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Volumn 16, Issue 13, 2015, Pages 1959-1981

Therapeutic potential of α-glucosidase inhibitors in type 2 diabetes mellitus: An evidence-based review

Author keywords

acarbose; cardiovascular disease; diabetes mellitus; miglitol; postprandial hyperglycemia; type 2; voglibose; glucosidase inhibitors

Indexed keywords

ACARBOSE; ALPHA GLUCOSIDASE INHIBITOR; GLUCOSE; INCRETIN; INSULIN; ANTIDIABETIC AGENT; GLUCOSE BLOOD LEVEL; GLYCOSIDASE INHIBITOR;

EID: 84939807380     PISSN: 14656566     EISSN: 17447666     Source Type: Journal    
DOI: 10.1517/14656566.2015.1070827     Document Type: Review
Times cited : (264)

References (194)
  • 1
    • 0034641568 scopus 로고    scopus 로고
    • Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (ukpds 35): Prospective observational study
    • Stratton IM, Adler AI, Neil HA, et al. Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study. BMJ 2000; 321: 405-12
    • (2000) BMJ , vol.321 , pp. 405-412
    • Stratton, I.M.1    Adler, A.I.2    Neil, H.A.3
  • 2
    • 75549085658 scopus 로고    scopus 로고
    • Target for glycemic control: Concentrating on glucose
    • Monnier L, Colette C. Target for glycemic control: concentrating on glucose. Diabetes Care 2009; 32 (Suppl 2): S199-204
    • (2009) Diabetes Care , vol.32 , pp. 199-204
    • Monnier, L.1    Colette, C.2
  • 3
    • 0042166232 scopus 로고    scopus 로고
    • Contributions of fasting and postprandial plasma glucose increments to the overall diurnal hyperglycemia of type 2 diabetic patients: Variations with increasing levels of hba(1c)
    • Monnier L, Lapinski H, Colette C. Contributions of fasting and postprandial plasma glucose increments to the overall diurnal hyperglycemia of type 2 diabetic patients: variations with increasing levels of HbA(1c). Diabetes Care 2003; 26: 881-5
    • (2003) Diabetes Care , vol.26 , pp. 881-885
    • Monnier, L.1    Lapinski, H.2    Colette, C.3
  • 4
    • 78649912825 scopus 로고    scopus 로고
    • Cardiovascular disease mortality in europeans in relation to fasting and 2-h plasma glucose levels within a normoglycemic range
    • DECODE Study Group
    • Ning F, Tuomilehto J, Pyörälä K, et al. DECODE Study Group. Cardiovascular disease mortality in Europeans in relation to fasting and 2-h plasma glucose levels within a normoglycemic range. Diabetes Care 2010; 33: 2211-16
    • (2010) Diabetes Care , vol.33 , pp. 2211-2216
    • Ning, F.1    Tuomilehto, J.2    Pyörälä, K.3
  • 5
    • 0035847591 scopus 로고    scopus 로고
    • Glucose tolerance and cardiovascular mortality: Comparison of fasting and 2-hour diagnostic criteria
    • DECODE Study Group; the European Diabetes Epidemiology Group
    • DECODE Study Group; the European Diabetes Epidemiology Group. Glucose tolerance and cardiovascular mortality: comparison of fasting and 2-hour diagnostic criteria. Arch Intern Med 2001; 161: 397-405
    • (2001) Arch Intern Med , vol.161 , pp. 397-405
  • 6
    • 0034893909 scopus 로고    scopus 로고
    • Acute hyperglycemia induces an oxidative stress in healthy subjects
    • Marfella R, Quagliaro L, Nappo F, et al. Acute hyperglycemia induces an oxidative stress in healthy subjects. J Clin Invest 2001; 108: 635-6
    • (2001) J Clin Invest , vol.108 , pp. 635-636
    • Marfella, R.1    Quagliaro, L.2    Nappo, F.3
  • 7
    • 0033165758 scopus 로고    scopus 로고
    • Hyperglycemia rapidly suppresses flow-mediated endothelium-dependent vasodilation of brachial artery
    • Kawano H, Motoyama T, Hirashima O, et al. Hyperglycemia rapidly suppresses flow-mediated endothelium-dependent vasodilation of brachial artery. J Am Coll Cardiol 1999; 34: 146-54
    • (1999) J Am Coll Cardiol , vol.34 , pp. 146-154
    • Kawano, H.1    Motoyama, T.2    Hirashima, O.3
  • 8
    • 0037109184 scopus 로고    scopus 로고
    • Inflammatory cytokine concentrations are acutely increased by hyperglycemia in humans: Role of oxidative stress
    • Esposito K, Nappo F, Marfella R, et al. Inflammatory cytokine concentrations are acutely increased by hyperglycemia in humans: role of oxidative stress. Circulation 2002; 106: 2067-72
    • (2002) Circulation , vol.106 , pp. 2067-2072
    • Esposito, K.1    Nappo, F.2    Marfella, R.3
  • 9
    • 66749181130 scopus 로고    scopus 로고
    • Postprandial hyperglycemia as an etiological factor in vascular failure
    • Node K, Inoue T. Postprandial hyperglycemia as an etiological factor in vascular failure. Cardiovasc Diabetol 2009; 8: 23
    • (2009) Cardiovasc Diabetol , vol.8 , pp. 23
    • Node, K.1    Inoue, T.2
  • 10
    • 43149105882 scopus 로고    scopus 로고
    • International Diabetes Federation. Available from [Last accessed on 05 March 2015]
    • International Diabetes Federation. Guideline for management of postmeal Glucose. 2011. Available from: http://www.idf.org/sites/default/files/postmeal%20glucose%20guidelines.pdf. [Last accessed on 05 March 2015]
    • (2011) Guideline for Management of Postmeal Glucose
  • 11
    • 84892649479 scopus 로고    scopus 로고
    • Standards of medical care in diabetes-2014
    • American Diabetes Association
    • American Diabetes Association. Standards of medical care in diabetes-2014. Diabetes Care 2014; 37 (Suppl 1): S14-80
    • (2014) Diabetes Care , vol.37 , pp. 14-80
  • 12
    • 0029907571 scopus 로고    scopus 로고
    • Source and amount of carbohydrate affect postprandial glucose and insulin in normal subjects
    • Wolever TM, Bolognesi C. Source and amount of carbohydrate affect postprandial glucose and insulin in normal subjects. J Nutr 1996; 126: 2798-806
    • (1996) J Nutr , vol.126 , pp. 2798-2806
    • Wolever, T.M.1    Bolognesi, C.2
  • 13
    • 78651249826 scopus 로고    scopus 로고
    • Post-prandial carbohydrate modulation via gut-indian perspective
    • Joshi SR. Post-prandial Carbohydrate Modulation via Gut-Indian Perspective. J Assoc Physicians India 2010; 58: 665
    • (2010) J Assoc Physicians India , vol.58 , pp. 665
    • Joshi, S.R.1
  • 14
    • 84861097936 scopus 로고    scopus 로고
    • Transcultural diabetes nutrition therapy algorithm: The asian indian application
    • Joshi SR, Mohan V, Joshi SS, et al. Transcultural diabetes nutrition therapy algorithm: the Asian Indian application. Curr Diab Rep 2012; 12: 204-12
    • (2012) Curr Diab Rep , vol.12 , pp. 204-212
    • Joshi, S.R.1    Mohan, V.2    Joshi, S.S.3
  • 15
    • 84911439416 scopus 로고    scopus 로고
    • Results from a dietary survey in an indian T2DM population: A starch study
    • Joshi SR, Bhansali A, Bajaj S, et al. Results from a dietary survey in an Indian T2DM population: a STARCH study. BMJ Open 2014; 4: e005138
    • (2014) BMJ Open , vol.4 , pp. 005138
    • Joshi, S.R.1    Bhansali, A.2    Bajaj, S.3
  • 16
    • 36849034866 scopus 로고    scopus 로고
    • Pre-diabetes, dysglycaemia and early glucose intolerance and vascular health
    • Joshi SR, Karne R. Pre-diabetes, dysglycaemia and early glucose intolerance and vascular health. J Assoc Physicians India 2007; 55: 829-31
    • (2007) J Assoc Physicians India , vol.55 , pp. 829-831
    • Joshi, S.R.1    Karne, R.2
  • 17
    • 84904189466 scopus 로고    scopus 로고
    • Acarbose improves glycemic control as add-on or monotherapy in indian type-2 diabetes: Findings from the glucovip multinational observational study
    • Philip E, Sundaram ML, Das R, et al. Acarbose improves glycemic control as add-on or monotherapy in Indian type-2 diabetes: Findings from the GlucoVIP multinational observational study. Indian J Endocrinol Metab 2013; 17 (Suppl 3): S674-9
    • (2013) Indian J Endocrinol Metab , vol.17 , pp. 674-679
    • Philip, E.1    Sundaram, M.L.2    Das, R.3
  • 18
    • 0042354826 scopus 로고    scopus 로고
    • Age-And sex-specific prevalences of diabetes and impaired glucose regulation in 13 european cohorts
    • DECODE Study Group
    • DECODE Study Group. Age-And sex-specific prevalences of diabetes and impaired glucose regulation in 13 European cohorts. Diabetes Care 2003; 26: 61-9
    • (2003) Diabetes Care , vol.26 , pp. 61-69
  • 19
    • 0041668137 scopus 로고    scopus 로고
    • Age-And sex-specific prevalence of diabetes and impaired glucose regulation in 11 asian cohorts
    • DECODA Study Group
    • Qiao Q, Hu G, Tuomilehto J, et al. DECODA Study Group. Age-And sex-specific prevalence of diabetes and impaired glucose regulation in 11 Asian cohorts. Diabetes Care 2003; 26: 1770-80
    • (2003) Diabetes Care , vol.26 , pp. 1770-1780
    • Qiao, Q.1    Hu, G.2    Tuomilehto, J.3
  • 20
    • 0036228590 scopus 로고    scopus 로고
    • Complications and cardiovascular risk factors in south asians and europeans with early-onset type 2 diabetes
    • Chowdhury TA, Lasker SS. Complications and cardiovascular risk factors in South Asians and Europeans with early-onset type 2 diabetes. QJM 2002; 95: 241-6
    • (2002) QJM , vol.95 , pp. 241-246
    • Chowdhury, T.A.1    Lasker, S.S.2
  • 21
    • 84875641584 scopus 로고    scopus 로고
    • Type 2 diabetes in east asians: Similarities and differences with populations in europe and the United States
    • Ma RC, Chan JC. Type 2 diabetes in East Asians: similarities and differences with populations in Europe and the United States. Ann N Y Acad Sci 2013; 1281: 64-91
    • (2013) Ann n y Acad Sci , vol.1281 , pp. 64-91
    • Ma, R.C.1    Chan, J.C.2
  • 22
    • 34547905810 scopus 로고    scopus 로고
    • Visceral adipose tissue accumulation differs according to ethnic background: Results of the multicultural community health assessment trial (m-chat)
    • Lear SA, Humphries KH, Kohli S, et al. Visceral adipose tissue accumulation differs according to ethnic background: results of the Multicultural Community Health Assessment Trial (M-CHAT). Am J Clin Nutr 2007; 86: 353-9
    • (2007) Am J Clin Nutr , vol.86 , pp. 353-359
    • Lear, S.A.1    Humphries, K.H.2    Kohli, S.3
  • 23
    • 80051986265 scopus 로고    scopus 로고
    • Globalization of diabetes: The role of diet, lifestyle, and genes
    • Hu FB. Globalization of diabetes: the role of diet, lifestyle, and genes. Diabetes Care 2011; 34: 1249-57
    • (2011) Diabetes Care , vol.34 , pp. 1249-1257
    • Hu, F.B.1
  • 25
    • 0036712540 scopus 로고    scopus 로고
    • Postprandial hyperglycemia and insulin sensitivity differ among lean young adults of different ethnicities
    • Dickinson S, Colagiuri S, Faramus E, et al. Postprandial hyperglycemia and insulin sensitivity differ among lean young adults of different ethnicities. J Nutr 2002; 132: 2574-9
    • (2002) J Nutr , vol.132 , pp. 2574-2579
    • Dickinson, S.1    Colagiuri, S.2    Faramus, E.3
  • 26
    • 66149131064 scopus 로고    scopus 로고
    • Diabetes in Asia: Epidemiology, risk factors, and pathophysiology
    • Chan JC, Malik V, Jia W, et al. Diabetes in Asia: epidemiology, risk factors, and pathophysiology. JAMA 2009; 301: 2129-40
    • (2009) JAMA , vol.301 , pp. 2129-2140
    • Chan, J.C.1    Malik, V.2    Jia, W.3
  • 27
    • 0038681585 scopus 로고    scopus 로고
    • Lean, nondiabetic asian indians have decreased insulin sensitivity and insulin clearance, and raised leptin compared to caucasians and Chinese subjects
    • Liew CF, Seah ES, Yeo KP, et al. Lean, nondiabetic Asian Indians have decreased insulin sensitivity and insulin clearance, and raised leptin compared to Caucasians and Chinese subjects. Int J Obes Relat Metab Disord 2003; 27: 784-9
    • (2003) Int J Obes Relat Metab Disord , vol.27 , pp. 784-789
    • Liew, C.F.1    Seah, E.S.2    Yeo, K.P.3
  • 28
    • 0033609485 scopus 로고    scopus 로고
    • Cardiovascular and cancer mortality among canadians of european, south asian and Chinese origin from 1979 to 1993: An analysis of 1.2 million deaths
    • Sheth T, Nair C, Nargundkar M, et al. Cardiovascular and cancer mortality among Canadians of European, south Asian and Chinese origin from 1979 to 1993: an analysis of 1.2 million deaths. CMAJ 1999; 161: 132-8
    • (1999) CMAJ , vol.161 , pp. 132-138
    • Sheth, T.1    Nair, C.2    Nargundkar, M.3
  • 29
    • 33746458945 scopus 로고    scopus 로고
    • South-Asian type 2 diabetic patients have higher incidence and faster progression of renal disease compared with Dutch-european diabetic patients
    • Chandie Shaw PK, Baboe F, van Es LA, et al. South-Asian type 2 diabetic patients have higher incidence and faster progression of renal disease compared with Dutch-European diabetic patients. Diabetes Care 2006; 29: 1383-5
    • (2006) Diabetes Care , vol.29 , pp. 1383-1385
    • Chandie Shaw, P.K.1    Baboe, F.2    Van Es, L.A.3
  • 30
    • 84866268783 scopus 로고    scopus 로고
    • Management of hyperglycemia in type 2 diabetes: A patient-centered approach: Position statement of the American diabetes association (ada) and the european association for the study of diabetes (easd)
    • American Diabetes Association (ADA);European Association for the Study of Diabetes (EASD).
