Loss of hepatic chaperone-mediated autophagy accelerates proteostasis failure in aging

Aging Cell

Volumn 14, Issue 2, 2015, Pages 249-264

  Schneider, Jaime L ^a   Villarroya, Joan ^a,b   Diaz Carretero, Antonio ^a   Patel, Bindi ^a   Urbanska, Aleksandra M ^a   Thi, Mia M ^a   Villarroya, Francesc ^c   Santambrogio, Laura ^a   Cuervo, Ana Maria ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b HOSPITAL DE LA SANTA CREU I SANT PAU   (Spain)

^c UNIVERSITY OF BARCELONA   (Spain)

Author keywords

Autophagy; Lysosomal protein degradation; Macroautophagy; Oxidative stress; Protein aggregation; Proteotoxicity; Ubiquitin proteasome system

Indexed keywords

FIBROBLAST GROWTH FACTOR 21; LYSOSOME ASSOCIATED MEMBRANE PROTEIN; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 2A; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; CHAPERONE;

AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOLYSOSOME; CELL VACUOLE; CHAPERONE-MEDIATED AUTOPHAGY; CONTROLLED STUDY; GENE DELETION; IN VIVO STUDY; LIPID METABOLISM; LIVER; LIVER DYSFUNCTION; LIVER LYSOSOME; LIVER PROTECTION; LYSOSOME MEMBRANE; MACROAUTOPHAGY; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DEGRADATION; PROTEIN HOMEOSTASIS; PROTEIN QUALITY; UPREGULATION; ANIMAL; AUTOPHAGY; C57BL MOUSE; HOMEOSTASIS; HUMAN; LYSOSOME; PHYSIOLOGY; PROTEINOSIS;

MUS;

AGING; ANIMALS; AUTOPHAGY; HOMEOSTASIS; HUMANS; LIVER; LYSOSOMES; MALE; MICE; MICE, INBRED C57BL; MOLECULAR CHAPERONES; OXIDATIVE STRESS; PROTEIN AGGREGATION, PATHOLOGICAL;

EID: 84924235659     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/acel.12310     Document Type: Article

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