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Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 23, 2012, Pages 7155-7162

Structure-based bioisosterism design, synthesis and biological evaluation of novel 1,2,4-triazin-6-ylthioacetamides as potent HIV-1 NNRTIs

(9) Zhan, Peng a Li, Xiao a Li, Zhenyu a Chen, Xuwang a Tian, Ye a Chen, Wenmin a Liu, Xinyong a Pannecouque, Christophe b Clercq, Erik De b

a SHANDONG UNIVERSITY (China)

b REGA INSTITUTE FOR MEDICAL RESEARCH (Belgium)

Author keywords

1,2,4 Triazine; Anti HIV 1 activity; Heterocycle; HIV reverse transcriptase; NNRTIs; SAR; Structure based bioisosterism strategy; Synthesis

Indexed keywords

1,2,4 TRIAZIN 6 YLTHIOACETAMIDE; 3,4 DIHYDROISOQUINOLIN (1H) YL ETHANONE; ACETAMIDE DERIVATIVE; ANTIVIRUS AGENT; DELAVIRDINE; EFAVIRENZ; NEVIRAPINE; PYRIDINE DERIVATIVE; RDEA 806; UNCLASSIFIED DRUG; VRX 480773; ZALCITABINE; ZIDOVUDINE; ZP7;

ANTIVIRAL ACTIVITY; ANTIVIRAL RESISTANCE; ARTICLE; BINDING AFFINITY; BIOLOGICAL ACTIVITY; CYTOTOXICITY; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; HUMAN IMMUNODEFICIENCY VIRUS 2; HYDROGEN BOND; IC 50; STRUCTURE ACTIVITY RELATION; VIRUS REPLICATION; VIRUS STRAIN;

BINDING SITES; CELL LINE; DRUG DESIGN; HIV REVERSE TRANSCRIPTASE; HIV-1; HUMANS; MOLECULAR DOCKING SIMULATION; PROTEIN STRUCTURE, TERTIARY; REVERSE TRANSCRIPTASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; THIOGLYCOLATES; TRIAZINES;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 84869080624 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2012.09.062 Document Type: Article

Times cited : (51)

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