536306 scopus 로고    scopus 로고
    • Astrocytes as antigen-presenting cells: expression of IL-12/IL-23
    • COI: 1:CAS:528:DC%2BD2MXhtFegu7vM
    • Constantinescu CS, Tani M, Ransohoff RM, et al. Astrocytes as antigen-presenting cells: expression of IL-12/IL-23. J Neurochem 2005;95:331-340.
    • (2005) J Neurochem , vol.95 , pp. 331-340
    • Constantinescu, C.S.1    Tani, M.2    Ransohoff, R.M.3
  • 133
    • 65049084189 scopus 로고    scopus 로고
    • Tumor-associated macrophages and the related myeloid-derived suppressor cells as a paradigm of the diversity of macrophage activation
    • COI: 1:CAS:528:DC%2BD1MXltVCrtLw%3D
    • Mantovani A, Sica A, Allavena P, Garlanda C, Locati M. Tumor-associated macrophages and the related myeloid-derived suppressor cells as a paradigm of the diversity of macrophage activation. Hum Immunol 2009;70:325-330.
    • (2009) Hum Immunol , vol.70 , pp. 325-330
    • Mantovani, A.1    Sica, A.2    Allavena, P.3    Garlanda, C.4    Locati, M.5
  • 134
    • 77749242648 scopus 로고    scopus 로고
    • Brucella abortus induces the secretion of proinflammatory mediators from glial cells leading to astrocyte apoptosis
    • Garcia Samartino C, Delpino MV, Pott Godoy C, et al. Brucella abortus induces the secretion of proinflammatory mediators from glial cells leading to astrocyte apoptosis. Am J Pathol 2010;176:1323-1338.
    • (2010) Am J Pathol , vol.176 , pp. 1323-1338
    • Garcia Samartino, C.1    Delpino, M.V.2    Pott Godoy, C.3
  • 135
    • 30344446249 scopus 로고    scopus 로고
    • Chemokines in multiple sclerosis: CXCL12 and CXCL13 up-regulation is differentially linked to CNS immune cell recruitment
    • Krumbholz M, Theil D, Cepok S, et al. Chemokines in multiple sclerosis: CXCL12 and CXCL13 up-regulation is differentially linked to CNS immune cell recruitment. Brain 2006;129:200-211.
    • (2006) Brain , vol.129 , pp. 200-211
    • Krumbholz, M.1    Theil, D.2    Cepok, S.3
  • 136
    • 20244384231 scopus 로고    scopus 로고
    • BAFF is produced by astrocytes and up-regulated in multiple sclerosis lesions and primary central nervous system lymphoma
    • COI: 1:CAS:528:DC%2BD2MXot12msA%3D%3D
    • Krumbholz M, Theil D, Derfuss T, et al. BAFF is produced by astrocytes and up-regulated in multiple sclerosis lesions and primary central nervous system lymphoma. J Exp Med 2005;201:195-200.
    • (2005) J Exp Med , vol.201 , pp. 195-200
    • Krumbholz, M.1    Theil, D.2    Derfuss, T.3
  • 137
    • 67349216357 scopus 로고    scopus 로고
    • cell responses in the central nervous system
    • Goverman J. Autoimmune T cell responses in the central nervous system. Nat Rev Immunol 2009;9:393-407.
    • (2009) Nat Rev Immunol , vol.9 , pp. 393-407
    • Goverman, J.1    Autoimmune, T.2
  • 138
    • 84867586343 scopus 로고    scopus 로고
    • Inflammatory mediators alter the astrocyte transcriptome and calcium signaling elicited by multiple G-protein-coupled receptors
    • COI: 1:CAS:528:DC%2BC38XhsFKrsrjF
    • Hamby ME, Coppola G, Ao Y, Geschwind DH, Khakh BS, Sofroniew MV. Inflammatory mediators alter the astrocyte transcriptome and calcium signaling elicited by multiple G-protein-coupled receptors. J Neurosci 2012;32:14489-14510.
    • (2012) J Neurosci , vol.32 , pp. 14489-14510
    • Hamby, M.E.1    Coppola, G.2    Ao, Y.3    Geschwind, D.H.4    Khakh, B.S.5    Sofroniew, M.V.6
  • 139
    • 67650739168 scopus 로고    scopus 로고
    • Transcriptome profiling reveals TGF-beta signaling involvement in epileptogenesis
    • COI: 1:CAS:528:DC%2BD1MXovFegtbs%3D
    • Cacheaux LP, Ivens S, David Y, et al. Transcriptome profiling reveals TGF-beta signaling involvement in epileptogenesis. J Neurosci 2009;29:8927-8935.
