Transcriptional response of pancreatic beta cells to metabolic stimulation: Large scale identification of immediate-early and secondary response genes

BMC Molecular Biology

Volumn 8, Issue , 2007, Pages

  Glauser, Dominique A ^a   Brun, Thierry ^b   Gauthier, Benoit R ^b   Schlegel, Werner ^a  

^a UNIVERSITY OF GENEVA   (Switzerland)

^b University Medical Center   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; TRANSCRIPTION FACTOR AP 1; CYCLIC AMP; GLUCAGON LIKE PEPTIDE 1; GLUCOSE; LUCIFERASE; PRIMER DNA;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL SECRETION; CELL STIMULATION; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GENE IDENTIFICATION; GENE TARGETING; GENETIC TRANSCRIPTION; IMMEDIATE EARLY GENE; MALE; METABOLIC REGULATION; METABOLISM; MICROARRAY ANALYSIS; NONHUMAN; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL FUNCTION; PROMOTER REGION; RAT; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; ANIMAL; CELL LINE; COMPARATIVE STUDY; DNA MICROARRAY; GENE EXPRESSION PROFILING; GENETICS; IMMUNOHISTOCHEMISTRY; MOUSE; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; WISTAR RAT;

RATTUS;

ANIMALS; BLOTTING, WESTERN; CELL LINE; CYCLIC AMP; DNA PRIMERS; GENE EXPRESSION PROFILING; GENES, REPORTER; GLUCAGON-LIKE PEPTIDE 1; GLUCOSE; IMMUNOHISTOCHEMISTRY; INSULIN-SECRETING CELLS; LUCIFERASES; MALE; MICE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 34547761232     PISSN: None     EISSN: 14712199     Source Type: Journal    
DOI: 10.1186/1471-2199-8-54     Document Type: Article

References (45)

