Chemokines are differentially expressed by astrocytes, microglia and inflammatory leukocytes in Toxoplasma encephalitis and critically regulated by interferon-γ

Acta Neuropathologica

Volumn 103, Issue 5, 2002, Pages 458-468

  Strack, Andreas ^a   Asensio, Valérie C ^b   Campbell, Iain L ^b   Schlüter, Dirk ^c   Deckert, Martina ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Astrocyte; Chemokines; Encephalitis; Interferon ; Microglia; T cells

Indexed keywords

CHEMOKINE; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; MONOKINE; RANTES; RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BLOOD BRAIN BARRIER; CELL INVASION; CELL KINETICS; CONTROLLED STUDY; ENCEPHALITIS; FEMALE; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; INFLAMMATORY INFILTRATE; LEUKOCYTE; MACROPHAGE; MICROGLIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RIBONUCLEASE PROTECTION ASSAY; T LYMPHOCYTE; TOXOPLASMA GONDII; TOXOPLASMOSIS;

ANIMALS; ASTROCYTES; BRAIN; CHEMOKINE CCL2; CHEMOKINES; CHEMOKINES, CXC; ENCEPHALITIS; ENDOTHELIUM, VASCULAR; FEMALE; INTERFERON TYPE II; LEUKOCYTES; MACROPHAGE INFLAMMATORY PROTEIN-1; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; MICROGLIA; MONOKINES; NEUROGLIA; RANTES; RNA, MESSENGER; TOXOPLASMOSIS, ANIMAL;

EID: 0036942730     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00401-001-0491-7     Document Type: Article

References (63)

