Increase developmental plasticity of human keratinocytes with gene suppression

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 31, 2011, Pages 12793-12798

  Li, Shengwen Calvin ^a,b   Jin, Yangsun ^a   Loudon, William G ^b   Song, Yahui ^a   Ma, Zhiwei ^c   Weiner, Leslie P ^a   Zhong, Jiang F ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b CHILDREN S HOSPITAL OF ORANGE COUNTY   (United States)

^c Good Samaritan Hospital Medical Center   (United States)

Author keywords

Cancer development; Neural development; Transdifferentiation

Indexed keywords

ALKALINE PHOSPHATASE; OCTAMER TRANSCRIPTION FACTOR 4; PROTEIN P53;

ANIMAL EXPERIMENT; ARTICLE; CELL LINEAGE; CELL MEMBRANE POTENTIAL; DNA FINGERPRINTING; GENE REPRESSION; GENE SWITCHING; HUMAN; HUMAN CELL; IN VIVO STUDY; KARYOTYPE; KERATINOCYTE; MOUSE; NERVE CELL DIFFERENTIATION; NONHUMAN; NUCLEAR REPROGRAMMING; PLASTICITY; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CELL DIFFERENTIATION; CELL LINEAGE; CELL TRANSPLANTATION; CELLS, CULTURED; EMBRYONIC STEM CELLS; FIBROBLASTS; GREEN FLUORESCENT PROTEINS; HEK293 CELLS; HUMANS; INDUCED PLURIPOTENT STEM CELLS; KARYOTYPING; KERATINOCYTES; MICE; MICE, SCID; MICE, TRANSGENIC; MICROSCOPY, FLUORESCENCE; NEURAL STEM CELLS; OCTAMER TRANSCRIPTION FACTOR-3; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; TERATOMA; TRANSPLANTATION, HETEROLOGOUS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 79961227372     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1100509108     Document Type: Article

References (44)

