Phosphorylation and degradation of tomosyn-2 de-represses insulin secretion

Journal of Biological Chemistry

Volumn 289, Issue 36, 2014, Pages 25276-25286

  Bhatnagar, Sushant ^a   Soni, Mufaddal S ^a   Wrighton, Lindsay S ^a   Hebert, Alexander S ^b   Zhou, Amber S ^a   Paul, Pradyut K ^a   Gregg, Trillian ^a   Rabaglia, Mary E ^a   Keller, Mark P ^a   Coon, Joshua J ^b   Attie, Alan D ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN; MASS SPECTROMETRY; PHOSPHORYLATION; PHYSIOLOGY;

FUNCTIONAL ACTIVITIES; NEGATIVE REGULATORS; PHOSPHORYLATION SITES; PROTEASOMAL PATHWAY; PROTEIN TURNOVERS; SHORT HAIRPIN RNA; SITE DIRECTED MUTAGENESIS; UBIQUITIN LIGASES;

PROTEINS;

CYCLIC AMP DEPENDENT PROTEIN KINASE; GREEN FLUORESCENT PROTEIN; HRD 1 PROTEIN; PEPTIDES AND PROTEINS; PROTEIN KINASE C; SHORT HAIRPIN RNA; TOMOSYN 2 PROTEIN; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; GLUCOSE; INSULIN; PROTEIN BINDING; SERINE; STXBP5L PROTEIN, MOUSE; SYNAPTOBREVIN; SYVN1 PROTEIN, HUMAN; UBIQUITIN PROTEIN LIGASE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; INSULIN RELEASE; NONHUMAN; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RAT; SIGNAL TRANSDUCTION; UBIQUITINATION; ANIMAL; BINDING SITE; CELL CULTURE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; GENETICS; HEK293 CELL LINE; IMMUNOBLOTTING; METABOLISM; MOUSE; MUTATION; PANCREAS ISLET BETA CELL; PHOSPHORYLATION; PROTEIN TERTIARY STRUCTURE; RNA INTERFERENCE; SECRETION (PROCESS); TUMOR CELL LINE;

ANIMALS; BINDING SITES; CELL LINE, TUMOR; CELLS, CULTURED; GLUCOSE; HEK293 CELLS; HUMANS; IMMUNOBLOTTING; INSULIN; INSULIN-SECRETING CELLS; MICE; MODELS, MOLECULAR; MUTATION; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEOLYSIS; R-SNARE PROTEINS; RNA INTERFERENCE; SERINE; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 84906971929     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.575985     Document Type: Article

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