1. Amichay D, Gazzinelli RT, Karupiah G, Moench TR, Sher A, Farber JM (1996) Genes for chemokines MuMIG and CRG-2 are induced in protozoan and viral infections in response to IFN-gamma with patterns of tissue expression that suggest nonredundant roles in vivo. J Immunol 157:4511-4520
2. Asensio VC, Campbell IL (1997) Chemokine gene expression in the brains of mice with lymphocytic choriomeningitis. J Virol 71:7832-7840
3. Asensio VC, Campbell IL (1999) Chemokines in the CNS: plurifunctional mediators in diverse states. Trends Neurosci 22: 504-512
4. Asensio VC, Kincaid C, Campbell IL (1999) Chemokines and the inflammatory response to viral infection in the central nervous system with a focus on lymphocytic choriomeningitis virus. J Neurovirol 5:65-75
5. Baggiolini M (1998) Chemokines and leukocyte traffic. Nature 392:565-568
6. Baggiolini M, Dewald B, Moser B (1994) Interleukin-8 and related chemotactic cytokines-CXC and CC chemokines. Adv Immunol 55:97-179
7. Barna BP, Pettay J, Barnett GH, Zhou P, Iwasaki K, Estes ML (1994) Regulation of monocyte chemoattractant protein-1 expression in adult human non-neoplastic astrocytes is sensitive to tumor necrosis factor (TNF) or antibody to the 55-kDa TNF receptor. J Neuroimmunol 50:101-107
8. + myelin peptide-specific T cells: importance of IFN-inducible protein 10. J Immunol 160:444-448
9. Bliss SK, Marshall AJ, Zhang Y, Denkers EY (1999) Human polymorphonuclear leukocytes produce IL-12, TNF-alpha, and the chemokines macrophage-inflammatory protein-1 alpha and -1 beta in response to Toxoplasma gondii antigens. J Immunol 162:7369-7375
10. Bonecchi R, Bianchi G, Bordignon PP, D'Ambrosio D, Lang R, Borsatti A, Sozzani S, Allavena P, Gray PA, Mantovani A, Sinigaglia F (1998) Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s. J Exp Med 187:129-134
11. Carr MW, Alon R, Springer TA (1996) The C-C chemokine MCP-1 differentially modulates the avidity of beta 1 and beta 2 integrins on T lymphocytes. Immunity 4:179-187
12. Charles PC, Chen X, Horwitz MS, Brosnan CF (1999) Differential chemokine induction by the mouse adenovirus type-1 in the central nervous system of susceptible and resistant strains of mice. J Neurovirol 5:55-64
13. Deckert-Schlüter M, Schlüter D, Hof H, Wiestler OD, Lassmann H (1994) Differential expression of ICAM-1, VCAM-1 and their ligands LFA-1, Mac-1, CD43, VLA-4, and MHC class II antigens in murine Toxoplasma encephalitis: a light microscopic and ultrastructural immunohistochemical study. J Neuropathol Exp Neurol 53:457-468
14. Deckert-Schlüter M, Rang A, Weiner D, Huang S, Wiestler OD, Hof H, Schlüter D (1996) Interferon-gamma receptor-deficiency renders mice highly susceptible to toxoplasmosis by decreased macrophage activation. Lab Invest 75:827-841
15. Deckert-Schlüter M, Bluethmann H, Kaefer N, Rang A, Schlüter D (1999). Interferon-gamma receptor-mediated but not tumor necrosis factor receptor type 1- or type 2-mediated signaling is crucial for the activation of cerebral blood vessel endothelial cells and microglia in murine Toxoplasma encephalitis. Am J Pathol 154:1549-1561
16. Deckert-Schlüter M, Buck C, Schlüter D (1999) Kinetics and differential expression of heat-stable antigen and GL7 in the normal and Toxoplasma gondii-infected murine brain. Acta Neuropathol 98:97-106
17. Farber JM (1992) A collection of mRNA species that are inducible in the RAW 264.7 mouse macrophage cell line by gamma interferon and other agents. Mol Cell Biol 12:1535-1545
18. Farber JM (1993) HuMig: a new human member of the chemokine family of cytokines. Biochem Biophys Res Commun 192: 223-230
19. Fisher SN, Vanguri P, Shin HS, Shin ML (1995) Regulatory mechanisms of MuRantes and CRG-2 chemokine gene induction in central nervous system glial cells by virus. Brain Behav Immun 9:331-344
20. + T lymphocytes in IFN-gamma production and protective immunity induced by an attenuated Toxoplasma gondii vaccine. J Immunol 146:286-292
21. + T lymphocytes is required to reactivate chronic infection with Toxoplasma gondii. J Immunol 149:175-180
22. Glabinski AR, Tani M, Strieter RM, Tuohy VK, Ransohoff RM (1997) Synchronous synthesis of alpha- and beta-chemokines by cells of diverse lineage in the central nervous system of mice with relapses of chronic experimental autoimmune encephalomyelitis. Am J Pathol 150:617-630