    • Inzucchi SE, Bergenstal RM, Buse JB, et al. American Diabetes Association (ADA);European Association for the Study of Diabetes (EASD). Management of hyperglycemia in type 2 diabetes: a patient-centered approach: position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care 2012; 35: 1364-79
    • (2012) Diabetes Care , vol.35 , pp. 1364-1379
    • Inzucchi, S.E.1    Bergenstal, R.M.2    Buse, J.B.3
  • 31
    • 53749085064 scopus 로고    scopus 로고
    • Incretin-based therapies in type 2 diabetes mellitus
    • Chia CW, Egan JM. Incretin-based therapies in type 2 diabetes mellitus. J Clin Endocrinol Metab 2008; 93: 3703-16
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 3703-3716
    • Chia, C.W.1    Egan, J.M.2
  • 32
    • 0033578476 scopus 로고    scopus 로고
    • Pharmacologic therapy for type 2 diabetes mellitus
    • DeFronzo RA. Pharmacologic therapy for type 2 diabetes mellitus. Ann Intern Med 1999; 131: 281-303
    • (1999) Ann Intern Med , vol.131 , pp. 281-303
    • DeFronzo, R.A.1
  • 33
    • 84928108305 scopus 로고    scopus 로고
    • Continual evolution of type 2 diabetes: An update on pathophysiology and emerging treatment options
    • Cornell S. Continual evolution of type 2 diabetes: an update on pathophysiology and emerging treatment options. Ther Clin Risk Manag 2015; 11: 621-32
    • (2015) Ther Clin Risk Manag , vol.11 , pp. 621-632
    • Cornell, S.1
  • 34
    • 84890171908 scopus 로고    scopus 로고
    • Acarbose compared with metformin as initial therapy in patients with newly diagnosed type 2 diabetes: An open-label, non-inferiority randomized trial
    • Yang W, Liu J, Shan Z, et al. Acarbose compared with metformin as initial therapy in patients with newly diagnosed type 2 diabetes: an open-label, non-inferiority randomized trial. Lancet Diabetes Endocrinol 2014; 2: 46-55
    • (2014) Lancet Diabetes Endocrinol , vol.2 , pp. 46-55
    • Yang, W.1    Liu, J.2    Shan, Z.3
  • 35
    • 84929308131 scopus 로고    scopus 로고
    • International Diabetes Federation, Clinical Guidelines Task Force. Available from [Last accessed 18 Mar 2015]
    • International Diabetes Federation, Clinical Guidelines Task Force. Global Guideline for Type 2 Diabetes-2012. 2012. Available from: http://www.idf.org/sites/default/files/IDF%20T2DM%20Guideline.pdf. [Last accessed 18 Mar 2015]
    • (2012) Global Guideline for Type 2 Diabetes-2012
  • 36
    • 84882276623 scopus 로고    scopus 로고
    • Aace comprehensive diabetes management algorithm 2013
    • American Association of Clinical Endocrinologists
    • Garber AJ, Abrahamson MJ, Barzilay JI, et al. American Association of Clinical Endocrinologists. AACE comprehensive diabetes management algorithm 2013. Endocr Pract 2013; 19: 327-36
    • (2013) Endocr Pract , vol.19 , pp. 327-336
    • Garber, A.J.1    Abrahamson, M.J.2    Barzilay, J.I.3
  • 37
    • 84917737231 scopus 로고    scopus 로고
    • China guideline for type 2 diabetes
    • Chinese Diabetes Society
    • Chinese Diabetes Society. China guideline for type 2 diabetes. Chin J Dia 2010 (Suppl 2): 1-56
    • (2010) Chin J Dia , pp. 1-56
  • 38
    • 84861970240 scopus 로고    scopus 로고
    • 2011 clinical practice guidelines for type 2 diabetes in korea
    • Committee of Clinical Practice Guidelines, Korean Diabetes Association
    • Ko SH, Kim SR, Kim DJ, et al. Committee of Clinical Practice Guidelines, Korean Diabetes Association. 2011 clinical practice guidelines for type 2 diabetes in Korea. Diabetes Metab J 2011; 35: 431-6
    • (2011) Diabetes Metab J , vol.35 , pp. 431-436
    • Ko, S.H.1    Kim, S.R.2    Kim, D.J.3
  • 39
    • 84939786714 scopus 로고    scopus 로고
    • Japan Diabetes Society. Available from [Last accessed 18 March 2015]
    • Japan Diabetes Society. Treatment guideline for diabetes. 2012-2013. Available from: http://www.jds.or.jp/common/fckeditor/editor/filemanager/connectors/php/transfer.php?file=/uid000025-54726561746D656E745F47756964655F666F725F44696162657465735F323031322D323031332E706466. [Last accessed 18 March 2015]
    • (2012) Treatment Guideline for Diabetes
  • 41
    • 79957995294 scopus 로고    scopus 로고
    • Addressing the burden of type 2 diabetes and cardiovascular disease through the management of postprandial hyperglycaemia: An asian-pacific perspective and expert recommendations
    • Sheu WH, Rosman A, Mithal A, et al. Addressing the burden of type 2 diabetes and cardiovascular disease through the management of postprandial hyperglycaemia: an Asian-Pacific perspective and expert recommendations. Diabetes Res Clin Pract 2011; 92: 312-21
    • (2011) Diabetes Res Clin Pract , vol.92 , pp. 312-321
    • Sheu, W.H.1    Rosman, A.2    Mithal, A.3
  • 42
    • 84855418089 scopus 로고    scopus 로고
    • API-ICP Guidelines on Diabetes 2007
    • API-ICP Guidelines on Diabetes 2007. J Assoc Physicians India 2007; 55: 1-50
    • (2007) J Assoc Physicians India , vol.55 , pp. 1-50
  • 43
    • 77953046644 scopus 로고    scopus 로고
    • Costs and consequences associated with newer medications for glycemic control in type 2 diabetes
    • Sinha A, Rajan M, Hoerger T, et al. Costs and consequences associated with newer medications for glycemic control in type 2 diabetes. Diabetes Care 2010; 33 (4): 695-700
    • (2010) Diabetes Care , vol.33 , Issue.4 , pp. 695-700
    • Sinha, A.1    Rajan, M.2    Hoerger, T.3
  • 44
    • 84906969392 scopus 로고    scopus 로고
    • Alpha-glucosidase inhibitors
    • In: Goldstein BJ, Mueller-Wieland D, editors. 2nd edition. CRC press, Boca Raton, FL, USA; p.
