Intratumoral heterogeneity of Von Hippel-Lindau gene deletions in renal cell carcinoma detected by fluorescence in situ hybridization

Cancer Research

Volumn 58, Issue 11, 1998, Pages 2304-2309

  Moch, Holger ^a,b   Schraml, Peter ^a   Bubendorf, Lukas ^a   Richter, Jan ^a   Gasser, Thomas C ^a   Mihatsch, Michael J ^a   Sauter, Guido ^a  

^a UNIVERSITY OF BASEL   (Switzerland)

^b UNIVERSITY HOSPITAL BASEL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

KI 67 ANTIGEN;

ARTICLE; CENTROMERE; CHROMOSOME 17P; CHROMOSOME 3P; CHROMOSOME 8P; CHROMOSOME DELETION; DNA PROBE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE DELETION; GENETIC HETEROGENEITY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KIDNEY CARCINOMA; MAJOR CLINICAL STUDY; PHENOTYPE; PREVALENCE; PRIORITY JOURNAL; VON HIPPEL LINDAU DISEASE;

CARCINOMA, RENAL CELL; CHROMOSOMES, HUMAN, PAIR 17; CHROMOSOMES, HUMAN, PAIR 8; GENE DELETION; GENES, TUMOR SUPPRESSOR; GENETIC HETEROGENEITY; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; KI-67 ANTIGEN; KIDNEY NEOPLASMS; LIGASES; PROTEINS; TUMOR SUPPRESSOR PROTEINS; UBIQUITIN-PROTEIN LIGASES; VON HIPPEL-LINDAU TUMOR SUPPRESSOR PROTEIN;