23. Glabinski AR, Tuohy VK, Ransohoff RM (1998) Expression of chemokines RANTES, MIP-lalpha and GRO-alpha correlates with inflammation in acute experimental autoimmune encephalomyelitis. Neuroimmunomodulation 5:166-171
24. Guo H, Jin YX, Ishikawa M, Huang YM, van der Meide PH, Link H, Xiao BG (1998) Regulation of beta-chemokine mRNA expression in adult rat astrocytes by lipopolysaccharide, proinflammatory and immunoregulatory cytokines. Scand J Immunol 48:502-508
25. Hayashi M, Luo Y, Laning J, Strieter RM, Dorf ME (1995) Production and function of monocyte chemoattractant protein-1 and other beta-chemokines in murine glial cells. J Neuroimmunol 60:143-150
26. Hurwitz AA, Lyman WD, Berman JW (1995) Tumor necrosis factor alpha and transforming growth factor beta upregulate astrocyte expression of monocyte chemoattractant protein-1. J Neuroimmunol 57:193-198
27. Karpus WJ (1999) Chemokine regulation of inflammatory-mediated nervous system diseases. J Neurovirol 5:1-2
28. Karpus WJ, Lukacs NW, McRae BL, Strieter RM, Kunkel SL, Miller SD (1995) An important role for the chemokine macrophage inflammatory protein-1 alpha in the pathogenesis of the T cell-mediated autoimmune disease, experimental autoimmune encephalomyelitis. J Immunol 155:5003-5010
29. Karpus WJ, Lukacs NW, Kennedy KJ, Smith WS, Hurst SD, Barrett TA (1997) Differential CC chemokine-induced enhancement of T helper cell cytokine production. J Immunol 158:4129-4136
30. Khan IA, MacLean JA, Lec FS, Casciotti L, DeHaan E, Schwartzman JD, Luster AD (2000) IP-10 is crucial for effector T cell trafficking and host survival in Toxoplasma gondii infection. Immunity 12:483-494
31. Kopydlowski KM, Salkowski CA, Cody MJ, Rooijen N van, Major J, Hamilton TA, Vogel SN (1999) Regulation of macrophage chemokine expression by lipopolysaccharide in vitro and in vivo. J Immunol 163:1537-1544
32. Lane TE, Asensio VC, Yu N, Paoletti AD, Campbell IL, Buchmeier MJ (1998) Dynamic regulation of alpha- and beta-chemokine expression in the central nervous system during mouse hepatitis virus-induced demyelinating disease. J Immunol 160:970-978
33. Laudanna C, Campbell JJ, Butcher EC (1996) Role of Rho in chemoattractant-activated leukocyte adhesion through integrins. Science 271:981-983
34. Luster AD (1998) Chemokines - chemotactic cytokines that mediate inflammation. N Engl J Med 338:436-445
35. Luster AD, Unkeless JC, Ravetch JV (1985) Gamma-interferon transcriptionally regulates an early-response gene containing homology to platelet proteins. Nature 315:672-676
36. Moser B, Loetscher M, Piali L, Loetscher P (1998) Lymphocyte responses to chemokines. Int Rev Immunol 16:323-344
37. Murphy WJ, Tian ZG, Asai O, Rotter P, Heny M, Strieter RM, Kunkel SL, Longo DL, Taub DD (1996) Chemokines and T lymphocyte activation. II. Facilitation of human T cell trafficking in severe combined immunodeficiency mice. J Immunol 156:2104-2111
38. Oh JW, Schwiebert LM, Benveniste EN (1999) Cytokine regulation of CC and CXC chemokine expression by human astrocytes. J Neurovirol 5:82-94
39. Peterson PK, Hu S, Salak-Johnson J, Molitor TW, Chao CC (1997) Differential production of and migratory response to beta chemokines by human microglia and astrocytes. J Infect Dis 175:478-481
40. Piali L, Weber C, LaRosa G, Springer TA, Clark-Lewis I, Moser B (1998) The chemokine receptor CXCR3 mediates rapid and shear-resistant adhesion-induction of effector T lymphocytes by the chemokines IP10 and Mig. Eur J Immunol 28:961-972
41. Prieschl EE, Kulmburg, PA, Baumruker T (1995) The nomenclature of chemokines. Int Arch Allergy Immunol 107:475-483
42. Rajan AJ, Asensio VC, Campbell IL, Brosnan CF (2000) Experimental autoimmune encephalomyelitis in the SJL mouse: effect of gamma delta T cell depletion on chemokine and chemokine receptor expression in the central nervous system. J Immunol 164:2120-2130
43. Reichmann G, Villegas EN, Craig L, Peach R, Hunter CA (1999) The CD28/B7 interaction is not required for resistance to Toxoplasma gondii in the brain but contributes to the development of immunopathology. J Immunol 163:3354-3362