    • Hanefeld M. Alpha-glucosidase inhibitors. In: Goldstein BJ, Mueller-Wieland D.,. editors. Alpha-glucosidase inhibitors: principles and practice. 2nd edition. CRC press, Boca Raton, FL, USA; 2007. p. 121-34
    • (2007) Alpha-glucosidase Inhibitors: Principles and Practice , pp. 121-134
    • Hanefeld, M.1
  • 45
    • 84922683718 scopus 로고    scopus 로고
    • Efficacy of acarbose in different geographical regions of the world: Analysis of a real-life database
    • Weng J, Soegondo S, Schnell O, et al. Efficacy of acarbose in different geographical regions of the world: analysis of a real-life database. Diabetes Metab Res Rev 2015; 31 (2): 155-67
    • (2015) Diabetes Metab Res Rev , vol.31 , Issue.2 , pp. 155-167
    • Weng, J.1    Soegondo, S.2    Schnell, O.3
  • 46
    • 84939801094 scopus 로고    scopus 로고
    • Available from [Last accessed 05 March 2015]
    • Precose 2011. Available from: http://www.accessdata.fda.gov/drugsatfda-docs/label/2011/020482s024lbl.pdf. [Last accessed 05 March 2015]
    • (2011) Precose
  • 47
    • 0000008612 scopus 로고    scopus 로고
    • Pharmacology of glucosidase inhibitors
    • Puls W. Pharmacology of glucosidase inhibitors. Oral Antidiabetics 1996; 119: 497-525
    • (1996) Oral Antidiabetics , vol.119 , pp. 497-525
    • Puls, W.1
  • 49
    • 33644851838 scopus 로고    scopus 로고
    • Voglibose (basen, ao-128), one of the most important alpha-glucosidase inhibitors
    • Chen X, Zheng Y, Shen Y. Voglibose (Basen, AO-128), one of the most important alpha-glucosidase inhibitors. Curr Med Chem 2006; 13: 109-16
    • (2006) Curr Med Chem , vol.13 , pp. 109-116
    • Chen, X.1    Zheng, Y.2    Shen, Y.3
  • 50
    • 84995426667 scopus 로고    scopus 로고
    • Untapped diamonds for untamed diabetes: The alpha-glucosidase inhibitors
    • Kalra S, Chadha M, Sharma SK, et al. Untapped diamonds for untamed diabetes: The alpha-glucosidase inhibitors. Indian J Endocrinol Metab 2014; 18: 138-41
    • (2014) Indian J Endocrinol Metab , vol.18 , pp. 138-141
    • Kalra, S.1    Chadha, M.2    Sharma, S.K.3
  • 52
    • 84872311972 scopus 로고    scopus 로고
    • Critical evaluation of the role of acarbose in the treatment of diabetes: Patient considerations
    • Rosak C, Mertes G. Critical evaluation of the role of acarbose in the treatment of diabetes: patient considerations. Diab Metab Syndr Obes 2012; 5: 357-67
    • (2012) Diab Metab Syndr Obes , vol.5 , pp. 357-367
    • Rosak, C.1    Mertes, G.2
  • 53
    • 0142026917 scopus 로고    scopus 로고
    • Study of the inhibition of four alpha amylases by acarbose and its 4iv-Alpha-maltohexaosyl and 4iv-Alpha-maltododecaosyl analogues
    • Yoon SH, Robyt JF. Study of the inhibition of four alpha amylases by acarbose and its 4IV-Alpha-maltohexaosyl and 4IV-Alpha-maltododecaosyl analogues. Carbohydr Res 2003; 338: 1969-80
    • (2003) Carbohydr Res , vol.338 , pp. 1969-1980
    • Yoon, S.H.1    Robyt, J.F.2
  • 54
    • 84939796911 scopus 로고    scopus 로고
    • Alpha glucosidase inhibitors
    • Kalra S. Alpha glucosidase inhibitors. J Pak Med Assoc 2014; 474: 6
    • (2014) J Pak Med Assoc , vol.474 , pp. 6
    • Kalra, S.1
  • 55
    • 84939854396 scopus 로고    scopus 로고
    • Available from [Last accessed 05 March 2015]
    • Voglibose dispersible tablets. Available from: http://www.biocon.com/docs/prescribing-information/diabetology/volicose-pi.pdf. [Last accessed 05 March 2015]
    • Voglibose Dispersible Tablets
  • 56
    • 0034006999 scopus 로고    scopus 로고
    • Review of its therapeutic potential in type 2 diabetes mellitus
    • Scott LJ, Spencer CM, Miglitol-A. Review of its Therapeutic Potential in Type 2 Diabetes Mellitus. Drugs 2000; 59: 521-49
    • (2000) Drugs , vol.59 , pp. 521-549
    • Scott, L.J.1    Spencer, C.M.2    Miglitol, A.3
  • 57
    • 84939816160 scopus 로고    scopus 로고
    • Available from [Last accessed 05 March 2015]
    • Glyset® miglitol tablets 2008. Available from: http://www.accessdata.fda.gov/drugsatfda-docs/label/2009/020682s008lbl.pdf. [Last accessed 05 March 2015]
    • (2008) Glyset® Miglitol Tablets
  • 58
  • 59
    • 84911057707 scopus 로고    scopus 로고
    • Alfa glucosidase inhibitor: Voglibose can prevent progression of impaired glucose tolerance stage to type II diabetes mellitus
    • Agrawal D, Kumar S, et al. Alfa glucosidase inhibitor: voglibose can prevent progression of impaired glucose tolerance stage to type ii diabetes mellitus. RJPBCS 2014; 5: 654-61
    • (2014) RJPBCS , vol.5 , pp. 654-661
    • Agrawal, D.1    Kumar, S.2
  • 60
    • 84872025929 scopus 로고    scopus 로고
    • Management of type-2 diabetes mellitus in adults: Focus on individualizing non-insulin therapies
    • Brunetti L, Kalabalik J. Management of type-2 diabetes mellitus in adults: focus on individualizing non-insulin therapies. P T 2012; 37: 687-96
    • (2012) P T , vol.37 , pp. 687-696
    • Brunetti, L.1    Kalabalik, J.2
  • 61
    • 0028828123 scopus 로고
    • The effect of the timing and the administration of acarbose on postprandial hyperglycaemia
    • Rosak C, Nitzsche G, König P, et al. The effect of the timing and the administration of acarbose on postprandial hyperglycaemia. Diabet Med 1995; 12: 979-84
    • (1995) Diabet Med , vol.12 , pp. 979-984
    • Rosak, C.1    Nitzsche, G.2    König, P.3
  • 62
    • 84904153398 scopus 로고    scopus 로고
    • Acarbose plus metformin fixed-dose combination in the management of type 2 diabetes
    • Joshi SR, Ramachandran A, Chadha M, et al. Acarbose plus metformin fixed-dose combination in the management of type 2 diabetes. Expert Opin Pharmacother 2014; 15: 1611-20
    • (2014) Expert Opin Pharmacother , vol.15 , pp. 1611-1620
    • Joshi, S.R.1    Ramachandran, A.2    Chadha, M.3
  • 63
    • 84904679719 scopus 로고    scopus 로고
    • Application of tlc in the screening of acarbose-producing actinomycetes
    • Ren F, Chen L, Tong Q. Application of TLC in the Screening of Acarbose-producing Actinomycetes. Adv J Food Sci Technol 2014; 6: 629-33
    • (2014) Adv J Food Sci Technol , vol.6 , pp. 629-633
    • Ren, F.1    Chen, L.2    Tong, Q.3
  • 64
    • 84939854397 scopus 로고    scopus 로고
    • Acarbose, Miglitol and Voglibose. Available from [Last accessed 18 March 2015]
    • Acarbose, Miglitol and Voglibose. Citeline Pharmaprojects®. 2015. Available from: http://www.citeline.com/category/pharmaprojects/. [Last accessed 18 March 2015]
    • (2015) Citeline Pharmaprojects®
  • 65
    • 1642473764 scopus 로고    scopus 로고
    • Current therapeutic options in type 2 diabetes mellitus: A practical approach
    • Sheehan MT. Current therapeutic options in type 2 diabetes mellitus: a practical approach. Clin Med Res 2003; 1: 189-200
    • (2003) Clin Med Res , vol.1 , pp. 189-200
    • Sheehan, M.T.1
  • 66
    • 77953392434 scopus 로고    scopus 로고
    • Diabetes mellitus type II: Review of oral treatment options
    • Ibrahim R. Diabetes mellitus type II: review of oral treatment options. Int J Pharm Pharmaceut Sci 2010; 2 (Suppl 1): 21-30
    • (2010) Int J Pharm Pharmaceut Sci , vol.2 , pp. 21-30
    • Ibrahim, R.1
  • 67
    • 84939854398 scopus 로고    scopus 로고
    • Available from [Last accessed 18 March 2015]
    • Newer Diabetes Medications, TZDs, and Combinations. Available from: http://www.hca.wa.gov/pdp/Documents/Linagliptin-report.pdf. [Last accessed 18 March 2015]
    • Newer Diabetes Medications, TZDs, and Combinations
  • 68
    • 34249898882 scopus 로고    scopus 로고
    • Post-marketing surveillance of acarbose treatment in patients with type 2 diabetes mellitus and subjects with impaired glucose tolerance in China
    • Pan CY, Landen H. Post-marketing surveillance of acarbose treatment in patients with type 2 diabetes mellitus and subjects with impaired glucose tolerance in China. Clin Drug Investig 2007; 27: 397-405
    • (2007) Clin Drug Investig , vol.27 , pp. 397-405
    • Pan, C.Y.1    Landen, H.2
  • 69
    • 0022655412 scopus 로고
    • Effects of prolonged (6 months) alpha-glucosidase inhibition on blood glucose control and insulin requirements in patients with insulin-dependent diabetes mellitus
    • Dimitriadis G, Karaiskos C, Raptis S. Effects of prolonged (6 months) alpha-glucosidase inhibition on blood glucose control and insulin requirements in patients with insulin-dependent diabetes mellitus. Horm Metab Res 1986; 18: 253-5
    • (1986) Horm Metab Res , vol.18 , pp. 253-255
    • Dimitriadis, G.1    Karaiskos, C.2    Raptis, S.3
  • 70
    • 0032144175 scopus 로고    scopus 로고
    • Effects of acarbose (glucobay) in persons with type 1 diabetes: A multicentre study
    • Sels JP, Verdonk HE, Wolffenbuttel BH. Effects of acarbose (Glucobay) in persons with type 1 diabetes: a multicentre study. Diabetes Res Clin Pract 1998; 41: 139-45
    • (1998) Diabetes Res Clin Pract , vol.41 , pp. 139-145
    • Sels, J.P.1    Verdonk, H.E.2    Wolffenbuttel, B.H.3
  • 71
    • 0032709937 scopus 로고    scopus 로고
    • Efficacy and safety of acarbose in the treatment of type 1 diabetes mellitus: A placebo-controlled, double-blind, multicentre study
    • Riccardi G, Giacco R, Parillo M, et al. Efficacy and safety of acarbose in the treatment of Type 1 diabetes mellitus: a placebo-controlled, double-blind, multicentre study. Diabet Med 1999; 16: 228-32
    • (1999) Diabet Med , vol.16 , pp. 228-232
    • Riccardi, G.1    Giacco, R.2    Parillo, M.3
  • 72
    • 0031748116 scopus 로고    scopus 로고
    • European study on dose-response relationship of acarbose as a first-line drug in non-insulin-dependent diabetes mellitus: Efficacy and safety of low and high doses
    • Fischer S, Hanefeld M, Spengler M, et al. European study on dose-response relationship of acarbose as a first-line drug in non-insulin-dependent diabetes mellitus: efficacy and safety of low and high doses. Acta Diabetol 1998; 35: 34-40
    • (1998) Acta Diabetol , vol.35 , pp. 34-40
    • Fischer, S.1    Hanefeld, M.2    Spengler, M.3
  • 73
    • 41749106662 scopus 로고    scopus 로고
    • Comparison of vildagliptin and acarbose monotherapy in patients with type 2 diabetes: A 24-week, double-blind, randomized trial
    • Pan C, Yang W, Barona JP, et al. Comparison of vildagliptin and acarbose monotherapy in patients with Type 2 diabetes: a 24-week, double-blind, randomized trial. Diabet Med 2008; 25: 435-41
    • (2008) Diabet Med , vol.25 , pp. 435-441
    • Pan, C.1    Yang, W.2    Barona, J.P.3
  • 74
    • 69849094766 scopus 로고    scopus 로고
    • A comparison of efficacy and tolerance of nateglinide and acarbose monotherapy in type 2 diabetes mellitus
    • Pan CY, Gao Y, Li GW, et al a comparison of efficacy and tolerance of nateglinide and acarbose monotherapy in type 2 diabetes mellitus. Zhonghua Nei Ke Za Zhi 2009; 48: 304-7
    • (2009) Zhonghua Nei Ke za Zhi , vol.48 , pp. 304-307
    • Pan, C.Y.1    Gao, Y.2    Li, G.W.3
  • 75
    • 0028357199 scopus 로고
    • Efficacy of 24-week monotherapy with acarbose, glibenclamide, or placebo in niddm patients: The essen study
    • Hoffmann J, Spengler M. Efficacy of 24-week monotherapy with acarbose, glibenclamide, or placebo in NIDDM patients: the Essen Study. Diabetes Care 1994; 17: 561-6
    • (1994) Diabetes Care , vol.17 , pp. 561-566
    • Hoffmann, J.1    Spengler, M.2
  • 76
    • 0031460261 scopus 로고    scopus 로고
    • Efficacy of 24-week monotherapy with acarbose, metformin, or placebo in dietary-Treated niddm patients: The essen-II study
    • Hoffmann J, Spengler M. Efficacy of 24-week monotherapy with acarbose, metformin, or placebo in dietary-Treated NIDDM patients: the Essen-II Study. Am J Med 1997; 103: 483-90
    • (1997) Am J Med , vol.103 , pp. 483-490
    • Hoffmann, J.1    Spengler, M.2
  • 77
    • 84939803950 scopus 로고    scopus 로고
    • March2: Comparative assessment of therapeutic effects of acarbose and metformin in newly diagnosed type 2 diabetes patients
    • Wang G, Liu J, Yang N, et al. MARCH2: comparative assessment of therapeutic effects of acarbose and metformin in newly diagnosed type 2 diabetes patients. PLoS One 2014; 9: e105698
    • (2014) PLoS One , vol.9 , pp. 105698
    • Wang, G.1    Liu, J.2    Yang, N.3
  • 78
    • 84878613856 scopus 로고    scopus 로고
    • A prospective, randomized, open-label study comparing the efficacy and safety of preprandial and prandial insulin in combination with acarbose in elderly, insulin-requiring patients with type 2 diabetes mellitus
    • Yang G, Li C, Gong Y, et al a prospective, randomized, open-label study comparing the efficacy and safety of preprandial and prandial insulin in combination with acarbose in elderly, insulin-requiring patients with type 2 diabetes mellitus. Diabetes Technol Ther 2013; 15: 513-19
