Isatin based Schiff bases as inhibitors of α-glucosidase: Synthesis, characterization, in vitro evaluation and molecular docking studies

Bioorganic Chemistry

Volumn 60, Issue , 2015, Pages 42-48

  Rahim, Fazal ^a   Malik, Fazal ^a   Ullah, Hayat ^a   Wadood, Abdul ^b   Khan, Fahad ^a   Javid, Muhammad Tariq ^a   Taha, Muhammad ^c,d   Rehman, Wajid ^a   Ur Rehman, Ashfaq ^b   Khan, Khalid Mohammed ^e  

^a HAZARA UNIVERSITY   (Pakistan)

^b ABDUL WALI KHAN UNIVERSITY   (Pakistan)

^c UNIVERSITI TEKNOLOGI MARA   (Malaysia)

^d Faculty of Civil Engineering (UiTM)   (Malaysia)

^e UNIVERSITY OF KARACHI   (Pakistan)

Author keywords

Isatin; Molecular docking; Schiff bases; Synthesis; Glucosidase inhibition

Indexed keywords

2 (2,4 DICHLOROPHENYL) N (2 OXOINDOLIN 3 YLIDENE)ACETOHYDRAZIDE; 2 (2,4 DICHLOROPHENYL) N' (2 OXO 1 PROPYLINDOLIN 3 YLIDENE)ACETOHYDRAZIDE; 2 (3,4 DICHLOROPHENYL) N' (2 OXOINDOLIN 3 YLIDENE)ACETOHYDRAZIDE; 2 CHLORO N' (2 OXO 1 PROPYLINDOLIN 3 YLIDENE)BENZOHYDRAZIDE; 2 HYDROXY N' (2 OXO 1 PROPYLINDOLIN 3 YLIDENE)BENZOHYDRAZIDE; 2 HYDROXY N' (2 OXOINDOLIN 3 YLIDENE)BENZOHYDRAZIDE; 2,5 DIMETHOXY N' (2 OXO 1 PROPYLINDOLIN 3 YLIDENE)BENZOHYDRAZIDE; 3 METHYL N' (2 OXO 1 PROPYLINDOLIN 3 YLIDENE)BENZOHYDRAZIDE; 4 METHYL N (2 OXOINDOLIN 3 YLIDENE)BENZOHYDRAZIDE; 4 METHYL N' (2 OXO 1 PROPYLINDOLIN 3 YLIDENE)BENZOHYDRAZIDE; ACARBOSE; ALPHA GLUCOSIDASE INHIBITOR; ISATIN; N (5 BROMO 2 OXOINDOLIN 3 YLIDENE)DODECANEHYDRAZIDE; N' (2 OXOINDOLIN 3 YLIDENE)DODECANEHYDRAZIDE; N' (5 CHLORO 2 OXOINDOLIN 3 YLIDENE) 2 (2,4 DICHLOROPHENYL)ACETOHYDRAZIDE; N' (5 CHLORO 2 OXOINDOLIN 3 YLIDENE) 2 (3,4 DICHLOROPHENYL)ACETOHYDRAZIDE; N' (5 CHLORO 2 OXOINDOLIN 3 YLIDENE) 4 METHYLBENZOHYDRAZIDE; N' (6 BROMO 2 OXOINDOLIN 3 YLIDENE) 2 (2,4 DICHLOROPHENYL)ACETOHYDRAZIDE; N' (6 BROMO 2 OXOINDOLIN 3 YLIDENE) 2 (3,4 DICHLOROPHENYL)ACETOHYDRAZIDE; N' (6 BROMO 2 OXOINDOLIN 3 YLIDENE) 2 HYDROXYBENZOHYDRAZIDE; N' (6 BROMO 2 OXOINDOLIN 3 YLIDENE) 4 METHYLBENZOHYDRAZIDE; N' (6 BROMO 2 OXOINDOLIN 3 YLIDENE)DODECANEHYDRAZIDE; SCHIFF BASE; UNCLASSIFIED DRUG; ALPHA GLUCOSIDASE; GLYCOSIDASE INHIBITOR;

ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; ELECTROSPRAY MASS SPECTROMETRY; IC50; IN VITRO STUDY; MOLECULAR DOCKING; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; STANDARD; ANALOGS AND DERIVATIVES; CHEMISTRY; ENZYMOLOGY; HUMAN; METABOLISM; SACCHAROMYCES CEREVISIAE; STRUCTURE ACTIVITY RELATION;

ALPHA-GLUCOSIDASES; GLYCOSIDE HYDROLASE INHIBITORS; HUMANS; ISATIN; MOLECULAR DOCKING SIMULATION; SACCHAROMYCES CEREVISIAE; SCHIFF BASES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84928815461     PISSN: 00452068     EISSN: 10902120     Source Type: Journal    
DOI: 10.1016/j.bioorg.2015.03.005     Document Type: Article

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