44. Sasseville VG, Smith MM, Mackay CR, Pauley DR, Mansfield KG, Ringler DJ, Lackner AA (1996) Chemokine expression in simian immunodeficiency virus-induced AIDS encephalitis. Am J Pathol 149:1459-1467
45. Schall TJ, Bacon K, Toy KJ, Goeddel DV (1990) Selective attraction of monocytes and T lymphocytes of the memory phenotype by cytokine RANTES. Nature 347:669-671
46. Schall TJ, Bacon K, Camp RD, Kaspari JW, Goeddel DV (1993) Human macrophage inflammatory protein alpha (MIP-1 alpha) and MIP-1 beta chemokines attract distinct populations of lymphocytes. J Exp Med 177:1821-1826
47. Scharton-Kersten TM, Wynn TA, Denkers EY, Bala S, Grunvald E, Hieny S, Gazzinelli RT, Sher A (1996) In the absence of endogenous IFN-gamma, mice develop unimpaired IL-12 responses to Taxoplasma gondii while failing to control acute infection. J Immunol 157:4045-4054
48. Schlüter D, Löhler J, Deckert M, Hof H, Schwendemann G (1991) Toxoplasma encephalitis of immunocompetent and nude mice: immunohistochemical characterisation of Toxoplasma antigen, infiltrates and major histocompatibility complex gene products. J Neuroimmunol 31:185-198
49. Schlüter D, Deckert-Schlüter M, Schwendemann G, Brunner H, Hof H (1993) Expression of major histocompatibility complex class II antigens and levels of interferon-gamma, tumour necrosis factor, and interleukin-6 in cerebrospinal fluid and serum in Toxoplasma gondii-infected SCID and immunocompetent C.B-17 mice. Immunology 78:430-435
50. Schlüter D. Kaefer N. Hof H, Wiestler OD, Deckert-Schlüter M (1997) Expression pattern and cellular origin of cytokines in the normal and Toxoplasma gondii-infected murine brain. Am J Pathol 150:1021-1035
51. Simpson JE, Newcombe J, Cuzner ML, Woodroofe MN (1998) Expression of monocyte chemoattractant protein-1 and other beta-chemokines by resident glia and inflammatory cells in multiple sclerosis lesions. J Neuroimmunol 84:238-249
52. Steffen BJ, Butcher EC, Engelhardt B (1994) Evidence for involvement of ICAM-1 and VCAM-1 in lymphocyte interaction with endothelium in experimental autoimmune encephalomyelitis in the central nervous system in the SJL/J mouse. Am J Pathol 145:189-201
53. Stein JV, Rot A, Luo Y, Narasimhaswamy M, Nakano H, Gunn MD, Matsuzawa A, Quackenbush EJ, Dorf ME, Adrian UH von (2000) The CC chemokine thymus-derived chemotactic agent 4 (TCA-4, secondary lymphoid tissue chemokine, 6Ckine, exodus-2) triggers lymphocyte function-associated antigen 1-mediated arrest of rolling T lymphocytes in peripheral lymph node high endothelial venules. J Exp Med 191:61-76
54. + T cells in mice. J Immunol 140:3943-3946
55. Suzuki Y, Orellana MA, Schreiber RD, Remington JS (1988) Interferon-gamma: the major mediator of resistance against Toxoplasma gondii. Science 240:516-518
56. Tani M, Glabinski AR, Tuohy VK, Stoler MH, Estes ML, Ransohoff RM (1996) In situ hybridization analysis of glial fibrillary acidic protein mRNA reveals evidence of biphasic astrocyte activation during acute experimental autoimmune encephalomyelitis. Am J Pathol 148:889-896
57. Tran EH, Prince EN, Owens T (2000) IFN-gamma shapes immune invasion of the central nervous system via regulation of chemokines. J Immunol 164:2759-2130
58. Uguccioni M, D'Apuzzo M, Loetscher M, Dewald B, Baggiolini M (1995) Actions of the chemotactic cytokines MCP-l, MCP-2, MCP-3, RANTES, MIP-1 alpha and MIP-1 beta on human monocytes. Eur J Immunol 25:64-68
59. Van Der Voorn P, Tekstra J, Beelen RH, Tensen CP, Van Der Valk P, De Groot CJ (1999) Expression of MCP-1 by reactive astrocytes in demyelinating multiple sclerosis lesions. Am J Pathol 154:45-51
60. Ward SG, Bacon K, Westwick J (1998) Chemokines and T lymphocytes: more than an attraction. Immunity 9: 1-11
61. Weiss JM, Downie SA, Lyman WD, Berman JW (1998) Astrocyte-derived monocyte-chemoattractant protein-1 directs the transmigration of leukocytes across a model of the human blood-brain barrier. J Immunol 161:6896-6903
62. Wong D, Prameya R, Dorovini-Zis K (1999) In vitro adhesion and migration of T lymphocytes across monolayers of human brain microvessel endothelial cells: regulation by ICAM-1, VCAM-1, E-selectin and PECAM-1. J Neuropathol Exp Neurol 58:138-152
63. Zlotnik A, Morales J, Hedrick JA (1999) Recent advances in chemokines and chemokine receptors. Crit Rev Immunol 19: 147