Leukocyte infiltration, but not neurodegeneration, in the CNS of transgenic mice with astrocyte production of the CXC chemokine ligand 10

Journal of Immunology

Volumn 169, Issue 3, 2002, Pages 1505-1515

  Boztug, Kaan ^a   Carson, Monica J ^a   Pham Mitchell, Ngan ^a   Asensio, Valérie C ^a   DeMartino, Julie ^a   Campbell, Iain L ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA CHEMOKINE; CD3 ANTIGEN; CHEMOKINE; CHEMOKINE RECEPTOR CXCR3; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GLIAL FIBRILLARY ACIDIC PROTEIN; PERTUSSIS TOXIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; ASTROCYTE; BRAIN REGION; CELL INFILTRATION; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOSE RESPONSE; GENE EXPRESSION; IMMUNIZATION; LEUKOCYTE; MOUSE; NERVE DEGENERATION; NEUTROPHIL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SPLEEN; TRANSGENE; TRANSGENIC MOUSE;

EID: 0036681779     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.169.3.1505     Document Type: Article

References (84)

1. γ-interferon transcriptionally regulates an early-response gene containing homology to platelet proteins
2. Biochemical characterization of a γ interferon-inducible cytokine (1P-10)
3. Identification of CRG-2: An interferon-inducible mRNA predicted to encode a murine monokine
4. Recombinant human-interferon inducible protein 10 is a chemoattractant for human monocytes and T lymphocytes and promotes T cell adhesion to endothelial cells
5. The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions
6. Chemokine receptor specific for 1P10 and Mig: Structure, function, and expression in activated T-lymphocytes
7. The interferon-inducible chemokines MuMig and Crg-2 exhibit antiviral activity in vivo
8. - CXC chemokines display defensin-like antimicrobial activity
9. Human interferon-inducible protein 10 is a potent inhibitor of angiogenesis in vivo
10. Interferon γ-inducible protein 10 (IP-10), a member of the C-X-C chemokine family, is an inhibitor of angiogenesis
11. The 1P-10 chemokine binds to a specific cell surface heparan sulfate site shared with platelet factor 4 and inhibits endothelial cell proliferation
12. Interferon-inducible protein-10 identified as a mediator of tumor necrosis in vivo
13. Inhibition of angiogenesis by interleukin-12 is mediated by the interferon-inducible protein 10
14. Human Mig chemokine: Biochemical and functional characterization
15. Interferon-inducible T cell α chemoattractant (1-TAC): A novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3
16. The CC chemokine 6Ckine binds the CXC chemokine receptor CXCR3
17. Cutting edge: Species specificity of the CC chemokine 6Ckine signaling through the CXC chemokine receptor CXCR3: Human 6Ckine is not a ligand for the human or mouse CXCR3 receptors
18. Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s
19. IP-10 is critical for effector T cell trafficking and host survival in Toxoplasma gondii infection
20. Requirement of the chemokine receptor CXCR3 for acute allograft rejection
21. A functional IFN-γinducible protein-10/CXCL10-specific receptor expressed by epithelial and endothelial cells that is neither CXCR3 nor glycosaminoglycan
22. Expression of the chemokine receptor CXCR3 on neurons and the elevated expression of its ligand 1P-10 in reactive astrocytes: In vitro ERK1/2 activation and role in Alzheimer's disease
23. Expression of specific chemokines and chemokine receptors in the central nervous system of multiple sclerosis patients
24. + T cells are increased in multiple sclerosis and their ligands MIP-1α and 1P-10 are expressed in demyelinating brain lesions
25. Identification of a T cell chemotactic factor in the cerebrospinal fluid of HIV-1 infected individuals as interferon-γ inducible protein 10
26. Chemokines and receptors in HIV encephalitis
27. Chemotactic activity on mononuclear cells in the cerebrospinal fluid of patients with viral meningitis is mediated by interferon-γ inducible protein-10 and monocyte chemotactic protein-1
28. Synchronous synthesis of α- and β-chemokines by cells of diverse lineage in the central nervous system of mice with relapses of chronic experimental autoimmune encephalomyelitis
29. Astrocyte expression of mRNA encoding cytokines 1P-10 and JE/MCP-1 in experimental autoimmune encephalomyelitis
30. Chemokine expression in murine experimental allergic encephalomyelitis
31. C10 is a novel chemokine expressed in experimental inflammatory demyelinating disorders that promotes the recruitment of macrophages to the central nervous system
32. Chemokine regulation of experimental autoimmune encephalomyelitis: Temporal and spatial expression patterns govern disease pathogenesis
33. Chemokine gene expression in the brain of mice with lymphocytic choriomeningitis
34. Chemokines and the inflammatory response to viral infection in the central nervous system with a focus on lymphocytic choriomeningitis virus
35. Dynamic regulation of α- and β-chemokine expression in the central nervous system during mouse hepatitis virus-induced demyelinating disease
36. Alterations in cytokine but not chemokine mRNA expression during three distinct Theiler's virus infections
37. Biphasic and regionally-restricted chemokine expression in the central nervous system in the Theiler's virus model of multiple sclerosis
38. Selective chemokine mRNA accumulation in the rat spinal cord after contusion injury
39. Prolonged expression of interferon-inducible protein-10 in ischemic cortex after permanent occlusion of the middle cerebral artery in rat
