Intratumoral genetic heterogeneity in pilocytic astrocytomas revealed by CGH-analysis of microdissected tumor cells and FISH on tumor tissue sections

International Journal of Oncology

Volumn 28, Issue 2, 2006, Pages 353-360

  Wemmert, Silke ^a   Romeike, Bernd F M ^a   Ketter, Ralf ^a   Steudel, Wolf Ingo ^a   Zang, Klaus D ^a   Urbschat, Steffi ^a  

^a SAARLAND UNIVERSITY   (Germany)

Author keywords

CGH; FISH; Heterogeneity; Microdissection; Pilocytic astrocytoma

Indexed keywords

ADOLESCENT; ADULT; ARTICLE; ASTROCYTOMA; CENTRAL NERVOUS SYSTEM TUMOR; CHILD; CHROMOSOME 17; CHROMOSOME 7; CHROMOSOME 8; CHROMOSOME ABERRATION; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENETIC HETEROGENEITY; GENETICS; HUMAN; INFANT; MALE; MICRODISSECTION; MONOSOMY; NUCLEIC ACID HYBRIDIZATION; PATHOLOGY; PRESCHOOL CHILD; TUMOR SUPPRESSOR GENE;

ADOLESCENT; ADULT; ASTROCYTOMA; CENTRAL NERVOUS SYSTEM NEOPLASMS; CHILD; CHILD, PRESCHOOL; CHROMOSOME ABERRATIONS; CHROMOSOMES, HUMAN, PAIR 17; CHROMOSOMES, HUMAN, PAIR 7; CHROMOSOMES, HUMAN, PAIR 8; FEMALE; GENES, P53; GENETIC HETEROGENEITY; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; INFANT; MALE; MICRODISSECTION; MONOSOMY; NUCLEIC ACID HYBRIDIZATION;

EID: 33749499419     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.28.2.353     Document Type: Article

References (31)