    • (2009) J Neurosci , vol.29 , pp. 8927-8935
    • Cacheaux, L.P.1    Ivens, S.2    David, Y.3
  • 140
    • 0031656782 scopus 로고    scopus 로고
    • Late-onset chronic inflammatory encephalopathy in immune-competent and severe combined immune-deficient (SCID) mice with astrocyte-targeted expression of tumor necrosis factor
    • COI: 1:CAS:528:DyaK1cXmtFKnu78%3D
    • Stalder AK, Carson MJ, Pagenstecher A, et al. Late-onset chronic inflammatory encephalopathy in immune-competent and severe combined immune-deficient (SCID) mice with astrocyte-targeted expression of tumor necrosis factor. Am J Pathol 1998;153:767-783.
    • (1998) Am J Pathol , vol.153 , pp. 767-783
    • Stalder, A.K.1    Carson, M.J.2    Pagenstecher, A.3
  • 141
    • 0030639621 scopus 로고    scopus 로고
    • Astrocyte-specific but not neuron-specific transmembrane TNF triggers inflammation and degeneration in the central nervous system of transgenic mice
    • COI: 1:CAS:528:DyaK2sXhsVWguw%3D%3D
    • Akassoglou K, Probert L, Kontogeorgos G, Kollias G. Astrocyte-specific but not neuron-specific transmembrane TNF triggers inflammation and degeneration in the central nervous system of transgenic mice. J Immunol 1997;158:438-445.
    • (1997) J Immunol , vol.158 , pp. 438-445
    • Akassoglou, K.1    Probert, L.2    Kontogeorgos, G.3    Kollias, G.4
  • 142
    • 0036681779 scopus 로고    scopus 로고
    • Leukocyte infiltration, but not neurodegeneration, in the CNS of transgenic mice with astrocyte production of the CXC chemokine ligand 10
    • COI: 1:CAS:528:DC%2BD38XlslWht7Y%3D
    • Boztug K, Carson MJ, Pham-Mitchell N, Asensio VC, DeMartino J, Campbell IL. Leukocyte infiltration, but not neurodegeneration, in the CNS of transgenic mice with astrocyte production of the CXC chemokine ligand 10. J Immunol 2002;169:1505-1515.
    • (2002) J Immunol , vol.169 , pp. 1505-1515
    • Boztug, K.1    Carson, M.J.2    Pham-Mitchell, N.3    Asensio, V.C.4    DeMartino, J.5    Campbell, I.L.6
  • 143
    • 80054981620 scopus 로고    scopus 로고
    • Opposing roles for CXCR3 signaling in central nervous system versus ocular inflammation mediated by the astrocyte-targeted production of IL-12
    • COI: 1:CAS:528:DC%2BC3MXhsFCmu7rE
    • Krauthausen M, Ellis SL, Zimmermann J, et al. Opposing roles for CXCR3 signaling in central nervous system versus ocular inflammation mediated by the astrocyte-targeted production of IL-12. Am J Pathol 2011;179:2346-2359.
    • (2011) Am J Pathol , vol.179 , pp. 2346-2359
    • Krauthausen, M.1    Ellis, S.L.2    Zimmermann, J.3
  • 144
    • 84874549416 scopus 로고    scopus 로고
    • CNS-targeted production of IL-17A induces glial activation, microvascular pathology and enhances the neuroinflammatory response to systemic endotoxemia
    • COI: 1:CAS:528:DC%2BC3sXjvV2hur8%3D
    • Zimmermann J, Krauthausen M, Hofer MJ, Heneka MT, Campbell IL, Muller M. CNS-targeted production of IL-17A induces glial activation, microvascular pathology and enhances the neuroinflammatory response to systemic endotoxemia. PLoS One 2013;8:e57307.
    • (2013) PLoS One , vol.8
    • Zimmermann, J.1    Krauthausen, M.2    Hofer, M.J.3    Heneka, M.T.4    Campbell, I.L.5    Muller, M.6
  • 145
    • 79955636935 scopus 로고    scopus 로고
    • IL-17 receptor signaling and T helper 17-mediated autoimmune demyelinating disease
    • COI: 1:CAS:528:DC%2BC3MXlvVemur0%3D
    • Zepp J, Wu L, Li X. IL-17 receptor signaling and T helper 17-mediated autoimmune demyelinating disease. Trends Immunol 2011;32:232-239.