    • (2013) Diabetes Technol Ther , vol.15 , pp. 513-519
    • Yang, G.1    Li, C.2    Gong, Y.3
  • 79
    • 0036319032 scopus 로고    scopus 로고
    • Dose-dependent efficacy of miglitol, an alpha-glucosidase inhibitor, in type 2 diabetic patients on diet alone: Results of a 24-week double-blind placebo-controlled study
    • Drent ML, Tollefsen AT, van Heusden FH, et al. Dose-dependent efficacy of miglitol, an alpha-glucosidase inhibitor, in type 2 diabetic patients on diet alone: results of a 24-week double-blind placebo-controlled study. Diabetes Nutr Metab 2002; 15: 152-9
    • (2002) Diabetes Nutr Metab , vol.15 , pp. 152-159
    • Drent, M.L.1    Tollefsen, A.T.2    Van Heusden, F.H.3
  • 80
    • 0031755644 scopus 로고    scopus 로고
    • Advantages of alpha-glucosidase inhibition as monotherapy in elderly type 2 diabetic patients
    • Johnston PS, Lebovitz HE, Coniff RF, et al. Advantages of alpha-glucosidase inhibition as monotherapy in elderly type 2 diabetic patients. J Clin Endocrinol Metab 1998; 83: 1515-22
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 1515-1522
    • Johnston, P.S.1    Lebovitz, H.E.2    Coniff, R.F.3
  • 82
    • 77958110167 scopus 로고    scopus 로고
    • Efficacy and safety of vildagliptin and voglibose in Japanese patients with type 2 diabetes: A 12-week, randomized, double-blind, active-controlled study
    • Iwamoto Y, Kashiwagi A, Yamada N, et al. Efficacy and safety of vildagliptin and voglibose in Japanese patients with type 2 diabetes: a 12-week, randomized, double-blind, active-controlled study. Diabetes Obes Metab 2010; 12: 700-8
    • (2010) Diabetes Obes Metab , vol.12 , pp. 700-708
    • Iwamoto, Y.1    Kashiwagi, A.2    Yamada, N.3
  • 83
    • 73349125507 scopus 로고    scopus 로고
    • Effects of changeover from voglibose to acarbose on postprandial triglycerides in type 2 diabetes mellitus patients
    • Matsumura M, Monden T, Miyashita Y, et al. Effects of changeover from voglibose to acarbose on postprandial triglycerides in type 2 diabetes mellitus patients. Adv Ther 2009; 26: 660-6
    • (2009) Adv Ther , vol.26 , pp. 660-666
    • Matsumura, M.1    Monden, T.2    Miyashita, Y.3
  • 84
    • 84879461786 scopus 로고    scopus 로고
    • Comparison of the hypoglycemic effect of acarbose monotherapy in patients with type 2 diabetes mellitus consuming an eastern or western diet: A systematic meta-Analysis
    • Zhu Q, Tong Y, Wu T, et al. Comparison of the hypoglycemic effect of acarbose monotherapy in patients with type 2 diabetes mellitus consuming an Eastern or Western diet: a systematic meta-Analysis. Clin Ther 2013; 35: 880-99
    • (2013) Clin Ther , vol.35 , pp. 880-899
    • Zhu, Q.1    Tong, Y.2    Wu, T.3
  • 85
    • 0035030824 scopus 로고    scopus 로고
    • Safety and efficacy of acarbose in the treatment of type 2 diabetes: Data from a 5-year surveillance study
    • Mertes G. Safety and efficacy of acarbose in the treatment of Type 2 diabetes: data from a 5-year surveillance study. Diabetes Res Clin Pract 2001; 52: 193-204
    • (2001) Diabetes Res Clin Pract , vol.52 , pp. 193-204
    • Mertes, G.1
  • 86
    • 0035374524 scopus 로고    scopus 로고
    • The synergistic effect of miglitol plus metformin combination therapy in the treatment of type 2 diabetes
    • Miglitol Canadian University Investigator Group
    • Chiasson JL, Naditch L,; Miglitol Canadian University Investigator Group. The synergistic effect of miglitol plus metformin combination therapy in the treatment of type 2 diabetes. Diabetes Care 2001; 24: 989-94
    • (2001) Diabetes Care , vol.24 , pp. 989-994
    • Chiasson, J.L.1    Naditch, L.2
  • 87
    • 0026528139 scopus 로고
    • Alpha-glucosidase inhibition by miglitol in niddm patients
    • Kingma PJ, Menheere PP, Sels JP, et al. Alpha-Glucosidase inhibition by miglitol in NIDDM patients. Diabetes Care 1992; 15: 478-83
    • (1992) Diabetes Care , vol.15 , pp. 478-483
    • Kingma, P.J.1    Menheere, P.P.2    Sels, J.P.3
  • 88
    • 84929992530 scopus 로고    scopus 로고
    • Switching alpha-glucosidase inhibitors to miglitol reduced glucose fluctuations and circulating cardiovascular disease risk factors in type 2 diabetic Japanese patients
    • Hariya N, Mochizuki K, Inoue S, et al. Switching alpha-glucosidase inhibitors to miglitol reduced glucose fluctuations and circulating cardiovascular disease risk factors in type 2 diabetic Japanese patients. Drugs R D 2014; 14: 177-84
    • (2014) Drugs R D , vol.14 , pp. 177-184
    • Hariya, N.1    Mochizuki, K.2    Inoue, S.3
  • 89
    • 0036139934 scopus 로고    scopus 로고
    • Efficacy and safety of voglibose in comparison with acarbose in type 2 diabetic patients
    • Vichayanrat A, Ploybutr S, Tunlakit M, et al. Efficacy and safety of voglibose in comparison with acarbose in type 2 diabetic patients. Diabetes Res Clin Pract 2002; 55: 99-103
    • (2002) Diabetes Res Clin Pract , vol.55 , pp. 99-103
    • Vichayanrat, A.1    Ploybutr, S.2    Tunlakit, M.3
  • 90
    • 0033884254 scopus 로고    scopus 로고
    • Efficacy and safety of acarbose add-on therapy in the treatment of overweight patients with type 2 diabetes inadequately controlled with metformin: A double-blind, placebo-controlled study
    • Halimi S, Le Berre MA, Grangé V. Efficacy and safety of acarbose add-on therapy in the treatment of overweight patients with Type 2 diabetes inadequately controlled with metformin: a double-blind, placebo-controlled study. Diabetes Res Clin Pract 2000; 50: 49-56
    • (2000) Diabetes Res Clin Pract , vol.50 , pp. 49-56
    • Halimi, S.1    Le Berre, M.A.2    Grangé, V.3
  • 91
    • 0012638922 scopus 로고    scopus 로고
    • Acarbose improves glycemic control in overweight type 2 diabetic patients insufficiently treated with metformin
    • Phillips P, Karrasch J, Scott R, et al. Acarbose improves glycemic control in overweight type 2 diabetic patients insufficiently treated with metformin. Diabetes Care 2003; 26: 269-73
    • (2003) Diabetes Care , vol.26 , pp. 269-273
    • Phillips, P.1    Karrasch, J.2    Scott, R.3
  • 92
    • 0031765720 scopus 로고    scopus 로고
    • Efficacy and safety of acarbose in metformin-Treated patients with type 2 diabetes
    • Rosenstock J, Brown A, Fischer J, et al. Efficacy and safety of acarbose in metformin-Treated patients with type 2 diabetes. Diabetes Care 1998; 21: 2050-5
    • (1998) Diabetes Care , vol.21 , pp. 2050-2055
    • Rosenstock, J.1    Brown, A.2    Fischer, J.3
  • 93
    • 84876006243 scopus 로고    scopus 로고
    • A prospective, parallel group, open-labeled, comparative, multi-centric, active controlled study to evaluate the safety, tolerability and benefits of fixed dose combination of acarbose and metformin versus metformin alone in type 2 diabetes
    • 687
    • Jayaram S, Hariharan RS, Madhavan R, et al a prospective, parallel group, open-labeled, comparative, multi-centric, active controlled study to evaluate the safety, tolerability and benefits of fixed dose combination of acarbose and metformin versus metformin alone in type 2 diabetes. J Assoc Physicians India 2010; 58: 679-82, 687
    • (2010) J Assoc Physicians India , vol.58 , pp. 679-82
    • Jayaram, S.1    Hariharan, R.S.2    Madhavan, R.3
  • 94
    • 0032885589 scopus 로고    scopus 로고
    • Comparison of acarbose and metformin in patients with type 2 diabetes mellitus insufficiently controlled with diet and sulphonylureas: A randomized, placebo-controlled study
    • Willms B, Ruge D. Comparison of acarbose and metformin in patients with Type 2 diabetes mellitus insufficiently controlled with diet and sulphonylureas: a randomized, placebo-controlled study. Diabet Med 1999; 16: 755-61
    • (1999) Diabet Med , vol.16 , pp. 755-761
    • Willms, B.1    Ruge, D.2
  • 95
    • 84981276349 scopus 로고    scopus 로고
    • Effectiveness and safety of fixed dose combination of acarbose/metformin in indian type 2 diabetes patients: Results from observational globe study
    • behalf of GLOBE Investigators
    • Saboo B, Reddy GC, Juneja S, behalf of GLOBE Investigators. Effectiveness and safety of fixed dose combination of acarbose/metformin in Indian Type 2 diabetes patients: Results from observational GLOBE Study. Indian J Endocrinol Metab 2015; 19: 129-35
    • (2015) Indian J Endocrinol Metab , vol.19 , pp. 129-135
    • Saboo, B.1    Reddy, G.C.2    Juneja, S.3
  • 96
    • 0036316750 scopus 로고    scopus 로고
    • The effect of combination treatment with acarbose and glibenclamide on postprandial glucose and insulin profiles: Additive blood glucose lowering effect and decreased hypoglycaemia
    • Rosak C, Haupt E, Walter T, et al. The effect of combination treatment with acarbose and glibenclamide on postprandial glucose and insulin profiles: additive blood glucose lowering effect and decreased hypoglycaemia. Diabetes Nutr Metab 2002; 15: 143-51
    • (2002) Diabetes Nutr Metab , vol.15 , pp. 143-151
    • Rosak, C.1    Haupt, E.2    Walter, T.3
  • 97
    • 84877001126 scopus 로고    scopus 로고
    • Effect of additional administration of acarbose on blood glucose fluctuations and postprandial hyperglycemia in patients with type 2 diabetes mellitus under treatment with alogliptin
    • Kusunoki Y, Katsuno T, Myojin M, et al. Effect of additional administration of acarbose on blood glucose fluctuations and postprandial hyperglycemia in patients with type 2 diabetes mellitus under treatment with alogliptin. Endocr J 2013; 60: 431-9
    • (2013) Endocr J , vol.60 , pp. 431-439
    • Kusunoki, Y.1    Katsuno, T.2    Myojin, M.3
  • 98
    • 67649378996 scopus 로고    scopus 로고
    • Metabolic effect of repaglinide or acarbose when added to a double oral antidiabetic treatment with sulphonylureas and metformin: A double-blind, cross-over, clinical trial
    • Derosa G, Salvadeo SA, DAngelo A, et al. Metabolic effect of repaglinide or acarbose when added to a double oral antidiabetic treatment with sulphonylureas and metformin: a double-blind, cross-over, clinical trial. Curr Med Res Opin 2009; 25: 607-15
    • (2009) Curr Med Res Opin , vol.25 , pp. 607-615
    • Derosa, G.1    Salvadeo, S.A.2    DAngelo, A.3
  • 99
    • 0029143428 scopus 로고
    • Acarbose for the treatment of type II diabetes: The results of a canadian multi-centre trial
    • SUPPL
    • Josse RG. Acarbose for the treatment of type II diabetes: the results of a Canadian multi-centre trial. Diabetes Res Clin Pract 1995; 28 (Suppl): S167-72
    • (1995) Diabetes Res Clin Pract , vol.28 , pp. 167-172
    • Josse, R.G.1
  • 100
    • 0034872965 scopus 로고    scopus 로고
    • Effect of treatment with acarbose and insulin in patients with non-insulin-dependent diabetes mellitus associated with non-Alcoholic liver cirrhosis
    • Gentile S, Turco S, Guarino G, et al. Effect of treatment with acarbose and insulin in patients with non-insulin-dependent diabetes mellitus associated with non-Alcoholic liver cirrhosis. Diabetes Obes Metab 2001; 3: 33-40
    • (2001) Diabetes Obes Metab , vol.3 , pp. 33-40
    • Gentile, S.1    Turco, S.2    Guarino, G.3
  • 101
    • 79953321391 scopus 로고    scopus 로고
    • Evaluation of the efficacy and tolerability of miglitol in Chinese patients with type 2 diabetes mellitus inadequately controlled by diet and sulfonylureas
    • Hsieh SH, Shih KC, Chou CW, et al. Evaluation of the efficacy and tolerability of miglitol in Chinese patients with type 2 diabetes mellitus inadequately controlled by diet and sulfonylureas. Acta Diabetol 2011; 48: 71-7
    • (2011) Acta Diabetol , vol.48 , pp. 71-77
    • Hsieh, S.H.1    Shih, K.C.2    Chou, C.W.3
  • 102
    • 0035179630 scopus 로고    scopus 로고
    • Miglitol combined with metformin improves glycaemic control in type 2 diabetes
    • Van Gaal L, Maislos M, Schernthaner G, et al. Miglitol combined with metformin improves glycaemic control in type 2 diabetes. Diabetes Obes Metab 2001; 3: 326-31
    • (2001) Diabetes Obes Metab , vol.3 , pp. 326-331
    • Van Gaal, L.1    Maislos, M.2    Schernthaner, G.3
  • 103
    • 0035107074 scopus 로고    scopus 로고
    • Improved glycaemic control with miglitol in inadequately-controlled type 2 diabetics
    • Standl E, Schernthaner G, Rybka J, et al. Improved glycaemic control with miglitol in inadequately-controlled type 2 diabetics. Diabetes Res Clin Pract 2001; 51: 205-13
    • (2001) Diabetes Res Clin Pract , vol.51 , pp. 205-213
    • Standl, E.1    Schernthaner, G.2    Rybka, J.3
  • 104
    • 0031820774 scopus 로고    scopus 로고
    • Long-Term effectiveness of a new alpha-glucosidase inhibitor (bay m1099-miglitol) in insulin-Treated type 2 diabetes mellitus
