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Volumn 62, Issue , 2015, Pages 15-21
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Synthesis, in vitro evaluation and molecular docking studies of thiazole derivatives as new inhibitors of α-glucosidase
a
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Author keywords
Molecular docking; Synthesis; Thiazole; Glucosidase inhibition
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Indexed keywords
1 [ [2 [4 (4 CHLOROPHENYL) THIAZOL 2 YL]HYDRAZONO]METHYL] 3 [ [2 [4 (4 CHLOROPHENYL)THIAZOL 2 YL]METHYL]BENZENE;
1 [ [2 [4 (4 METHOXYPHENYL)THIAZOL 2 YL]HYDRAZONO] METHYL] 3 [[2 [4 (4 METHOXY PHENYL)THIAZOL 2 YL]HYDRAZONO ]METHYL]BENZENE;
2 METHOXY 5 [[2 [4 (4 METHOXYPHENYL)THIAZOL 2 YL]HYDRAZONO]METHYL] PHENOL;
2 [2 (ANTHRACEN 9 YLMETHYLENE)HYDRAZINYL] 4 (4 METHOXYPHENYL)THIAZOLE;
2 [2 [1 (2 BROMO 4 NITROPHENYL)ETHYLIDENE]HYDRAZINYL] 4 (4 CHLOROPHENYL)THIAZOLE;
2 [2 [4 (BENZYLOXY)BENZYLIDENE]HYDRAINYL] 4 (4 METHOXYPHENYL)THIAZOLE;
2 [2 [4 (BENZYLOXY)BENZYLIDENE]HYDRAZINYL] 4 (4 CHLOROPHENYL)THIAZOLE;
2,6 DI T BUTYL 4 [[2 [4 (4 CHLOROPHENYL)THIAZOLE 2 YL] HYDRAZONO]METHYL] PHENOL;
2,6 DII TERT BUTYL 4 [[2 [4 (4 METHOXYPHENYL)THIAZOL 2 YL] HYDRAZONO] METHYL]PHENOL;
4 (4 CHLOROPHENYL) 2 [2 (2 NITROBENZYLIDENE)HYDRAZINYL]THIAZOLE;
4 (4 CHLOROPHENYL) 2 [2 (3 NITROBENZYLIDENE)HYDRAZINYL]THIAZOLE;
4 (4 CHLOROPHENYL) 2 [2 (NAPHTHALENE 2 YL METHYLENE) HYDRAZINYL]THIAZOLE;
4 (4 CHLOROPHENYL) 2 [2 [1 [4 (PIPERIDIN 1 YL)PHENYL] ETHYLIDENE]HYDRA ZINYL]THIAZOLE;
4 (4 METHOXYPHENYL) 2 [2 (NAPHTHALEN 2 YL METHYLENE) HYDRAZINYL]THIAZOLE;
4 (4 METHOXYPHENYL) 2 [2 [1 (3 NITROPHENYL) ETHYLIDENE]HYDRAZINYL]THIA ZOL;
4 [[2 [4 (4 CHLOROPHENYL)THIAZOL 2 YL]HYDRAZONO]METHYL] N,N DIMETHYL ANILINE;
4 [[2 [4 (4 METHOXYPHENYL)THIAZOL 2 YL]HYDRAZONO] METHYL] N,N DIMETHYLANILINE;
4 [[2 [4 (4 METHOXYPHENYL)THIAZOL 2 YL]HYDRAZONO] METHYL]BENZENE 1,2 DIOL;
5 (4 CHLOROPHENYL) 2 [2 [4 [[2 [4 (4 CHLOROPHENYL) THIAZOL 2 YL]HYDRAZONO]METHYL]BENZYLIDENE]HYDRAZINYL]THIAZOLE;
5 (4 METHOXYPHENYL) 2 [ 2 [4 (4 METHOXYPHENYL)THIAZOL 2 YL]HYDRAZONO]METHYL]BENZYLIDENE]HYDRAZINYL]THIAZOLE;
5 [[2 [4 (4 CHLOROPHENYL)THIAZOLE 2 YL]HYDRAZONO] METHYL] 2 METHOXY PHENOL;
ACARBOSE;
ALPHA GLUCOSIDASE INHIBITOR;
THIAZOLE DERIVATIVE;
UNCLASSIFIED DRUG;
2,6-DI-T-BUTYL-4-((2-(4-(4-CHLOROPHENYL)THIAZOLE-2-YL)HYDRAZONO)METHYL)-PHENOL;
2-(2-(4-(BENZYLOXY)BENZYLIDENE)HYDRAZINYL)-4-(4-CHLOROPHENYL)THIAZOLE;
ALPHA GLUCOSIDASE;
GLYCOSIDASE INHIBITOR;
HYDRAZINE DERIVATIVE;
PHENOL DERIVATIVE;
SACCHAROMYCES CEREVISIAE PROTEIN;
ARTICLE;
CARBON NUCLEAR MAGNETIC RESONANCE;
CONTROLLED STUDY;
DRUG BINDING;
DRUG STRUCTURE;
DRUG SYNTHESIS;
ENZYME INHIBITION;
HYDROGEN BOND;
IN VITRO STUDY;
MOLECULAR DOCKING;
MOLECULAR MODEL;
PRIORITY JOURNAL;
PROTON NUCLEAR MAGNETIC RESONANCE;
SACCHAROMYCES CEREVISIAE;
CHEMISTRY;
DRUG EFFECTS;
SYNTHESIS;
ACARBOSE;
ALPHA-GLUCOSIDASES;
GLYCOSIDE HYDROLASE INHIBITORS;
HYDRAZINES;
MOLECULAR DOCKING SIMULATION;
PHENOLS;
SACCHAROMYCES CEREVISIAE PROTEINS;
THIAZOLES;
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EID: 84935492350
PISSN: 00452068
EISSN: 10902120
Source Type: Journal
DOI: 10.1016/j.bioorg.2015.06.006 Document Type: Article |
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Times cited : (122)
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References (35)
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