Synthesis, in vitro evaluation and molecular docking studies of novel triazine-triazole derivatives as potential α-glucosidase inhibitors

European Journal of Medicinal Chemistry

Volumn 125, Issue , 2017, Pages 423-429

  Wang, Guangcheng ^a   Peng, Zhiyun ^a   Wang, Jing ^a   Li, Xin ^a   Li, Juan ^a  

^a JISHOU UNIVERSITY   (China)

Author keywords

1,2,3 Triazole; 1,2,4 Triazine; Click chemistry; Molecular docking; Glucosidase inhibitor

Indexed keywords

2 [4 [[(5,6 DIPHENYL 1,2,4 TRIAZIN 3 YL)THIO]METHYL] 1H 1,2,3 TRIAZOL 1 YL) N [3 (TRIFLUOROMETHYL)PHENYL]ACETAMIDE; 2 [4 [[(5,6 DIPHENYL 1,2,4 TRIAZIN 3 YL)THIO]METHYL] 1H 1,2,3 TRIAZOL 1 YL] N (2 ETHOXYPHENYL)ACETAMIDE; 2 [4 [[(5,6 DIPHENYL 1,2,4 TRIAZIN 3 YL)THIO]METHYL] 1H 1,2,3 TRIAZOL 1 YL] N (4 ETHOXYPHENYL)ACETAMIDE; 2 [4 [[(5,6 DIPHENYL 1,2,4 TRIAZIN 3 YL)THIO]METHYL] 1H 1,2,3 TRIAZOL 1 YL] N (4 METHOXYPHENYL)ACETAMIDE; 2 [4 [[(5,6 DIPHENYL 1,2,4 TRIAZIN 3 YL)THIO]METHYL] 1H 1,2,3 TRIAZOL 1 YL] N (M TOLYL)ACETAMIDE; 2 [4 [[(5,6 DIPHENYL 1,2,4 TRIAZIN 3 YL)THIO]METHYL] 1H 1,2,3 TRIAZOL 1 YL] N (O TOLYL)ACETAMIDE; 2 [4 [[(5,6 DIPHENYL 1,2,4 TRIAZIN 3 YL)THIO]METHYL] 1H 1,2,3 TRIAZOL 1 YL] N (P TOLYL)ACETAMIDE; 2 [4 [[(5,6 DIPHENYL 1,2,4 TRIAZIN 3 YL)THIO]METHYL] 1H 1,2,3 TRIAZOL 1 YL] N PHENYLACETAMIDE; 2 [4 [[(5,6 DIPHENYL 1,2,4TRIAZIN 3 YL)THIO]METHYL] 1H 1,2,3 TRIAZOL1 YL] N (4 FLUOROPHENYL)ACETAMIDE; ACARBOSE; ALPHA GLUCOSIDASE INHIBITOR; N (2,4 DICHLOROPHENYL) 2 [4 [[(5,6 DIPHENYL 1,2,4 TRIAZIN 3 YL)THIO]METHYL] 1H 1,2,3 TRIAZOL 1 YL]ACETAMIDE; N (2,4 DIMETHYLPHENYL) 2 [4 [[(5,6 DIPHENYL 1,2,4 TRIAZIN 3 YL)THIO]METHYL] 1H 1,2,3 TRIAZOL 1 YL]ACETAMIDE; N (2,5 DICHLOROPHENYL) 2 [4 [[(5,6 DIPHENYL 1,2,4 TRIAZIN 3 YL)THIO]METHYL] 1H 1,2,3 TRIAZOL 1 YL]ACETAMIDE; N (4 CHLOROPHENYL) 2 [4 [[(5,6 DIPHENYL 1,2,4 TRIAZIN 3 YL)THIO]METHYL] 1H 1,2,3 TRIAZOL 1 YL]ACETAMIDE; OLIGO 1,6 GLUCOSIDASE; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; ALPHA GLUCOSIDASE; ANTIDIABETIC AGENT; GLYCOSIDASE INHIBITOR; TRIAZINE DERIVATIVE;

ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ASSAY; ENZYME INHIBITION; ENZYME STRUCTURE; HYDROGEN BOND; IC50; MOLECULAR DOCKING; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; SACCHAROMYCES CEREVISIAE; STRUCTURE ACTIVITY RELATION; CHEMISTRY; CLICK CHEMISTRY; HUMAN; METABOLISM; SYNTHESIS;

ALPHA-GLUCOSIDASES; CLICK CHEMISTRY; DRUG DESIGN; GLYCOSIDE HYDROLASE INHIBITORS; HUMANS; HYPOGLYCEMIC AGENTS; MOLECULAR DOCKING SIMULATION; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZINES; TRIAZOLES;

EID: 84988699887     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2016.09.067     Document Type: Article

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