Activation of the transcription factor EB rescues lysosomal abnormalities in cystinotic kidney cells

Kidney International

Volumn 89, Issue 4, 2016, Pages 862-873

  Rega, Laura R ^a   Polishchuk, Elena ^b   Montefusco, Sandro ^b   Napolitano, Gennaro ^b   Tozzi, Giulia ^a   Zhang, Jinzhong ^c   Bellomo, Francesco ^a   Taranta, Anna ^a   Pastore, Anna ^a   Polishchuk, Roman ^b   Piemonte, Fiorella ^a   Medina, Diego L ^b   Catz, Sergio D ^c   Ballabio, Andrea ^b   Emma, Francesco ^a  

^a BAMBINO GESÙ CHILDREN S HOSPITAL   (Italy)

^b TELETHON INSTITUTE OF GENETICS AND MEDICINE TIGEM   (Italy)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

cystinosis; pediatric nephrology; proximal tubule; renal pathology

Indexed keywords

CARRIER PROTEIN; CYSTINE; CYSTINOSIN; GENISTEIN; MERCAPTAMINE; REGULATOR PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR EB; UNCLASSIFIED DRUG; AMINO ACID TRANSPORTER; BASIC HELIX LOOP HELIX LEUCINE ZIPPER TRANSCRIPTION FACTOR; CTNS PROTEIN, HUMAN; TFEB PROTEIN, HUMAN;

ARTICLE; AUTOPHAGY; CELL COMPARTMENTALIZATION; CELL IMMORTALIZATION; CELL NUCLEUS; CONTROLLED STUDY; CYSTINOTIC KIDNEY CELL; EPITHELIUM CELL; HUMAN; HUMAN CELL; KIDNEY CELL; KIDNEY DISEASE; KIDNEY EPITHELIUM; KIDNEY PROXIMAL TUBULE; LYSOSOME; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; TRANSCRIPTION INITIATION; URINALYSIS; VOLUNTEER; CELL LINE; CYSTINOSIS; GENETICS; METABOLISM;

AMINO ACID TRANSPORT SYSTEMS, NEUTRAL; BASIC HELIX-LOOP-HELIX LEUCINE ZIPPER TRANSCRIPTION FACTORS; CELL LINE; CELL NUCLEUS; CYSTINE; CYSTINOSIS; HUMANS; LYSOSOMES;

EID: 84964677449     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1016/j.kint.2015.12.045     Document Type: Article

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