40. Chemical-induced hippocampal neurodegeneration and elevations in TNFα TNFβ, IL-1αIP-10, and MCP-1 mRNA in osteopetrotic (op/op) mice
41. Interferon-independent, human immunodeficiency virus-1-gp120-mediated induction of CXCL10/1P-10 gene expression by astrocytes in vivo and in vitro
42. Identification of upregulated genes in scrapie-infected brain tissue
43. + T cell accummulation in the central nervous system during experimental autoimmune encephalomyelitis
44. Neutralization of the chemokine CXCL10 reduces inflammatory call invasion and demyelination and improves neurological function in a viral model of multiple sclerosis
45. Cutting edge: The T cell chemoattractant IFN-inducible protein 10 is essential in host defense against viral-induced neurologic disease
46. Expression of Mig (monokine induced by interferon-γ) is important in T lymphocyte recruitment and host defense following viral infection of the central nervous system
47. Transgenic models to study the actions of cytokines in the central nervous system
48. Cytokine involvement in CNS disease: Implications from transgenic mice
49. Neurologic disease induced in transgenic mice by the cerebral overexpression of interleukin 6
50. Macrophage/microglial-mediated primary demyelination and motor disease induced by the central nervous system production of interleukin-3 in transgenic mice
51. Late-onset chronic inflammatory encephalopathy in immune-competent and severe combined immune-deficient (SCID) mice with astrocyte-targeted expression of tumor necrosis factor
52. Transgenic expression of IFN-α in the central nervous system of mice protects against lethal neurotropic viral infection but induces inflammation and neurodegeneration
53. + RNA
54. Simultaneous analysis of multiple cytokine receptor mRNAs by RNase protection assay in LPS-induced endotoxemia
55. + T cells from young and old mice
56. Astrocyte-targeted expression of IL-12 induces active cellular immune responses in the central nervous system and modulates experimental allergic encephalomyelitis
57. RNase protection assays for the simultaneous and semiquantitative analysis of multiple murine matrix metalloproteinase (MMP) and MMP inhibitor mRNAs
58. Reactive gliosis as a consequence of interleukin-6 expression in the brain: Studies in transgenic mice
59. Induction of type 1 immune pathology in the brain following immunization without central nervous system autoantigen in transgenic mice with astrocyte-targeted expression of IL-12
60. Normal adult ramified microglia separated from other central nervous system macrophages by flow cytometric sorting
61. Mature microglia resemble immature antigen-presenting cells
62. Structural and functional impact of the transgenic expression of cytokines in the CNS
63. Adjuvant-guided type-1 and type-2 immunity: Infectious/noninfectious dichotomy defines the class of response
64. IP-10, a γ-interferon-inducible protein related to interleukin-8, lacks neutrophil activating properties
65. Cytokine-mediated inflammation and signaling in the intact central nervous system
66. Delayed wound healing and disorganized neovascularization in transgenic mice expressing the 1P-10 chemokine
67. Ectopic expression of the murine chemokines CCL21a and CCL21b induces the formation of lymph node-like structures in pancreas, but not skin, of transgenic mice
68. Keratinocyte-derived monocyte chemoattractant protein (MCP-1): Analysis in a transgenic model demonstrates MCP-1 can recruit dendritic and Langerhans cells to skin
69. Transgenic monocyte chemoattractant protein-1 (MCP-1) in pancreatic islets produces monocyte-rich insulitis without diabetes
70. Controlled recruitment of monocytes and macrophages to specific organs through transgenic expression of monocyte chemoattractant protein-1
71. Neutrophil infiltration, glial reaction, and neurological disease in transgenic mice expressing the chemokine N51/KC in oligodendrocytes
72. Central nervous system inflammation and neurological disease in transgenic mice expressing the CC chemokine CCL21 in oligodendrocytes
73. Interactions of migrating T lymphocytes, inflammatory mediators, and the extracellular matrix
74. α and β chemokines induce NK cell migration and enhance NK-mediated cytolysis
75. Polymorphic expression of a neutrophil differentiation antigen revealed by monoclonal antibody 7/4
76. Antigen markers of macrophage differentiation in murine tissues
77. The enhanced antigen-specific production of cytokines induced by pertussis toxin is due to clonal expansion of T cells and not to altered effector functions of long-term memory cells
78. Neutrophil receptors for interleukin-8 and related CXC chemokines
79. CCL7 and CXCL10 orchestrate oxidative stress induced neutrophilic lung inflammation
80. Gene expression and production of the monokine induced by IFN-γ (M1G), 1FN-inducible T cell α chemoattractant (I-TAC), and 1FN-γ-inducible protein-10 (1P-10) chemokines by human neutrophils
81. Characterization and regulation of RB6-8C5 antigen expression on murine bone marrow cells
82. Regulation of glial fibrillary acidic protein (GFAP) expression in CNS development and in pathological states
83. Glial fibrillary acidic protein (GFA) in normal neural cells and in pathological conditions
84. Evolution of neuropathologic abnormalities associated with blood-brain barrier breakdown in transgenic mice expressing interleukin-6 in astrocytes