1. Drucker DJ Glucagon-like peptides: Regulators of cell proliferation, differentiation, and apoptosis Mol Endocrinol 2003 17 2 161-171 10.1210/ me.2002-0306 12554744
2. Hinke SA Hellemans K Schuit FC Plasticity of the beta cell insulin secretory competence: Preparing the pancreatic beta cell for the next meal J Physiol 2004 558 Pt 2 369-380 1664983 15181163 10.1113/ jphysiol.2004.064881
3. Schuit F Flamez D De Vos A Pipeleers D Glucose-regulated gene expression maintaining the glucose-responsive state of beta-cells Diabetes 2002 51 Suppl 3 S326 32 10.2337/diabetes.51.2007.S326 12475771
4. Bouwens L Rooman I Regulation of pancreatic beta-cell mass Physiol Rev 2005 85 4 1255-1270 10.1152/physrev.00025.2004 16183912
5. Jonas JC Sharma A Hasenkamp W Ilkova H Patane G Laybutt R Bonner-Weir S Weir GC Chronic hyperglycemia triggers loss of pancreatic beta cell differentiation in an animal model of diabetes J Biol Chem 1999 274 20 14112-14121 10.1074/jbc.274.20.14112 10318828
6. Weir GC Bonner-Weir S Five stages of evolving beta-cell dysfunction during progression to diabetes Diabetes 2004 53 Suppl 3 S16-21 10.2337/ diabetes.53.suppl_3.S16 15561905
7. Ohsugi M Cras-Meneur C Zhou Y Warren W Bernal-Mizrachi E Permutt MA Glucose and insulin treatment of insulinoma cells results in transcriptional regulation of a common set of genes Diabetes 2004 53 6 1496-1508 10.2337/diabetes.53.6.1496 15161754
8. Webb GC Akbar MS Zhao C Steiner DF Expression profiling of pancreatic beta cells: Glucose regulation of secretory and metabolic pathway genes Proc Natl Acad Sci U S A 2000 97 11 5773-5778 18509 10811900 10.1073/ pnas.100126597
9. Susini S Roche E Prentki M Schlegel W Glucose and glucoincretin peptides synergize to induce c-fos, c-jun, junB, zif-268, and nur-77 gene expression in pancreatic beta(INS-1) cells Faseb J 1998 12 12 1173-1182 9737720
10. Josefsen K Sorensen LR Buschard K Birkenbach M Glucose induces early growth response gene (Egr-1) expression in pancreatic beta cells Diabetologia 1999 42 2 195-203 10.1007/s001250051139 10064100
11. Blenis J Signal transduction via the MAP kinases: Proceed at your own RSK Proc Natl Acad Sci U S A 1993 90 13 5889-5892 46831 8392180 10.1073/ pnas.90.13.5889
12. Hazzalin CA Mahadevan LC MAPK-regulated transcription: A continuously variable gene switch? Nat Rev Mol Cell Biol 2002 3 1 30-40 10.1038/ nrm715 11823796
13. Glauser DA Schlegel W Sequential actions of ERK1/2 on the AP-1 transcription factor allow temporal integration of metabolic signals in pancreatic beta cells FASEB J 17504975
14. Susini S Van Haasteren G Li S Prentki M Schlegel W Essentiality of intron control in the induction of c-fos by glucose and glucoincretin peptides in INS-1 beta-cells Faseb J 2000 14 1 128-136 10627287
15. Bernal-Mizrachi E Wen W Srinivasan S Klenk A Cohen D Permutt MA Activation of Elk-1, an Ets transcription factor, by glucose and EGF treatment of insulinoma cells Am J Physiol Endocrinol Metab 2001 281 6 E1286-99 11701445
16. Bernal-Mizrachi E Wice B Inoue H Permutt MA Activation of serum response factor in the depolarization induction of Egr-1 transcription in pancreatic islet beta-cells J Biol Chem 2000 275 33 25681 25689 10.1074/ jbc.M003424200 10829028
17. Jonas JC Laybutt DR Steil GM Trivedi N Pertusa JG Van de Casteele M Weir GC Henquin JC High glucose stimulates early response gene c-Myc expression in rat pancreatic beta cells J Biol Chem 2001 276 38 35375-35381 10.1074/jbc.M105020200 11457846
18. Glauser DA Schlegel W Mechanisms of transcriptional regulation underlying temporal integration of signals Nucleic Acids Research 2006 34 18 5175-5183 1636431 16998184 10.1093/nar/gkl654
19. Swiss-Prot http://www.expasy.org/sprot/
20. Kim J Seo J Lee YS Kim S TFExplorer: Integrated analysis database for predicted transcription regulatory elements Bioinformatics 2005 21 4 548 550 10.1093/bioinformatics/bti048 15466909
21. Kaminska B Pyrzynska B Ciechomska I Wisniewska M Modulation of the composition of AP-1 complex and its impact on transcriptional activity Acta Neurobiol Exp (Wars) 2000 60 3 395-402 11016082
22. Olive M Krylov D Echlin DR Gardner K Taparowsky E Vinson C A dominant negative to activation protein-1 (AP1) that abolishes DNA binding and inhibits oncogenesis J Biol Chem 1997 272 30 18586-18594 10.1074/ jbc.272.30.18586 9228025
23. Halazonetis TD Georgopoulos K Greenberg ME Leder P c-Jun dimerizes with itself and with c-Fos, forming complexes of different DNA binding affinities Cell 1988 55 5 917-924 10.1016/0092-8674(88)90147-X 3142692
