Synthesis and in vitro evaluation of novel 1,2,4-triazine derivatives as neuroprotective agents

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 12, 2010, Pages 4224-4230

  Irannejad, Hamid ^a   Amini, Mohsen ^a   Khodagholi, Fariba ^b   Ansari, Niloufar ^a,b   Tusi, Solaleh Khoramian ^b   Sharifzadeh, Mohammad ^c   Shafiee, Abbas ^d  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d Tehran University of Medical Science   (Iran)

Author keywords

1,2,4 Triazine; Alzheimer's disease; Oxidative stress; PC12 cells

Indexed keywords

1,2,4 TRIAZINE DERIVATIVE; 3 THIO N BUTYL 5,6 (4 DICHOLOROPHENYL) 1,2,4 TRIAZINE; 3 THIO N BUTYL 5,6 DIPHENYL 1,2,4 TRIAZINE; 3 THIO N PROPYL 5,6 (4 DICHLOROPHENYL) 1,2,4 TRIAZINE; 3 THIO N PROPYL 5,6 DIPHENYL 1,2,4 TRIAZINE; 3 THIOETHYL 5,6 DIPHENYL 1,2,4 TRIAZINE; 3 THIOMETHYL 5,6 (4 DICHOLROPHENYL) 1,2,4 TRIAZINE; 3 THIOMETHYL 5,6 DIPHENYL 1,2,4 TRIAZINE; CASPASE 3; HYDROGEN PEROXIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NEUROPROTECTIVE AGENT; UNCLASSIFIED DRUG; 1,2,4-TRIAZINE; REACTIVE OXYGEN METABOLITE; TRIAZINE DERIVATIVE;

ANIMAL CELL; ARTICLE; CELL DEATH; CELL DIFFERENTIATION; CONTROLLED STUDY; DEGENERATIVE DISEASE; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INACTIVATION; GENE CONTROL; IN VITRO STUDY; INFLAMMATION; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PHEOCHROMOCYTOMA CELL; RAT; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG EFFECTS; METABOLISM; PC12 CELL LINE; SYNTHESIS;

ANIMALS; CASPASE 3; HYDROGEN PEROXIDE; NEUROPROTECTIVE AGENTS; NF-KAPPA B; OXIDATIVE STRESS; PC12 CELLS; RATS; REACTIVE OXYGEN SPECIES; TRIAZINES;

RATTUS;

EID: 77953136142     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.04.097     Document Type: Article

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