    • Mitrakou A, Tountas N, Raptis AE, et al. Long-Term effectiveness of a new alpha-glucosidase inhibitor (BAY m1099-miglitol) in insulin-Treated type 2 diabetes mellitus. Diabet Med 1998; 15: 657-60
    • (1998) Diabet Med , vol.15 , pp. 657-660
    • Mitrakou, A.1    Tountas, N.2    Raptis, A.E.3
  • 105
    • 84901776545 scopus 로고    scopus 로고
    • Efficacy of adding once-And thrice-daily voglibose in Japanese type 2 diabetic patients treated with alogliptin
    • Takahara M, Shiraiwa T, Katakami N, et al. Efficacy of adding once-And thrice-daily voglibose in Japanese type 2 diabetic patients treated with alogliptin. Endocr J 2014; 61: 447-56
    • (2014) Endocr J , vol.61 , pp. 447-456
    • Takahara, M.1    Shiraiwa, T.2    Katakami, N.3
  • 106
    • 84939815823 scopus 로고    scopus 로고
    • Efficacy and safety of voglibose as an add-on triple drug in patients of type two diabetes mellitus uncontrolled with glimepiride and metformin in punjabi population
    • Jindal A, Jindal M, Kaur M, et al. Efficacy and safety of voglibose as an add-on triple drug in patients of type two diabetes mellitus uncontrolled with glimepiride and metformin in Punjabi population. Indian J Basic Appl Med Res 2014; 3: 111-16
    • (2014) Indian J Basic Appl Med Res , vol.3 , pp. 111-116
    • Jindal, A.1    Jindal, M.2    Kaur, M.3
  • 107
    • 0032446801 scopus 로고    scopus 로고
    • Effect of an alpha-glucosidase inhibitor (voglibose), in combination with sulphonylureas, on glycaemic control in type 2 diabetes patients
    • Saito N, Sakai H, Suzuki S, et al. Effect of an alpha-glucosidase inhibitor (voglibose), in combination with sulphonylureas, on glycaemic control in type 2 diabetes patients. J Int Med Res 1998; 26: 219-32
    • (1998) J Int Med Res , vol.26 , pp. 219-232
    • Saito, N.1    Sakai, H.2    Suzuki, S.3
  • 108
    • 79957995797 scopus 로고    scopus 로고
    • Nateglinide and acarbose for postprandial glucose control after optimizing fasting glucose with insulin glargine in patients with type 2 diabetes
    • Kim MK, Suk JH, Kwon MJ, et al. Nateglinide and acarbose for postprandial glucose control after optimizing fasting glucose with insulin glargine in patients with type 2 diabetes. Diabetes Res Clin Pract 2011; 92: 322-8
    • (2011) Diabetes Res Clin Pract , vol.92 , pp. 322-328
    • Kim, M.K.1    Suk, J.H.2    Kwon, M.J.3
  • 109
    • 35048874614 scopus 로고    scopus 로고
    • Acarbose and metabolic control in patients with type 2 diabetes with newly initiated insulin therapy
    • Acarbose-Insulin Combination Study Group
    • Schnell O, Mertes G, Standl E,; Acarbose-Insulin Combination Study Group. Acarbose and metabolic control in patients with type 2 diabetes with newly initiated insulin therapy. Diabetes Obes Metab 2007; 9: 853-8
    • (2007) Diabetes Obes Metab , vol.9 , pp. 853-858
    • Schnell, O.1    Mertes, G.2    Standl, E.3
  • 110
    • 84900812689 scopus 로고    scopus 로고
    • Comparison of acarbose and voglibose in diabetes patients who are inadequately controlled with basal insulin treatment: Randomized, parallel, open-label, active-controlled study
    • Lee MY, Choi DS, Lee MK, et al. Comparison of acarbose and voglibose in diabetes patients who are inadequately controlled with basal insulin treatment: randomized, parallel, open-label, active-controlled study. J Korean Med Sci 2014; 29: 90-7
    • (2014) J Korean Med Sci , vol.29 , pp. 90-97
    • Lee, M.Y.1    Choi, D.S.2    Lee, M.K.3
  • 111
    • 84863809543 scopus 로고    scopus 로고
    • Differential effects of alpha-glucosidase inhibitors on postprandial plasma glucose and lipid profile in patients with type 2 diabetes under control with insulin lispro mix 50/50
    • Kimura T, Suzuki J, Ichikawa M, et al. Differential effects of alpha-glucosidase inhibitors on postprandial plasma glucose and lipid profile in patients with type 2 diabetes under control with insulin lispro mix 50/50. Diabetes Technol Ther 2012; 14: 545-51
    • (2012) Diabetes Technol Ther , vol.14 , pp. 545-551
    • Kimura, T.1    Suzuki, J.2    Ichikawa, M.3
  • 112
    • 78549280114 scopus 로고    scopus 로고
    • The alpha-glucosidase inhibitor miglitol decreases glucose fluctuations and inflammatory cytokine gene expression in peripheral leukocytes of Japanese patients with type 2 diabetes mellitus
    • Osonoi T, Saito M, Mochizuki K, et al. The alpha-glucosidase inhibitor miglitol decreases glucose fluctuations and inflammatory cytokine gene expression in peripheral leukocytes of Japanese patients with type 2 diabetes mellitus. Metabolism 2010; 59: 1816-22
    • (2010) Metabolism , vol.59 , pp. 1816-1822
    • Osonoi, T.1    Saito, M.2    Mochizuki, K.3
  • 113
    • 0028057764 scopus 로고
    • Effects of the carbohydrase inhibitor miglitol in sulfonylurea-Treated niddm patients
    • Johnston PS, Coniff RF, Hoogwerf BJ, et al. Effects of the carbohydrase inhibitor miglitol in sulfonylurea-Treated NIDDM patients. Diabetes Care 1994; 17: 20-9
    • (1994) Diabetes Care , vol.17 , pp. 20-29
    • Johnston, P.S.1    Coniff, R.F.2    Hoogwerf, B.J.3
  • 114
    • 84871161705 scopus 로고    scopus 로고
    • Effect of the addition of sitagliptin and miglitol on insulin-Treated type 2 diabetes
    • Kishimoto M, Noda M. Effect of the addition of sitagliptin and miglitol on insulin-Treated type 2 diabetes. Diabetes Ther 2012; 3: 11
    • (2012) Diabetes Ther , vol.3 , pp. 11
    • Kishimoto, M.1    Noda, M.2
  • 115
    • 35748959376 scopus 로고    scopus 로고
    • Combination therapy of pioglitazone with voglibose improves glycemic control safely and rapidly in Japanese type 2-diabetic patients on hemodialysis
    • Abe M, Kikuchi F, Kaizu K, et al. Combination therapy of pioglitazone with voglibose improves glycemic control safely and rapidly in Japanese type 2-diabetic patients on hemodialysis. Clin Nephrol 2007; 68: 287-94
    • (2007) Clin Nephrol , vol.68 , pp. 287-294
    • Abe, M.1    Kikuchi, F.2    Kaizu, K.3
  • 116
    • 47249102500 scopus 로고    scopus 로고
    • Alpha glucosidase inhibitor voglibose can prevent pioglitazone-induced body weight gain in type 2 diabetic patients
    • Negishi M, Shimomura K, Proks P, et al. Alpha glucosidase inhibitor voglibose can prevent pioglitazone-induced body weight gain in Type 2 diabetic patients. Br J Clin Pharmacol 2008; 66: 318-19
    • (2008) Br J Clin Pharmacol , vol.66 , pp. 318-319
    • Negishi, M.1    Shimomura, K.2    Proks, P.3
  • 117
    • 84866516615 scopus 로고    scopus 로고
    • Effects on lipid profile of dipeptidyl peptidase 4 inhibitors, pioglitazone, acarbose, and sulfonylureas: Meta-Analysis of placebo-controlled trials
    • Monami M, Vitale V, Ambrosio ML, et al. Effects on lipid profile of dipeptidyl peptidase 4 inhibitors, pioglitazone, acarbose, and sulfonylureas: meta-Analysis of placebo-controlled trials. Adv Ther 2012; 29: 736-46
    • (2012) Adv Ther , vol.29 , pp. 736-746
    • Monami, M.1    Vitale, V.2    Ambrosio, M.L.3
  • 118
    • 0038455703 scopus 로고    scopus 로고
    • Acarbose treatment and the risk of cardiovascular disease and hypertension in patients with impaired glucose tolerance: The stop-niddm trial
    • STOP-NIDDM Trial Research Group
    • Chiasson JL, Josse RG, Gomis R, et al. STOP-NIDDM Trial Research Group. Acarbose treatment and the risk of cardiovascular disease and hypertension in patients with impaired glucose tolerance: the STOP-NIDDM trial. JAMA 2003; 290: 486-94
    • (2003) JAMA , vol.290 , pp. 486-494
    • Chiasson, J.L.1    Josse, R.G.2    Gomis, R.3
  • 119
    • 84939813636 scopus 로고    scopus 로고
    • Differential responses to acarbose between obese and non-obese patients with type 2 diabetes mellitus
    • Chou CW, Ou YH, Hsiao SH, et al. Differential Responses to Acarbose Between Obese and Non-obese Patients with Type 2 Diabetes Mellitus. Int J Endocrinol Metab 2006; 4: 63-9
    • (2006) Int J Endocrinol Metab , vol.4 , pp. 63-69
    • Chou, C.W.1    Ou, Y.H.2    Hsiao, S.H.3
  • 120
    • 84902532676 scopus 로고    scopus 로고
    • Post-meal beta-cell function predicts the efficacy of glycemic control in patients with type 2 diabetes inadequately controlled by metformin monotherapy after addition of glibenclamide or acarbose
    • Chen PH, Tsai YT, Wang JS, et al. Post-meal beta-cell function predicts the efficacy of glycemic control in patients with type 2 diabetes inadequately controlled by metformin monotherapy after addition of glibenclamide or acarbose. Diabetol Metab Syndr 2014; 6: 68
    • (2014) Diabetol Metab Syndr , vol.6 , pp. 68
    • Chen, P.H.1    Tsai, Y.T.2    Wang, J.S.3
  • 121
    • 18144377715 scopus 로고    scopus 로고
    • Glycemic control continues to deteriorate after sulfonylureas are added to metformin among patients with type 2 diabetes
    • Cook MN, Girman CJ, Stein PP, et al. Glycemic control continues to deteriorate after sulfonylureas are added to metformin among patients with type 2 diabetes. Diabetes Care 2005; 28: 995-1000
    • (2005) Diabetes Care , vol.28 , pp. 995-1000
    • Cook, M.N.1    Girman, C.J.2    Stein, P.P.3
  • 122
    • 34548119217 scopus 로고    scopus 로고
    • Secondary failure of glycemic control for patients adding thiazolidinedione or sulfonylurea therapy to a metformin regimen
    • Riedel AA, Heien H, Wogen J, et al. Secondary failure of glycemic control for patients adding thiazolidinedione or sulfonylurea therapy to a metformin regimen. Am J Manag Care 2007; 13: 457-63
    • (2007) Am J Manag Care , vol.13 , pp. 457-463
    • Riedel, A.A.1    Heien, H.2    Wogen, J.3
  • 123
    • 0035986333 scopus 로고    scopus 로고
    • Acarbose improves indirectly both insulin resistance and secretion in obese type 2 diabetic patients
    • Delgado H, Lehmann T, Bobbioni-Harsch E, et al. Acarbose improves indirectly both insulin resistance and secretion in obese type 2 diabetic patients. Diabetes Metab 2002; 28: 195-200
    • (2002) Diabetes Metab , vol.28 , pp. 195-200
    • Delgado, H.1    Lehmann, T.2    Bobbioni-Harsch, E.3
  • 124
    • 0036175966 scopus 로고    scopus 로고
    • Different effects of acarbose and glibenclamide on proinsulin and insulin profiles in people with type 2 diabetes
    • Hanefeld M, Haffner SM, Menschikowski M, et al. Different effects of acarbose and glibenclamide on proinsulin and insulin profiles in people with Type 2 diabetes. Diabetes Res Clin Pract 2002; 55: 221-7
    • (2002) Diabetes Res Clin Pract , vol.55 , pp. 221-227
    • Hanefeld, M.1    Haffner, S.M.2    Menschikowski, M.3
  • 125
    • 0037097039 scopus 로고    scopus 로고
    • Acarbose for prevention of type 2 diabetes mellitus: The stop-niddm randomised trial
    • STOP-NIDDM Trail Research Group
    • Chiasson JL, Josse RG, Gomis R, et al. STOP-NIDDM Trail Research Group. Acarbose for prevention of type 2 diabetes mellitus: the STOP-NIDDM randomised trial. Lancet 2002; 359: 2072-7
    • (2002) Lancet , vol.359 , pp. 2072-2077
    • Chiasson, J.L.1    Josse, R.G.2    Gomis, R.3
  • 126
    • 78650679019 scopus 로고    scopus 로고
    • Acarbose actions on insulin resistance and inflammatory parameters during an oral fat load
    • Derosa G, Maffioli P, Ferrari I, et al. Acarbose actions on insulin resistance and inflammatory parameters during an oral fat load. Eur J Pharmacol 2011; 651 (1-3): 240-50
    • (2011) Eur J Pharmacol , vol.651 , Issue.13 , pp. 240-250
    • Derosa, G.1    Maffioli, P.2    Ferrari, I.3
  • 127
    • 0033855806 scopus 로고    scopus 로고
    • Effect of acarbose on insulin sensitivity in elderly patients with diabetes
    • Meneilly GS, Ryan EA, Radziuk J, et al. Effect of acarbose on insulin sensitivity in elderly patients with diabetes. Diabetes Care 2000; 23: 1162-7
    • (2000) Diabetes Care , vol.23 , pp. 1162-1167
    • Meneilly, G.S.1    Ryan, E.A.2    Radziuk, J.3
  • 128
    • 77950891085 scopus 로고    scopus 로고
    • Effect of noninsulin antidiabetic drugs added to metformin therapy on glycemic control, weight gain, and hypoglycemia in type 2 diabetes
    • Phung OJ, Scholle JM, Talwar M, et al. Effect of noninsulin antidiabetic drugs added to metformin therapy on glycemic control, weight gain, and hypoglycemia in type 2 diabetes. JAMA 2010; 303: 1410-18
    • (2010) JAMA , vol.303 , pp. 1410-1418
    • Phung, O.J.1    Scholle, J.M.2    Talwar, M.3
  • 130
    • 79956351014 scopus 로고    scopus 로고
    • Effect of antihyperglycemic agents added to metformin and a sulfonylurea on glycemic control and weight gain in type 2 diabetes: A network meta-Analysis
    • Diabetes and Endocrinology Meta-Analysis Group (DEMA).
