The intermediate filament GFAP is important for the control of experimental murine Staphylococcus aureus-induced brain abscess and Toxoplasma encephalitis

Journal of Neuropathology and Experimental Neurology

Volumn 63, Issue 6, 2004, Pages 631-640

  Stenzel, Werner ^a   Soltek, Sabine ^b   Schlüter, Dirk ^b   Deckert, Martina ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Astrocyte; Brain abscess; Encephalitis; Glial fibrillary acidic protein (GFAP); Staphylococcus aureus; Toxoplasma gondii

Indexed keywords

GLIAL FIBRILLARY ACIDIC PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BACTERIAL GROWTH; BRAIN ABSCESS; BRAIN EDEMA; BRAIN PROTECTION; BRAIN VENTRICULITIS; CELL ACTIVATION; CELL FUNCTION; CELL INFILTRATION; CENTRAL NERVOUS SYSTEM INFECTION; CONTROLLED STUDY; DISEASE COURSE; ENCEPHALITIS; FEMALE; HEMISPHERE; HOST RESISTANCE; INFLAMMATION; INTERMEDIATE FILAMENT; LEUKOCYTE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEIZURE; STAPHYLOCOCCUS AUREUS; TISSUE NECROSIS; TOXOPLASMA; VASCULITIS; WEIGHT REDUCTION;

EID: 2942538162     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1093/jnen/63.6.631     Document Type: Article

References (35)