    • (2011) Trends Immunol , vol.32 , pp. 232-239
    • Zepp, J.1    Wu, L.2    Li, X.3
  • 146
    • 0141535180 scopus 로고    scopus 로고
    • Interleukin-1beta enhances NMDA receptor-mediated intracellular calcium increase through activation of the Src family of kinases
    • COI: 1:CAS:528:DC%2BD3sXnvVWmu74%3D
    • Viviani B, Bartesaghi S, Gardoni F, et al. Interleukin-1beta enhances NMDA receptor-mediated intracellular calcium increase through activation of the Src family of kinases. J Neurosci 2003;23:8692-8700.
    • (2003) J Neurosci , vol.23 , pp. 8692-8700
    • Viviani, B.1    Bartesaghi, S.2    Gardoni, F.3
  • 147
    • 0035130526 scopus 로고    scopus 로고
    • Reduction of inflammatory response in the mouse brain with adenoviral-mediated transforming growth factor- 1 expression
    • COI: 1:CAS:528:DC%2BD3MXhtlymsb4%3D
    • Pang L, Ye W, Che XM, Roessler BJ, Betz AL, Yang GY. Reduction of inflammatory response in the mouse brain with adenoviral-mediated transforming growth factor- 1 expression. Stroke 2001;32:544-552.
    • (2001) Stroke , vol.32 , pp. 544-552
    • Pang, L.1    Ye, W.2    Che, X.M.3    Roessler, B.J.4    Betz, A.L.5    Yang, G.Y.6
  • 148
    • 33750591957 scopus 로고    scopus 로고
    • Deficiency in neuronal TGF-beta signaling promotes neurodegeneration and Alzheimer's pathology
    • COI: 1:CAS:528:DC%2BD28XhtFyrsb7P
    • Tesseur I, Zou K, Esposito L, et al. Deficiency in neuronal TGF-beta signaling promotes neurodegeneration and Alzheimer's pathology. J Clin Invest 2006;116:3060-3069.
    • (2006) J Clin Invest , vol.116 , pp. 3060-3069
    • Tesseur, I.1    Zou, K.2    Esposito, L.3
  • 149
    • 0030914438 scopus 로고    scopus 로고
    • Impaired resistance to the development of toxoplasmic encephalitis in interleukin-6-deficient mice
    • COI: 1:CAS:528:DyaK2sXjsFWntbg%3D
    • Suzuki Y, Rani S, Liesenfeld O, et al. Impaired resistance to the development of toxoplasmic encephalitis in interleukin-6-deficient mice. Infect Immun 1997;65:2339-2345.
    • (1997) Infect Immun , vol.65 , pp. 2339-2345
    • Suzuki, Y.1    Rani, S.2    Liesenfeld, O.3
  • 150
    • 84857091100 scopus 로고    scopus 로고
    • Interferon-gamma- and perforin-mediated immune responses for resistance against Toxoplasma gondii in the brain
    • Suzuki Y, Sa Q, Gehman M, Ochiai E. Interferon-gamma- and perforin-mediated immune responses for resistance against Toxoplasma gondii in the brain. Expert Rev Mol Med 2011;13:e31.
    • (2011) Expert Rev Mol Med , vol.13
    • Suzuki, Y.1    Sa, Q.2    Gehman, M.3    Ochiai, E.4
  • 151
    • 0037452698 scopus 로고    scopus 로고
    • Insights into glutamate transport regulation in human astrocytes: cloning of the promoter for excitatory amino acid transporter 2 (EAAT2)
    • COI: 1:CAS:528:DC%2BD3sXhsFGrsL4%3D
    • Su ZZ, Leszczyniecka M, Kang DC, et al. Insights into glutamate transport regulation in human astrocytes: cloning of the promoter for excitatory amino acid transporter 2 (EAAT2). Proc Natl Acad Sci U S A 2003;100:1955-1960.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 1955-1960
    • Su, Z.Z.1    Leszczyniecka, M.2    Kang, D.C.3
  • 152
    • 27144441829 scopus 로고    scopus 로고
    • Differential promotion of glutamate transporter expression and function by glucocorticoids in astrocytes from various brain regions
    • COI: 1:CAS:528:DC%2BD2MXhtVyks7zJ
    • Zschocke J, Bayatti N, Clement AM, et al. Differential promotion of glutamate transporter expression and function by glucocorticoids in astrocytes from various brain regions. J Biol Chem 2005;280:34924-34932.