    • Gross JL, Kramer CK, Leitão CB, et al. Diabetes and Endocrinology Meta-Analysis Group (DEMA). Effect of antihyperglycemic agents added to metformin and a sulfonylurea on glycemic control and weight gain in type 2 diabetes: a network meta-Analysis. Ann Intern Med 2011; 154: 672-9
    • (2011) Ann Intern Med , vol.154 , pp. 672-679
    • Gross, J.L.1    Kramer, C.K.2    Leitão, C.B.3
  • 131
    • 80051560065 scopus 로고    scopus 로고
    • Second-line therapy in patients with type 2 diabetes inadequately controlled with metformin monotherapy: A systematic review and mixed-Treatment comparison meta-Analysis
    • McIntosh B, Cameron C, Singh SR, et al. Second-line therapy in patients with type 2 diabetes inadequately controlled with metformin monotherapy: a systematic review and mixed-Treatment comparison meta-Analysis. Open Med 2011; 5: e35-48
    • (2011) Open Med , vol.5 , pp. 35-48
    • McIntosh, B.1    Cameron, C.2    Singh, S.R.3
  • 132
    • 0034826473 scopus 로고    scopus 로고
    • Inhibition of gastric emptying by acarbose is correlated with glp-1 response and accompanied by cck release
    • Enç FY, Imeryüz N, Akin L, et al. Inhibition of gastric emptying by acarbose is correlated with GLP-1 response and accompanied by CCK release. Am J Physiol Gastrointest Liver Physiol 2001; 281: G752-63
    • (2001) Am J Physiol Gastrointest Liver Physiol , vol.281 , pp. 752-763
    • Enç, F.Y.1    Imeryüz, N.2    Akin, L.3
  • 133
    • 0031847292 scopus 로고    scopus 로고
    • An asian multicenter clinical trial to assess the efficacy and tolerability of acarbose compared with placebo in type 2 diabetic patients previously treated with diet asian acarbose study group
    • Chan JC, Chan KW, Ho LL, et al. An Asian multicenter clinical trial to assess the efficacy and tolerability of acarbose compared with placebo in type 2 diabetic patients previously treated with diet. Asian Acarbose Study Group. Diabetes Care 1998; 21: 1058-61
    • (1998) Diabetes Care , vol.21 , pp. 1058-1061
    • Chan, J.C.1    Chan, K.W.2    Ho, L.L.3
  • 134
    • 84897147031 scopus 로고    scopus 로고
    • Acarbose improves glycemic control and reduces body weight: Subanalysis data of south Asia region
    • Kalra S, Sahay RK, Schnell O, et al. Acarbose improves glycemic control and reduces body weight: Subanalysis data of South Asia region. Indian J Endocrinol Metab 2013; 17 (Suppl 1): S304-6
    • (2013) Indian J Endocrinol Metab , vol.17 , pp. 304-306
    • Kalra, S.1    Sahay, R.K.2    Schnell, O.3
  • 135
    • 84916210163 scopus 로고    scopus 로고
    • Acarbose monotherapy and weight loss in eastern and western populations with hyperglycaemia: An ethnicity-specific meta-Analysis
    • Li Y, Tong Y, Zhang Y, et al. Acarbose monotherapy and weight loss in Eastern and Western populations with hyperglycaemia: an ethnicity-specific meta-Analysis. Int J Clin Pract 2014; 68: 1318-32
    • (2014) Int J Clin Pract , vol.68 , pp. 1318-1332
    • Li, Y.1    Tong, Y.2    Zhang, Y.3
  • 136
    • 0029064970 scopus 로고
    • Multicenter, placebo-controlled trial comparing acarbose (bay g 5421) with placebo, tolbutamide, and tolbutamide-plus-Acarbose in non-insulin-dependent diabetes mellitus
    • Coniff RF, Shapiro JA, Seaton TB, et al. Multicenter, placebo-controlled trial comparing acarbose (BAY g 5421) with placebo, tolbutamide, and tolbutamide-plus-Acarbose in non-insulin-dependent diabetes mellitus. Am J Med 1995; 98: 443-51
    • (1995) Am J Med , vol.98 , pp. 443-451
    • Coniff, R.F.1    Shapiro, J.A.2    Seaton, T.B.3
  • 137
    • 84896491587 scopus 로고    scopus 로고
    • Comparison of three alpha-glucosidase inhibitors for glycemic control and bodyweight reduction in Japanese patients with obese type 2 diabetes
    • Sugihara H, Nagao M, Harada T, et al. Comparison of three alpha-glucosidase inhibitors for glycemic control and bodyweight reduction in Japanese patients with obese type 2 diabetes. J Diabetes Investig 2014; 5: 206-12
    • (2014) J Diabetes Investig , vol.5 , pp. 206-212
    • Sugihara, H.1    Nagao, M.2    Harada, T.3
  • 138
    • 0029609776 scopus 로고
    • The mechanism of alpha-glucosidase inhibition in the management of diabetes
    • Bischoff H. The mechanism of alpha-glucosidase inhibition in the management of diabetes. Clin Invest Med 1995; 18: 303-11
    • (1995) Clin Invest Med , vol.18 , pp. 303-311
    • Bischoff, H.1
  • 139
    • 0031872922 scopus 로고    scopus 로고
    • Effect of acarbose on postprandial lipid metabolism in type 2 diabetes mellitus
    • Kado S, Murakami T, Aoki A, et al. Effect of acarbose on postprandial lipid metabolism in type 2 diabetes mellitus. Diabetes Res Clin Pract 1998; 41: 49-55
    • (1998) Diabetes Res Clin Pract , vol.41 , pp. 49-55
    • Kado, S.1    Murakami, T.2    Aoki, A.3
  • 140
    • 1242273636 scopus 로고    scopus 로고
    • The effects of oral anti-hyperglycaemic medications on serum lipid profiles in patients with type 2 diabetes
    • Buse JB, Tan MH, Prince MJ, et al. The effects of oral anti-hyperglycaemic medications on serum lipid profiles in patients with type 2 diabetes. Diabetes Obes Metab 2004; 6: 133-56
    • (2004) Diabetes Obes Metab , vol.6 , pp. 133-156
    • Buse, J.B.1    Tan, M.H.2    Prince, M.J.3
  • 141
    • 33750398030 scopus 로고    scopus 로고
    • Postprandial hyperglycaemia and vascular damage-The benefits of acarbose
    • Båvenholm PN, Efendic S. Postprandial hyperglycaemia and vascular damage-The benefits of acarbose. Diab Vasc Dis Res 2006; 3: 72-9
    • (2006) Diab Vasc Dis Res , vol.3 , pp. 72-79
    • Båvenholm, P.N.1    Efendic, S.2
  • 142
    • 84899483362 scopus 로고    scopus 로고
    • On the potential of acarbose to reduce cardiovascular disease
    • Standl E, Theodorakis MJ, Erbach M, et al. On the potential of acarbose to reduce cardiovascular disease. Cardiovasc Diabetol 2014; 13: 81
    • (2014) Cardiovasc Diabetol , vol.13 , pp. 81
    • Standl, E.1    Theodorakis, M.J.2    Erbach, M.3
  • 143
    • 84863482399 scopus 로고    scopus 로고
    • Alpha-glucosidase inhibitors 2012-cardiovascular considerations and trial evaluation
    • Standl E, Schnell O. Alpha-glucosidase inhibitors 2012-cardiovascular considerations and trial evaluation. Diab Vasc Dis Res 2012; 9: 163-9
    • (2012) Diab Vasc Dis Res , vol.9 , pp. 163-169
    • Standl, E.1    Schnell, O.2
  • 144
    • 4444302990 scopus 로고    scopus 로고
    • Reduction of postprandial hyperglycemia in patients with type 2 diabetes reduces nf-kappab activation in pbmcs
    • Rudofsky G Jr, Reismann P, Schiekofer S, et al. Reduction of postprandial hyperglycemia in patients with type 2 diabetes reduces NF-kappaB activation in PBMCs. Horm Metab Res 2004; 36: 630-8
    • (2004) Horm Metab Res , vol.36 , pp. 630-638
    • Rudofsky, G.1    Reismann, P.2    Schiekofer, S.3
  • 145
    • 77952267060 scopus 로고    scopus 로고
    • Postprandial endothelial dysfunction in subjects with new-onset type 2 diabetes: An acarbose and nateglinide comparative study
    • Kato T, Inoue T, Node K. Postprandial endothelial dysfunction in subjects with new-onset type 2 diabetes: an acarbose and nateglinide comparative study. Cardiovasc Diabetol 2010; 9: 12
    • (2010) Cardiovasc Diabetol , vol.9 , pp. 12
    • Kato, T.1    Inoue, T.2    Node, K.3
  • 146
    • 84884958712 scopus 로고    scopus 로고
    • Effect of acarbose to delay progression of carotid intima-media thickness in early diabetes
    • Patel YR, Kirkman MS, Considine RV, et al. Effect of acarbose to delay progression of carotid intima-media thickness in early diabetes. Diabetes Metab Res Rev 2013; 29: 582-91
    • (2013) Diabetes Metab Res Rev , vol.29 , pp. 582-591
    • Patel, Y.R.1    Kirkman, M.S.2    Considine, R.V.3
  • 147
    • 48849116227 scopus 로고    scopus 로고
    • Effect of acarbose, an alpha-glucosidase inhibitor, on serum lipoprotein lipase mass levels and common carotid artery intima-media thickness in type 2 diabetes mellitus treated by sulfonylurea
    • Oyama T, Saiki A, Endoh K, et al. Effect of acarbose, an alpha-glucosidase inhibitor, on serum lipoprotein lipase mass levels and common carotid artery intima-media thickness in type 2 diabetes mellitus treated by sulfonylurea. J Atheroscler Thromb 2008; 15: 154-9
    • (2008) J Atheroscler Thromb , vol.15 , pp. 154-159
    • Oyama, T.1    Saiki, A.2    Endoh, K.3
  • 148
    • 77958165599 scopus 로고    scopus 로고
    • Impact of acarbose on carotid intima-media thickness in patients with newly diagnosed impaired glucose tolerance or mild type 2 diabetes mellitus: A one-year, prospective, randomized, open-label, parallel-group study in Japanese adults with established coronary artery disease
    • Koyasu M, Ishii H, Watarai M, et al. Impact of acarbose on carotid intima-media thickness in patients with newly diagnosed impaired glucose tolerance or mild type 2 diabetes mellitus: A one-year, prospective, randomized, open-label, parallel-group study in Japanese adults with established coronary artery disease. Clin Ther 2010; 32: 1610-17
    • (2010) Clin Ther , vol.32 , pp. 1610-1617
    • Koyasu, M.1    Ishii, H.2    Watarai, M.3
  • 149
    • 79961045895 scopus 로고    scopus 로고
    • Acarbose treatments improve arterial stiffness in patients with type 2 diabetes mellitus
    • Uzui H, Nakano A, Mitsuke Y, et al. Acarbose treatments improve arterial stiffness in patients with type 2 diabetes mellitus. J Diabetes Investig 2011; 2: 148-53
    • (2011) J Diabetes Investig , vol.2 , pp. 148-153
    • Uzui, H.1    Nakano, A.2    Mitsuke, Y.3
  • 150
    • 84861625843 scopus 로고    scopus 로고
    • Early improvement in carotid plaque echogenicity by acarbose in patients with acute coronary syndromes
    • Hirano M, Nakamura T, Obata JE, et al. Early improvement in carotid plaque echogenicity by acarbose in patients with acute coronary syndromes. Circ J 2012; 76: 1452-60