1. Eng LF, Vanderhaeghen JJ, Bignami A, et al. An acidic protein isolated from fibrous astrocytes. Brain Res 1971;28:351-4
2. Eliasson C, Sahlgren C, Berthold CH, et al. Intermediate filament protein partnership in astrocytes. J Biol Chem 1999;274:23996-4006
3. Liour SS, Yu RK. Differentiation of radial glia-like cells from embryonic stem cells. Glia 2003;42:109-17
4. Khelfaoui M, Guimiot F, Simonneau M. Early neuronal and glial determination from mouse E10.5 telencephalon embryonic stem cells: An in vitro study. Neuroreport 2002;13:1209-14
5. McLendon RE, Bigner DD. Immunohistochemistry of the glial fibrillary acidic protein: Basic and applied considerations. Brain Pathol 1994;4:221-28
6. Inagaki M, Nakamura Y, Takeda M, et al. Glial fibrillary acidic protein: Dynamic property and regulation by phosphorylation. Brain Pathol 1994;4:239-43
7. Eng LF, Ghirnikar RS, Lee YL. Glial fibrillary acidic protein: GFAP-thirty-one years (1969-2000). Neurochem Res 2000;25:1439-51
8. Eng LF, Ghirnikar RS. GFAP and astrogliosis. Brain Pathol 1994;4:229-37
9. Mucke L, Oldstone MB, Morris JC, et al. Rapid activation of astrocyte-specific expression of GFAP-IacZ transgene by focal injury. New Biol 1991;3:465-74
10. Gomi H, Yokoyama T, Fujimoto K, et al. Mice devoid of the glial fibrillary acidic protein develop normally and are susceptible to scrapie prions. Neuron 1995;14:29-41
11. Itoyama Y, Sekizawa T, Openshaw H, et al. Early loss of astrocytes in herpes simplex virus-induced central nervous system demyelination. Ann Neurol 1991;29:285-92
12. Rinaman L, Card JP, Enquist LW. Spatiotemporal responses of astrocytes, ramified microglia, and brain macrophages to central neuronal infection with pseudorabies virus. J Neurosci 1993;13:685-702
13. Mucke L, Eddleston M. Astrocytes in infectious and immune-mediated diseases of the central nervous system. Faseb J 1993;7:1226-32
14. Pekny M, Leveen P, Pekna M, et al. Mice lacking glial fibrillary acidic protein display astrocytes devoid of intermediate filaments but develop and reproduce normally. Embo J 1995;14:1590-98
15. Liedtke W, Edelmann W, Bieri PL, et al. GFAP is necessary for the integrity of CNS white matter architecture and long-term maintenance of myelination. Neuron 1996;17:607-15
16. Flaris NA, Hickey WF. Development and characterization of an experimental model of brain abscess in the rat. Am J Pathol 1992;141:1299-307
17. Kielian T, Hickey WF. Proinflammatory cytokine, chemokine, and cellular adhesion molecule expression during the acute phase of experimental brain abscess development. Am J Pathol 2000;157:647-58
18. Schluter D, Lohler J, Deckert M, Hof H, Schwendemann G. Toxoplasma encephalitis of immunocompetent and nude mice: Immunohistochemical characterisation of Toxoplasma antigen, infiltrates and major histocompatibility complex gene products. J Neuroimmunol 1991;31:185-98
19. Kielian T, Barry B, Hickey WF. CXC chemokine receptor-2 ligands are required for neutrophil-mediated host defense in experimental brain abscesses. J Immunol 2001;166:4634-43
20. Yao L, Berman JW, Factor SM, et al. Correlation of histopathologic and bacteriologic changes with cytokine expression in an experimental murine model of bacteremic Staphylococcus aureus infection. Infect Immun 1997;65:3889-95
21. Remick DG, Strieter RM, Eskandari MK, et al. Role of tumor necrosis factor-alpha in lipopolysaccharide-induced pathologic alterations. Am J Pathol 1990;136:49-60
22. Rozalska B, Wadstrom T. Interferon-gamma, interleukin-1 and tumour necrosis factor-alpha synthesis during experimental murine staphylococcal infection. FEMS Immunol Med Microbiol 1993;7:145-52
23. Deckert-Schluter M, Schluter D, Theisen F, et al. Activation of the innate immune system in murine congenital Toxoplasma encephalitis. J Neuroimmunol 1994;53:47-51
24. Deckert M, Soltek S, Geginat G, et al. Endogenous interleukin-10 is required for prevention of a hyperinflammatory intracerebral immune response in Listeria monocytogenes meningoencephalitis. Infect Immun 2001;69:4561-71
25. Deckert-Schluter M, Schluter D, Hof H, et al. Differential expression of ICAM-1, VCAM-1 and their ligands LFA-1, Mac-1, CD43, VLA-4, and MHC class II antigens in murine Toxoplasma encephalitis: A light microscopic and ultrastructural immunohistochemical study. J Neuropathol Exp Neurol 1994;53:457-68
26. Horvitz MS, Evans CF, Klier FG, et al. Detailed in vivo analysis of interferon-gamma induced major histocompatibility complex expression in the central nervous system: Astrocytes fail to express major histocompatibility complex class I and class II. Lab Invest 1999;79:235-42
27. Matsumoto Y, Ohmori K, Fujiwara M. Immune regulation by brain cells in the central nervous system: Microglia but not astrocytes present myelin basic protein to encephalitogenic T cells under in vivo mimicking conditions. Immunology 1992;76:209-16
28. Liedtke W, Edelmann W, Chiu FC, et al. Experimental autoimmune encephalomyelitis in mice lacking glial fibrillary acidic protein is characterized by a more severe clinical course and an infiltrative central nervous system lesion. Am J Pathol 1998;152:251-59
29. Lepekhin EA, Eliasson C, Berthold CH, et al. Intermediate filaments regulate astrocyte motility. J Neurochem 2001;79:617-25
30. Gimenez YRM, Langa F, Menet V, et al. Comparative anatomy of the cerebellar cortex in mice lacking vimentin, GFAP, and both vimentin and GFAP. Glia 2000;31:69-83
31. Pekny M, Eliasson C, Chien CL, et al. GFAP-deficient astrocytes are capable of stellation in vitro when cocultured with neurons and exhibit a reduced amount of intermediate filaments and an increased cell saturation density. Exp Cell Res 1998;239:332-43
32. Pekny M, Stanness KA, Eliasson C, et al. Impaired induction of blood-brain barrier properties in aortic endothelial cells by astrocytes from GFAP-deficient mice. Glia 1998;22:390-400
33. Yao D, Kuwajima M, Kido H. Pathologic mechanisms of influenza encephalitis with an abnormal expression of inflammatory cytokines and accumulation of mini-plasmin. J Med Invest 2003;50:1-8
34. Pekny M, Johansson CB, Eliasson C, et al. Abnormal reaction to central nervous system injury in mice lacking glial fibrillary acidic protein and vimentin. J Cell Biol 1999;145:503-14
35. Nawashiro H, Messing A, Azzam N, et al. Mice lacking GFAP are hypersensitive to traumatic cerebrospinal injury. Neuroreport 1998;9:1691-96