TLR4 activation under lipotoxic conditions leads to synergistic macrophage cell death through a trif-dependent pathway

Journal of Immunology

Volumn 190, Issue 3, 2013, Pages 1285-1296

  Schilling, Joel D ^a   Machkovech, Heather M ^a   He, Li ^a   Diwan, Abhinav ^a   Schaffer, Jean E ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CERAMIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON REGULATORY FACTOR 3; LIPID; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; PALMITIC ACID; REACTIVE OXYGEN METABOLITE; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR ADAPTOR MOLECULE 1; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR EB; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; GENE OVEREXPRESSION; INNATE IMMUNITY; LIPID METABOLISM; LIPOTOXICITY; LYSOSOME; LYSOSOME MEMBRANE; MACROPHAGE; MEMBRANE DAMAGE; MOLECULAR INTERACTION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PERITONEUM MACROPHAGE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, VESICULAR TRANSPORT; ANIMALS; BASIC HELIX-LOOP-HELIX LEUCINE ZIPPER TRANSCRIPTION FACTORS; CELL DEATH; CELL LINE, TRANSFORMED; CELLS, CULTURED; DIABETES COMPLICATIONS; HEK293 CELLS; HUMANS; IMMUNITY, INNATE; INTRACELLULAR MEMBRANES; LIPID METABOLISM; LIPOPOLYSACCHARIDES; LYSOSOMES; MACROPHAGES, PERITONEAL; MICE; MICE, INBRED C57BL; PALMITATES; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4; TRANSFECTION;

EID: 84872741148     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1202208     Document Type: Article

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