    • (2012) Circ J , vol.76 , pp. 1452-1460
    • Hirano, M.1    Nakamura, T.2    Obata, J.E.3
  • 151
    • 0346727578 scopus 로고    scopus 로고
    • Acarbose reduces the risk for myocardial infarction in type 2 diabetic patients: Meta-Analysis of seven long-Term studies
    • Hanefeld M, Cagatay M, Petrowitsch T, et al. Acarbose reduces the risk for myocardial infarction in type 2 diabetic patients: meta-Analysis of seven long-Term studies. Eur Heart J 2004; 25: 10-16
    • (2004) Eur Heart J , vol.25 , pp. 10-16
    • Hanefeld, M.1    Cagatay, M.2    Petrowitsch, T.3
  • 152
    • 77954501338 scopus 로고    scopus 로고
    • Single administration of alpha-glucosidase inhibitors on endothelial function and incretin secretion in diabetic patients with coronary artery disease-juntendo university trial: Effects of miglitol on endothelial vascular reactivity in type 2 diabetic patients with coronary heart disease (j-Mach)
    • Hiki M, Shimada K, Kiyanagi T, et al. Single administration of alpha-glucosidase inhibitors on endothelial function and incretin secretion in diabetic patients with coronary artery disease-Juntendo University trial: effects of miglitol on endothelial vascular reactivity in type 2 diabetic patients with coronary heart disease (J-MACH). Circ J 2010; 74: 1471-8
    • (2010) Circ J , vol.74 , pp. 1471-1478
    • Hiki, M.1    Shimada, K.2    Kiyanagi, T.3
  • 153
    • 84857026851 scopus 로고    scopus 로고
    • Effects of miglitol in platelet-derived microparticle, adiponectin, and selectin level in patients with type 2 diabetes mellitus
    • Nomura S, Omoto S, Yokoi T, et al. Effects of miglitol in platelet-derived microparticle, adiponectin, and selectin level in patients with type 2 diabetes mellitus. Int J Gen Med 2011; 4: 539-45
    • (2011) Int J Gen Med , vol.4 , pp. 539-545
    • Nomura, S.1    Omoto, S.2    Yokoi, T.3
  • 154
    • 84905858733 scopus 로고    scopus 로고
    • Dpp-4 inhibitor and alpha-glucosidase inhibitor equally improve endothelial function in patients with type 2 diabetes: Edge study
    • Nakamura K, Oe H, Kihara H, et al. DPP-4 inhibitor and alpha-glucosidase inhibitor equally improve endothelial function in patients with type 2 diabetes: EDGE study. Cardiovasc Diabetol 2014; 13: 110
    • (2014) Cardiovasc Diabetol , vol.13 , pp. 110
    • Nakamura, K.1    Oe, H.2    Kihara, H.3
  • 155
    • 13844275225 scopus 로고    scopus 로고
    • Alpha-glucosidase inhibitor reduces the progression of carotid intima-media thickness
    • Yamasaki Y, Katakami N, Hayaishi-Okano R, et al. Alpha-Glucosidase inhibitor reduces the progression of carotid intima-media thickness. Diabetes Res Clin Pract 2005; 67: 204-10
    • (2005) Diabetes Res Clin Pract , vol.67 , pp. 204-210
    • Yamasaki, Y.1    Katakami, N.2    Hayaishi-Okano, R.3
  • 156
    • 63649097810 scopus 로고    scopus 로고
    • Effects of the alpha glucosidase inhibitor acarbose on endothelial function after a mixed meal in newly diagnosed type 2 diabetes
    • Pistrosch F, Schaper F, Passauer J, et al. Effects of the alpha glucosidase inhibitor acarbose on endothelial function after a mixed meal in newly diagnosed type 2 diabetes. Horm Metab Res 2009; 41: 104-8
    • (2009) Horm Metab Res , vol.41 , pp. 104-108
    • Pistrosch, F.1    Schaper, F.2    Passauer, J.3
  • 157
    • 33644821275 scopus 로고    scopus 로고
    • Effects of a single administration of acarbose on postprandial glucose excursion and endothelial dysfunction in type 2 diabetic patients: A randomized crossover study
    • Shimabukuro M, Higa N, Chinen I, et al. Effects of a single administration of acarbose on postprandial glucose excursion and endothelial dysfunction in type 2 diabetic patients: a randomized crossover study. J Clin Endocrinol Metab 2006; 91: 837-42
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 837-842
    • Shimabukuro, M.1    Higa, N.2    Chinen, I.3
  • 158
    • 83555168228 scopus 로고    scopus 로고
    • Effect of 3-month repeated administration of miglitol on vascular endothelial function in patients with diabetes mellitus and coronary artery disease
    • Emoto T, Sawada T, Hashimoto M, et al. Effect of 3-month repeated administration of miglitol on vascular endothelial function in patients with diabetes mellitus and coronary artery disease. Am J Cardiol 2012; 109: 42-6
    • (2012) Am J Cardiol , vol.109 , pp. 42-46
    • Emoto, T.1    Sawada, T.2    Hashimoto, M.3
  • 159
    • 0029863531 scopus 로고    scopus 로고
    • Post-meal coagulation activation in diabetes mellitus: The effect of acarbose
    • Ceriello A, Taboga C, Tonutti L, et al. Post-meal coagulation activation in diabetes mellitus: the effect of acarbose. Diabetologia 1996; 39: 469-73
    • (1996) Diabetologia , vol.39 , pp. 469-473
    • Ceriello, A.1    Taboga, C.2    Tonutti, L.3
  • 160
    • 33750409312 scopus 로고    scopus 로고
    • Decreased fibrinogen by treatment with the alpha-glucosidase inhibitor acarbose [ada abstract 766]
    • Tschoepe D. Decreased fibrinogen by treatment with the alpha-glucosidase inhibitor acarbose [ADA abstract 766]. Diabetes 2004; 53 (Suppl 2): A189
    • (2004) Diabetes , vol.53 , pp. 189
    • Tschoepe, D.1
  • 161
    • 84862122513 scopus 로고    scopus 로고
    • Efficacy and safety profile evaluation of acarbose alone and in association with other antidiabetic drugs: A systematic review
    • Derosa G, Maffioli P. Efficacy and safety profile evaluation of acarbose alone and in association with other antidiabetic drugs: a systematic review. Clin Ther 2012; 34: 1221-36
    • (2012) Clin Ther , vol.34 , pp. 1221-1236
    • Derosa, G.1    Maffioli, P.2
  • 162
    • 35548940574 scopus 로고    scopus 로고
    • Comparison of serum c-reactive protein level in different glucose tolerance subjects and the change in serum crp level in igt subjects with acarbose [abstract 1634]
    • Wang X, Lu J, Pan C. Comparison of serum C-reactive protein level in different glucose tolerance subjects and the change in serum CRP level in IGT subjects with acarbose [abstract 1634]. Chin J Endocrinol Metab 2003; 19: 254-6
    • (2003) Chin J Endocrinol Metab , vol.19 , pp. 254-256
    • Wang, X.1    Lu, J.2    Pan, C.3
  • 163
    • 84862753019 scopus 로고    scopus 로고
    • Conversion of igt to type 2 diabetes mellitus is associated with incident cases of hypertension: A post-hoc analysis of the stop-niddm trial
    • Hanefeld M, Pistrosch F, Koehler C, et al. Conversion of IGT to type 2 diabetes mellitus is associated with incident cases of hypertension: a post-hoc analysis of the STOP-NIDDM trial. J Hypertens 2012; 30: 1440-3
    • (2012) J Hypertens , vol.30 , pp. 1440-1443
    • Hanefeld, M.1    Pistrosch, F.2    Koehler, C.3
  • 164
    • 0036395954 scopus 로고    scopus 로고
    • Effects on blood pressure of the alpha-glucosidase inhibitor acarbose compared with the insulin enhancer glibenclamide in patients with hypertension and type 2 diabetes mellitus
    • Rosenthal JH, Mauersberger H. Effects on blood pressure of the alpha-glucosidase inhibitor acarbose compared with the insulin enhancer glibenclamide in patients with hypertension and type 2 diabetes mellitus. Clin Drug Invest 2002; 22: 695-701
    • (2002) Clin Drug Invest , vol.22 , pp. 695-701
    • Rosenthal, J.H.1    Mauersberger, H.2
  • 165
    • 84902959136 scopus 로고    scopus 로고
    • Rationale for and design of the acarbose cardiovascular evaluation (ace) trial
    • Holman RR, Bethel MA, Chan JC, et al. Rationale for and design of the Acarbose Cardiovascular Evaluation (ACE) trial. Am Heart J 2014; 168: 23-9.e2
    • (2014) Am Heart J , vol.168 , pp. 23-23e2
    • Holman, R.R.1    Bethel, M.A.2    Chan, J.C.3
  • 166
    • 65449150953 scopus 로고    scopus 로고
    • Voglibose for prevention of type 2 diabetes mellitus: A randomised, double-blind trial in Japanese individuals with impaired glucose tolerance
    • Voglibose Ph-3 Study Group
    • Kawamori R, Tajima N, Iwamoto Y, et al. Voglibose Ph-3 Study Group. Voglibose for prevention of type 2 diabetes mellitus: a randomised, double-blind trial in Japanese individuals with impaired glucose tolerance. Lancet 2009; 373: 1607-14
    • (2009) Lancet , vol.373 , pp. 1607-1614
    • Kawamori, R.1    Tajima, N.2    Iwamoto, Y.3
  • 167
    • 84899676296 scopus 로고    scopus 로고
    • Impact of the gut microbiota on the development of obesity and type 2 diabetes mellitus
    • Moreno-Indias I, Cardona F, Tinahones FJ, et al. Impact of the gut microbiota on the development of obesity and type 2 diabetes mellitus. Front Microbiol 2014; 5: 190
    • (2014) Front Microbiol , vol.5 , pp. 190
    • Moreno-Indias, I.1    Cardona, F.2    Tinahones, F.J.3
  • 169
    • 27644555550 scopus 로고    scopus 로고
    • Acarbose attenuates the hypotensive response to sucrose and slows gastric emptying in the elderly
    • Gentilcore D, Bryant B, Wishart JM, et al. Acarbose attenuates the hypotensive response to sucrose and slows gastric emptying in the elderly. Am J Med 2005; 118: 1289
    • (2005) Am J Med , vol.118 , pp. 1289
    • Gentilcore, D.1    Bryant, B.2    Wishart, J.M.3
  • 170
    • 84883280108 scopus 로고    scopus 로고
    • Miglitol, alpha-glycosidase inhibitor, reduces visceral fat accumulation and cardiovascular risk factors in subjects with the metabolic syndrome: A randomized comparable study
    • Shimabukuro M, Higa M, Yamakawa K, et al. Miglitol, alpha-glycosidase inhibitor, reduces visceral fat accumulation and cardiovascular risk factors in subjects with the metabolic syndrome: a randomized comparable study. Int J Cardiol 2013; 167: 2108-13
    • (2013) Int J Cardiol , vol.167 , pp. 2108-2113
    • Shimabukuro, M.1    Higa, M.2    Yamakawa, K.3
  • 171
    • 84876988563 scopus 로고    scopus 로고