    • (2005) J Biol Chem , vol.280 , pp. 34924-34932
    • Zschocke, J.1    Bayatti, N.2    Clement, A.M.3
  • 153
    • 0030812843 scopus 로고    scopus 로고
    • Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1
    • COI: 1:CAS:528:DyaK2sXjvV2mtrk%3D
    • Tanaka K, Watase K, Manabe T, et al. Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1. Science 1997;276:1699-1702.
    • (1997) Science , vol.276 , pp. 1699-1702
    • Tanaka, K.1    Watase, K.2    Manabe, T.3
  • 154
    • 27744437016 scopus 로고    scopus 로고
    • Autoantigen specific T cells inhibit glutamate uptake in astrocytes by decreasing expression of astrocytic glutamate transporter GLAST: a mechanism mediated by tumor necrosis factor-alpha
    • COI: 1:CAS:528:DC%2BD2MXht1emsbnN
    • Korn T, Magnus T, Jung S. Autoantigen specific T cells inhibit glutamate uptake in astrocytes by decreasing expression of astrocytic glutamate transporter GLAST: a mechanism mediated by tumor necrosis factor-alpha. FASEB J 2005;19:1878-1880.
    • (2005) FASEB J , vol.19 , pp. 1878-1880
    • Korn, T.1    Magnus, T.2    Jung, S.3
  • 155
    • 0033945533 scopus 로고    scopus 로고
    • Human T-cell lymphotropic virus type 1-infected T lymphocytes impair catabolism and uptake of glutamate by astrocytes via Tax-1 and tumor necrosis factor alpha
    • COI: 1:CAS:528:DC%2BD3cXks1KmtbY%3D
    • Szymocha R, Akaoka H, Dutuit M, et al. Human T-cell lymphotropic virus type 1-infected T lymphocytes impair catabolism and uptake of glutamate by astrocytes via Tax-1 and tumor necrosis factor alpha. J Virol 2000;74:6433-6441.
    • (2000) J Virol , vol.74 , pp. 6433-6441
    • Szymocha, R.1    Akaoka, H.2    Dutuit, M.3
  • 156
    • 84892498884 scopus 로고    scopus 로고
    • Regulation of activity of P2X7 receptor by its splice variants in cultured mouse astrocytes
    • Kido Y, Kawahara C, Terai Y, et al. Regulation of activity of P2X7 receptor by its splice variants in cultured mouse astrocytes. Glia 2014;62:440-451.
    • (2014) Glia , vol.62 , pp. 440-451
    • Kido, Y.1    Kawahara, C.2    Terai, Y.3
  • 157
    • 33750473352 scopus 로고    scopus 로고
    • Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor
    • COI: 1:CAS:528:DC%2BD28XhtFChsrzM
    • Pelegrin P, Surprenant A. Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor. EMBO J 2006;25:5071-5082.
    • (2006) EMBO J , vol.25 , pp. 5071-5082
    • Pelegrin, P.1    Surprenant, A.2
  • 158
    • 0031731776 scopus 로고    scopus 로고
    • Evidence supporting the existence of an activity-dependent astrocyte-neuron lactate shuttle
    • COI: 1:CAS:528:DyaK1cXntl2lsLc%3D
    • Pellerin L, Pellegri G, Bittar PG, et al. Evidence supporting the existence of an activity-dependent astrocyte-neuron lactate shuttle. Develop Neurosci 1998;20:291-299.
    • (1998) Develop Neurosci , vol.20 , pp. 291-299
    • Pellerin, L.1    Pellegri, G.2    Bittar, P.G.3
  • 159
    • 82955168362 scopus 로고    scopus 로고
    • Brain energy metabolism: focus on astrocyte-neuron metabolic cooperation
    • COI: 1:CAS:528:DC%2BC3MXhs1SksbfI
    • Belanger M, Allaman I, Magistretti PJ. Brain energy metabolism: focus on astrocyte-neuron metabolic cooperation. Cell Metab 2011;14:724-738.
