SUMOylation of pancreatic glucokinase regulates its cellular stability and activity

Journal of Biological Chemistry

Volumn 288, Issue 8, 2013, Pages 5951-5962

  Aukrust, Ingvild ^a   Bjorkhaug, Lise ^a,b   Negahdar, Maria ^a   Molnes, Janne ^c   Johansson, Bente B ^b   Müller, Yvonne ^b,c   Haas, Wilhelm ^a,b   Gygi, Steven P ^a   Sovik, Oddmund ^a,b   Flatmark, Torgeir ^b,c   Kulkarni, Rohit N ^c   Njolstad, Pal R ^a,b  

^a UNIVERSITY OF BERGEN   (Norway)

^b HAUKELAND UNIVERSITY HOSPITAL   (Norway)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOHYDRATE METABOLISM; CELLULAR STABILITY; GLUCOKINASE; IN-VITRO; POST-TRANSLATIONAL MODIFICATIONS; REGULATORY FUNCTIONS; SUMO CONJUGATION; SUMOYLATION;

BIOCHEMISTRY; BIOLOGY;

CARBOHYDRATES;

GLUCOKINASE; GLYCOPROTEIN E2; LYSINE; PROTEIN UBC9; RECOMBINANT ENZYME; SUMO 1 PROTEIN; UBIQUITIN PROTEIN LIGASE E3;

AMINO TERMINAL SEQUENCE; ARTICLE; CATALYSIS; CELL ACTIVITY; CELL ISOLATION; CELL STRAIN INS 1; CELL STRAIN MIN6; CELLULAR STABILITY; CELLULAR, SUBCELLULAR AND MOLECULAR BIOLOGICAL PHENOMENA AND FUNCTIONS; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; IN VITRO STUDY; MASS SPECTROMETRY; MOLECULAR DOCKING; PANCREAS ISLET BETA CELL; PLASMID; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; REGULATORY MECHANISM; SUMOYLATION; TWO DIMENSIONAL ELECTROPHORESIS;

ANIMALS; CARBOHYDRATES; CATALYSIS; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUCOKINASE; INSULIN-SECRETING CELLS; KINETICS; LIVER; MASS SPECTROMETRY; MICE; MUTATION; PANCREAS; PROTEIN ISOFORMS; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECOMBINANT PROTEINS; SUMOYLATION;

EID: 84874294413     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.393769     Document Type: Article

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