EID: 0032101568     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Wolman, S. R., Camuto, P. M., Golimbu, M., and Schinella, R. Cytogenetic, flow cytometric, and ultrastructural studies of twenty-nine nonfamilial human renal carcinomas. Cancer Res., 48: 2890-2897, 1988.
2. Dal Cin, P., Li, F., Prout, G., Huben, R., Limon, J., Ferti-Passantonopoulou, A., Richi, J., and Sandberg, A. Involvement of chromosome 3 and 5 in renal cell carcinoma. Cancer Genet. Cytogenet., 35: 41-46, 1988.
3. Kovacs, G. Papillary renal cell carcinoma: a morphologic and cytogenetic study of 11 cases. Am. J. Pathol., 134: 27-34, 1989.
4. Renshaw, A., and Fletcher, J. Trisomy 3 in renal cell carcinoma. Mod. Pathol., 10: 481-484, 1997.
5. Yoshida, M., Ohyashiki, K., Ochi, H., Gibas, Z., Pontes, J., Prout, G., Huben, R., and Sandberg, A. Cytogenetic studies of tumor tissue from patients with nonfamilial renal cell carcinoma. Cancer Res., 46: 2139-2147, 1986.
6. Presti, J., Rao, H., Chen, Q., Reuter, V., Li, F., Fair, W., and Jhanwar, S. Histopathological, cytogenetic, and molecular characterization of renal cortical tumors. Cancer Res., 51: 1544-1552, 1991.
7. Kovacs, G., and Frisch, S. Clonal chromosome abnormalities in tumor cells from patients with sporadic renal carcinomas. Cancer Res., 49: 651-659, 1989.
8. Zbar, B., Brauch, H., Talmadge, C., and Linehan, M. Loss of alleles of loci on the short arm of chromosome 3 in renal cell carcinoma. Nature (Lond.), 327: 721-727, 1987.
9. Anglard, P., Tory, K., Brauch, H., Weiss, G. H., Latif, F., Merino, M. J., Lerman, M. I., Zbar, B., and Linehan, W. M. Molecular analysis of genetic changes in the origin and development of renal cell carcinoma. Cancer Res., 51: 1071-1077, 1991.
10. Presti, J., Reuter, V., Cordon-Cardo, C., Mazumdar, M., Fair, W., and Jhanwar, S. Allelic deletions in renal tumors: histopathological correlations. Cancer Res., 53: 5780-5783, 1993.
11. Bugert, P., and Kovacs, G. Molecular differential diagnosis of renal cell carcinomas by microsatellite analysis. Am. J. Pathol., 149: 2081-2088, 1996.
12. Tory, K., Brauch, H., Linehan, M., Barba, D., Oldfield, E., Filling-Katz, M., Seizinger, B., Nakamura, Y., White, R., and Marshall, F. Specific genetic change in tumors associated with von Hippel-Lindau disease. J. Natl. Cancer Inst., 81: 1097-1101, 1989.
13. Bergerheim, U., Nordenskjöld, M., and Collins, V. Deletion mapping in human renal cell carcinoma. Cancer Res., 49: 1390-1398, 1989.
14. van der Hout, A. H., van der Vlies, P., Wijmenga, C., Li, F. P., Oosterhuis, J. W., and Buys, C. H. The region of common allelic losses in sporadic renal cell carcinoma is bordered by the loci D3S2 and THRB. Genomics, 11: 537-542, 1991.
15. Yamakawa, K., Morita, R., Takahashi, E., Hori, T., Ishikawa, J., and Nakamura, Y. A detailed deletion mapping of the short arm of chromosome 3 in sporadic renal cell carcinoma. Cancer Res., 51: 4707-4711, 1991.
16. Lubinski, J., Hadaczek, P., Podolski, J., Toloczko, A., Sikorski, A., McCue, P., Druck, T., and Huebner, K. Common regions of deletion in chromosome regions 3p12 and 3p14.2 in primary clear cell renal carcinomas. Cancer Res., 54: 3710-3713, 1994.
17. Druck, T., Kastury, K., Hadaczek, P., Podolski, J., Toloczko, A., Sikorski, A., Ohta, M., LaForgia, S., Lasota, J., McCue, P., Lubinski, J., and Huebner, K. Loss of heterozygosity at the familial RCC t(3;8) locus in most clear cell renal carcinomas. Cancer Res., 55: 5348-5353, 1995.
18. Latif, F., Tory, K., Gnarra, J., Yao, M., Duh, F. M., Orcutt, M. L., Stackhouse, T., Kuzmin, I., Modi, W., and Geil, L. Identification of the von Hippel-Lindau disease tumor suppressor gene. Science (Washington DC), 260: 1317-1320, 1993.
19. Herman, J. G., Latif, F., Weng, Y., Lerman, M. I., Zbar, B., Liu, S., Samid, D., Duan, D. S., Gnarra, J. R., Linehan, W. M., and Baylin, S. B. Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma. Proc. Natl. Acad. Sci. USA, 91: 9700-9704, 1994.
20. van den Berg, A., and Buys, C. Involvement of multiple loci on chromosome 3 in renal cell cancer development. Genes Chromosomes Cancer, 19: 59-76, 1997.
21. Thrash-Bingham, C., Salazar, H., Freed, J., Greenberg, R., and Tartof, K. Genomic alterations and instabilities in renal cell carcinomas and their relationship to tumor pathology. Cancer Res., 55: 6189-6195, 1995.
22. Sauter, G., Moch, H., Moore, D., Carroll, P., Kerschmann, R., Chew, K., Mihatsch, M., Gudat, F., and Waldman, F. Heterogeneity of erbB-2 gene amplification in bladder cancer. Cancer Res., 53: 2199-2203, 1993.
23. Wagner, U., Bubendorf, L., Gasser, T., Moch, H., Görög, J., Richter, J., Mihatsch, M., and Sauter, G. Chromosome 8p deletions are associated with invasive tumor growth in urinary bladder cancer. Am. J. Pathol., 151: 753-759, 1997.
24. Sauter, G., Deng, G., Moch, H., Kerschmann, R., Matsumura, K., DeVries, S., George, T., Fuentes, J., Carroll, P., Mihatsch, M. J., and Waldman, F. M. Physical deletion of the p53 gene in bladder cancer: detection by fluorescence in-situ hybridization. Am. J. Pathol., 144: 756-766, 1994.
25. van der Hout, A. H., van den Berg, E., van der Vlies, P., Dijkhuizen, T., Störkel, S., Oosterhuis, J. W., de Jong, B., and Buys, C. H. Loss of heterozygosity at the short arm of chromosome 3 in renal-cell cancer correlates with the cytological tumour type. Int. J. Cancer, 53: 353-357, 1993.
26. Shridhar, V., Rivard, S., Shridhar, R., Mullins, C., Bostick, L., Sakr, W., Grignon, D., Miller, O. J., and Smith, D. I. A gene from human chromosomal band 3p21.1 encodes a highly conserved arginine-rich protein and is mutated in renal cell carcinomas. Oncogene, 12: 1931-1939, 1996.
27. Walker, C., Ahn, Y. T., Everitt, J., and Yuan, X. Renal cell carcinoma development in the rat independent of alterations at the VHL gene locus. Mol. Carcinog., 15: 154-161, 1996.
28. Gronwald, J., Störkel, S., Holtgreve-Grez, H., Hadaczek, P., Brinkschmidt, C., Jauch, A., Lubinski, J., and Cremer, T. Comparison of DNA gains and losses in primary renal clear cell carcinomas and metastatic sites: importance of Iq and 3p copy number changes in metastatic events. Cancer Res., 57: 481-487, 1997.
29. Richter, J., Jiang, F., Görög, J., Sartorius, G., Egenter, C., Gasser, T., Moch, H., Mihatsch, M., and Sauter, G. Marked genetic differences between stage pTa and stage pT1 papillary bladder cancer detected by comparative genomic hybridization. Cancer Res., 57: 2860-2864, 1997.
30. Kallioniemi, A., Kallioniemi, O. P., Piper, J., Tanner, M., Stokke, T., Chen, L., Smith, H. S., Pinkel, D., Gray, J. W., and Waldman, F. M. Detection and mapping of amplified DNA sequences in breast cancer by comparative genomic hybridization. Proc. Natl. Acad. Sci. USA, 91: 2156-2160, 1994.
31. Moch, H., Presti, J. C., Jr., Sauter, G., Buchholz, N., Jordan, P., Mihatsch, M. J., and Waldman, F. M. Genetic aberrations detected by comparative genomic hybridization are associated with clinical outcome in renal cell carcinoma, Cancer Res., 56: 27-30, 1996.
32. Moch, H., Sauter, G., Gasser, T., Bubendorf, L., Presti, J., Mihatsch, M. J., and Waldman, F. M. EGF-r gene copy number gains detected by fluorescence in-situ hybridization in renal cell carcinoma. J. Pathol., 184: 424-429, 1998.
33. Wolman, S. R., Waldman, F. M., and Balazs, M. Complementarity of interphase and metaphase chromosome analysis in human renal tumors. Genes Chromosomes Cancer, 6: 17-23, 1993.