24. D'Alonzo RC Selvamurugan N Karsenty G Partridge NC Physical interaction of the activator protein-1 factors c-Fos and c-Jun with Cbfa1 for collagenase-3 promoter activation J Biol Chem 2002 277 1 816-822 10.1074/ jbc.M107082200 11641401
25. Stein B Baldwin AS Jr. Ballard DW Greene WC Angel P Herrlich P Cross-coupling of the NF-kappa B p65 and Fos/Jun transcription factors produces potentiated biological function Embo J 1993 12 10 3879-3891 413671 8404856
26. Joiakim A Mathieu PA Elliott AA Reiners JJ Jr. Superinduction of CYP1A1 in MCF10A cultures by cycloheximide, anisomycin, and puromycin: A process independent of effects on protein translation and unrelated to suppression of aryl hydrocarbon receptor proteolysis by the proteasome Mol Pharmacol 2004 66 4 936-947 15385644
27. Hershko DD Robb BW Wray CJ Luo GJ Hasselgren PO Superinduction of IL-6 by cycloheximide is associated with mRNA stabilization and sustained activation of p38 map kinase and NF-kappaB in cultured caco-2 cells J Cell Biochem 2004 91 5 951-961 10.1002/jcb.20014 15034930
28. Srinivasan S Bernal-Mizrachi E Ohsugi M Permutt MA Glucose promotes pancreatic islet beta-cell survival through a PI 3-kinase/Akt-signaling pathway Am J Physiol Endocrinol Metab 2002 283 4 E784-93 12217896
29. Chipuk JE Bouchier-Hayes L Kuwana T Newmeyer DD Green DR PUMA couples the nuclear and cytoplasmic proapoptotic function of p53 Science 2005 309 5741 1732-1735 10.1126/science.1114297 16151013
30. Tran H Brunet A Grenier JM Datta SR Fornace AJ Jr. DiStefano PS Chiang LW Greenberg ME DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein Science 2002 296 5567 530-534 10.1126/science.1068712 11964479
31. Glauser DA Schlegel W The emerging role of FOXO transcription factors in pancreatic beta cells J Endocrinol 2007 193 2 195-207 10.1677/ JOE-06-0191 17470511
32. Rhee SG Kang SW Jeong W Chang TS Yang KS Woo HA Intracellular messenger function of hydrogen peroxide and its regulation by peroxiredoxins Curr Opin Cell Biol 2005 17 2 183-189 10.1016/j.ceb.2005.02.004 15780595
33. Findlay VJ Townsend DM Morris TE Fraser JP He L Tew KD A novel role for human sulfiredoxin in the reversal of glutathionylation Cancer Res 2006 66 13 6800-6806 10.1158/0008-5472.CAN-06-0484 16818657
34. Evans JL Goldfine ID Maddux BA Grodsky GM Are oxidative stress-activated signaling pathways mediators of insulin resistance and beta-cell dysfunction? Diabetes 2003 52 1 1-8 10.2337/diabetes.52.1.1 12502486
35. Lilla V Webb G Rickenbach K Maturana A Steiner DF Halban PA Irminger JC Differential gene expression in well-regulated and dysregulated pancreatic beta-cell (MIN6) sublines Endocrinology 2003 144 4 1368-1379 10.1210/en.2002-220916 12639920
36. Pipeleers DG in't Veld PA Van de Winkel M Maes E Schuit FC Gepts W A new in vitro model for the study of pancreatic A and B cells Endocrinology 1985 117 3 806-816 2862019
37. Gauthier BR Brun T Sarret EJ Ishihara H Schaad O Descombes P Wollheim CB Oligonucleotide microarray analysis reveals PDX1 as an essential regulator of mitochondrial metabolism in rat islets J Biol Chem 2004 279 30 31121-31130 10.1074/jbc.M405030200 15151993
38. Liu WM Mei R Di X Ryder TB Hubbell E Dee S Webster TA Harrington CA Ho MH Baid J Smeekens SP Analysis of high density expression microarrays with signed-rank call algorithms Bioinformatics 2002 18 12 1593-1599 10.1093/bioinformatics/18.12.1593 12490443
39. Hubbell E Liu WM Mei R Robust estimators for expression analysis Bioinformatics 2002 18 12 1585-1592 10.1093/bioinformatics/18.12.1585 12490442
40. Brun T Franklin I St-Onge L Biason-Lauber A Schoenle EJ Wollheim CB Gauthier BR The diabetes-linked transcription factor PAX4 promotes {beta}-cell proliferation and survival in rat and human islets J Cell Biol 2004 167 6 1123-1135 10.1083/jcb.200405148 15596543
41. TFExplorer http://tfexplorer.org/
42. Schreiber E Matthias P Muller MM Schaffner W Identification of a novel lymphoid specific octamer binding protein (OTF-2B) by proteolytic clipping bandshift assay (PCBA) Embo J 1988 7 13 4221-4229 455135 3072196
43. Steinmuller L Cibelli G Moll JR Vinson C Thiel G Regulation and composition of activator protein 1 (AP-1) transcription factors controlling collagenase and c-Jun promoter activities Biochem J 2001 360 Pt 3 599-607 1222262 11736649 10.1042/0264-6021:3600599
44. Reffas S Schlegel W Compartment-specific regulation of extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) mitogen-activated protein kinases (MAPKs) by ERK-dependent and non-ERK-dependent inductions of MAPK phosphatase (MKP)-3 and MKP-1 in differentiating P19 cells Biochem J 2000 352 Pt 3 701-708 1221507 11104676 10.1042/0264-6021:3520701
45. Array Express http://www.ebi.ac.uk/arrayexpress