Negative clonal selection in tumor evolution

Genetics

Volumn 171, Issue 4, 2005, Pages 2123-2131

  Beckman, Robert A ^a   Loeb, Lawrence A ^b  

^a Centocor ^*  (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS; ARTICLE; AUTOSOMAL DOMINANT INHERITANCE; AUTOSOMAL RECESSIVE INHERITANCE; CARCINOGENESIS; CELL LINEAGE; CELL PROLIFERATION; CELL SELECTION; CLONE; FITNESS; GENE ACTIVATION; GENE MUTATION; GENOME; MATHEMATICAL ANALYSIS; MATHEMATICAL GENETICS; MATHEMATICAL MODEL; MUTATION RATE; MUTATOR GENE; ONCOGENE; PRECANCER; PRIORITY JOURNAL; RECESSIVE GENE;

CELL LINEAGE; CLONE CELLS; COMPUTER SIMULATION; EVOLUTION, MOLECULAR; MODELS, GENETIC; MUTATION; NEOPLASMS; SELECTION (GENETICS);

EID: 33645124560     PISSN: 00166731     EISSN: 00166731     Source Type: Journal    
DOI: 10.1534/genetics.105.040840     Document Type: Article

References (35)

1. ALBERTINI, R. J., J. A. NICKLAS, J. P. O'NEILL and S. H. ROBISON, 1990 In vivo somatic mutations in humans: measurement and analysis. Annu. Rev. Genet. 24: 305-326.
2. BACA, O. G., O. S. TACHEENI, E. T. AKPORIAYE, R. DEBLASIE and H. A. CRISSMAN, 1985 Cell cycle distribution patterns and generation times of L929 fibroblast cells persistently infected with Coxiella burnetti. Infect. Immun. 47: 366-369.
3. BAKER, F. L., L. J. SANGER, R. W. RODGERS, K. JABBOURY and O. R. MANGINI, 1995 Cell proliferation kinetics of normal and tumour tissue in vitro: quiescent reproductive cells and the cycling reproductive fraction. Cell Proliferation 28: 1-15.
4. BECKMAN, R. A., and L. A. LOEB, 1993 Multistage proofreading in DNA replication. Q. Rev. Biophys. 26: 225-331.
5. BIELAS, J. H., and L. A. LOEB, 2005 Quantitation of random genetic mutations. Nat. Methods 2: 285-290.
6. CERVANTES, R. B., J. R. STRINGER, C. SHAO, J. A. TISHCFIELD and P. J. STAMBROOK, 2002 Embryonic stem cells and somatic cells differ in mutation frequency and type. Proc. Natl. Acad. Sci. USA 99: 3586-3590.
7. DATTA, A., J. L. SCHMEITS, N. S. AMIN, P. J. LAU, K. MYUNG et al., 2000 Checkpoint-dependent activation of mutagenic repair in Saccharomyces cerevisiae pol2-01 mutants. Mol. Cell 6: 593-603.
8. EYRE-WALKER, A., and P. D. KEIGHTLEY, 1999 High genomic deleterious mutation rates in hominids. Nature 397: 344-347.
9. FELLER, W., 1957 An Introduction to Probability Theory and Its Applications, pp. 313-314. John Wiley & Sons, New York.
10. FISHEL, R., M. K. LESCOE, M.R. S. RAO, N. G. COPELAND, N. G. JENKINS et al., 1993 The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer. Cell 75: 1027-1038.
11. FUTREAL, P. A., L. COIN, M. MARSHALL, T. DOWN, T. HUBBARD et al., 2004 A census of human cancer genes. Nat. Rev. Cancer 4: 117-183.
12. GOLDSBY, R. E., N. A. LAWRENCE, L. E. HAYS, E. A. OLMSTED, X. CHEN et al., 2001 Defective DNA polymerase-d proofreading causes cancer susceptibility in mice. Nat. Med. 7: 638-639.
13. GUO, H. H., J. CHOE and L. A. LOEB, 2004 Protein tolerance to random amino acid substitution. Proc. Natl. Acad. Sci. USA 101: 9205-9210.