    • (2011) Cell Metab , vol.14 , pp. 724-738
    • Belanger, M.1    Allaman, I.2    Magistretti, P.J.3
  • 160
    • 0036362236 scopus 로고    scopus 로고
    • Thrombospondin-1 as an endogenous inhibitor of angiogenesis and tumor growth
    • COI: 1:CAS:528:DC%2BD38XksVCjt74%3D
    • Lawler J. Thrombospondin-1 as an endogenous inhibitor of angiogenesis and tumor growth. J Cell Mol Med 2002;6:1-12.
    • (2002) J Cell Mol Med , vol.6 , pp. 1-12
    • Lawler, J.1
  • 161
    • 0028073226 scopus 로고
    • Thrombospondin promotes chemotaxis and haptotaxis of human peripheral blood monocytes
    • Mansfield PJ, Suchard SJ. Thrombospondin promotes chemotaxis and haptotaxis of human peripheral blood monocytes. J Immunol 1994;153(9):4219–4229.
    • (1994) J Immunol , vol.153 , Issue.9 , pp. 4219-4229
    • Mansfield, P.J.1    Suchard, S.J.2
  • 162
    • 52549084801 scopus 로고    scopus 로고
    • Thrombospondins 1 and 2 are necessary for synaptic plasticity and functional recovery after stroke
    • Liauw J, Hoang S, Choi M, et al. Thrombospondins 1 and 2 are necessary for synaptic plasticity and functional recovery after stroke. J Cereb Blood Flow Metab 2008;28(10):1722–1732.
    • (2008) J Cereb Blood Flow Metab , vol.28 , Issue.10 , pp. 1722-1732
    • Liauw, J.1    Hoang, S.2    Choi, M.3
  • 163
    • 84940376898 scopus 로고    scopus 로고
    • SnapShot: Astrocytes in health and disease
    • COI: 1:CAS:528:DC%2BC2MXhsVensLfN
    • Liddelow S, Barres B. SnapShot: Astrocytes in health and disease. Cell 2015;162:1170- e1.
    • (2015) Cell , vol.162 , pp. 1170-1171
    • Liddelow, S.1    Barres, B.2
  • 164
    • 39849101009 scopus 로고    scopus 로고
    • Proteomic analysis of active multiple sclerosis lesions reveals therapeutic targets
    • COI: 1:CAS:528:DC%2BD1cXisFWjtrg%3D
    • Han MH, Hwang SI, Roy DB, et al. Proteomic analysis of active multiple sclerosis lesions reveals therapeutic targets. Nature 2008;451:1076-1081.
    • (2008) Nature , vol.451 , pp. 1076-1081
    • Han, M.H.1    Hwang, S.I.2    Roy, D.B.3
  • 165
    • 84865154517 scopus 로고    scopus 로고
    • A role for ephrin-A5 in axonal sprouting, recovery, and activity-dependent plasticity after stroke
    • COI: 1:CAS:528:DC%2BC38XhsVamt7rK
    • Overman JJ, Clarkson AN, Wanner IB, et al. A role for ephrin-A5 in axonal sprouting, recovery, and activity-dependent plasticity after stroke. Proc Natl Acad Sci U S A 2012;109:E2230-E2229.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. E2229-E2230
    • Overman, J.J.1    Clarkson, A.N.2    Wanner, I.B.3
  • 166
    • 84966658995 scopus 로고    scopus 로고
    • Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor
    • COI: 1:CAS:528:DC%2BC28XnsV2ksLg%3D
    • Rothhammer V, Mascanfroni ID, Bunse L, et al. Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor. Nat Med 2016;22:586-597.
    • (2016) Nat Med , vol.22 , pp. 586-597
    • Rothhammer, V.1    Mascanfroni, I.D.2    Bunse, L.3
  • 167
    • 84953709732 scopus 로고    scopus 로고
    • Purification and characterization of progenitor and mature human astrocytes reveals transcriptional and functional differences with mouse
    • COI: 1:CAS:528:DC%2BC2MXitVSksb%2FO
    • Zhang Y, Sloan SA, Clarke LE, et al. Purification and characterization of progenitor and mature human astrocytes reveals transcriptional and functional differences with mouse. Neuron 2016;89:37-53.
    • (2016) Neuron , vol.89 , pp. 37-53
    • Zhang, Y.1    Sloan, S.A.2    Clarke, L.E.3


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