1. Takahashi K, et al. (2007) Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131:861-872. (Pubitemid 350138099)
2. Yu J, et al. (2007) Induced pluripotent stem cell lines derived from human somatic cells. Science 318:1917-1920.
3. Hochedlinger K, Plath K (2009) Epigenetic reprogramming and induced pluripotency. Development 136:509-523.
4. Utikal J, et al. (2009) Immortalization eliminates a roadblock during cellular reprogramming into iPS cells. Nature 460:1145-1148.
5. Takahashi K, Ichisaka T, Yamanaka S (2006) Identification of genes involved in tumorlike properties of embryonic stem cells. Methods Mol Biol 329:449-458.
6. Zhao Y, et al. (2008) Two supporting factors greatly improve the efficiency of human iPSC generation. Cell Stem Cell 3:475-479.
7. Marión RM, et al. (2009) A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity. Nature 460:1149-1153.
8. Kawamura T, et al. (2009) Linking the p53 tumour suppressor pathway to somatic cell reprogramming. Nature 460:1140-1144.
9. Lane DP (1992) Worrying about p53. Curr Biol 2:581-583.
10. Lane DP (1992) Cancer. p53, guardian of the genome. Nature 358:15-16.
11. Zuckerman V, Wolyniec K, Sionov RV, Haupt S, Haupt Y (2009) Tumour suppression by p53: The importance of apoptosis and cellular senescence. J Pathol 219:3-15.
12. Subramanian S, et al. (2010) Genome-wide transcriptome analyses reveal p53 inactivation mediated loss of miR-34a expression in malignant peripheral nerve sheath tumours. J Pathol 220:58-70.
13. Lozano G (2010) Mouse models of p53 functions. Cold Spring Harb Perspect Biol 2:a001115.
14. Puca R, Nardinocchi L, Givol D, D'Orazi G (2010) Regulation of p53 activity by HIPK2: Molecular mechanisms and therapeutical implications in human cancer cells. Oncogene 29:4378-4387.
15. Gottlieb E, Vousden KH (2010) p53 regulation of metabolic pathways. Cold Spring Harb Perspect Biol 2:a001040.
16. Hong H, et al. (2009) Suppression of induced pluripotent stem cell generation by the p53-p21 pathway. Nature 460:1132-1135.
17. Zhong JF, et al. (2007) Gene regulation networks related to neural differentiation of hESC. Gene Expr 14:23-34. (Pubitemid 350012962)
18. Zhong JF, Weiner LP, Jin Y, Lu W, Taylor CR (2010) A real-time pluripotency reporter for human stem cells. Stem Cells Dev 19:47-52.
19. Takahashi K, Yamanaka S (2006) Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126:663-676. (Pubitemid 44233629)
20. Li SC, Loudon WG (2008) A novel and generalizable organotypic slice platform to evaluate stem cell potential for targeting pediatric brain tumors. Cancer Cell Int 8:9.
21. Li SC, et al. (2009) Stem cell engineering for treatment of heart diseases: Potentials and challenges. Cell Biol Int 33:255-267.
22. Moore BW, Perez VJ, Gehring M (1968) Assay and regional distribution of a soluble protein characteristic of the nervous system. J Neurochem 15:265-272.
23. Cole MF, Johnstone SE, Newman JJ, Kagey MH, Young RA (2008) Tcf3 is an integral componentof the core regulatory circuitry of embryonic stemcells.GenesDev 22:746-755. (Pubitemid 351439106)
24. Boyer LA, et al. (2005) Core transcriptional regulatory circuitry in human embryonic stem cells. Cell 122:947-956. (Pubitemid 41345211)
25. Kanatsu-Shinohara M, et al. (2004) Generation of pluripotent stem cells from neonatal mouse testis. Cell 119:1001-1012. (Pubitemid 40037613)
26. Giorgetti A, et al. (2009) Generation of induced pluripotent stem cells from human cord blood using OCT4 and SOX2. Cell Stem Cell 5:353-357.
27. Li H, et al. (2009) The Ink4/Arf locus is a barrier for iPS cell reprogramming. Nature 460:1136-1139.
28. Marion RM, et al. (2009) Telomeres acquire embryonic stem cell characteristics in induced pluripotent stem cells. Cell Stem Cell 4:141-154.
29. Hollstein M, Sidransky D, Vogelstein B, Harris CC (1991) p53 mutations in human cancers. Science 253:49-53. (Pubitemid 21917115)
30. Kuerbitz SJ, Plunkett BS, Walsh WV, Kastan MB (1992) Wild-type p53 is a cell cycle checkpoint determinant following irradiation. Proc Natl Acad Sci USA 89:7491-7495.
31. Donehower LA, et al. (1992) Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 356:215-221.
32. Tong C, Li P, Wu NL, Yan Y, Ying QL (2010) Production of p53 gene knockout rats by homologous recombination in embryonic stem cells. Nature 467:211-213.
33. Kemp CJ, Donehower LA, Bradley A, Balmain A (1993) Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors. Cell 74:813-822. (Pubitemid 23270601)
34. Yamamoto M, et al. (2000) p53 knockout mice (-/-) aremore susceptible than (+/-) or (+/+) mice to N-methyl-N-nitrosourea stomach carcinogenesis. Carcinogenesis 21:1891-1897.
35. Li SC, Han YP, Dethlefs BA, Loudon WG (2010) Therapeutic window, a critical developmental stage for stem cell therapies. Curr Stem Cell Res Ther 5:297-303.
36. Wilmut I, Schnieke AE, McWhir J, Kind AJ, Campbell KH (1997) Viable offspring derived from fetal and adult mammalian cells. Nature 385:810-813. (Pubitemid 27106068)
37. Gilyarov AV (2008) Nestin in central nervous system cells. Neurosci Behav Physiol 38:165-169.
38. Schwartz PH, et al. (2003) Isolation and characterization of neural progenitor cells from post-mortem human cortex. J Neurosci Res 74:838-851. (Pubitemid 37490416)
39. Li S, Kirov I, Klassen HK, Schwartz PH (2007) Characterization of stem cells using reverse transcriptase polymerase chain reaction. Human Stem Cell Manual: A Laboratory Guide, eds Loring JF, Wesselschmidt RL, Schwartz PH (Elsevier, New York), pp 127-148.
40. Ju X, et al. (2007) Akt1 governs breast cancer progression in vivo. Proc Natl Acad Sci USA 104:7438-7443. (Pubitemid 47185924)
41. Li S, Couet J, Lisanti MP (1996) Src tyrosine kinases, Galpha subunits, and H-Ras share a common membrane-anchored scaffolding protein, caveolin. Caveolin binding negatively regulates the auto-activation of Src tyrosine kinases. J Biol Chem271:29182-29190. (Pubitemid 26382628)
42. Li S, et al. (1995) Evidence for a regulated interaction between heterotrimeric G proteins and caveolin. J Biol Chem 270:15693-15701.
43. Flanagan LA, Ziaeian B, Palmer T, Schwartz PH (2007) Immunocytochemical analysis of stem cells. Human Stem Cell Manual: A Laboratory Guide, eds Loring JF, Wesselschmidt RL, Schwartz PH (Elsevier, New York), pp 108-126.
44. Shi SR, Chaiwun B, Young L, Cote RJ, Taylor CR (1993) Antigen retrieval technique utilizing citrate buffer or urea solution for immunohistochemical demonstration of androgen receptor in formalin-fixed paraffin sections. J Histochem Cytochem 41:1599-1604. (Pubitemid 23317103)