    • Effects of 24-week treatment with acarbose on glucagon-like peptide 1 in newly diagnosed type 2 diabetic patients: A preliminary report
    • Zheng MY, Yang JH, Shan CY, et al. Effects of 24-week treatment with acarbose on glucagon-like peptide 1 in newly diagnosed type 2 diabetic patients: a preliminary report. Cardiovasc Diabetol 2013; 12: 73
    • (2013) Cardiovasc Diabetol , vol.12 , pp. 73
    • Zheng, M.Y.1    Yang, J.H.2    Shan, C.Y.3
  • 172
    • 67649321238 scopus 로고    scopus 로고
    • Are the effects of alpha-glucosidase inhibitors on cardiovascular events related to elevated levels of hydrogen gas in the gastrointestinal tract
    • Suzuki Y, Sano M, Hayashida K, et al. Are the effects of alpha-glucosidase inhibitors on cardiovascular events related to elevated levels of hydrogen gas in the gastrointestinal tract? FEBS Lett 2009; 583: 2157-9
    • (2009) FEBS Lett , vol.583 , pp. 2157-2159
    • Suzuki, Y.1    Sano, M.2    Hayashida, K.3
  • 173
    • 41349120002 scopus 로고    scopus 로고
    • Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance
    • Kajiyama S, Hasegawa G, Asano M, et al. Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance. Nutr Res 2008; 28: 137-43
    • (2008) Nutr Res , vol.28 , pp. 137-143
    • Kajiyama, S.1    Hasegawa, G.2    Asano, M.3
  • 174
    • 84855357614 scopus 로고    scopus 로고
    • The therapeutic potential of manipulating gut microbiota in obesity and type 2 diabetes mellitus
    • Kootte RS, Vrieze A, Holleman F, et al. The therapeutic potential of manipulating gut microbiota in obesity and type 2 diabetes mellitus. Diabetes Obes Metab 2012; 14: 112-20
    • (2012) Diabetes Obes Metab , vol.14 , pp. 112-120
    • Kootte, R.S.1    Vrieze, A.2    Holleman, F.3
  • 176
    • 0023638829 scopus 로고
    • Glucagon-like peptide-1 7-36: A physiological incretin in man
    • Kreymann B, Williams G, Ghatei MA, Bloom SR. Glucagon-like peptide-1 7-36: a physiological incretin in man. Lancet 1987; 2: 1300-4
    • (1987) Lancet , vol.2 , pp. 1300-1304
    • Kreymann, B.1    Williams, G.2    Ghatei, M.A.3    Bloom, S.R.4
  • 177
    • 0344357096 scopus 로고
    • Glucagon-like peptide i stimulates insulin gene expression and increases cyclic amp levels in a rat islet cell line
    • Drucker DJ, Philippe J, Mojsov S, et al. Glucagon-like peptide I stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell line. Proc Natl Acad Sci USA 1987; 84: 3434-8
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 3434-3438
    • Drucker, D.J.1    Philippe, J.2    Mojsov, S.3
  • 178
    • 78650631727 scopus 로고    scopus 로고
    • Nitric oxide-The endothelium-derived relaxing factor and its role in endothelial functions
    • Bauer V, Sotníková R. Nitric oxide-The endothelium-derived relaxing factor and its role in endothelial functions. Gen Physiol Biophys 2010; 29: 319-40
    • (2010) Gen Physiol Biophys , vol.29 , pp. 319-340
    • Bauer, V.1    Sotníková, R.2
  • 179
    • 77953365793 scopus 로고    scopus 로고
    • Voglibose, an alpha-glucosidase inhibitor, to increase active glucagon-like peptide-1 levels
    • Moritoh Y, Takeuchi K, Hazama M. Voglibose, an Alpha-glucosidase Inhibitor, to Increase Active Glucagon-like Peptide-1 Levels. Mol Cell Pharmacol 2009; 1: 188-92
    • (2009) Mol Cell Pharmacol , vol.1 , pp. 188-192
    • Moritoh, Y.1    Takeuchi, K.2    Hazama, M.3
  • 180
    • 84862756200 scopus 로고    scopus 로고
    • Miglitol administered before breakfast increased plasma active glucagon-like peptide-1 (glp-1) levels after lunch in patients with type 2 diabetes treated with sitagliptin
    • Aoki K, Kamiyama H, Yoshimura K, et al. Miglitol administered before breakfast increased plasma active glucagon-like peptide-1 (GLP-1) levels after lunch in patients with type 2 diabetes treated with sitagliptin. Acta Diabetol 2012; 49: 225-30
    • (2012) Acta Diabetol , vol.49 , pp. 225-230
    • Aoki, K.1    Kamiyama, H.2    Yoshimura, K.3
  • 181
    • 79959781838 scopus 로고    scopus 로고
    • Loss of incretin effect is a specific, important, and early characteristic of type 2 diabetes
    • Holst JJ, Knop FK, Vilsboll T, et al. Loss of incretin effect is a specific, important, and early characteristic of type 2 diabetes. Diabetes Care 2011; 34 (Suppl 2): S251-7
    • (2011) Diabetes Care , vol.34 , pp. 251-257
    • Holst, J.J.1    Knop, F.K.2    Vilsboll, T.3
  • 182
    • 79952310049 scopus 로고    scopus 로고
    • Secretion of glucagon-like peptide-1 (glp-1) in type 2 diabetes: What is up, what is down
    • Nauck MA, Vardarli I, Deacon CF, et al. Secretion of glucagon-like peptide-1 (GLP-1) in type 2 diabetes: what is up, what is down? Diabetologia 2011; 54: 10-18
    • (2011) Diabetologia , vol.54 , pp. 10-18
    • Nauck, M.A.1    Vardarli, I.2    Deacon, C.F.3
  • 183
    • 80052706816 scopus 로고    scopus 로고
    • The beneficial effect of alpha-glucosidase inhibitor on glucose variability compared with sulfonylurea in taiwanese type 2 diabetic patients inadequately controlled with metformin: Preliminary data
    • Lin SD, Wang JS, Hsu SR, et al. The beneficial effect of alpha-glucosidase inhibitor on glucose variability compared with sulfonylurea in Taiwanese type 2 diabetic patients inadequately controlled with metformin: preliminary data. J Diabetes Complications 2011; 25: 332-8
    • (2011) J Diabetes Complications , vol.25 , pp. 332-338
    • Lin, S.D.1    Wang, J.S.2    Hsu, S.R.3
  • 184
    • 0034072806 scopus 로고    scopus 로고
    • Voglibose administration before the evening meal improves nocturnal hypoglycemia in insulin-dependent diabetic patients with intensive insulin therapy
    • Taira M, Takasu N, Komiya I, et al. Voglibose administration before the evening meal improves nocturnal hypoglycemia in insulin-dependent diabetic patients with intensive insulin therapy. Metabolism 2000; 49: 440-3
    • (2000) Metabolism , vol.49 , pp. 440-443
    • Taira, M.1    Takasu, N.2    Komiya, I.3
  • 185
    • 11844294865 scopus 로고    scopus 로고
    • Alpha-glucosidase inhibitors for patients with type 2 diabetes: Results from a cochrane systematic review and meta-Analysis
    • van de Laar FA, Lucassen PL, Akkermans RP, et al. Alpha-glucosidase inhibitors for patients with type 2 diabetes: results from a Cochrane systematic review and meta-Analysis. Diabetes Care 2005; 28: 154-63
    • (2005) Diabetes Care , vol.28 , pp. 154-163
    • Van De Laar, F.A.1    Lucassen, P.L.2    Akkermans, R.P.3
  • 186
    • 84866168894 scopus 로고    scopus 로고
    • Functional interactions between the gut microbiota and host metabolism
    • Tremaroli V, Bäckhed F. Functional interactions between the gut microbiota and host metabolism. Nature 2012; 489: 242-9
    • (2012) Nature , vol.489 , pp. 242-249
    • Tremaroli, V.1    Bäckhed, F.2
  • 187
    • 0027724063 scopus 로고
    • Acarbose an update of its pharmacology and therapeutic use in diabetes mellitus
    • Balfour JA, McTavish D. Acarbose. An update of its pharmacology and therapeutic use in diabetes mellitus. Drugs 1993; 46: 1025-54
    • (1993) Drugs , vol.46 , pp. 1025-1054
    • Balfour, J.A.1    McTavish, D.2
  • 188
    • 0028798236 scopus 로고
    • Efficacy and tolerability of stepwise increasing dosage of acarbose in patients with non-insulin-dependent diabetes mellitus (niddm), treated with sulphonylureas
    • May C. Efficacy and tolerability of stepwise increasing dosage of acarbose in patients with non-insulin-dependent diabetes mellitus (NIDDM), treated with sulphonylureas. Diabetes Stoffwechsel 1995; 4: 3-8
    • (1995) Diabetes Stoffwechsel , vol.4 , pp. 3-8
    • May, C.1
  • 189
    • 0036211095 scopus 로고    scopus 로고
    • Acarbose: An update of its therapeutic use in diabetes treatment
    • Laube H. Acarbose: an update of its therapeutic use in diabetes treatment. Clin Drug Invest 2002; 22: 141-56
    • (2002) Clin Drug Invest , vol.22 , pp. 141-156
    • Laube, H.1
  • 190
    • 84939854401 scopus 로고    scopus 로고
    • Avaialable from [Last accessed 18 March 2015]
    • GLUCOBAY® 50, 100 2003. Avaialable from http://home.intekom.com/pharm/bayer/glucobay.html. [Last accessed 18 March 2015]
    • (2003) GLUCOBAY® 50, 100
  • 191
    • 0033761633 scopus 로고    scopus 로고
    • Miglitol: Assessment of its role in the treatment of patients with diabetes mellitus
    • Campbell LK, Baker DE, Campbell RK. Miglitol: assessment of its role in the treatment of patients with diabetes mellitus. Ann Pharmacother 2000; 34: 1291-301
    • (2000) Ann Pharmacother , vol.34 , pp. 1291-1301
    • Campbell, L.K.1    Baker, D.E.2    Campbell, R.K.3
  • 192
    • 84878709716 scopus 로고    scopus 로고
    • Gut metagenome in european women with normal, impaired and diabetic glucose control
    • Karlsson FH, Tremaroli V, Nookaew I, et al. Gut metagenome in European women with normal, impaired and diabetic glucose control. Nature 2013; 498: 99-103
    • (2013) Nature , vol.498 , pp. 99-103
    • Karlsson, F.H.1    Tremaroli, V.2    Nookaew, I.3
  • 193
    • 84899478129 scopus 로고    scopus 로고
    • Effect of acarbose on fecal bifidobacteria content in patients with type 2 diabetes mellitus
    • Liu HX, Li J, Liu B, et al. Effect of acarbose on fecal bifidobacteria content in patients with type 2 diabetes mellitus. Chin J Endocrinol Metab 2011; 27: 47-50
    • (2011) Chin J Endocrinol Metab , vol.27 , pp. 47-50
    • Liu, H.X.1    Li, J.2    Liu, B.3
  • 194
    • 0024203941 scopus 로고
    • Effect of starch malabsorption on colonic function and metabolism in humans
    • Scheppach W, Fabian C, Ahrens F, et al. Effect of starch malabsorption on colonic function and metabolism in humans. Gastroenterology 1988; 95: 1549-55
    • (1988) Gastroenterology , vol.95 , pp. 1549-1555
    • Scheppach, W.1    Fabian, C.2    Ahrens, F.3


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