Synthesis and biological characterisation of novel N-alkyl-deoxynojirimycin glucosidase inhibitors

ChemBioChem

Volumn 10, Issue 6, 2009, Pages 1101-1105

  Rawlings, Amy J ^a,b   Lomas, Hannah ^a   Pilling, Adam W ^a,b   Lee, Marvin J R ^a   Alonzi, Dominic S ^a   Rountree, J S Shane ^a,b   Jenkinson, Sarah F ^b   Fleet, George W J ^b   Dwek, Raymund A ^a   Jones, John H ^b   Butters, Terry D ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Glycosylation; Imino sugars; Nitrophenyl; Oligosaccharides; Photolabile groups

Indexed keywords

1 DEOXYNOJIRIMYCIN DERIVATIVE; ALPHA GLUCOSIDASE; ALPHA GLUCOSIDASE 1; ALPHA GLUCOSIDASE 2; ALPHA GLUCOSIDASE INHIBITOR; N (6' AZIDOHEXYL) 1 DEOXYNOJIRIMYCIN; N (7' PHENYLHEPTYL) 1 DEOXYNOJIRIMYCIN; N [4' (2'',4'' DINITROPHENYLAMINO)BUTYL] 1 DEOXYNOJIRIMYCIN; N [5' (2'',4'' DINITROPHENYLAMINO)PENTYL] 1 DEOXYNOJIRIMYCIN; N [6' (2'',4'' DINITROPHENYLAMINO)HEXYL] 1 DEOXYNOJIRIMYCIN; N [6' (4'' AZIDO 2'' NITROPHENYLAMINO)HEXYL] 1 DEOXYNOJIRIMYCIN; N [6' (4'' NITROPHENYLAMINO)HEXYL] 1 DEOXYNOJIRIMYCIN; OLIGOSACCHARIDE; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN HL 60; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENDOPLASMIC RETICULUM; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; MOLECULAR PROBE; PHOTOAFFINITY LABELING; PRIORITY JOURNAL; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

1-DEOXYNOJIRIMYCIN; AFFINITY LABELS; ALPHA-GLUCOSIDASES; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ENDOPLASMIC RETICULUM; ENZYME INHIBITORS; HL-60 CELLS; HUMANS; IMINO SUGARS; OLIGOSACCHARIDES; RATS;

EID: 65549138440     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.200900025     Document Type: Article

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