Glucolipotoxicity diminishes cardiomyocyte TFEB and inhibits lysosomal autophagy during obesity and diabetes

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

Volumn 1861, Issue 12, 2016, Pages 1893-1910

  Trivedi, Purvi C ^a   Bartlett, Jordan J ^a   Perez, Lester J ^a   Brunt, Keith R ^a   Legare, Jean Francois ^a   Hassan, Ansar ^a   Kienesberger, Petra C ^a   Pulinilkunnil, Thomas ^a  

^a DALHOUSIE UNIVERSITY   (Canada)

Author keywords

Cardiomyopathy; Glucolipotoxicity; LAMP 2A; Lysosomal autophagy; Obesity and diabetes; TFEB

Indexed keywords

CATHEPSIN B; HEAT SHOCK COGNATE PROTEIN 70; HEAT SHOCK PROTEIN 90; OLEIC ACID; PALMITIC ACID; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR EB PROTEIN; UNCLASSIFIED DRUG; BASIC HELIX LOOP HELIX LEUCINE ZIPPER TRANSCRIPTION FACTOR; LYSOSOMAL PROTEINS; PALMITIC ACID DERIVATIVE; PROTEIN;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; CARDIAC MUSCLE CELL; CONTROLLED STUDY; DIET INDUCED OBESITY; ENZYME ACTIVITY; EX VIVO STUDY; HEART INJURY; HUMAN; HUMAN TISSUE; IN VIVO STUDY; INSULIN DEPENDENT DIABETES MELLITUS; LYSOSOME; MALE; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; ANIMAL; APOPTOSIS; AUTOPHAGOSOME; C57BL MOUSE; CELL LINE; DIABETES MELLITUS; METABOLISM; OBESITY; PHYSIOLOGY; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

ANIMALS; APOPTOSIS; AUTOPHAGOSOMES; AUTOPHAGY; BASIC HELIX-LOOP-HELIX LEUCINE ZIPPER TRANSCRIPTION FACTORS; CELL LINE; DIABETES MELLITUS; HUMANS; LYSOSOMES; MALE; MICE; MICE, INBRED C57BL; MYOCYTES, CARDIAC; OBESITY; OLEIC ACID; PALMITATES; PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION;

EID: 84988661115     PISSN: 13881981     EISSN: 18792618     Source Type: Journal    
DOI: 10.1016/j.bbalip.2016.09.004     Document Type: Article

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