Single-Cell RNAseq reveals that pancreatic β-cells from very old male mice have a young gene signature

Endocrinology

Volumn 157, Issue 9, 2016, Pages 3431-3438

  Xin, Yurong ^a   Okamoto, Haruka ^a   Kim, Jinrang ^a   Ni, Min ^a   Adler, Christina ^a   Cavino, Katie ^a   Na, Erqian ^a   Murphy, Andrew J ^a   Yancopoulos, George D ^a   Lin, Calvin ^a   Gromada, Jesper ^a  

^a REGENERON PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 1; ACTIVATING TRANSCRIPTION FACTOR 3; EARLY GROWTH RESPONSE FACTOR 1; GLUCOSE; HEAT SHOCK TRANSCRIPTION FACTOR 1; HEPATOCYTE NUCLEAR FACTOR 3GAMMA; HIGH MOBILITY GROUP B2 PROTEIN; INTERFERON REGULATORY FACTOR 6; KRUPPEL LIKE FACTOR 6; MITOGEN ACTIVATED PROTEIN KINASE 10; NUCLEAR RECEPTOR NUR77; PROTEIN FOS; RNA; SMAD2 PROTEIN; SMAD5 PROTEIN; STAT1 PROTEIN; STAT6 PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FOSB; TRANSCRIPTION FACTOR FOSL2; TRANSCRIPTION FACTOR FOXJ2; TRANSCRIPTION FACTOR JUN; TRANSCRIPTION FACTOR JUNB; TRANSCRIPTION FACTOR RREB1; TRANSCRIPTION FACTOR SP3; TRANSCRIPTION FACTOR SRF; TRANSCRIPTION FACTOR SS18L1; TRANSCRIPTION FACTOR ZBTB24; TRANSCRIPTION FACTOR ZEB1; TRANSCRIPTOME; UNCLASSIFIED DRUG;

AGE; AGED; AGING; ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BODY WEIGHT; CELL CYCLE; CELL MOTION; CELL SURVIVAL; CONTROLLED STUDY; CORRELATIONAL STUDY; DOWN REGULATION; GENE; GENE EXPRESSION REGULATION; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL FUNCTION; PRIORITY JOURNAL; RNA SEQUENCE; SENESCENCE; SIGNAL TRANSDUCTION; SINGLE CELL ANALYSIS; TRANSCRIPTOMICS; VERY ELDERLY; ANIMAL; C57BL MOUSE; CELL AGING; HOMEOSTASIS; METABOLISM; SEQUENCE ANALYSIS;

AGING; ANIMALS; CELL AGING; GLUCOSE; HOMEOSTASIS; INSULIN-SECRETING CELLS; MALE; MICE, INBRED C57BL; SEQUENCE ANALYSIS, RNA; SINGLE-CELL ANALYSIS; TRANSCRIPTION FACTORS; TRANSCRIPTOME;

EID: 84985955357     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2016-1235     Document Type: Article

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