Anticonvulsant evaluation of clubbed indole-1,2,4-triazine derivatives: A synthetic approach

European Journal of Medicinal Chemistry

Volumn 80, Issue , 2014, Pages 509-522

  Ahuja, Priya ^a   Siddiqui, Nadeem ^a  

^a HAMDARD UNIVERSITY   (India)

Author keywords

Anticonvulsant; GABA; Quantification; Sodium channel; Triazine

Indexed keywords

1 (5 AMINO 3 THIOXO 2,3,4,5 TETRAHYDRO 1,2,4 TRIAZIN 6 YL) 2 PHENYL 5 (TRIFLUOROMETHYL) 1H INDOLE 3 CARBOXYLIC ACID; 1 (5 AMINO 3 THIOXO 2,3,4,5 TETRAHYDRO 1,2,4 TRIAZIN 6 YL) 2 PHENYL 5 (TRIFLUOROMETHYL) 1H INDOLE 3 SULFONAMIDE; 1 (5 AMINO 3 THIOXO 2,3,4,5 TETRAHYDRO 1,2,4 TRIAZIN 6 YL) 5 (METHYLTHIO) 2 PHENYL 1H INDOLE 3 SULFONAMIDE; 1 (5 AMINO 3 THIOXO 2,3,4,5 TETRAHYDRO 1,2,4 TRIAZIN 6 YL) 5 CHLORO 2 PHENYL 1H INDOLE 3 CARBOXYLIC ACID; 1 (5 AMINO 3 THIOXO 2,3,4,5 TETRAHYDRO 1,2,4 TRIAZIN 6 YL) 5 CHLORO 2 PHENYL 1H INDOLE 3 SULFONAMIDE; 1 (5 AMINO 3 THIOXO 2,3,4,5 TETRAHYDRO 1,2,4 TRIAZIN 6 YL) 5 FLUORO 2 PHENYL 1H INDOLE 3 CARBOXYLIC ACID; 1 (5 AMINO 3 THIOXO 2,3,4,5 TETRAHYDRO 1,2,4 TRIAZIN 6 YL) 5 FLUORO 2 PHENYL 1H INDOLE 3 SULFONAMIDE; 1 (5 AMINO 3 THIOXO 2,3,4,5 TETRAHYDRO 1,2,4 TRIAZIN 6 YL) 5 METHOXY 2 PHENYL 1H INDOLE 3 CARBOXYLIC ACID; 1 (5 AMINO 3 THIOXO 2,3,4,5 TETRAHYDRO 1,2,4 TRIAZIN 6 YL) 5 METHOXY 2 PHENYL 1H INDOLE 3 SULFONAMIDE; 1 (5 AMINO 3 THIOXO 2,3,4,5 TETRAHYDRO 1,2,4 TRIAZIN 6 YL) 5 NITRO 2 PHENYL 1H INDOLE 3 CARBOXAMIDE; 1 (5 AMINO 3 THIOXO 2,3,4,5 TETRAHYDRO 1,2,4 TRIAZIN 6 YL) 5 NITRO 2 PHENYL 1H INDOLE 3 CARBOXYLIC ACID; 1 (5 AMINO 3 THIOXO 2,3,4,5 TETRAHYDRO 1,2,4 TRIAZIN 6 YL) 5 NITRO 2 PHENYL 1H INDOLE 3 SULFONAMIDE; 1 [1 (5 AMINO 3 THIOXO 2,3,4,5 TETRAHYDRO 1,2,4 TRIAZIN 6 YL) 2 PHENYL 5 (TRIFLUOROMETHYL) 1H INDOL 3 YL]ETHANONE; 1 [1 (5 AMINO 3 THIOXO 2,3,4,5 TETRAHYDRO 1,2,4 TRIAZIN 6 YL) 5 (METHYLTHIO) 2 PHENYL 1H INDOL 3 YL]ETHANONE; 1 [1 (5 AMINO 3 THIOXO 2,3,4,5 TETRAHYDRO 1,2,4 TRIAZIN 6 YL) 5 CHLORO 2 PHENYL 1H INDOL 3 YL]ETHANONE; 1 [1 (5 AMINO 3 THIOXO 2,3,4,5 TETRAHYDRO 1,2,4 TRIAZIN 6 YL) 5 FLUORO 2 PHENYL 1H INDOL 3 YL]ETHANONE; 1 [1 (5 AMINO 3 THIOXO 2,3,4,5 TETRAHYDRO 1,2,4 TRIAZIN 6 YL) 5 METHOXY 2 PHENYL 1H INDOL 3 YL]ETHANONE; 1 [1 (5 AMINO 3 THIOXO 2,3,4,5 TETRAHYDRO 1,2,4 TRIAZIN 6 YL) 5 NITRO 2 PHENYL 1H INDOL 3 YL]ETHANONE; 1,2,4 TRIAZINE DERIVATIVE; 4 AMINOBUTYRIC ACID; 6 (3 ALLYL 5 CHLORO 2 PHENYL 1H INDOL 1 YL) 5 AMINO 4,5 DIHYDRO 1,2,4 TRIAZINE 3 (2H)THIONE; 6 (3 ALLYL 5 FLUORO 2 PHENYL 1H INDOL 1 YL) 5 AMINO 4,5 DIHYDRO 1,2,4 TRIAZINE 3 (2H)THIONE; 6 (3 ALLYL 5 METHOXY 2 PHENYL 1H INDOL 1 YL) 5 AMINO 4,5 DIHYDRO 1,2,4 TRIAZINE 3 (2H)THIONE; 6 (3 ALLYL 5 NITRO 2 PHENYL 1H INDOL 1 YL) 5 AMINO 4,5 DIHYDRO 1,2,4 TRIAZINE 3 (2H)THIONE; 6 [3 ALLYL 2 PHENYL 5 (TRIFLUOROMETHYL) 1H INDOL 1 YL] 5 AMINO 4,5 DIHYDRO 1,2,4 TRIAZINE 3 (2H)THIONE; 6 [3 ALLYL 5 (METHYLTHIO) 2 PHENYL 1H INDOL 1 YL] 5 AMINO 4,5 DIHYDRO 1,2,4 TRIAZINE 3 (2H)THIONE; ANTICONVULSIVE AGENT; PENTETRAZOLE; SODIUM CHANNEL; UNCLASSIFIED DRUG; UNINDEXED DRUG; 1,2,4-TRIAZINE; TRIAZINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; BINDING ASSAY; CLONUS; CONTROLLED STUDY; DRUG EFFICACY; ELECTRIC SHOCK; EPILEPSY; GABAERGIC SYSTEM; IN VITRO STUDY; MALE; MOTOR DYSFUNCTION; NEUROTOXICITY; NONHUMAN; PROSPECTIVE STUDY; RAT; SEIZURE; ANIMAL; BRAIN; CHEMISTRY; DRUG EFFECTS; METABOLISM; MOTOR ACTIVITY; MOUSE; SYNTHESIS;

ANIMALS; ANTICONVULSANTS; BRAIN; CHEMISTRY TECHNIQUES, SYNTHETIC; GAMMA-AMINOBUTYRIC ACID; MALE; MICE; MOTOR ACTIVITY; SODIUM CHANNELS; TRIAZINES;

EID: 84899885782     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.04.043     Document Type: Article

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