1. Giannini C and Scheithauer BW: Classification and grading of low-grade astrocytic tumors in children. Brain Pathol 7: 785-798, 1997.
2. Kleihues P and Cavenee WK (eds): Pathology and Genetics of Tumors of the Nervous System. World Health Organization Classification of Tumours. IARC Press, Lyon, 2000.
3. Cheng Y, Pang JC, Ng HK, Ding M, Zhang SF, Zheng J, Liu DG and Poon WS: Pilocytic astrocytomas do not show most of the genetic changes commonly seen in diffuse astrocytomas. Histopathology 37: 437-444, 2000.
4. Ransom DT, Ritland SR, Kimmel DW, Moertel CA, Dahl RJ, Scheithauer BW, Kelly PJ and Jenkins RB: Cytogenetic and loss of heterozygosity studies in ependymomas, pilocytic astrocytomas, and oligodendrogliomas. Genes Chromosomes Cancer 5: 348-356, 1992.
5. Karnes PS, Tran TN, Cui MY, Raffel C, Gilles FH, Barranger JA and Ying KL: Cytogenetic analysis of 39 pediatric central nervous system tumors. Cancer Genet Cytogenet 59: 12-19, 1992.
6. Thiel G, Losanowa T, Kintzel D, Nisch G, Martin H, Vorpahl K and Witkowski R: Karyotypes in 90 human gliomas. Cancer Genet Cytogenet 58: 109-120, 1992.
7. Zattara-Cannoni H, Gambarelli D, Lena G, Dufour H, Choux M, Grisoli F and Vagner-Capodano AM: Are juvenile pilocytic astrocytomas benign tumors? A cytogenetic study in 24 cases. Cancer Genet Cytogenet 104: 157-160, 1998.
8. Agamanolis DP and Malone JM: Chromosomal abnormalities in 47 pediatric brain tumors. Cancer Genet Cytogenet 81: 125-134, 1995.
9. Bigner SH, McLendon RE, Fuchs H, McKeever PE and Friedman HS: Chromosomal characteristics of childhood brain tumors. Cancer Genet Cytogenet 97: 125-134, 1997.
10. Bhattacharjee MB, Armstrong DD, Vogel H and Cooley LD: Cytogenetic analysis of 120 primary pediatric brain tumors and literature review. Cancer Genet Cytogenet 97: 39-53, 1997.
11. Jenkins RB, Kimmel DW, Moertel CA, Schultz CG, Scheithauer BW, Kelly PJ and Dewald GW: A cytogenetic study of 53 human gliomas. Cancer Genet Cytogenet 39: 253-279, 1989.
12. Sanoudou D, Tingby O, Ferguson-Smith MA, Collins VP and Coleman N: Analysis of pilocytic astrocytoma by comparative genomic hybridization. Br J Cancer 82: 1218-1222, 2000.
13. Shlomit R, Ayala AG, Michal D, Ninett A, Frida S, Boleslaw G, Gad B, Gideon R and Shlomi C: Gains and losses of DNA sequences in childhood brain tumors analyzed by comparative genomic hybridization. Cancer Genet Cytogenet 121: 67-72, 2000.
14. Warr T, Ward S, Burrows J, Harding B, Wilkins P, Harkness W, Hayward R, Darling J and Thomas D: Identification of extensive genomic loss and gain by comparative genomic hybridisation in malignant astrocytoma in children and young adults. Genes Chromosomes Cancer 31: 15-22, 2001.
15. Szymas J, Wolf G, Petersen S, Schluens K, Nowak S and Petersen I: Comparative genomic hybridization indicating two distinct subgroups of pilocytic astrocytomas. Neurosurg Focus 8: 1-6, 2000.
16. White FV, Anthony DC, Yunis EJ, Tarbell NJ, Scott RM and Schofield DE: Nonrandom chromosomal gains in pilocytic astrocytomas of childhood. Hum Pathol 26: 979-986, 1995.
17. Willert JR, Daneshvar L, Sheffield VC and Cogen PH: Deletion of chromosome arm 17p DNA sequences in pediatric highgrade and juvenile pilocytic astrocytomas. Genes Chromosomes Cancer 12: 165-172, 1995.
18. Hayes VM, Dirven CM, Dam A, Verlind E, Molenaar WM, Mooij JJ, Hofstra RM and Buys CG: High frequency of TP53 mutations in juvenile pilocytic astrocytomas indicates role of TP53 in the development of these tumors. Brain Pathol 9: 463-467, 1999.
19. Collins VP: Gliomas. Cancer Surv 32: 37-51, 1998.
20. Von Deimling A, Fimmers R, Schmidt MC, et al: Comprehensive allelotype and genetic anaysis of 466 human nervous system tumors. J Neuropathol Exp Neurol 59: 544-558, 2000.
21. Von Eckardstein K, Gries H, Bolik E, Cervos-Navarro J, Tschairkin IN and Patt S: p53 mutation and protein alteration in 50 gliomas. Retrospective study by DNA-sequencing techniques and immunohistochemistry. Histol Histopathol 12: 611-616, 1997.
22. Ishii N, Sawamura Y, Tada M, Daub DM, Janzer RC, Meagher-Villemure M, De Tribolet N and van Meir EG: Absence of p53 gene mutations in a tumor panel representative of pilocytic astrocytoma diversity using a p53 functional assay. Int J Cancer 76: 797-800, 1998.
23. Von Deimling A, Louis DN, Menon AG, von Ammon K, Petersen I, Ellison D, Wiestler OD and Seizinger BR: Deletions on the long arm of chromosome 17 in pilocytic astrocytoma. Acta Neuropathol 86: 81-85, 1993.
24. Platten M, Giordano MJ, Dirven CM, Gutmann DH and Louis DN: Up-regulation of specific NF 1 gene transcripts in sporadic pilocytic astrocytomas. Am J Pathol 149: 621-627, 1996.
25. Scheurlen WG and Senf L: Analysis of the GAP-related domain of the neurofibromatosis type 1 (NF1) gene in childhood brain tumors. Int J Cancer 64: 234-238, 1995.
26. Jung V, Romeike BF, Henn W, Feiden W, Moringlane JR, Zang KD and Urbschat S: Evidence of focal genetic microheterogeneity in glioblastoma multiforme by area-specific CGH on microdissected tumor cells. J Neuropathol Exp Neurol 58: 993-999, 1999.
27. Lutz S, Welter C, Zang KD, Seitz G, Blin N and Urbschat K: A two-colour technique for chromosome in situ hybridization in tissue sections. J Pathol 167: 279-282, 1992.
28. Hopman AH, Ramaekers FC, Raap AK, Beck JL, Devilee P, van der Ploeg M and Vooijs GP: In situ hybridization as a tool to study numerical chromosome aberrations in solid bladder tumors. Histochemistry 89: 307-316, 1988.
29. Mondello C, Moralli D, Franceschi C and Nuzzo F: Occurrence and expansion of trisomy 7 in a fibroblast strain from a centenarian individual. Exp Gerontol 34: 715-719, 1999.
30. Nishizaki T, Ozaki S, Harada K, Ito H, Arai H, Bepppu T and Sasaki K: Investigation of genetic alterations associated with the grade of astrocytic tumor by comparative genomic hybridization. Genes Chromosomes Cancer 21: 340-346, 1998.
31. Loeper S, Romeike BFM, Heckmann N, Jung V, Henn W, Feiden W, Zang KD and Urbschat S: Frequent mitotic errors in tumor cells of genetically micro-heterogeneous glioblastomas. Cytogenetic Cell Genetic 94: 1-8, 2001.