Lipid-induced NOX2 activation inhibits autophagic flux by impairing lysosomal enzyme activity

Journal of Lipid Research

Volumn 56, Issue 3, 2015, Pages 546-561

  Jaishy, Bharat ^a,b   Zhang, Quanjiang ^a,b   Chung, Heaseung S ^c   Riehle, Christian ^a,b   Soto, Jamie ^a,b   Jenkins, Stephen ^a   Abel, Patrick ^a   Cowart, L Ashley ^e   Van Eyk, Jennifer E ^c,d,f   Abel, E Dale ^a,b  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF IOWA   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d JOHNS HOPKINS UNIVERSITY   (United States)

^e MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^f Barbara Streisand Women's Heart Center   (United States)

Author keywords

Autophagy; Cardiomyocytes; Fatty acids; Lysosomes; NADPH oxidase 2; Protein kinase C

Indexed keywords

LYSOSOME ENZYME; PALMITIC ACID; PROTEIN KINASE C; PROTEIN KINASE C BETA2; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; UNCLASSIFIED DRUG; CYBB PROTEIN, MOUSE; CYBB PROTEIN, RAT; FAT INTAKE; MEMBRANE PROTEIN; PRKCB1 PROTEIN, MOUSE; PRKCB1 PROTEIN, RAT; PROTEIN KINASE C BETA; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUPEROXIDE;

ACIDIFICATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CELL CULTURE; CELL FRACTIONATION; CONTROLLED STUDY; ENZYME ACTIVATION; HEART; HEART MUSCLE CELL; LIPID METABOLISM; LIPOTOXICITY; MALE; MOUSE; NONHUMAN; OBESITY; OXIDATIVE STRESS; PRIORITY JOURNAL; REGULATORY MECHANISM; ANIMAL; CARDIAC MUSCLE CELL; CELL LINE; CYTOLOGY; DRUG EFFECTS; ENZYMOLOGY; FAT INTAKE; GENETICS; LYSOSOME; METABOLISM; PHARMACOLOGY; RAT;

ANIMALS; AUTOPHAGY; CELL LINE; DIETARY FATS; ENZYME ACTIVATION; LYSOSOMES; MEMBRANE GLYCOPROTEINS; MICE; MYOCYTES, CARDIAC; NADPH OXIDASE; PALMITIC ACID; PROTEIN KINASE C BETA; RATS; SUPEROXIDES;

EID: 84924618437     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M055152     Document Type: Article

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