14. HANAHAN, D., and R. A. WEINBERG, 2000 The hallmarks of cancer. Cell 100: 57-70.
15. INTERNATIONAL HUMAN GENOME SEQUENCING CONSORTIUM, 2004 Finishing the euchromatic sequence of the human genome. Nature 431: 931-945.
16. IONOV, Y., M. A. PEINADO, S. MALKHOSYAN, S. SHIBATA and M. PERUCHO, 1993 Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis. Nature 363: 558-561.
17. IWASA, Y., F. MICHOR and M. A. NOWAK, 2004 Stochastic tunnels in evolutionary dynamics. Genetics 166: 1571-1579.
18. KNUDSON, A. G., 1971 Mutation and cancer: statistical study of retinoblastoma. Proc. Natl. Acad. Sci. USA 68: 820-823.
19. KOMAROVA, N. L., and D. WODARZ, 2003 Evolutionary dynamics of mutator phenotypes in cancer: implications for chemotherapy. Cancer Res. 63: 6335-6342.
20. KOMAROVA, N. L., A. SENGUPTA and M. A. NOWAK, 2003 Mutationselection networks of cancer initiation: tumor suppressor genes and chromosomal instability. J. Theor. Biol. 223: 433-450.
21. LENGAUER, C., K. W. KINZLER and B. VOGELSTEIN, 1998 Genetic instabilities in human cancers. Nature 396: 643-649.
22. LEVINE, A. J., 1997 p53, the cellular gatekeeper for growth and division. Cell 88: 323-331.
23. LOEB, L. A., 1991 Mutator phenotype may be required for multistage carcinogenesis. Cancer Res. 51: 3075-3079.
24. LOEB, L. A., 1998 Cancer cells exhibit a mutator phenotype. Adv. Cancer Res. 72: 25-56.
25. LOEB, L. A., C. F. Springgate and N. Battula, 1974 Errors in DNA replication as a basis of malignant changes. Cancer Res. 34: 2311-2321.
26. LOEB, L. A., K. R. LOEB and J. P. ANDERSON, 2003 Multiple mutations in cancer. Proc. Natl. Acad. Sci. USA 100: 776-781.
27. MARKIEWICZ, P., L. G. KLEINA, C. CRUZ, S. EHRET and J. H. MILLER, 1994 Genetic studies of the lac repressor. XIV. Analysis of 400 altered Escherichia coli lac repressors reveals essential and nonessential residues, as well as "spacers" which do not require a specific sequence. J. Mol. Biol. 240: 421-433.
28. MITOPENCOURSEWARE, 2005 Cell, tissue and tumor kinetics (http://ocw.mit.edu).
29. MOOLGAVKAR, S. H., and A. G. KNUDSON, 1981 Mutation and cancer: a model for human carcinogenesis. J. Natl. Cancer Inst. 66: 1037-1052.
30. MORRISON, A., A. L. JOHNSON, L. H. JOHNSTON and A. SUGINO, 1993 Pathway correcting DNA replication errors in Saccharomyces cerevisiae. EMBO J. 12: 1467-1473.
31. NOWAK, M. A., N. L. KOMAROVA, A. SENGUPTA, P. V. JALLEPALLI, I. M. SHIN et al., 2002 The role of chromosomal instability in tumor initiation. Proc. Natl. Acad. Sci. USA 99: 16226-16231.
32. NOWELL, P. C., 1976 The clonal evolution of tumor cell populations. Science 194: 23-28.
33. SHERR, C. J., and F. MCCORMICK, 2002 The RB and p53 pathways in cancer. Cancer Cell 2: 103-112.
34. TOMLINSON, I., P. SASIENI and W. BODMER, 2002 How many mutations in a cancer? Am. J. Pathol. 160: 755-758.
35. WOOD, R. D., M. MITCHELL, J. SGOUROS and T. LINDAHL, 2001 Human DNA repair genes. Science 29: 1284-1289.