Synthesis, Biological Activity, and Molecular Modeling Studies of 1H-1,2,3-Triazole Derivatives of Carbohydrates as a-Glucosidases Inhibitors

Journal of Medicinal Chemistry

Volumn 53, Issue 6, 2010, Pages 2364-2375

  Ferreira, Sabrinab ^a,d   Sodero, Ana C R ^b   Cardoso, Mariana F C ^d   Lima, Emerson S ^c   Kaiser, Carlos R ^a   Silva Jr , Floriano P ^b   Ferreira, Vitor F ^d  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b INSTITUTO OSWALDO CRUZ   (Brazil)

^c FEDERAL UNIVERSITY OF AMAZONAS   (Brazil)

^d FLUMINENSE FEDERAL UNIVERSITY   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

1 O METHYL 2,3 O ISOPROPYLIDENE 5 (4 CARBOXYLATE ETHYL 1H 1,2,3 TRIAZOL 1 YL) BETA DEXTRO RIBOFURANOSE; 1 O METHYL 2,3 O ISOPROPYLIDENE 5 (4 CYCLOHEXENE 1H 1,2,3 TRIAZOL 1 YL) BETA DEXTRO RIBOFURANOSE; 1 O METHYL 2,3 O ISOPROPYLIDENE 5 (4 HYDROXYMETHYL 1H 1,2,3 TRIAZOL 1 YL) BETA DEXTRO RIBOFURANOSE; 1 O METHYL 2,3 O ISOPROPYLIDENE 5 (4 METHYLACETATE 1H 1,2,3 TRIAZOLE 1 YL) BETA DEXTRO RIBOFURANOSE; 1 O METHYL 2,3 O ISOPROPYLIDENE 5 (4 PHENOXYMETHYL 1H 1,2,3 TRIAZOL 1 YL) BETA DEXTRO RIBOFURANOSE; 1 O METHYL 2,3 O ISOPROPYLIDENE 5 (4 PHENYL 1H 1,2,3 TRIAZOL 1 YL) BETA DEXTRO RIBOFURANOSE; 1 O METHYL 2,3 O ISOPROPYLIDENE 5 (4 PROPYL 1H 1,2,3 TRIAZOL 1 YL) BETA DEXTRO RIBOFURANOSE; 1 O METHYL 2,3 O ISOPROPYLIDENE 5 [4 (1 HYDROXY 1 METHYLETHYL) 1H 1,2,3 TRIAZOL 1 YL] BETA DEXTRO RIBOFURANOSE; 1 O METHYL 2,3 O ISOPROPYLIDENE 5 [4 (1 HYDROXY 1 METHYLPROPYL) 1H 1,2,3 TRIAZOL 1 YL] BETA DEXTRO RIBOFURANOSE; 1 O METHYL 2,3 O ISOPROPYLIDENE 5 [4 (1 HYDROXY 1,3 DIMETHYLBUTYL) 1H 1,2,3 TRIAZOLE 1 YL] BETA DEXTRO RIBOFURANOSE; 1 O METHYL 2,3 O ISOPROPYLIDENE 5 [4 (1 HYDROXYCYCLOHEXIL) 1H 1,2,3 TRIAZOL 1 YL] BETA DEXTRO RIBOFURANOSE; 1 O METHYL 2,3 O ISOPROPYLIDENE 5 [4 (3 CHLOROPROPYL) 1H 1,2,3 TRIAZOL 1 YL] BETA DEXTRO RIBOFURANOSE; 1 O METHYL 2,3 O ISOPROPYLIDENE 5 [4 (TETRAHYDRO 2H PYRAN)METHYL) 1H 1,2,3 TRIAZOLE 1 YL] BETA DEXTRO RIBOFURANOSE; 1,2:3,4 DI O ISOPROPYLIDENE 6 (4 PHENYL 1H 1,2,3 TRIAZOLE 1 YL) ALPHA DEXTRO GALACTOPYRANOSE; 1,2:5,6 DI O ISOPROPYLIDENE 3 (4 PHENYL 1H 1,2,3 TRIAZOLE 1 YL) ALPHA DEXTRO ALOFURANOSE; 5 DEOXY 1,2 O ISOPROPYLIDENE 5 (4 HYDROXYMETHYL 1H 1,2,3 TRIAZOLE 1 YL) ALPHA DEXTRO XYLOFURANOSE; 5 DEOXY 1,2 O ISOPROPYLIDENE 5 (4 PHENYL 1H 1,2,3 TRIAZOLE 1 YL) ALPHA DEXTRO XYLOFURANOSE; 5 DEOXY 1,2 O ISOPROPYLIDENE 5 [4 (1 CYCLOHEXENE) 1H 1,2,3 TRIAZOLE 1 YL] ALPHA DEXTRO XYLOFURANOSE; ACARBOSE; ALLOSE; ALPHA GLUCOSIDASE INHIBITOR; GALACTOSE; RIBOSE; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; XYLOSE;

ARTICLE; BIOLOGICAL ACTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; MALE; MOLECULAR MODEL; NONHUMAN; RAT;

ALPHA-GLUCOSIDASES; AMINO ACID SEQUENCE; BINDING SITES; CARBOHYDRATE SEQUENCE; CARBOHYDRATES; CATALYSIS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FUNGAL PROTEINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES; YEASTS;

EID: 77949838793     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm901265h     Document Type: Article

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